메뉴 건너뛰기




Volumn 221, Issue 3, 2010, Pages 248-263

The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape

Author keywords

Classical Hodgkin's lymphoma; Immune escape; Therapeutic targets; Tumour microenvironment

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; BLEOMYCIN; CHEMOKINE; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; IBRITUMOMAB TIUXETAN; L16 ANTIBODY; L19 ANTIBODY I 131; LENALIDOMIDE; PENTOSTATIN; PREDNISONE; PROCARBAZINE; RITUXIMAB; TOSITUMOMAB; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

EID: 77953534075     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2711     Document Type: Review
Times cited : (231)

References (137)
  • 1
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B cell malignancies: a target for new treatment strategies. Blood 2009; 114: 3367-3375.
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 3
    • 57749171165 scopus 로고    scopus 로고
    • The biology of Hodgkin's lymphoma
    • Küppers R. The biology of Hodgkin's lymphoma. Nat Rev Cancer 2009; 9: 15-27.
    • (2009) Nat Rev Cancer , vol.9 , pp. 15-27
    • Küppers, R.1
  • 4
    • 0037097818 scopus 로고    scopus 로고
    • The role of cytokines in classical Hodgkin lymphoma
    • DOI 10.1182/blood-2002-01-0099
    • Skinnider BF, Mak TW. The role of cytokines in classical Hodgkin lymphoma. Blood 2002; 99: 4283-4297. (Pubitemid 34627193)
    • (2002) Blood , vol.99 , Issue.12 , pp. 4283-4297
    • Skinnider, B.F.1    Mak, T.W.2
  • 5
    • 65249135978 scopus 로고    scopus 로고
    • Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma
    • Schreck S, Friebel D, Buettner M, Distel L, Grabenbauer G, Young LS, et al . Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma. Hematol Oncol 2009; 27: 31-39.
    • (2009) Hematol Oncol , vol.27 , pp. 31-39
    • Schreck, S.1    Friebel, D.2    Buettner, M.3    Distel, L.4    Grabenbauer, G.5    Young, L.S.6
  • 7
    • 54049094815 scopus 로고    scopus 로고
    • Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α
    • Lamprecht B, Kreher S, Anagnostopoulos I, Jöhrens K, Monteleone G, Jundt F, et al . Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α. Blood 2008; 112: 3339-3347.
    • (2008) Blood , vol.112 , pp. 3339-3347
    • Lamprecht, B.1    Kreher, S.2    Anagnostopoulos, I.3    Jöhrens, K.4    Monteleone, G.5    Jundt, F.6
  • 9
    • 0028908965 scopus 로고
    • Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines
    • Carbone A, Gloghini A, Gattei V, Aldinucci D, Degan M, De Paoli P, et al . Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines. Blood 1995; 85: 780-789.
    • (1995) Blood , vol.85 , pp. 780-789
    • Carbone, A.1    Gloghini, A.2    Gattei, V.3    Aldinucci, D.4    Degan, M.5    De Paoli, P.6
  • 10
    • 3242888905 scopus 로고    scopus 로고
    • Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells
    • DOI 10.1080/10428190410001683633
    • Aldinucci D, Lorenzon D, Olivo K, Rapana B, Gattei V. Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells. Leuk Lymphoma 2004; 45: 1731-1739. (Pubitemid 38997138)
    • (2004) Leukemia and Lymphoma , vol.45 , Issue.9 , pp. 1731-1739
    • Aldinucci, D.1    Lorenzon, D.2    Olivo, K.3    Rapana, B.4    Gattei, V.5
  • 12
    • 38349059732 scopus 로고    scopus 로고
    • Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: Involvement of CCL5/RANTES in tumour cell growth and microenvironmental interactions
    • Aldinucci D, Lorenzon D, Cattaruzza L, Pinto A, Gloghini A, Carbone A, et al . Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/RANTES in tumour cell growth and microenvironmental interactions. Int J Cancer 2008; 122: 769-776.
    • (2008) Int J Cancer , vol.122 , pp. 769-776
    • Aldinucci, D.1    Lorenzon, D.2    Cattaruzza, L.3    Pinto, A.4    Gloghini, A.5    Carbone, A.6
  • 13
    • 67650087810 scopus 로고    scopus 로고
    • Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumour cell growth and microenvironmental interactions of Hodgkin's lymphoma
    • Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, et al . Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: involvement of IL-7 in tumour cell growth and microenvironmental interactions of Hodgkin's lymphoma. Int J Cancer 2009; 125: 1092-1101.
