Synthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Keerthy, Hosadurga K ^a   Garg, Manoj ^b   Mohan, Chakrabhavi D ^c   Madan, Vikas ^b   Kanojia, Deepika ^b   Shobith, Rangappa ^d   Nanjundaswamy, Shivananju ^c   Mason, Daniel J ^e   Bender, Andreas ^e   Basappa, ^a   Rangappa, Kanchugarakoppal S ^c   Koeffler, H Phillip ^b,f  

^a BANGALORE UNIVERSITY   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF MYSORE   (India)

^d SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f Cedar Sinai Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 (1H INDOL 3 YL) 4H BENZO[G]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (1H INDOL 3 YL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (2 BUTYL 4 CHLORO 1H IMIDAZOL 5 YL) 4H BENZO[G]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (2 BUTYL 4 CHLORO 1H IMIDAZOL 5 YL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (2 BUTYL 4 CHLORO 1H IMIDAZOL 5 YL) 7 HYDROXY 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 (2 METHYL 1H INDOL 3 YL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (2 NITROPHENYL) 4H BENZO[G]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (2,6 DICHLOROPHENYL) 4H BENZO[G]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (3 NITROPHENYL) 4H BENZO[G]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (3,4 DIMETHOXYPHENYL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 BROMOPHENYL) 4H BENZO[G]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 BROMOPHENYL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 FLUOROPHENYL) 4H BENZO[G]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 FLUOROPHENYL) 7 HYDROXY 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 OXO 4H CHROMEN 3 YL) 4H BENZO[G]CHROMENE 3 CARBONITRILE; 2 AMINO 5 OXO 4 (4 OXO 4H CHROMEN 3 YL) 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 7 HYDROXY 4 (1H INDOL 3 YL) 4H CHROMENE 3 CARBONITRILE; 2 AMINOCHROMENE 3 CARBONITRILE DERIVATIVE; 2 AMINOCHROMENENITRILE DERIVATIVE; 2' AMINO 7' HYDROXY 4 OXO 4H 4' [3,4' BICHROMENE] 3' CARBONITRILE; ALCOHOL DERIVATIVE; ANTILEUKEMIC AGENT; CASPASE 9; DIMETHYL SULFOXIDE; MALANONITRILE; NAVITOCLAX; NITRILE; PHENOL DERIVATIVE; PROTEIN BCL 2; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTINEOPLASTIC AGENT; BCL2 PROTEIN, HUMAN; BENZOPYRAN DERIVATIVE;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOLECULAR DOCKING; MOLECULAR INTERACTION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; IC50; LEUKEMIA, MYELOID, ACUTE; MOLECULARLY TARGETED THERAPY; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZOPYRANS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA, MYELOID, ACUTE; MOLECULAR DOCKING SIMULATION; MOLECULAR TARGETED THERAPY; NITRILES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84907486209     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107118     Document Type: Article

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