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Volumn 34, Issue , 2015, Pages 14-21

Lymphomagenesis in Hodgkin lymphoma

Author keywords

Classical Hodgkin lymphoma; Hodgkin and Reed Sternberg cells; JAK STAT; Microenvironment; NF B

Indexed keywords

CD30 LIGAND; CD40 LIGAND; EOTAXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 8; INTERLEUKIN 9; JANUS KINASE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROGRAMMED DEATH 1 LIGAND 1; RANTES; STAT PROTEIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNINDEXED DRUG; CHEMOKINE; CYTOKINE;

EID: 84942292736     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2015.02.002     Document Type: Review
Times cited : (29)

References (121)
  • 1
    • 0001785009 scopus 로고
    • On some morbid appearances of the absorbent glands and spleen
    • Hodgkin On some morbid appearances of the absorbent glands and spleen. Med-Chir Trans 1832, 17:68-114.
    • (1832) Med-Chir Trans , vol.17 , pp. 68-114
  • 3
    • 0029952779 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
    • Kanzler H., Kuppers R., Hansmann M.L., Rajewsky K. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 1996, 184:1495-1505.
    • (1996) J Exp Med , vol.184 , pp. 1495-1505
    • Kanzler, H.1    Kuppers, R.2    Hansmann, M.L.3    Rajewsky, K.4
  • 4
    • 17044443197 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription
    • Marafioti T., Hummel M., Foss H.D., Laumen H., Korbjuhn P., Anagnostopoulos I., et al. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 2000, 95:1443-1450.
    • (2000) Blood , vol.95 , pp. 1443-1450
    • Marafioti, T.1    Hummel, M.2    Foss, H.D.3    Laumen, H.4    Korbjuhn, P.5    Anagnostopoulos, I.6
  • 7
    • 36348975831 scopus 로고    scopus 로고
    • A clinicopathological study of B-cell differentiation markers and transcription factors in classical Hodgkin's lymphoma: a potential prognostic role of MUM1/IRF4
    • Valsami S., Pappa V., Rontogianni D., Kontsioti F., Papageorgiou E., Dervenoulas J., et al. A clinicopathological study of B-cell differentiation markers and transcription factors in classical Hodgkin's lymphoma: a potential prognostic role of MUM1/IRF4. Haematologica 2007, 92:1343-1350.
    • (2007) Haematologica , vol.92 , pp. 1343-1350
    • Valsami, S.1    Pappa, V.2    Rontogianni, D.3    Kontsioti, F.4    Papageorgiou, E.5    Dervenoulas, J.6
  • 8
    • 0028007479 scopus 로고
    • Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development
    • Kuppers R., Rajewsky K., Zhao M., Simons G., Laumann R., Fischer R., et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci U S A 1994, 91:10962-10966.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10962-10966
    • Kuppers, R.1    Rajewsky, K.2    Zhao, M.3    Simons, G.4    Laumann, R.5    Fischer, R.6
  • 9
    • 0034658050 scopus 로고    scopus 로고
    • Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease
    • Seitz V., Hummel M., Marafioti T., Anagnostopoulos I., Assaf C., Stein H. Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease. Blood 2000, 95:3020-3024.
    • (2000) Blood , vol.95 , pp. 3020-3024
    • Seitz, V.1    Hummel, M.2    Marafioti, T.3    Anagnostopoulos, I.4    Assaf, C.5    Stein, H.6
  • 11
    • 18844465632 scopus 로고    scopus 로고
    • Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
    • Bargou R.C., Emmerich F., Krappmann D., Bommert K., Mapara M.Y., Arnold W., et al. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Investig 1997, 100:2961-2969.
    • (1997) J Clin Investig , vol.100 , pp. 2961-2969
    • Bargou, R.C.1    Emmerich, F.2    Krappmann, D.3    Bommert, K.4    Mapara, M.Y.5    Arnold, W.6
  • 12
    • 0033611588 scopus 로고    scopus 로고
    • Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells
    • Krappmann D., Emmerich F., Kordes U., Scharschmidt E., Dorken B., Scheidereit C. Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene 1999, 18:943-953.
    • (1999) Oncogene , vol.18 , pp. 943-953
    • Krappmann, D.1    Emmerich, F.2    Kordes, U.3    Scharschmidt, E.4    Dorken, B.5    Scheidereit, C.6
  • 14
    • 0037079728 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
    • Skinnider B.F., Elia A.J., Gascoyne R.D., Patterson B., Trumper L., Kapp U., et al. Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 2002, 99:618-626.
    • (2002) Blood , vol.99 , pp. 618-626
    • Skinnider, B.F.1    Elia, A.J.2    Gascoyne, R.D.3    Patterson, B.4    Trumper, L.5    Kapp, U.6
  • 15
    • 84878232331 scopus 로고    scopus 로고
    • JAK/STAT signaling in hematological malignancies
    • Vainchenker W., Constantinescu S.N. JAK/STAT signaling in hematological malignancies. Oncogene 2013, 32:2601-2613.
    • (2013) Oncogene , vol.32 , pp. 2601-2613
    • Vainchenker, W.1    Constantinescu, S.N.2
  • 18
    • 38049105629 scopus 로고    scopus 로고
    • Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells
    • Flavell J.R., Baumforth K.R., Wood V.H., Davies G.L., Wei W., Reynolds G.M., et al. Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. Blood 2008, 111:292-301.
    • (2008) Blood , vol.111 , pp. 292-301
    • Flavell, J.R.1    Baumforth, K.R.2    Wood, V.H.3    Davies, G.L.4    Wei, W.5    Reynolds, G.M.6
  • 19
    • 46749136862 scopus 로고    scopus 로고
    • Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells
    • Baumforth K.R., Birgersdotter A., Reynolds G.M., Wei W., Kapatai G., Flavell J.R., et al. Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells. Am J Pathol 2008, 173:195-204.
    • (2008) Am J Pathol , vol.173 , pp. 195-204
    • Baumforth, K.R.1    Birgersdotter, A.2    Reynolds, G.M.3    Wei, W.4    Kapatai, G.5    Flavell, J.R.6
  • 20
    • 0032536860 scopus 로고    scopus 로고
    • Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor
    • Kilger E., Kieser A., Baumann M., Hammerschmidt W. Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J 1998, 17:1700-1709.
    • (1998) EMBO J , vol.17 , pp. 1700-1709
    • Kilger, E.1    Kieser, A.2    Baumann, M.3    Hammerschmidt, W.4
  • 21
    • 0033770573 scopus 로고    scopus 로고
    • The expression and function of Epstein-Barr virus encoded latent genes
    • Young L.S., Dawson C.W., Eliopoulos A.G. The expression and function of Epstein-Barr virus encoded latent genes. Mol Pathol 2000, 53:238-247.