    • (2009) Int J Cancer , vol.125 , pp. 1092-1101
    • Cattaruzza, L.1    Gloghini, A.2    Olivo, K.3    Di Francia, R.4    Lorenzon, D.5    De Filippi, R.6
  • 14
    • 57049165326 scopus 로고    scopus 로고
    • Elevated pretreatment interleukin-10 serum level is an international prognostic score (IPS)-independent risk factor for early treatment failure in advanced stage Hodgkin lymphoma
    • Rautert R, Schinköthe T, Franklin J, Weihrauch M, Boll B, Pogge E, et al . Elevated pretreatment interleukin-10 serum level is an international prognostic score (IPS)-independent risk factor for early treatment failure in advanced stage Hodgkin lymphoma. Leuk Lymphoma 2008; 49: 2091-2098.
    • (2008) Leuk Lymphoma , vol.49 , pp. 2091-2098
    • Rautert, R.1    Schinköthe, T.2    Franklin, J.3    Weihrauch, M.4    Boll, B.5    Pogge, E.6
  • 16
    • 51149087933 scopus 로고    scopus 로고
    • Treatment of Hodgkin lymphoma: The past, present, and future
    • Evens AM, Hutchings M, Diehl V. Treatment of Hodgkin lymphoma: the past, present, and future. Nat Clin Pract Oncol 2008; 5: 543-556.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 543-556
    • Evens, A.M.1    Hutchings, M.2    Diehl, V.3
  • 18
    • 51649092609 scopus 로고    scopus 로고
    • Vorinostat inhibits STAT6- Mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines
    • Buglio D, Georgakis GV, Hanabuchi S, Arima K, Khaskhely NM, Liu YJ, et al . Vorinostat inhibits STAT6- mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines. Blood 2008; 112: 1424-1433.
    • (2008) Blood , vol.112 , pp. 1424-1433
    • Buglio, D.1    Georgakis, G.V.2    Hanabuchi, S.3    Arima, K.4    Khaskhely, N.M.5    Liu, Y.J.6
  • 20
    • 0034654411 scopus 로고    scopus 로고
    • A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells
    • Falini B, Fizzotti M, Pucciarini A, Bigerna B, Marafioti T, Gambacorta M, et al . A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 2000; 95: 2084-2092.
    • (2000) Blood , vol.95 , pp. 2084-2092
    • Falini, B.1    Fizzotti, M.2    Pucciarini, A.3    Bigerna, B.4    Marafioti, T.5    Gambacorta, M.6
  • 22
    • 0028857781 scopus 로고
    • CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease
    • Carbone A, Gloghini A, Gruss HJ, Pinto A. CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease. Am JPathol 1995; 147: 912-922.
    • (1995) Am JPathol , vol.147 , pp. 912-922
    • Carbone, A.1    Gloghini, A.2    Gruss, H.J.3    Pinto, A.4
  • 23
    • 1442283424 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma
    • Marshall NA, Christie LE, Munro LR, Culligan DJ, Johnston PW, Barker RN, et al . Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 2004; 103: 1755-1762.
    • (2004) Blood , vol.103 , pp. 1755-1762
    • Marshall, N.A.1    Christie, L.E.2    Munro, L.R.3    Culligan, D.J.4    Johnston, P.W.5    Barker, R.N.6
  • 24
    • 42449147063 scopus 로고    scopus 로고
    • PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
    • Yamamoto R, Nishikori M, Kitawaki T, Sakai T, Hishizawa M, Tashima M, et al . PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. Blood 2008; 111: 3220-3224.
    • (2008) Blood , vol.111 , pp. 3220-3224
    • Yamamoto, R.1    Nishikori, M.2    Kitawaki, T.3    Sakai, T.4    Hishizawa, M.5    Tashima, M.6
  • 25
    • 33746877544 scopus 로고    scopus 로고
    • Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma
    • DOI 10.1097/01.pas.0000209855.28282.ce, PII 0000047820060700000003
    • Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ. Programmed death-1 (PD-1) is a marker of germinal centerassociated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 2006; 30: 802-810. (Pubitemid 44264969)
    • (2006) American Journal of Surgical Pathology , vol.30 , Issue.7 , pp. 802-810
    • Dorfman, D.M.1    Brown, J.A.2    Shahsafaei, A.3    Freeman, G.J.4
  • 26
    • 11144230063 scopus 로고    scopus 로고
    • The CD28 family: A T-cell rheostat for therapeutic control of T-cell activation
    • Riley JL, June CH. The CD28 family: A T-cell rheostat for therapeutic control of T-cell activation. Blood 2005; 105: 13-21.
    • (2005) Blood , vol.105 , pp. 13-21
    • Riley, J.L.1    June, C.H.2
  • 27
    • 13744253833 scopus 로고    scopus 로고
    • Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: Implications for tumor immunotherapy
    • DOI 10.1007/s00262-004-0593-x
    • Blank C, Gajewski TF, Mackensen A. Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy. Cancer Immunol Immunother 2005; 54: 307-314. (Pubitemid 40238924)
    • (2005) Cancer Immunology, Immunotherapy , vol.54 , Issue.4 , pp. 307-314
    • Blank, C.1    Gajewski, T.F.2    Mackensen, A.3
  • 28
    • 13444270323 scopus 로고    scopus 로고
    • Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
    • Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, et al . Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 2005; 65: 1089-1096.
