Investigation of the mechanism and apoptotic pathway induced by 4b cinnamido linked podophyllotoxins against human lung cancer cells A549

Apoptosis

Volumn 20, Issue 11, 2015, Pages 1518-1529

  Kamal, Ahmed ^a,b   Nayak, V Lakshma ^a   Bagul, Chandrakant ^b   Vishnuvardhan, M V P S ^a   Mallareddy, Adla ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Annexin V FITC; Anticancer activity; Apoptosis; Topoisomerase II and II ; Western blot analysis

Indexed keywords

4BETA CINNAMIDO LINKED PODOPHYLLOTOXIN; ACETYLCYSTEINE; CASPASE 3; CYTOCHROME C; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) A; ETOPOSIDE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PODOPHYLLOTOXIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; LUNG NEOPLASMS; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CYTOCHROMES C; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR STRUCTURE; PODOPHYLLOTOXIN; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES;

EID: 84942552908     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1173-6     Document Type: Article

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