    • (2000) Mol Pathol , vol.53 , pp. 238-247
    • Young, L.S.1    Dawson, C.W.2    Eliopoulos, A.G.3
  • 22
    • 0037423201 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling
    • Dawson C.W., Tramountanis G., Eliopoulos A.G., Young L.S. Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J Biol Chem 2003, 278:3694-3704.
    • (2003) J Biol Chem , vol.278 , pp. 3694-3704
    • Dawson, C.W.1    Tramountanis, G.2    Eliopoulos, A.G.3    Young, L.S.4
  • 23
    • 28844476555 scopus 로고    scopus 로고
    • Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes
    • Chaganti S., Bell A.I., Pastor N.B., Milner A.E., Drayson M., Gordon J., et al. Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes. Blood 2005, 106:4249-4252.
    • (2005) Blood , vol.106 , pp. 4249-4252
    • Chaganti, S.1    Bell, A.I.2    Pastor, N.B.3    Milner, A.E.4    Drayson, M.5    Gordon, J.6
  • 24
    • 0037441887 scopus 로고    scopus 로고
    • Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
    • Schwering I., Brauninger A., Klein U., Jungnickel B., Tinguely M., Diehl V., et al. Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 2003, 101:1505-1512.
    • (2003) Blood , vol.101 , pp. 1505-1512
    • Schwering, I.1    Brauninger, A.2    Klein, U.3    Jungnickel, B.4    Tinguely, M.5    Diehl, V.6
  • 26
    • 33644765802 scopus 로고    scopus 로고
    • Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma
    • Ushmorov A., Leithauser F., Sakk O., Weinhausel A., Popov S.W., Moller P., et al. Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma. Blood 2006, 107:2493-2500.
    • (2006) Blood , vol.107 , pp. 2493-2500
    • Ushmorov, A.1    Leithauser, F.2    Sakk, O.3    Weinhausel, A.4    Popov, S.W.5    Moller, P.6
  • 27
    • 8644227858 scopus 로고    scopus 로고
    • Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression
    • Ushmorov A., Ritz O., Hummel M., Leithauser F., Moller P., Stein H., et al. Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression. Blood 2004, 104:3326-3334.
    • (2004) Blood , vol.104 , pp. 3326-3334
    • Ushmorov, A.1    Ritz, O.2    Hummel, M.3    Leithauser, F.4    Moller, P.5    Stein, H.6
  • 28
    • 0037173743 scopus 로고    scopus 로고
    • Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma
    • Hertel C.B., Zhou X.G., Hamilton-Dutoit S.J., Junker S. Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma. Oncogene 2002, 21:4908-4920.
    • (2002) Oncogene , vol.21 , pp. 4908-4920
    • Hertel, C.B.1    Zhou, X.G.2    Hamilton-Dutoit, S.J.3    Junker, S.4
  • 29
    • 31344451370 scopus 로고    scopus 로고
    • Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
    • Mathas S., Janz M., Hummel F., Hummel M., Wollert-Wulf B., Lusatis S., et al. Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma. Nat Immunol 2006, 7:207-215.
    • (2006) Nat Immunol , vol.7 , pp. 207-215
    • Mathas, S.1    Janz, M.2    Hummel, F.3    Hummel, M.4    Wollert-Wulf, B.5    Lusatis, S.6
  • 30
    • 78650385740 scopus 로고    scopus 로고
    • IRF4 silencing inhibits Hodgkin lymphoma cell proliferation, survival and CCL5 secretion
    • Aldinucci D., Celegato M., Borghese C., Colombatti A., Carbone A. IRF4 silencing inhibits Hodgkin lymphoma cell proliferation, survival and CCL5 secretion. Br J Haematol 2011, 152:182-190.
    • (2011) Br J Haematol , vol.152 , pp. 182-190
    • Aldinucci, D.1    Celegato, M.2    Borghese, C.3    Colombatti, A.4    Carbone, A.5
  • 31
    • 72249086157 scopus 로고    scopus 로고
    • IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma
    • Aldinucci D., Rapana B., Olivo K., Lorenzon D., Gloghini A., Colombatti A., et al. IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma. Br J Haematol 2010, 148:115-118.
    • (2010) Br J Haematol , vol.148 , pp. 115-118
    • Aldinucci, D.1    Rapana, B.2    Olivo, K.3    Lorenzon, D.4    Gloghini, A.5    Colombatti, A.6
  • 32
    • 49449100160 scopus 로고    scopus 로고
    • Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma
    • Jundt F., Acikgoz O., Kwon S.H., Schwarzer R., Anagnostopoulos I., Wiesner B., et al. Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma. Leukemia 2008, 22:1587-1594.
    • (2008) Leukemia , vol.22 , pp. 1587-1594
    • Jundt, F.1    Acikgoz, O.2    Kwon, S.H.3    Schwarzer, R.4    Anagnostopoulos, I.5    Wiesner, B.6
  • 33
    • 0036566557 scopus 로고    scopus 로고
    • Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
    • Jundt F., Anagnostopoulos I., Forster R., Mathas S., Stein H., Dorken B. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 2002, 99:3398-3403.
    • (2002) Blood , vol.99 , pp. 3398-3403
    • Jundt, F.1    Anagnostopoulos, I.2    Forster, R.3    Mathas, S.4    Stein, H.5    Dorken, B.6
  • 34
    • 84859648359 scopus 로고    scopus 로고
    • Notch is an essential upstream regulator of NF-kappaB and is relevant for survival of Hodgkin and Reed-Sternberg cells
    • Schwarzer R., Dorken B., Jundt F. Notch is an essential upstream regulator of NF-kappaB and is relevant for survival of Hodgkin and Reed-Sternberg cells. Leukemia 2012, 26:806-813.
    • (2012) Leukemia , vol.26 , pp. 806-813
    • Schwarzer, R.1    Dorken, B.2    Jundt, F.3
  • 35
    • 33746584772 scopus 로고    scopus 로고
    • Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma
    • Renne C., Martin-Subero J.I., Eickernjager M., Hansmann M.L., Kuppers R., Siebert R., et al. Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma. Am J Pathol 2006, 169:655-664.
    • (2006) Am J Pathol , vol.169 , pp. 655-664
    • Renne, C.1    Martin-Subero, J.I.2    Eickernjager, M.3    Hansmann, M.L.4    Kuppers, R.5    Siebert, R.6
  • 36
    • 33947586159 scopus 로고    scopus 로고
    • Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications
    • Jost P.J., Ruland J. Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood 2007, 109:2700-2707.