    • (2005) Cancer Res , vol.65 , pp. 1089-1096
    • Hirano, F.1    Kaneko, K.2    Tamura, H.3    Dong, H.4    Wang, S.5    Ichikawa, M.6
  • 29
    • 13844294372 scopus 로고    scopus 로고
    • PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
    • DOI 10.1093/intimm/dxh194
    • Iwai Y, Terawaki S, Honjo T. PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int Immunol 2005; 17: 133-144. (Pubitemid 40246578)
    • (2005) International Immunology , vol.17 , Issue.2 , pp. 133-144
    • Iwai, Y.1    Terawaki, S.2    Honjo, T.3
  • 30
    • 24944453584 scopus 로고    scopus 로고
    • Lymphocyte-rich classical Hodgkin's lymphoma: Clinical presentation and treatment outcome in 100 patients treated within German Hodgkin's Study Group trials
    • Shimabukuro-Vornhagen A, Haverkamp H, Engert A, Balleisen L, Majunke P, Heil G, et al . Lymphocyte-rich classical Hodgkin's lymphoma: clinical presentation and treatment outcome in 100 patients treated within German Hodgkin's Study Group trials. J Clin Oncol 2005; 23: 5739-5745.
    • (2005) J Clin Oncol , vol.23 , pp. 5739-5745
    • Shimabukuro-Vornhagen, A.1    Haverkamp, H.2    Engert, A.3    Balleisen, L.4    Majunke, P.5    Heil, G.6
  • 31
    • 0037381009 scopus 로고    scopus 로고
    • Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma
    • Bräuninger A, Wacker HH, Rajewsky K, Küppers R, Hansmann ML. Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma. Cancer Res 2003; 63: 1644-1651. (Pubitemid 36373657)
    • (2003) Cancer Research , vol.63 , Issue.7 , pp. 1644-1651
    • Brauninger, A.1    Wacker, H.-H.2    Rajewsky, K.3    Kuppers, R.4    Hansmann, M.-L.5
  • 33
    • 28844444995 scopus 로고    scopus 로고
    • Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas
    • DOI 10.1182/blood-2005-06-2342
    • Bechtel D, Kurth J, Unkel C, Kuppers R. Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas. Blood 2005; 106: 4345-4350. (Pubitemid 41775946)
    • (2005) Blood , vol.106 , Issue.13 , pp. 4345-4350
    • Bechtel, D.1    Kurth, J.2    Unkel, C.3    Kuppers, R.4
  • 34
    • 28844476555 scopus 로고    scopus 로고
    • Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes
    • DOI 10.1182/blood-2005-06-2327
    • Chaganti S, Bell AI, Pastor NB, Milner AE, Drayson M, Gordon J, et al . Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes. Blood 2005; 106: 4249-4252. (Pubitemid 41775933)
    • (2005) Blood , vol.106 , Issue.13 , pp. 4249-4252
    • Chaganti, S.1    Bell, A.I.2    Pastor, N.B.3    Milner, A.E.4    Drayson, M.5    Gordon, J.6    Rickinson, A.B.7
  • 35
    • 28844502383 scopus 로고    scopus 로고
    • Rescue of 'crippled' germinal center B cells from apoptosis by Epstein-Barr virus
    • Mancao C, Altmann M, Jungnickel B, Hammerschmidt W. Rescue of 'crippled' germinal center B cells from apoptosis by Epstein-Barr virus. Blood 2005; 106: 4339-4344.
    • (2005) Blood , vol.106 , pp. 4339-4344
    • Mancao, C.1    Altmann, M.2    Jungnickel, B.3    Hammerschmidt, W.4
  • 36
    • 33947275359 scopus 로고    scopus 로고
    • The relationships between Epstein-Barr virus latent membrane protein 1 and regulatory T cells in Hodgkin's lymphoma
    • DOI 10.1016/j.exphem.2007.01.030, PII S0301472X07000331
    • Marshall NA, Culligan DJ, Tighe J, Johnston PW, Barker RN, Vickers MA. The relationships between Epstein-Barr virus latent membrane protein 1 and regulatory T cells in Hodgkin's lymphoma. Exp Hematol 2007; 35: 596-604. (Pubitemid 46427965)
    • (2007) Experimental Hematology , vol.35 , Issue.4 , pp. 596-604
    • Marshall, N.A.1    Culligan, D.J.2    Tighe, J.3    Johnston, P.W.4    Barker, R.N.5    Vickers, M.A.6
  • 37
    • 0036265409 scopus 로고    scopus 로고
    • Chemokines, cytokines and their receptors in Hodgkin's lymphoma cell lines and tissues
    • Maggio E, van den Berg A, Diepstra A, Kluiver J, Visser L, Poppema S. Chemokines, cytokines and their receptors in Hodgkin's lymphoma cell lines and tissues. Ann Oncol 2002; 13: 52-56. (Pubitemid 34567402)
    • (2002) Annals of Oncology , vol.13 , Issue.SUPPL. 1 , pp. 52-56
    • Maggio, E.1    Van Den Berg, A.2    Diepstra, A.3    Kluiver, J.4    Visser, L.5    Poppema, S.6
  • 39
    • 46749136862 scopus 로고    scopus 로고
    • Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates up-regulation of CCL20 and the migration of regulatory T cells
    • Baumforth KR, Birgersdotter A, Reynolds GM, Wei W, Kapatai G, Flavell JR, et al . Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates up-regulation of CCL20 and the migration of regulatory T cells. Am J Pathol 2008; 173: 195-204.
