Antiinvasive, antiangiogenic and antitumour activity of Ephedra sinica extract

Phytotherapy Research

Volumn 17, Issue 1, 2003, Pages 70-76

  Nam, Nguyen Hai ^a   Lee, Chang Woo ^b   Hong, Dong Ho ^b   Kim, Hwan Mook ^b   Bae, Ki Hwan ^a   Ahn, Byung Zun ^a  

^a Chungnam National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Antiangiogenic activity; Antiinvasive activity; Antitumour activity; Cytotoxicity; Ephedra sinica

Indexed keywords

ACETIC ACID ETHYL ESTER; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BUTANOL; DOXORUBICIN; EPHEDRA SINICA EXTRACT; METHANOL; UNCLASSIFIED DRUG; WATER;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; ENDOTHELIUM CELL; EPHEDRA SINICA; EXTRACTION; HUMAN; HUMAN CELL; MELANOMA CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; EPHEDRA SINICA; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED STRAINS; NEOVASCULARIZATION, PATHOLOGIC; PHYTOTHERAPY; PLANT EXTRACTS;

EPHEDRA; EPHEDRA SINICA; MURINAE;

EID: 0037272578     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.901     Document Type: Article

References (29)

1. Al-Khalil S, Alkofahi A, El-Eisawi D, Al-Shibib A. 1998. Transtorine, a new quinoline alkaloid from Ephedra transitoria. J Nat Prod 61: 262-263.
2. Crum R, Szabo S, Folkman J. 1985. A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment. Science 230: 1375-1378.
3. D'Amato RJ, Loughnan MS, Flynn E, Folkman J. 1994. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci 91: 4082-4085.
4. Folkman J. 1990. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6.
5. Gastl G, Hermann T, Steurer M et al. 1997. Angiogenesis as a target for tumor treatment. Oncology 54: 177-184.
6. Hikino H, Ogata M, Konno C. 1982a. Structure of ephedradin D, a hypotensive principle of Ephedra roots. Heterocycles 17: 155-158.
7. Hikino H, Ogata M, Konno C. 1983. Structure of feruloylhistamine, a hypotensive principle of Ephedra roots. Planta Med 48: 108-110.
8. Hikino H, Shimoyama N, Kasahara Y, Takahashi M, Konno C. 1982c. Study on the constituents of Ephedra roots. 10. The validity of oriental medicines. 35. Structure of mahuanin A and B, hypotensive principle of Ephedra roots. Heterocycles 19: 1381-1384.
9. Hikino H, Takahashi M, Konno C. 1982b. Study on the constituents of Ephedra. 10. The validity of oriental medicines. 33. Structure of ephedrannin A, a hypotensive principle of Ephedra roots. Tetrahedron Lett23: 673-676.
10. Horikawa K, Mohri T, Tanaka Y, Tokiwa H. 1994. Moderate inhibition of mutagenicity and carcinogenicity of benzo[a]pyrene, 1,6-dinitropyrene and 3,9-dinitrofluoranthene by Chinese medicinal herbs. Mutagenesis 9: 523-526.
11. Ingber D, Fujita T, Kishimoto S. 1990. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348: 555-557.
12. Kasahara Y, Hikino H. 1983. Studies on the constituents of Ephedra. 15. Structure of mahuanin D, a hypotensive principle of Ephedra roots. Heterocycles 20: 1953-1956.
13. Kasahara Y, Shimoyama N, Konno C, Hikino H. 1983. Study on the constituents of Ephedra. 14. Validity of oriental medicines. 59. Structure of mahuanin C, a hypotensive principle of Ephedra roots. Heterocycles 20: 1741-1744.
14. Konno C, Taguchi T, Tamada T, Hikino H. 1979. Ephedroxane, antiinflammatory principle of Ephedra herbs. Phytochemistry 18: 697-698.
15. Konno C, Tamada M, Endo K, Hikino H. 1980. Structure of ephedradin C, a hypotensive principle of Ephedra roots. Heterocycles 14: 295-298.
16. Konno H, Tanaka T, Matsuda I. 1995. Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and mitomycin C on the growth and liver metastasis of human colon cancer. Int J Cancer 62: 268-271.
17. Kumazawa Y, Nakatsuru Y, Fujisawa H et al. 1985. Lymphocyte activation by a polysaccharide fraction separated from hot water extracts of Angelica acutiloba Kitagawa. J Pharmacobio Dyn 8: 417-424.
18. Ladenburg A, Oelschagel C. 1989. Uber das Pseudo-Ephedrine. Chem Ber22: 1823-1827.
19. Loi DT. 1997. Vietnamese Medicinal Plants and Prescriptions, 3rd edn, Science and Technology Publishing House, Hanoi, Vietnam.
20. Mori S, Ueda T, Kuratsu S. 1995. Suppression of pulmonary metastasis by angiogenesis inhibitor TNP-470 in murine osteosarcoma. Int J Cancer 61: 148-151.
21. O'Reilly MS, Homgren L, Shing Y. 1994. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315-328.
22. Price JT, Bonovich MT, Kohn EC. 1997. The biochemistry of cancer dissemination. Crit Rev Biochem Mol Biol 32: 175-253.
23. Skehan P, Storeng R, Scudiero D et al. 1990. New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst 82: 1107-1112.
24. Tamada M, Endo K, Hikino H. 1978. Study on the constituents of Ephedra. II. Maokonine, hypotensive principle of Ephedra roots. Planta Med 34: 291-293.
25. Tamada M, Endo K, Hikino H, Kabuto C. 1979a. Structure of ephedradin A, a hypotensive principle of Ephedra roots. Tetrahedron Lett 873-876.
26. Tamada M, Endo K, Hikino H. 1979b. Structure of ephedradin B, a hypotensive principle of Ephedra roots. Heterocycles 12:783-786.
27. Weinstat-Saslow DL, Zabrenetzky VS, VanHoutte K. 1994. Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. Cancer Res 54: 6504-6511.
28. Wu L, Smythe AM, Stinson SF et al. 1992. Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. Cancer Res 52: 3029-3034.
29. Zetter BR. 1998. Angiogenesis and tumor metastasis. Annu Rev Med 49: 407-724.