    • (2007) Blood , vol.109 , pp. 2700-2707
    • Jost, P.J.1    Ruland, J.2
  • 37
    • 85047695761 scopus 로고    scopus 로고
    • Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells
    • Horie R., Watanabe T., Morishita Y., Ito K., Ishida T., Kanegae Y., et al. Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells. Oncogene 2002, 21:2493-2503.
    • (2002) Oncogene , vol.21 , pp. 2493-2503
    • Horie, R.1    Watanabe, T.2    Morishita, Y.3    Ito, K.4    Ishida, T.5    Kanegae, Y.6
  • 38
    • 68249135153 scopus 로고    scopus 로고
    • Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases
    • Lake A., Shield L.A., Cordano P., Chui D.T., Osborne J., Crae S., et al. Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases. Int J Cancer 2009, 125:1334-1342.
    • (2009) Int J Cancer , vol.125 , pp. 1334-1342
    • Lake, A.1    Shield, L.A.2    Cordano, P.3    Chui, D.T.4    Osborne, J.5    Crae, S.6
  • 39
    • 77449151833 scopus 로고    scopus 로고
    • Mutations of NFKBIA in biopsy specimens from Hodgkin lymphoma
    • Liu X., Yu H., Yang W., Zhou X., Lu H., Shi D. Mutations of NFKBIA in biopsy specimens from Hodgkin lymphoma. Cancer Genet Cytogenet 2010, 197:152-157.
    • (2010) Cancer Genet Cytogenet , vol.197 , pp. 152-157
    • Liu, X.1    Yu, H.2    Yang, W.3    Zhou, X.4    Lu, H.5    Shi, D.6
  • 40
    • 0037082477 scopus 로고    scopus 로고
    • Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2
    • Joos S., Menz C.K., Wrobel G., Siebert R., Gesk S., Ohl S., et al. Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2. Blood 2002, 99:1381-1387.
    • (2002) Blood , vol.99 , pp. 1381-1387
    • Joos, S.1    Menz, C.K.2    Wrobel, G.3    Siebert, R.4    Gesk, S.5    Ohl, S.6
  • 42
    • 66049161737 scopus 로고    scopus 로고
    • A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme
    • Malynn B.A., Ma A. A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme. J Exp Med 2009, 206:977-980.
    • (2009) J Exp Med , vol.206 , pp. 977-980
    • Malynn, B.A.1    Ma, A.2
  • 43
    • 66049124247 scopus 로고    scopus 로고
    • TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
    • Schmitz R., Hansmann M.L., Bohle V., Martin-Subero J.I., Hartmann S., Mechtersheimer G., et al. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med 2009, 206:981-989.
    • (2009) J Exp Med , vol.206 , pp. 981-989
    • Schmitz, R.1    Hansmann, M.L.2    Bohle, V.3    Martin-Subero, J.I.4    Hartmann, S.5    Mechtersheimer, G.6
  • 44
    • 46749111541 scopus 로고    scopus 로고
    • Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells
    • Saitoh Y., Yamamoto N., Dewan M.Z., Sugimoto H., Martinez Bruyn V.J., Iwasaki Y., et al. Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Blood 2008, 111:5118-5129.
    • (2008) Blood , vol.111 , pp. 5118-5129
    • Saitoh, Y.1    Yamamoto, N.2    Dewan, M.Z.3    Sugimoto, H.4    Martinez Bruyn, V.J.5    Iwasaki, Y.6
  • 45
    • 84861529287 scopus 로고    scopus 로고
    • Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma
    • Otto C., Giefing M., Massow A., Vater I., Gesk S., Schlesner M., et al. Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma. Br J Haematol 2012, 157:702-708.
    • (2012) Br J Haematol , vol.157 , pp. 702-708
    • Otto, C.1    Giefing, M.2    Massow, A.3    Vater, I.4    Gesk, S.5    Schlesner, M.6
  • 46
    • 84868540424 scopus 로고    scopus 로고
    • Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival
    • Ranuncolo S.M., Pittaluga S., Evbuomwan M.O., Jaffe E.S., Lewis B.A. Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival. Blood 2012, 120:3756-3763.
    • (2012) Blood , vol.120 , pp. 3756-3763
    • Ranuncolo, S.M.1    Pittaluga, S.2    Evbuomwan, M.O.3    Jaffe, E.S.4    Lewis, B.A.5
  • 48
    • 33745619800 scopus 로고    scopus 로고
    • Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma
    • [author reply 2-3]
    • Martin-Subero J.I., Wlodarska I., Bastard C., Picquenot J.M., Hoppner J., Giefing M., et al. Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma. Blood 2006, 108:401-402. [author reply 2-3].
    • (2006) Blood , vol.108 , pp. 401-402
    • Martin-Subero, J.I.1    Wlodarska, I.2    Bastard, C.3    Picquenot, J.M.4    Hoppner, J.5    Giefing, M.6
  • 49
    • 0036707512 scopus 로고    scopus 로고
    • Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity
    • Hinz M., Lemke P., Anagnostopoulos I., Hacker C., Krappmann D., Mathas S., et al. Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J Exp Med 2002, 196:605-617.
    • (2002) J Exp Med , vol.196 , pp. 605-617
    • Hinz, M.1    Lemke, P.2    Anagnostopoulos, I.3    Hacker, C.4    Krappmann, D.5    Mathas, S.6
  • 50
    • 47149098995 scopus 로고    scopus 로고
    • IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis
    • Scheeren F.A., Diehl S.A., Smit L.A., Beaumont T., Naspetti M., Bende R.J., et al. IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis. Blood 2008, 111:4706-4715.
    • (2008) Blood , vol.111 , pp. 4706-4715
    • Scheeren, F.A.1    Diehl, S.A.2    Smit, L.A.3    Beaumont, T.4    Naspetti, M.5    Bende, R.J.6
  • 51
    • 0343820067 scopus 로고    scopus 로고
    • Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells
    • Joos S., Kupper M., Ohl S., von Bonin F., Mechtersheimer G., Bentz M., et al. Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells. Cancer Res 2000, 60:549-552.
    • (2000) Cancer Res , vol.60 , pp. 549-552
    • Joos, S.1    Kupper, M.2    Ohl, S.3    von Bonin, F.4    Mechtersheimer, G.5    Bentz, M.6
  • 52
    • 79954606783 scopus 로고    scopus 로고
    • JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma
    • Van Roosbroeck K., Cox L., Tousseyn T., Lahortiga I., Gielen O., Cauwelier B., et al. JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma. Blood 2011, 117:4056-4064.