    • (2008) Am J Pathol , vol.173 , pp. 195-204
    • Baumforth, K.R.1    Birgersdotter, A.2    Reynolds, G.M.3    Wei, W.4    Kapatai, G.5    Flavell, J.R.6
  • 40
    • 0035869293 scopus 로고    scopus 로고
    • CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the non-neoplastic leukocytic infiltrates of Hodgkin disease
    • Buri C, Korner M, Scharli P, Cefai D, Uguccioni M, Mueller C, et al . CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the non-neoplastic leukocytic infiltrates of Hodgkin disease. Blood 2001; 97: 1543-1548.
    • (2001) Blood , vol.97 , pp. 1543-1548
    • Buri, C.1    Korner, M.2    Scharli, P.3    Cefai, D.4    Uguccioni, M.5    Mueller, C.6
  • 41
    • 0141634201 scopus 로고    scopus 로고
    • Expression of CCL5/RANTES by Hodgkin and Reed-Sternberg cells and its possible role in the recruitment of mast cells into lymphomatous tissue
    • Fischer M, Juremalm M, Olsson N, Backlin C, Sundstrom C, Nilsson K, et al . Expression of CCL5/RANTES by Hodgkin and Reed-Sternberg cells and its possible role in the recruitment of mast cells into lymphomatous tissue. Int J Cancer 2003; 107: 197-201.
    • (2003) Int J Cancer , vol.107 , pp. 197-201
    • Fischer, M.1    Juremalm, M.2    Olsson, N.3    Backlin, C.4    Sundstrom, C.5    Nilsson, K.6
  • 42
    • 10744224815 scopus 로고    scopus 로고
    • Differential chemokine, chemokine receptor and cytokine expression in Epstein-Barr virus-associated lymphoproliferative diseases
    • Ohshima K, Karube K, Hamasaki M, Tutiya T, Yamaguchi T, Suefuji H, et al . Differential chemokine, chemokine receptor and cytokine expression in Epstein-Barr virus-associated lymphoproliferative diseases. Leuk Lymphoma 2003; 44: 1367-1378.
    • (2003) Leuk Lymphoma , vol.44 , pp. 1367-1378
    • Ohshima, K.1    Karube, K.2    Hamasaki, M.3    Tutiya, T.4    Yamaguchi, T.5    Suefuji, H.6
  • 43
    • 33645227964 scopus 로고    scopus 로고
    • Epstein-Barr virus, cytokines, and inflammation: A cocktail for the pathogenesis of Hodgkin's lymphoma?
    • Khan G. Epstein-Barr virus, cytokines, and inflammation: a cocktail for the pathogenesis of Hodgkin's lymphoma? Exp Hematol 2006; 34: 399-406.
    • (2006) Exp Hematol , vol.34 , pp. 399-406
    • Khan, G.1
  • 44
    • 20444374404 scopus 로고    scopus 로고
    • From Hodgkin disease to Hodgkin lymphoma: Biologic insights and therapeutic potential
    • Re D, Thomas RK, Behringer K, Diehl V. From Hodgkin disease to Hodgkin lymphoma: biologic insights and therapeutic potential. Blood 2005; 105: 4553-4560.
    • (2005) Blood , vol.105 , pp. 4553-4560
    • Re, D.1    Thomas, R.K.2    Behringer, K.3    Diehl, V.4
  • 45
    • 18544386197 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor
    • Aldinucci D, Poletto D, Nanni P, Degan M, Gloghini A, Di Francia R, et al . Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor. Br J Haematol 2002; 118: 1055-1064.
    • (2002) Br J Haematol , vol.118 , pp. 1055-1064
    • Aldinucci, D.1    Poletto, D.2    Nanni, P.3    Degan, M.4    Gloghini, A.5    Di Francia, R.6
  • 46
    • 0036169090 scopus 로고    scopus 로고
    • Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cells
    • Aldinucci D, Poletto D, Gloghini A, Nanni P, Degan M, Perin T, et al . Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cells. Am J Pathol 2002; 160: 585-596.
