2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7136-7150

  Kamal, Ahmed ^a,c   Srikanth, Y V V ^a   Naseer Ahmed Khan, M ^a   Ashraf, Md ^a   Kashi Reddy, M ^a   Sultana, Farheen ^a   Kaur, Tandeep ^b   Chashoo, Gousia ^b   Suri, Nitasha ^b   Sehar, Irum ^b   Wani, Zahoor A ^b   Saxena, Arpita ^b   Sharma, Parduman R ^b   Bhushan, Shashi ^b   Mondhe, Dilip M ^b   Saxena, Ajit K ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

2 Anilinonicotinyl aminothiazoles; Apoptosis; Caspases; Cell cycle arrest; Cytotoxicity; Triazolobenzothiadiazines

Indexed keywords

10 METHYL 2 [2 (3,4,5 TRIFLUOROANILINO) 3 PYRIDYL] 5,10 DIHYDRO 5 SIGMA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 (2 ANILINO 3 PYRIDYL) 10 METHYL 5,10 DIHYDRO 5 SIGMA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 [2 (4 CHLOROANILINO) 3 PYRIDYL] 10 METHYL 5,10 DIHYDRO 5 SIGMA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 [2 (4 METHOXYANILINO) 3 PYRIDYL] 10 METHYL 5,10 DIHYDRO 5 SIGMA 6 BENZO[E][1,2,4]TRIAZOLO[1,5 B][1,2,4]THIADIAZINE 5,5 DIONE; 2 ANILINONICOTINYL LINKED 2 AMINOBENZOTHIAZOLE DERIVATIVE; [1,2,4]TRIAZOLO[1,5 B][1,2,4]BENZOTHIADIAZINE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOTHIADIAZINE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; CASPASE 3; DNA; FLUOROURACIL; MITOMYCIN C; N 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL) 2 (3 CHLORO 4 FLUOROANILINO)NICOTINAMIDE; N 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL) 2 (4 CHLOROANILINO)NICOTINAMIDE; N 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL) 2 (4 FLUOROANILINO)NICOTINAMIDE; N 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL) 2 (4 METHOXYANILINO)NICOTINAMIDE; N 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL) 2 (PHENYLAMINO) 3 PYRIDINECARBOXAMIDE; N 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL) 2 [(2,4 DICHLOROPHENYL)AMINO] 3 PYRIDINECARBOXAMIDE; N 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL) 2 [(3,4,5 TRIFLUOROPHENYL)AMINO] 3 PYRIDINECARBOXAMIDE; N 3 [6 (METHYLOXY) 1,3 BENZOTHIAZOL 2 YL] 2 [(2,4 DICHLOROPHENYL)AMINO] 3 PYRIDINECARBOXAMIDE; N 3 [6 (METHYLOXY) 1,3 BENZOTHIAZOL 2 YL] 2 [(3,4,5 TRIFLUOROPHENYL)AMINO] 3 PYRIDINECARBOXAMIDE; N 3 [6 (METHYLOXY) 1,3 BENZOTHIAZOL 2 YL] 2 [(4 CHLORO 3 FLUOROPHENYL)AMINO] 3 PYRIDINECARBOXAMIDE; N 3 [6 (METHYLOXY) 1,3 BENZOTHIAZOL 2 YL] 2 [(4 CHLOROPHENYL)AMINO] 3 PYRIDINECARBOXAMIDE; N 3 [6 (METHYLOXY) 1,3 BENZOTHIAZOL 2 YL] 2 [(4 FLUOROPHENYL)AMINO] 3 PYRIDINECARBOXAMIDE; N 3 [6 (METHYLOXY) 1,3 BENZOTHIAZOL 2 YL] 2 [4 (METHYLOXY)PHENYL]AMINO 3 PYRIDINECARBOXAMIDE; N 3 [6 (METHYLOXY) 1,3 BENZOTHIAZOL 2 YL] 2(PHENYLAMINO) 3 PYRIDINECARBOXAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL DAMAGE; CELL DEATH; CELL NUCLEUS; CELL STRAIN HL 60; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME DEGRADATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; SCANNING ELECTRON MICROSCOPY;

ANILINE COMPOUNDS; ANIMALS; APOPTOSIS; BENZOTHIADIAZINES; CASPASES; CELL CYCLE; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GROWTH INHIBITORS; HAPLORHINI; HL-60 CELLS; HUMANS; MITOCHONDRIA; NICOTINE;

EID: 80655132866     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.060     Document Type: Article

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