    • (2011) Blood , vol.117 , pp. 4056-4064
    • Van Roosbroeck, K.1    Cox, L.2    Tousseyn, T.3    Lahortiga, I.4    Gielen, O.5    Cauwelier, B.6
  • 53
    • 33646382121 scopus 로고    scopus 로고
    • Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation
    • Weniger M.A., Melzner I., Menz C.K., Wegener S., Bucur A.J., Dorsch K., et al. Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation. Oncogene 2006, 25:2679-2684.
    • (2006) Oncogene , vol.25 , pp. 2679-2684
    • Weniger, M.A.1    Melzner, I.2    Menz, C.K.3    Wegener, S.4    Bucur, A.J.5    Dorsch, K.6
  • 54
    • 14944339657 scopus 로고    scopus 로고
    • Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR
    • Dutton A., Reynolds G.M., Dawson C.W., Young L.S., Murray P.G. Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR. J Pathol 2005, 205:498-506.
    • (2005) J Pathol , vol.205 , pp. 498-506
    • Dutton, A.1    Reynolds, G.M.2    Dawson, C.W.3    Young, L.S.4    Murray, P.G.5
  • 55
    • 33644859147 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma
    • Georgakis G.V., Li Y., Rassidakis G.Z., Medeiros L.J., Mills G.B., Younes A. Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma. Br J Haematol 2006, 132:503-511.
    • (2006) Br J Haematol , vol.132 , pp. 503-511
    • Georgakis, G.V.1    Li, Y.2    Rassidakis, G.Z.3    Medeiros, L.J.4    Mills, G.B.5    Younes, A.6
  • 56
    • 0042744812 scopus 로고    scopus 로고
    • MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival
    • Zheng B., Fiumara P., Li Y.V., Georgakis G., Snell V., Younes M., et al. MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival. Blood 2003, 102:1019-1027.
    • (2003) Blood , vol.102 , pp. 1019-1027
    • Zheng, B.1    Fiumara, P.2    Li, Y.V.3    Georgakis, G.4    Snell, V.5    Younes, M.6
  • 57
    • 79955877897 scopus 로고    scopus 로고
    • Molecular pathogenesis of Hodgkin's lymphoma: increasing evidence of the importance of the microenvironment
    • Steidl C., Connors J.M., Gascoyne R.D. Molecular pathogenesis of Hodgkin's lymphoma: increasing evidence of the importance of the microenvironment. J Clin Oncol 2011, 29:1812-1826.
    • (2011) J Clin Oncol , vol.29 , pp. 1812-1826
    • Steidl, C.1    Connors, J.M.2    Gascoyne, R.D.3
  • 58
    • 78650986640 scopus 로고    scopus 로고
    • STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma
    • Kis L.L., Gerasimcik N., Salamon D., Persson E.K., Nagy N., Klein G., et al. STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma. Blood 2011, 117:165-174.
    • (2011) Blood , vol.117 , pp. 165-174
    • Kis, L.L.1    Gerasimcik, N.2    Salamon, D.3    Persson, E.K.4    Nagy, N.5    Klein, G.6
  • 59
    • 0033591689 scopus 로고    scopus 로고
    • Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells
    • Kapp U., Yeh W.C., Patterson B., Elia A.J., Kagi D., Ho A., et al. Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells. J Exp Med 1999, 189:1939-1946.
    • (1999) J Exp Med , vol.189 , pp. 1939-1946
    • Kapp, U.1    Yeh, W.C.2    Patterson, B.3    Elia, A.J.4    Kagi, D.5    Ho, A.6
  • 60
    • 33846238425 scopus 로고    scopus 로고
    • Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL
    • Chiu A., Xu W., He B., Dillon S.R., Gross J.A., Sievers E., et al. Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood 2007, 109:729-739.
    • (2007) Blood , vol.109 , pp. 729-739
    • Chiu, A.1    Xu, W.2    He, B.3    Dillon, S.R.4    Gross, J.A.5    Sievers, E.6
  • 61
    • 67650087810 scopus 로고    scopus 로고
    • Functional coexpression of interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma
    • Cattaruzza L., Gloghini A., Olivo K., Di Francia R., Lorenzon D., De Filippi R., et al. Functional coexpression of interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma. Int J Cancer 2009, 125:1092-1101.
    • (2009) Int J Cancer , vol.125 , pp. 1092-1101
    • Cattaruzza, L.1    Gloghini, A.2    Olivo, K.3    Di Francia, R.4    Lorenzon, D.5    De Filippi, R.6
  • 62
    • 38349059732 scopus 로고    scopus 로고
    • Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions
    • Aldinucci D., Lorenzon D., Cattaruzza L., Pinto A., Gloghini A., Carbone A., et al. Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions. Int J Cancer 2008, 122:769-776.
    • (2008) Int J Cancer , vol.122 , pp. 769-776
    • Aldinucci, D.1    Lorenzon, D.2    Cattaruzza, L.3    Pinto, A.4    Gloghini, A.5    Carbone, A.6
  • 63
    • 84856098280 scopus 로고    scopus 로고
    • The role of CD40/CD40L and interferon regulatory factor 4 in Hodgkin lymphoma microenvironment
    • Aldinucci D., Gloghini A., Pinto A., Colombatti A., Carbone A. The role of CD40/CD40L and interferon regulatory factor 4 in Hodgkin lymphoma microenvironment. Leuk Lymphoma 2012, 53:195-201.
    • (2012) Leuk Lymphoma , vol.53 , pp. 195-201
    • Aldinucci, D.1    Gloghini, A.2    Pinto, A.3    Colombatti, A.4    Carbone, A.5
  • 64
    • 0033058533 scopus 로고    scopus 로고
    • High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltrate in Hodgkin's lymphoma
    • van den Berg A., Visser L., Poppema S. High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltrate in Hodgkin's lymphoma. Am J Pathol 1999, 154:1685-1691.
    • (1999) Am J Pathol , vol.154 , pp. 1685-1691
    • van den Berg, A.1    Visser, L.2    Poppema, S.3
  • 65
    • 0033567914 scopus 로고    scopus 로고
    • Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils
    • Jundt F., Anagnostopoulos I., Bommert K., Emmerich F., Muller G., Foss H.D., et al. Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils. Blood 1999, 94:2065-2071.