    • (2002) Am J Pathol , vol.160 , pp. 585-596
    • Aldinucci, D.1    Poletto, D.2    Gloghini, A.3    Nanni, P.4    Degan, M.5    Perin, T.6
  • 47
    • 0033567914 scopus 로고    scopus 로고
    • Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils
    • Jundt F, Anagnostopoulos I, Bommert K, Emmerich F, Muller G, Foss HD, et al . Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils. Blood 1999; 94: 2065-2071.
    • (1999) Blood , vol.94 , pp. 2065-2071
    • Jundt, F.1    Anagnostopoulos, I.2    Bommert, K.3    Emmerich, F.4    Muller, G.5    Foss, H.D.6
  • 48
    • 33745261751 scopus 로고    scopus 로고
    • Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege
    • Ishida T, Ishii T, Inagaki A, Yano H, Komatsu H, Iida S, et al . Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. Cancer Res 2006; 66: 5716-5722.
    • (2006) Cancer Res , vol.66 , pp. 5716-5722
    • Ishida, T.1    Ishii, T.2    Inagaki, A.3    Yano, H.4    Komatsu, H.5    Iida, S.6
  • 49
    • 0037082511 scopus 로고    scopus 로고
    • Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs
    • Hopken UE, Foss HD, Meyer D, Hinz M, Leder K, Stein H, et al . Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs. Blood 2002; 99: 1109-1116.
    • (2002) Blood , vol.99 , pp. 1109-1116
    • Hopken, U.E.1    Foss, H.D.2    Meyer, D.3    Hinz, M.4    Leder, K.5    Stein, H.6
  • 50
    • 0033815705 scopus 로고    scopus 로고
    • Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines
    • Majka M, Rozmyslowicz T, Honczarenko M, Ratajczak J, Wasik MA, Gaulton GN, et al . Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines. Leukemia 2000; 14: 1821-1832.
    • (2000) Leukemia , vol.14 , pp. 1821-1832
    • Majka, M.1    Rozmyslowicz, T.2    Honczarenko, M.3    Ratajczak, J.4    Wasik, M.A.5    Gaulton, G.N.6
  • 51
    • 0033058533 scopus 로고    scopus 로고
    • High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltrate in Hodgkin's lymphoma
    • Van den Berg A, Visser L, Poppema S. High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltrate in Hodgkin's lymphoma. Am J Pathol 1999; 154: 1685-1691.
    • (1999) Am J Pathol , vol.154 , pp. 1685-1691
    • Van Den Berg, A.1    Visser, L.2    Poppema, S.3
  • 52
    • 54049094815 scopus 로고    scopus 로고
    • Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α
    • Lamprecht B, Kreher S, Anagnostopoulos I, Jöhrens K, Monteleone G, Jundt F, et al . Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α. Blood 2008; 112: 3339-3347.
    • (2008) Blood , vol.112 , pp. 3339-3347
    • Lamprecht, B.1    Kreher, S.2    Anagnostopoulos, I.3    Jöhrens, K.4    Monteleone, G.5    Jundt, F.6
  • 53
    • 1242338864 scopus 로고    scopus 로고
    • Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells
    • Hanamoto H, Nakayama T, Miyazato H, Takegawa S, Hieshima K, Tatsumi Y, et al . Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells. Am J Pathol 2004; 164: 997-1006.
    • (2004) Am J Pathol , vol.164 , pp. 997-1006
    • Hanamoto, H.1    Nakayama, T.2    Miyazato, H.3    Takegawa, S.4    Hieshima, K.5    Tatsumi, Y.6
  • 54
    • 36049049415 scopus 로고    scopus 로고
    • Autocrine NGFβ/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines
    • DOI 10.1016/j.leukres.2007.05.019, PII S014521260700224X
    • Renné C, Minner S, Küppers R, Hansmann ML, Bräuninger A. Autocrine NGFβ/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines. Leuk Res 2008; 32: 163-167. (Pubitemid 350100851)
    • (2008) Leukemia Research , vol.32 , Issue.1 , pp. 163-167
    • Renne, C.1    Minner, S.2    Kuppers, R.3    Hansmann, M.-L.4    Brauninger, A.5
  • 55
    • 0035992266 scopus 로고    scopus 로고
    • The role of interleukin 13 in classical Hodgkin lymphoma
    • DOI 10.1080/10428190290026259
    • Skinnider BF, Kapp U, Mak TW. The role of interleukin 13 in classical Hodgkin lymphoma. Leuk Lymphoma 2002; 43: 1203-1210. (Pubitemid 34537964)
    • (2002) Leukemia and Lymphoma , vol.43 , Issue.6 , pp. 1203-1210
    • Skinnider, B.F.1    Kapp, U.2    Mak, T.W.3
  • 56
    • 33846238425 scopus 로고    scopus 로고
    • Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL
    • Chiu A, Xu W, He B, Dillon SR, Gross JA, Sievers E, et al . Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood 2007; 109: 729-739.
