Fermented So-Cheong-Ryong-Tang (FCY) induces apoptosis via the activation of caspases and the regulation of MAPK signaling pathways in cancer cells

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Yim, Nam Hui ^a   Kim, Aeyung ^a   Jung, Young Pil ^a   Kim, Taesoo ^a   Ma, Choong Je ^b   Ma, Jin Yeul ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

Apoptosis; Caspase activity; Fermentation; Mitogen activated protein kinases (MAPKs); Socheongryong tang (CY); Xenograft assay

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL FACTOR; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN B1; CYCLIN E1; EPHEDRINE; GINGEROL; GLYCYRRHIZIC ACID; GOMISIN A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PLANT MEDICINAL PRODUCT; PROTEIN P21; PROTEIN P27; SCHIZANDRIN; SO CHEONG RYONG TANG; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; HERBACEOUS AGENT; SHO-SEIRYU-TO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; FERMENTATION; G2 PHASE CELL CYCLE CHECKPOINT; GASTRIC CANCER CELL LINE; HERBAL MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PHYTOCHEMISTRY; PROTEIN EXPRESSION; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CELL CYCLE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HCT 116 CELL LINE; METABOLISM; NUDE MOUSE; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DRUGS, CHINESE HERBAL; FEMALE; FERMENTATION; HCT116 CELLS; HUMANS; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84942314233     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0821-2     Document Type: Article

References (44)