    • (1999) Blood , vol.94 , pp. 2065-2071
    • Jundt, F.1    Anagnostopoulos, I.2    Bommert, K.3    Emmerich, F.4    Muller, G.5    Foss, H.D.6
  • 66
    • 0026694782 scopus 로고
    • Expression of cytokine genes, cytokine receptor genes, and transcription factors in cultured Hodgkin and Reed-Sternberg cells
    • Gruss H.J., Brach M.A., Drexler H.G., Bonifer R., Mertelsmann R.H., Herrmann F. Expression of cytokine genes, cytokine receptor genes, and transcription factors in cultured Hodgkin and Reed-Sternberg cells. Cancer Res 1992, 52:3353-3360.
    • (1992) Cancer Res , vol.52 , pp. 3353-3360
    • Gruss, H.J.1    Brach, M.A.2    Drexler, H.G.3    Bonifer, R.4    Mertelsmann, R.H.5    Herrmann, F.6
  • 67
    • 0037097818 scopus 로고    scopus 로고
    • The role of cytokines in classical Hodgkin lymphoma
    • Skinnider B.F., Mak T.W. The role of cytokines in classical Hodgkin lymphoma. Blood 2002, 99:4283-4297.
    • (2002) Blood , vol.99 , pp. 4283-4297
    • Skinnider, B.F.1    Mak, T.W.2
  • 68
    • 84890513409 scopus 로고    scopus 로고
    • Hodgkin lymphoma: pathology, pathogenesis, and a plethora of potential prognostic predictors
    • King R.L., Howard M.T., Bagg A. Hodgkin lymphoma: pathology, pathogenesis, and a plethora of potential prognostic predictors. Adv Anat Pathol 2014, 21:12-25.
    • (2014) Adv Anat Pathol , vol.21 , pp. 12-25
    • King, R.L.1    Howard, M.T.2    Bagg, A.3
  • 69
    • 0033766957 scopus 로고    scopus 로고
    • Interaction between host T cells and Reed-Sternberg cells in Hodgkin lymphomas
    • Poppema S., van den Berg A. Interaction between host T cells and Reed-Sternberg cells in Hodgkin lymphomas. Sem Cancer Biol 2000, 10:345-350.
    • (2000) Sem Cancer Biol , vol.10 , pp. 345-350
    • Poppema, S.1    van den Berg, A.2
  • 70
    • 1442283424 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma
    • Marshall N.A., Christie L.E., Munro L.R., Culligan D.J., Johnston P.W., Barker R.N., et al. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 2004, 103:1755-1762.
    • (2004) Blood , vol.103 , pp. 1755-1762
    • Marshall, N.A.1    Christie, L.E.2    Munro, L.R.3    Culligan, D.J.4    Johnston, P.W.5    Barker, R.N.6
  • 71
    • 77953534075 scopus 로고    scopus 로고
    • The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape
    • Aldinucci D., Gloghini A., Pinto A., De Filippi R., Carbone A. The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape. J Pathol 2010, 221:248-263.
    • (2010) J Pathol , vol.221 , pp. 248-263
    • Aldinucci, D.1    Gloghini, A.2    Pinto, A.3    De Filippi, R.4    Carbone, A.5
  • 72
    • 34548395936 scopus 로고    scopus 로고
    • Hodgkin's Reed-Sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells
    • Tanijiri T., Shimizu T., Uehira K., Yokoi T., Amuro H., Sugimoto H., et al. Hodgkin's Reed-Sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells. J Leukoc Biol 2007, 82:576-584.
    • (2007) J Leukoc Biol , vol.82 , pp. 576-584
    • Tanijiri, T.1    Shimizu, T.2    Uehira, K.3    Yokoi, T.4    Amuro, H.5    Sugimoto, H.6
  • 73
    • 0029986054 scopus 로고    scopus 로고
    • Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease
    • Herbst H., Foss H.D., Samol J., Araujo I., Klotzbach H., Krause H., et al. Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease. Blood 1996, 87:2918-2929.
    • (1996) Blood , vol.87 , pp. 2918-2929
    • Herbst, H.1    Foss, H.D.2    Samol, J.3    Araujo, I.4    Klotzbach, H.5    Krause, H.6
  • 74
    • 0025297289 scopus 로고
    • Immunohistochemical evidence of a role for transforming growth factor beta in the pathogenesis of nodular sclerosing Hodgkin's disease
    • Kadin M.E., Agnarsson B.A., Ellingsworth L.R., Newcom S.R. Immunohistochemical evidence of a role for transforming growth factor beta in the pathogenesis of nodular sclerosing Hodgkin's disease. Am J Pathol 1990, 136:1209-1214.
    • (1990) Am J Pathol , vol.136 , pp. 1209-1214
    • Kadin, M.E.1    Agnarsson, B.A.2    Ellingsworth, L.R.3    Newcom, S.R.4
  • 75
    • 34548740090 scopus 로고    scopus 로고
    • The AP1-dependent secretion of galectin-1 by Reed-Sternberg cells fosters immune privilege in classical Hodgkin lymphoma
    • Juszczynski P., Ouyang J., Monti S., Rodig S.J., Takeyama K., Abramson J., et al. The AP1-dependent secretion of galectin-1 by Reed-Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci U S A 2007, 104:13134-13139.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13134-13139
    • Juszczynski, P.1    Ouyang, J.2    Monti, S.3    Rodig, S.J.4    Takeyama, K.5    Abramson, J.6
  • 76
    • 42549166115 scopus 로고    scopus 로고
    • The CD4+CD26- T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile
    • Ma Y., Visser L., Blokzijl T., Harms G., Atayar C., Poppema S., et al. The CD4+CD26- T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile. Lab Investig 2008, 88:482-490.
    • (2008) Lab Investig , vol.88 , pp. 482-490
    • Ma, Y.1    Visser, L.2    Blokzijl, T.3    Harms, G.4    Atayar, C.5    Poppema, S.6
  • 78
    • 34547652282 scopus 로고    scopus 로고
    • HLA class II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma
    • Diepstra A., van Imhoff G.W., Karim-Kos H.E., van den Berg A., te Meerman G.J., Niens M., et al. HLA class II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma. J Clin Oncol 2007, 25:3101-3108.
    • (2007) J Clin Oncol , vol.25 , pp. 3101-3108
    • Diepstra, A.1    van Imhoff, G.W.2    Karim-Kos, H.E.3    van den Berg, A.4    te Meerman, G.J.5    Niens, M.6
  • 79
    • 38849095307 scopus 로고    scopus 로고
    • HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma
    • Diepstra A., Poppema S., Boot M., Visser L., Nolte I.M., Niens M., et al. HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma. Tissue Antigens 2008, 71:219-226.