    • (2007) Blood , vol.109 , pp. 729-739
    • Chiu, A.1    Xu, W.2    He, B.3    Dillon, S.R.4    Gross, J.A.5    Sievers, E.6
  • 57
    • 0035525784 scopus 로고    scopus 로고
    • Functional expression of receptor activator of nuclear factor-κB in Hodgkin disease cell lines
    • Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Gillen-water AM, et al . Functional expression of receptor activator of nuclear factor-κB in Hodgkin disease cell lines. Blood 2001; 98: 2784-2790.
    • (2001) Blood , vol.98 , pp. 2784-2790
    • Fiumara, P.1    Snell, V.2    Li, Y.3    Mukhopadhyay, A.4    Younes, M.5    Gillen-water, A.M.6
  • 59
    • 68149139538 scopus 로고    scopus 로고
    • The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
    • Vereecke L, Beyaert R, van Loo G. The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology. Trends Immunol 2009; 30: 383-391.
    • (2009) Trends Immunol , vol.30 , pp. 383-391
    • Vereecke, L.1    Beyaert, R.2    Van Loo, G.3
  • 60
    • 66049124247 scopus 로고    scopus 로고
    • TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
    • Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, et al . TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med 2009; 206: 981-989.
    • (2009) J Exp Med , vol.206 , pp. 981-989
    • Schmitz, R.1    Hansmann, M.L.2    Bohle, V.3    Martin-Subero, J.I.4    Hartmann, S.5    Mechtersheimer, G.6
  • 61
    • 0042818084 scopus 로고    scopus 로고
    • A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis
    • DOI 10.1161/01.CIR.0000083718.76889.D0
    • Longo CR, Arvelo MB, Patel VI, Daniel S, Mahiou J, Grey ST, et al . A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. Circulation 2003; 108: 1113-1118. (Pubitemid 37071523)
    • (2003) Circulation , vol.108 , Issue.9 , pp. 1113-1118
    • Longo, C.R.1    Arvelo, M.B.2    Patel, V.I.3    Daniel, S.4    Mahiou, J.5    Grey, S.T.6    Ferran, C.7
  • 63
    • 67650388511 scopus 로고    scopus 로고
    • TRAF1 is involved in the classical NF-κB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells
    • Guo F, Sun A, Wang W, He J, Hou J, Zhou P, et al. TRAF1 is involved in the classical NF-κB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells. Mol Immunol 2009; 46: 2441-2448.
    • (2009) Mol Immunol , vol.46 , pp. 2441-2448
    • Guo, F.1    Sun, A.2    Wang, W.3    He, J.4    Hou, J.5    Zhou, P.6
  • 64
    • 0042744812 scopus 로고    scopus 로고
    • MEK/ERK pathway is aberrantly active in Hodgkin disease: A signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival
    • DOI 10.1182/blood-2002-11-3507
    • Zheng B, Fiumara P, Li YV, Georgakis G, Snell V, Younes M, et al . MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival. Blood 2003; 102: 1019-1027. (Pubitemid 36917799)
    • (2003) Blood , vol.102 , Issue.3 , pp. 1019-1027
    • Zheng, B.1    Flumara, P.2    Li, Y.V.3    Georgakis, G.4    Snell, V.5    Younes, M.6    Vauthey, J.N.7    Carbone, A.8    Younes, A.9
  • 65
    • 1542615073 scopus 로고    scopus 로고
    • CD30 is involved in inhibition of T-cell proliferation by Hodgkin's Reed-Sternberg cells
    • Su CC, Chiu HH, Chang CC, Chen JC, Hsu SM. CD30 is involved in inhibition of T-cell proliferation by Hodgkin's Reed-Sternberg cells. Cancer Res 2004; 64: 2148-2152.
    • (2004) Cancer Res , vol.64 , pp. 2148-2152
    • Su, C.C.1    Chiu, H.H.2    Chang, C.C.3    Chen, J.C.4    Hsu, S.M.5
  • 66
    • 34249041983 scopus 로고    scopus 로고
    • Groupe d'Etude des Lymphomes de l'Adulte. Plasma cytokine and soluble receptor signature predicts outcome of patients with classical Hodgkin's lymphoma: A study from the Groupe d'Etude des Lymphomes de l'Adulte
    • Casasnovas RO, Mounier N, Brice P, Divine M, Morschhauser F, Gabarre J, et al . Groupe d'Etude des Lymphomes de l'Adulte. Plasma cytokine and soluble receptor signature predicts outcome of patients with classical Hodgkin's lymphoma: a study from the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 2007; 25: 1732-1740.
    • (2007) J Clin Oncol , vol.25 , pp. 1732-1740
    • Casasnovas, R.O.1    Mounier, N.2    Brice, P.3    Divine, M.4    Morschhauser, F.5    Gabarre, J.6
  • 67
    • 52349091768 scopus 로고    scopus 로고
    • Biologic features of Hodgkin lymphoma and the development of biologic prognostic factors in Hodgkin lymphoma: Tumor and microenvironment
    • Hsi ED. Biologic features of Hodgkin lymphoma and the development of biologic prognostic factors in Hodgkin lymphoma: tumor and microenvironment. Leuk Lymphoma 2008; 49: 1668-1680.