1. Lee HJ, Lee EO, Rhee YH, Ahn KS, Li GX, Jiang C, et al. An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. Carcinogenesis. 2006;27:2455-63.
2. Zhang Z, Wang Y, Yao R, Li J, Yan Y, La Regina M, et al. Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models. Oncogene. 2004;23:3841-50.
3. Richardson MA, Straus SE. Complementary and alternative medicine: opportunities and challenges for cancer management and research. Semin Oncol. 2002;29:531-45.
4. Buchanan DR, White JD, O'Mara AM, Kelaghan JW, Smith WB, Minasian LM. Research-design issues in cancer-symptom-management trials using complementary and alternative medicine: lessons from the National Cancer Institute Community Clinical Oncology Program experience. J Clin Oncol. 2005;23:6682-9.
5. Zha Q, Lin S, Zhang C, Chang C, Xue H, Lu C, et al. Xiaoqinglong granules as add-on therapy for asthma: latent class analysis of symptom predictors of response. Evid Based Complement Alternat Med. 2013;2013:759476.
6. Tanaka A, Ohashi Y, Kakinoki Y, Washio Y, Yamada K, Nakai Y, et al. The herbal medicine shoseiryu-to inhibits allergen-induced synthesis of tumour necrosis factor alpha by peripheral blood mononuclear cells in patients with perennial allergic rhinitis. Acta Otolaryngol Suppl. 1998;538:118-25.
7. Hwang MW, Lee HJ, Song HJ, Kim BJ. Involvement of MAPKs and PLC pathways in modulation of pacemaking activity by So-Cheong-Ryong-Tang in interstitial cells of Cajal from murine small intestine. ScientificWorldJournal. 2013;2013:536350.
8. Zhang C, Feng L, Li M, Dong C, Zhang W. Effects of Xiaoqinglong decoction on gene expression profiles in a rat chronic obstructive pulmonary disease model. Biosci Trends. 2012;6:262-9.
9. Park C, Hong SH, Kim GY, Choi YH. So-Cheong-Ryong-Tang induces apoptosis through activation of the intrinsic and extrinsic apoptosis pathways, and inhibition of the PI3K/Akt signaling pathway in non-small-cell lung cancer A549 cells. BMC Complement Altern Med. 2015;15:113.
10. Lee JS, Oh SY, Seo S, Kim T, Ma JY. Protective effect of Socheongryong-Tang on hydrogen peroxide-induced hepatotoxicity. Korea J Herbology. 2011;26:133-7.
11. Nam NH, Lee CW, Hong DH, Kim HM, Bae KH, Ahn BZ. Antiinvasive, antiangiogenic and antitumour activity of Ephedra sinica extract. Phytother Res. 2003;17:70-6.
12. Tang SH, He RR, Huang T, Wang CZ, Cao YF, Zhang Y, et al. The protective effect of Schisandra lignans on stress-evoked hepatic metastases of P815 tumor cells in restraint mice. J Ethnopharmacol. 2011;134:141-6.
13. Kwon HK, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, et al. Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1. BMC Cancer. 2010;10:392.
14. Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra root. Food Chem Toxicol. 2007;45:2470-8.
15. Li GL, Jiang W, Xia Q, Chen SH, Ge XR, Gui SQ, et al. HPV E6 down-regulation and apoptosis induction of human cervical cancer cells by a novel lipid-soluble extract (PE) from Pinellia pedatisecta Schott in vitro. J Ethnopharmacol. 2010;132:56-64.
16. Elkady AI, Abuzinadah OA, Baeshen NA, Rahmy TR. Differential control of growth, apoptotic activity, and gene expression in human breast cancer cells by extracts derived from medicinal herbs Zingiber officinale. J Biomed Biotechnol. 2012;2012:614356.
17. Kundoor V, Zhang X, Bommareddy A, Khalifa S, Fahmy H, Dwivedi C. Chemopreventive effects of sarcotriol on ultraviolet B-induced skin tumor development in SKH-1 hairless mice. Mar Drugs. 2007;5:197-207.
18. Sarfaraz S, Adhami VM, Syed DN, Afaq F, Mukhtar H. Cannabinoids for cancer treatment: progress and promise. Cancer Res. 2008;68:339-42.
19. Fan M, Chambers TC. Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist Updat. 2001;4:253-67.
20. Dent P, Grant S. Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action. Clin Cancer Res. 2001;7:775-83.
21. Oh YC, Cho WK, Oh JH, Im GY, Jeong YH, Yang MC, et al. Fermentation by Lactobacillus enhances anti-inflammatory effect of Oyaksungisan on LPS-stimulated RAW 264.7 mouse macrophage cells. BMC Complement Altern Med. 2012;12:17.
22. Shim KS, Kim T, Ha H, Lee KJ, Cho CW, Kim HS, et al. Lactobacillus fermentation enhances the inhibitory effect of Hwangryun-haedok-tang in an ovariectomy-induced bone loss. BMC Complement Altern Med. 2013;13:106.
23. Oh YC, Cho WK, Jeong YH, Im GY, Yang MC, Ma JY. Fermentation improves anti-inflammatory effect of sipjeondaebotang on LPS-stimulated RAW 264.7 cells. Am J Chin Med. 2012;40:813-31.
24. Weon JB, Yang HJ, Lee B, Ma JY, Ma CJ. Simultaneous quantification of eleven chemical components in traditional herbal medicinal formula socheongryongtang by HPLC-DAD and LC-MS. J Liq Chromatogr Relat Technol. 2012;35:2243-54.
25. Shimada T, Kondoh M, Motonaga C, Kitamura Y, Cheng L, Shi H, et al. Enhancement of anti-allergic effects mediated by the Kampo medicine Shoseiryuto (Xiao-Qing-Long-Tang in Chinese) with lysed Enterococcus faecalis FK-23 in mice. Asian Pac J Allergy Immunol. 2010;28:59-66.
26. Yim NH, Jung YP, Kim A, Ma CJ, Cho WK, Ma JY. Oyaksungisan, a traditional herbal formula, inhibits cell proliferation by induction of autophagy via JNK activation in human colon cancer cells. Evid Based Complement Alternat Med. 2013;2013:231874.
27. Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007;130:769-74.
28. Xue T, Roy R. Studying traditional Chinese medicine. Science. 2003;300(5620):740-1.
29. Ko E, Rho S, Cho C, Choi H, Ko S, Lee Y, et al. So-Cheong-Ryong-Tang, tradititional Korean medicine, suppresses Th2 lineage development. Biol Pharm Bull. 2004;27:739-43.
30. Saraste A, Pulkki K. Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res. 2000;45:528-37.
31. Sheikh MS, Huang Y. Death receptors as targets of cancer therapeutics. Curr Cancer Drug Targets. 2004;4:97-104.
32. Vermeulen K, Van Bockstaele DR, Berneman ZN. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 2003;36:131-49.
33. Bartek J, Lukas J. Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol. 2001;13:738-47.
34. Lobrich M, Jeggo PA. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer. 2007;7:861-9.
35. Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci. 2006;31:268-75.
36. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr. 2000;130:2073S-85.
37. Izumi T, Piskula MK, Osawa S, Obata A, Tobe K, Saito M, et al. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr. 2000;130:1695-9.
38. Schubert SY, Lansky EP, Neeman I. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol. 1999;66:11-7.
39. Hibasami H, Iwase H, Yoshioka K, Takahashi H. Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells. Int J Mol Med. 2005;16:233-6.
40. Kim SJ, Min HY, Lee EJ, Kim YS, Bae K, Kang SS, et al. Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells. Phytother Res. 2010;24:193-7.
41. Waiwut P, Shin MS, Yokoyama S, Saiki I, Sakurai H. Gomisin A enhances tumor necrosis factor-alpha-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein. Biol Pharm Bull. 2012;35:1997-2003.
42. Chakraborty D, Bishayee K, Ghosh S, Biswas R, Mandal SK, Khuda-Bukhsh AR. [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells. Eur J Pharmacol. 2012;694:20-9.
43. Lin CB, Lin CC, Tsay GJ. 6-gingerol inhibits growth of colon cancer cell LoVo via induction of G2/M arrest. Evid Based Complement Alternat Med. 2012;2012:326096.
44. Jeong CH, Bode AM, Pugliese A, Cho YY, Kim HG, Shim JH, et al. [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res. 2009;69:5584-91.