    • (2008) Tissue Antigens , vol.71 , pp. 219-226
    • Diepstra, A.1    Poppema, S.2    Boot, M.3    Visser, L.4    Nolte, I.M.5    Niens, M.6
  • 80
    • 42449147063 scopus 로고    scopus 로고
    • PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
    • Yamamoto R., Nishikori M., Kitawaki T., Sakai T., Hishizawa M., Tashima M., et al. PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. Blood 2008, 111:3220-3224.
    • (2008) Blood , vol.111 , pp. 3220-3224
    • Yamamoto, R.1    Nishikori, M.2    Kitawaki, T.3    Sakai, T.4    Hishizawa, M.5    Tashima, M.6
  • 81
    • 78049370405 scopus 로고    scopus 로고
    • Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
    • Green M.R., Monti S., Rodig S.J., Juszczynski P., Currie T., O'Donnell E., et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood 2010, 116:3268-3277.
    • (2010) Blood , vol.116 , pp. 3268-3277
    • Green, M.R.1    Monti, S.2    Rodig, S.J.3    Juszczynski, P.4    Currie, T.5    O'Donnell, E.6
  • 82
    • 84856836302 scopus 로고    scopus 로고
    • High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas
    • Zocchi M.R., Catellani S., Canevali P., Tavella S., Garuti A., Villaggio B., et al. High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas. Blood 2012, 119:1479-1489.
    • (2012) Blood , vol.119 , pp. 1479-1489
    • Zocchi, M.R.1    Catellani, S.2    Canevali, P.3    Tavella, S.4    Garuti, A.5    Villaggio, B.6
  • 84
    • 1242338864 scopus 로고    scopus 로고
    • Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells
    • Hanamoto H., Nakayama T., Miyazato H., Takegawa S., Hieshima K., Tatsumi Y., et al. Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells. Am J Pathol 2004, 164:997-1006.
    • (2004) Am J Pathol , vol.164 , pp. 997-1006
    • Hanamoto, H.1    Nakayama, T.2    Miyazato, H.3    Takegawa, S.4    Hieshima, K.5    Tatsumi, Y.6
  • 85
    • 0141634201 scopus 로고    scopus 로고
    • Expression of CCL5/RANTES by Hodgkin and Reed-Sternberg cells and its possible role in the recruitment of mast cells into lymphomatous tissue
    • Fischer M., Juremalm M., Olsson N., Backlin C., Sundstrom C., Nilsson K., et al. Expression of CCL5/RANTES by Hodgkin and Reed-Sternberg cells and its possible role in the recruitment of mast cells into lymphomatous tissue. Int J Cancer 2003, 107:197-201.
    • (2003) Int J Cancer , vol.107 , pp. 197-201
    • Fischer, M.1    Juremalm, M.2    Olsson, N.3    Backlin, C.4    Sundstrom, C.5    Nilsson, K.6
  • 86
    • 36049049415 scopus 로고    scopus 로고
    • Autocrine NGFbeta/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines
    • Renne C., Minner S., Kuppers R., Hansmann M.L., Brauninger A. Autocrine NGFbeta/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines. Leuk Res 2008, 32:163-167.
    • (2008) Leuk Res , vol.32 , pp. 163-167
    • Renne, C.1    Minner, S.2    Kuppers, R.3    Hansmann, M.L.4    Brauninger, A.5
  • 87
    • 84893848695 scopus 로고    scopus 로고
    • Protrusion-guided extracellular vesicles mediate CD30 trans-signalling in the microenvironment of Hodgkin's lymphoma
    • Hansen H.P., Engels H.M., Dams M., Paes Leme A.F., Pauletti B.A., Simhadri V.L., et al. Protrusion-guided extracellular vesicles mediate CD30 trans-signalling in the microenvironment of Hodgkin's lymphoma. J Pathol 2014, 232:405-414.
    • (2014) J Pathol , vol.232 , pp. 405-414
    • Hansen, H.P.1    Engels, H.M.2    Dams, M.3    Paes Leme, A.F.4    Pauletti, B.A.5    Simhadri, V.L.6
  • 88
    • 3242888905 scopus 로고    scopus 로고
    • Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells
    • Aldinucci D., Lorenzon D., Olivo K., Rapana B., Gattei V. Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells. Leuk Lymphoma 2004, 45:1731-1739.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1731-1739
    • Aldinucci, D.1    Lorenzon, D.2    Olivo, K.3    Rapana, B.4    Gattei, V.5
  • 89
    • 84891352190 scopus 로고    scopus 로고
    • Bortezomib down-modulates the survival factor interferon regulatory factor 4 in Hodgkin lymphoma cell lines and decreases the protective activity of Hodgkin lymphoma-associated fibroblasts
    • Celegato M., Borghese C., Casagrande N., Carbone A., Colombatti A., Aldinucci D. Bortezomib down-modulates the survival factor interferon regulatory factor 4 in Hodgkin lymphoma cell lines and decreases the protective activity of Hodgkin lymphoma-associated fibroblasts. Leuk Lymphoma 2014, 55:149-159.
    • (2014) Leuk Lymphoma , vol.55 , pp. 149-159
    • Celegato, M.1    Borghese, C.2    Casagrande, N.3    Carbone, A.4    Colombatti, A.5    Aldinucci, D.6
  • 90
    • 84900987005 scopus 로고    scopus 로고
    • The NF-kappaB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma
    • Celegato M., Borghese C., Umezawa K., Casagrande N., Colombatti A., Carbone A., et al. The NF-kappaB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma. Cancer Lett 2014, 349:26-34.
    • (2014) Cancer Lett , vol.349 , pp. 26-34
    • Celegato, M.1    Borghese, C.2    Umezawa, K.3    Casagrande, N.4    Colombatti, A.5    Carbone, A.6
  • 91
    • 84891291773 scopus 로고    scopus 로고
    • The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1
    • Cader F.Z., Vockerodt M., Bose S., Nagy E., Brundler M.A., Kearns P., et al. The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1. Blood 2013, 122:4237-4245.
    • (2013) Blood , vol.122 , pp. 4237-4245
    • Cader, F.Z.1    Vockerodt, M.2    Bose, S.3    Nagy, E.4    Brundler, M.A.5    Kearns, P.6
  • 92
    • 36849085421 scopus 로고    scopus 로고
    • Retrospective analysis of the prognostic role of tissue eosinophil and mast cells in Hodgkin's lymphoma
    • Keresztes K., Szollosi Z., Simon Z., Tarkanyi I., Nemes Z., Illes A. Retrospective analysis of the prognostic role of tissue eosinophil and mast cells in Hodgkin's lymphoma. Pathol Oncol Res 2007, 13:237-242.