    • (2008) Leuk Lymphoma , vol.49 , pp. 1668-1680
    • Hsi, E.D.1
  • 69
    • 0028029111 scopus 로고
    • Interleukin-7, interleukin-8, soluble TNF receptor, and p53 protein levels are elevated in the serum of patients with Hodgkin's disease
    • Trümper L, Jung W, Dahl G, Diehl V, Gause A, Pfreundschuh M. Interleukin-7, interleukin-8, soluble TNF receptor, and p53 protein levels are elevated in the serum of patients with Hodgkin's disease. Ann Oncol 1994; 5: 93-96. (Pubitemid 24051326)
    • (1994) Annals of Oncology , vol.5 , Issue.SUPPL. 1 , pp. 93-96
    • Trumper, L.1    Jung, W.2    Dahl, G.3    Diehl, V.4    Gause, A.5    Pfreundschuh, M.6
  • 75
    • 34548033053 scopus 로고    scopus 로고
    • Galectin-1 mediated suppression of Epstein-Barr virus-specific T-cell immunity in classic Hodgkin lymphoma
    • DOI 10.1182/blood-2007-01-066100
    • Gandhi MK, Moll G, Smith C, Dua U, Lambley E, Ramuz O, et al . Galectin-1-mediated suppression of Epstein-Barr virus specific T-cell immunity in classic Hodgkin lymphoma. Blood 2007; 110: 1326-1329. (Pubitemid 47281432)
    • (2007) Blood , vol.110 , Issue.4 , pp. 1326-1329
    • Gandhi, M.K.1    Moll, G.2    Smith, C.3    Dua, U.4    Lambley, E.5    Ramuz, O.6    Gill, D.7    Marlton, P.8    Seymour, J.F.9    Khanna, R.10
  • 78
    • 33646229918 scopus 로고    scopus 로고
    • Immunobiology and pathophysiology of Hodgkin lymphomas
    • Poppema S. Immunobiology and pathophysiology of Hodgkin lymphomas. Hematol Am Soc Hematol Educ Program 2005; 231-238.
    • (2005) Hematol Am Soc Hematol Educ Program , pp. 231-238
    • Poppema, S.1
  • 80
    • 70349408300 scopus 로고    scopus 로고
    • + tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival
    • + tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival. Hum Pathol 2009; 40: 1715-1722.
    • (2009) Hum Pathol , vol.40 , pp. 1715-1722
    • Muenst, S.1    Hoeller, S.2    Dirnhofer, S.3    Tzankov, A.4
  • 81
    • 40449086384 scopus 로고    scopus 로고
    • Managing relapsed and refractory Hodgkin lymphoma
    • DOI 10.1111/j.1365-2141.2008.06998.x
    • Brice P. Managing relapsed and refractory Hodgkin lymphoma. Br J Haematol 2008; 141: 3-13. (Pubitemid 351347529)
    • (2008) British Journal of Haematology , vol.141 , Issue.1 , pp. 3-13
    • Brice, P.1
  • 82
    • 77949463615 scopus 로고    scopus 로고
    • Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma
    • Younes A. Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma. Hematol Am Soc Hematol Educ Program 2009; 507-519.
    • (2009) Hematol Am Soc Hematol Educ Program , pp. 507-519
    • Younes, A.1
  • 83
    • 68449100027 scopus 로고    scopus 로고
    • Drug development for recurrent and refractory classical Hodgkin lymphoma
    • Wildes TM, Bartlett NL. Drug development for recurrent and refractory classical Hodgkin lymphoma. Leuk Lymphoma 2009; 50: 529-540.
    • (2009) Leuk Lymphoma , vol.50 , pp. 529-540
    • Wildes, T.M.1    Bartlett, N.L.2
  • 85
    • 38949101159 scopus 로고    scopus 로고
    • Tumor-infiltrated immune response correlates with alterations in the apoptotic and cell cycle pathways in Hodgkin and Reed-Sternberg cells
    • Alvaro T, Lejeune M, García JF, Salvadó MT, López C, Bosch R, et al . Tumor-infiltrated immune response correlates with alterations in the apoptotic and cell cycle pathways in Hodgkin and Reed-Sternberg cells. Clin Cancer Res 2008; 14: 685-691.
    • (2008) Clin Cancer Res , vol.14 , pp. 685-691
    • Alvaro, T.1    Lejeune, M.2    García, J.F.3    Salvadó, M.T.4    López, C.5    Bosch, R.6
  • 86
    • 41349119388 scopus 로고    scopus 로고
    • Proteomics analysis of Hodgkin lymphoma: Identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes
    • Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G, et al . Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes. Blood 2008; 111: 2339-2346.