    • (2007) Pathol Oncol Res , vol.13 , pp. 237-242
    • Keresztes, K.1    Szollosi, Z.2    Simon, Z.3    Tarkanyi, I.4    Nemes, Z.5    Illes, A.6
  • 93
    • 0034651829 scopus 로고    scopus 로고
    • Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors
    • von Wasielewski R., Seth S., Franklin J., Fischer R., Hubner K., Hansmann M.L., et al. Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors. Blood 2000, 95:1207-1213.
    • (2000) Blood , vol.95 , pp. 1207-1213
    • von Wasielewski, R.1    Seth, S.2    Franklin, J.3    Fischer, R.4    Hubner, K.5    Hansmann, M.L.6
  • 94
    • 0034839397 scopus 로고    scopus 로고
    • Tissue eosinophilia in relation to immunopathological and clinical characteristics in Hodgkin's disease
    • Axdorph U., Porwit-MacDonald A., Grimfors G., Bjorkholm M. Tissue eosinophilia in relation to immunopathological and clinical characteristics in Hodgkin's disease. Leuk Lymphoma 2001, 42:1055-1065.
    • (2001) Leuk Lymphoma , vol.42 , pp. 1055-1065
    • Axdorph, U.1    Porwit-MacDonald, A.2    Grimfors, G.3    Bjorkholm, M.4
  • 95
    • 84870893593 scopus 로고    scopus 로고
    • Macrophage, mast cell and T lymphocyte infiltrations are independent predictive biomarkers of primary refractoriness or early relapse in classical Hodgkin lymphoma
    • Deau B., Bachy E., Ribrag V., Delarue R., Rubio M.T., Bosq J., et al. Macrophage, mast cell and T lymphocyte infiltrations are independent predictive biomarkers of primary refractoriness or early relapse in classical Hodgkin lymphoma. Leuk Lymphoma 2013, 54:41-45.
    • (2013) Leuk Lymphoma , vol.54 , pp. 41-45
    • Deau, B.1    Bachy, E.2    Ribrag, V.3    Delarue, R.4    Rubio, M.T.5    Bosq, J.6
  • 96
    • 79551650002 scopus 로고    scopus 로고
    • Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma
    • Kamper P., Bendix K., Hamilton-Dutoit S., Honore B., Nyengaard J.R., d'Amore F. Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma. Haematologica 2011, 96:269-276.
    • (2011) Haematologica , vol.96 , pp. 269-276
    • Kamper, P.1    Bendix, K.2    Hamilton-Dutoit, S.3    Honore, B.4    Nyengaard, J.R.5    d'Amore, F.6
  • 97
    • 84942297725 scopus 로고    scopus 로고
    • CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment
    • Touati M., Delage-Corre M., Monteil J., Abraham J., Moreau S., Remenieras L., et al. CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment. Leuk Lymphoma 2014, 1-10.
    • (2014) Leuk Lymphoma , pp. 1-10
    • Touati, M.1    Delage-Corre, M.2    Monteil, J.3    Abraham, J.4    Moreau, S.5    Remenieras, L.6
  • 98
    • 84897935943 scopus 로고    scopus 로고
    • CD163 immunohistochemistry is superior to CD68 in predicting outcome in classical Hodgkin lymphoma
    • Klein J.L., Nguyen T.T., Bien-Willner G.A., Chen L., Foyil K.V., Bartlett N.L., et al. CD163 immunohistochemistry is superior to CD68 in predicting outcome in classical Hodgkin lymphoma. Am J Clin Pathol 2014, 141:381-387.
    • (2014) Am J Clin Pathol , vol.141 , pp. 381-387
    • Klein, J.L.1    Nguyen, T.T.2    Bien-Willner, G.A.3    Chen, L.4    Foyil, K.V.5    Bartlett, N.L.6
  • 99
    • 77949345555 scopus 로고    scopus 로고
    • Tumor-associated macrophages and survival in classic Hodgkin's lymphoma
    • Steidl C., Lee T., Shah S.P., Farinha P., Han G., Nayar T., et al. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med 2010, 362:875-885.
    • (2010) N Engl J Med , vol.362 , pp. 875-885
    • Steidl, C.1    Lee, T.2    Shah, S.P.3    Farinha, P.4    Han, G.5    Nayar, T.6
  • 100
    • 0035084021 scopus 로고    scopus 로고
    • Percentage of activated cytotoxic T-lymphocytes in anaplastic large cell lymphoma and Hodgkin's disease: an independent biological prognostic marker
    • ten Berge R.L., Oudejans J.J., Dukers D.F., Meijer J.W., Ossenkoppele G.J., Meijer C.J. Percentage of activated cytotoxic T-lymphocytes in anaplastic large cell lymphoma and Hodgkin's disease: an independent biological prognostic marker. Leukemia 2001, 15:458-464.
    • (2001) Leukemia , vol.15 , pp. 458-464
    • ten Berge, R.L.1    Oudejans, J.J.2    Dukers, D.F.3    Meijer, J.W.4    Ossenkoppele, G.J.5    Meijer, C.J.6
  • 102
    • 20044367117 scopus 로고    scopus 로고
    • Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells
    • Alvaro T., Lejeune M., Salvado M.T., Bosch R., Garcia J.F., Jaen J., et al. Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res 2005, 11:1467-1473.
    • (2005) Clin Cancer Res , vol.11 , pp. 1467-1473
    • Alvaro, T.1    Lejeune, M.2    Salvado, M.T.3    Bosch, R.4    Garcia, J.F.5    Jaen, J.6
  • 103
    • 33750598940 scopus 로고    scopus 로고
    • Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin's lymphoma: a clinicopathologic study
    • Asano N., Oshiro A., Matsuo K., Kagami Y., Ishida F., Suzuki R., et al. Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin's lymphoma: a clinicopathologic study. J Clin Oncol 2006, 24:4626-4633.
    • (2006) J Clin Oncol , vol.24 , pp. 4626-4633
    • Asano, N.1    Oshiro, A.2    Matsuo, K.3    Kagami, Y.4    Ishida, F.5    Suzuki, R.6
  • 105
    • 0031808140 scopus 로고    scopus 로고
    • Prognostic value of follicular dendritic cells in nodular sclerosing Hodgkin's disease
    • Baur A.S., Meuge-Moraw C., Michel G., Delacretaz F. Prognostic value of follicular dendritic cells in nodular sclerosing Hodgkin's disease. Histopathology 1998, 32:512-520.
    • (1998) Histopathology , vol.32 , pp. 512-520
    • Baur, A.S.1    Meuge-Moraw, C.2    Michel, G.3    Delacretaz, F.4
  • 106
    • 84885621626 scopus 로고    scopus 로고
    • B cells in classical Hodgkin lymphoma are important actors rather than bystanders in the local immune reaction
    • Tudor C.S., Distel L.V., Eckhardt J., Hartmann A., Niedobitek G., Buettner M. B cells in classical Hodgkin lymphoma are important actors rather than bystanders in the local immune reaction. Hum Pathol 2013, 44:2475-2486.
    • (2013) Hum Pathol , vol.44 , pp. 2475-2486
    • Tudor, C.S.1    Distel, L.V.2    Eckhardt, J.3    Hartmann, A.4    Niedobitek, G.5    Buettner, M.6
  • 107
    • 84872467157 scopus 로고    scopus 로고
    • Expression of FOXP3, CD68, and CD20 at diagnosis in the microenvironment of classical Hodgkin lymphoma is predictive of outcome
    • Greaves P., Clear A., Coutinho R., Wilson A., Matthews J., Owen A., et al. Expression of FOXP3, CD68, and CD20 at diagnosis in the microenvironment of classical Hodgkin lymphoma is predictive of outcome. J Clin Oncol 2013, 31:256-262.
    • (2013) J Clin Oncol , vol.31 , pp. 256-262
    • Greaves, P.1    Clear, A.2    Coutinho, R.3    Wilson, A.4    Matthews, J.5    Owen, A.6
  • 109
    • 0033635585 scopus 로고    scopus 로고
    • Biological markers may add to prediction of outcome achieved by the International Prognostic Score in Hodgkin's disease
    • Axdorph U., Sjoberg J., Grimfors G., Landgren O., Porwit-MacDonald A., Bjorkholm M. Biological markers may add to prediction of outcome achieved by the International Prognostic Score in Hodgkin's disease. Ann Oncol 2000, 11:1405-1411.
    • (2000) Ann Oncol , vol.11 , pp. 1405-1411
    • Axdorph, U.1    Sjoberg, J.2    Grimfors, G.3    Landgren, O.4    Porwit-MacDonald, A.5    Bjorkholm, M.6
  • 110
    • 33947517368 scopus 로고    scopus 로고
    • Prognostic significance of serum B-lymphocyte stimulator in Hodgkin's lymphoma
    • Oki Y., Georgakis G.V., Migone T.S., Kwak L.W., Younes A. Prognostic significance of serum B-lymphocyte stimulator in Hodgkin's lymphoma. Haematologica 2007, 92:269-270.
    • (2007) Haematologica , vol.92 , pp. 269-270
    • Oki, Y.1    Georgakis, G.V.2    Migone, T.S.3    Kwak, L.W.4    Younes, A.5
  • 111
    • 34249041983 scopus 로고    scopus 로고
    • Plasma cytokine and soluble receptor signature predicts outcome of patients with classical Hodgkin's lymphoma: a study from the Groupe d'Etude des Lymphomes de l'Adulte
    • Casasnovas R.O., Mounier N., Brice P., Divine M., Morschhauser F., Gabarre J., et al. Plasma cytokine and soluble receptor signature predicts outcome of patients with classical Hodgkin's lymphoma: a study from the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 2007, 25:1732-1740.
    • (2007) J Clin Oncol , vol.25 , pp. 1732-1740
    • Casasnovas, R.O.1    Mounier, N.2    Brice, P.3    Divine, M.4    Morschhauser, F.5    Gabarre, J.6
  • 112
    • 0029029088 scopus 로고
    • Serum cytokine levels correlate with clinical parameters in Hodgkin's disease
    • Gorschluter M., Bohlen H., Hasenclever D., Diehl V., Tesch H. Serum cytokine levels correlate with clinical parameters in Hodgkin's disease. Ann Oncol 1995, 6:477-482.
    • (1995) Ann Oncol , vol.6 , pp. 477-482
    • Gorschluter, M.1    Bohlen, H.2    Hasenclever, D.3    Diehl, V.4    Tesch, H.5
  • 113
    • 0027162928 scopus 로고
    • Serum levels of soluble interleukin-2 receptor in Hodgkin disease. Relationship with clinical stage, tumor burden, and treatment outcome
    • Ambrosetti A., Nadali G., Vinante F., Carlini S., Veneri D., Todeschini G., et al. Serum levels of soluble interleukin-2 receptor in Hodgkin disease. Relationship with clinical stage, tumor burden, and treatment outcome. Cancer 1993, 72:201-206.
    • (1993) Cancer , vol.72 , pp. 201-206
    • Ambrosetti, A.1    Nadali, G.2    Vinante, F.3    Carlini, S.4    Veneri, D.5    Todeschini, G.6
  • 116
    • 0031840361 scopus 로고    scopus 로고
    • Soluble vascular cell adhesion molecule-1 (sVCAM-1) is an independent prognostic marker in Hodgkin's disease
    • Christiansen I., Sundstrom C., Enblad G., Totterman T.H. Soluble vascular cell adhesion molecule-1 (sVCAM-1) is an independent prognostic marker in Hodgkin's disease. Br J Haematol 1998, 102:701-709.
    • (1998) Br J Haematol , vol.102 , pp. 701-709
    • Christiansen, I.1    Sundstrom, C.2    Enblad, G.3    Totterman, T.H.4
  • 117
    • 63849185609 scopus 로고    scopus 로고
    • Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome
    • Chetaille B., Bertucci F., Finetti P., Esterni B., Stamatoullas A., Picquenot J.M., et al. Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome. Blood 2009, 113:2765-3775.
    • (2009) Blood , vol.113 , pp. 2765-3775
    • Chetaille, B.1    Bertucci, F.2    Finetti, P.3    Esterni, B.4    Stamatoullas, A.5    Picquenot, J.M.6
  • 119
    • 84875743842 scopus 로고    scopus 로고
    • Gene expression-based model using formalin-fixed paraffin-embedded biopsies predicts overall survival in advanced-stage classical Hodgkin lymphoma
    • Scott D.W., Chan F.C., Hong F., Rogic S., Tan K.L., Meissner B., et al. Gene expression-based model using formalin-fixed paraffin-embedded biopsies predicts overall survival in advanced-stage classical Hodgkin lymphoma. J Clin Oncol 2013, 31:692-700.
    • (2013) J Clin Oncol , vol.31 , pp. 692-700
    • Scott, D.W.1    Chan, F.C.2    Hong, F.3    Rogic, S.4    Tan, K.L.5    Meissner, B.6


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