    • (2008) Blood , vol.111 , pp. 2339-2346
    • Ma, Y.1    Visser, L.2    Roelofsen, H.3    De Vries, M.4    Diepstra, A.5    Van Imhoff, G.6
  • 88
    • 64649093421 scopus 로고    scopus 로고
    • Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkin's lymphoma and diffuse large B cell lymphoma: A systematic review
    • Terasawa T, Lau J, Bardet S, Couturier O, Hotta T, Hutchings M, et al . Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkin's lymphoma and diffuse large B cell lymphoma: a systematic review. J Clin Oncol 2009; 27: 1906-1914.
    • (2009) J Clin Oncol , vol.27 , pp. 1906-1914
    • Terasawa, T.1    Lau, J.2    Bardet, S.3    Couturier, O.4    Hotta, T.5    Hutchings, M.6
  • 91
    • 0029805434 scopus 로고    scopus 로고
    • Immunology of Hodgkin's disease
    • Poppema S. Immunology of Hodgkin's disease. Baillière's Clin Haematol 1996; 9: 447-457.
    • (1996) Baillière's Clin Haematol , vol.9 , pp. 447-457
    • Poppema, S.1
  • 92
    • 9344260220 scopus 로고    scopus 로고
    • CD30 ligand expression in nonmalignant and Hodgkin's disease-involved lymphoid tissues
    • Gruss HJ, Pinto A, Gloghini A, Wehnes E, Wright B, Boiani N, et al . CD30 ligand expression in nonmalignant and Hodgkin's disease-involved lymphoid tissues. Am J Pathol 1996; 149: 469-481.
    • (1996) Am J Pathol , vol.149 , pp. 469-481
    • Gruss, H.J.1    Pinto, A.2    Gloghini, A.3    Wehnes, E.4    Wright, B.5    Boiani, N.6
  • 93
    • 42549166115 scopus 로고    scopus 로고
    • - T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile
    • - T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile. Lab Invest 2008; 88: 482-490.
    • (2008) Lab Invest , vol.88 , pp. 482-490
    • Ma, Y.1    Visser, L.2    Blokzijl, T.3    Harms, G.4    Atayar, C.5    Poppema, S.6
  • 94
    • 55949108741 scopus 로고    scopus 로고
    • Inflammatory cells and immune microenvironment in malignant lymphoma
    • de Jong D, Enblad G. Inflammatory cells and immune microenvironment in malignant lymphoma. J Int Med 2008; 264: 528-536.
    • (2008) J Int Med , vol.264 , pp. 528-536
    • De Jong, D.1    Enblad, G.2
  • 96
    • 33845786517 scopus 로고    scopus 로고
    • Heterogeneous CD52 expression among hematologic neoplasms: Implications for the use of alemtuzumab (CAMPATH-1H)
    • Rodig SJ, Abramson JS, Pinkus GS, Treon SP, Dorfman DM, Dong HY, et al . Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H). Clin Cancer Res 2006; 12: 7174-7179.
    • (2006) Clin Cancer Res , vol.12 , pp. 7174-7179
    • Rodig, S.J.1    Abramson, J.S.2    Pinkus, G.S.3    Treon, S.P.4    Dorfman, D.M.5    Dong, H.Y.6
  • 97
    • 34548544801 scopus 로고    scopus 로고
    • Reduced-intensity conditioning for allogeneic haematopoietic stem cell transplantation in relapsed and refractory Hodgkin lymphoma: Impact of alemtuzumab and donor lymphocyte infusions on long-term outcomes
    • Peggs KS, Sureda A, Qian W, Caballero D, Hunter A, Urbano- Ispizua A, et al . Reduced-intensity conditioning for allogeneic haematopoietic stem cell transplantation in relapsed and refractory Hodgkin lymphoma: impact of alemtuzumab and donor lymphocyte infusions on long-term outcomes. Br J Haematol 2007; 139: 70-80.
    • (2007) Br J Haematol , vol.139 , pp. 70-80
    • Peggs, K.S.1    Sureda, A.2    Qian, W.3    Caballero, D.4    Hunter, A.5    Urbano- Ispizua, A.6
  • 98
    • 43849085755 scopus 로고    scopus 로고
    • Superiority of reduced-intensity allogeneic transplantation over conventional treatment for relapse of Hodgkin's lymphoma following autologous stem cell transplantation
    • Thomson KJ, Peggs KS, Smith P, Cavet J, Hunter A, Parker A, et al . Superiority of reduced-intensity allogeneic transplantation over conventional treatment for relapse of Hodgkin's lymphoma following autologous stem cell transplantation. Bone Marrow Transpl 2008; 41: 765-770.
    • (2008) Bone Marrow Transpl , vol.41 , pp. 765-770
    • Thomson, K.J.1    Peggs, K.S.2    Smith, P.3    Cavet, J.4    Hunter, A.5    Parker, A.6
  • 99
    • 30644461685 scopus 로고    scopus 로고
    • Refractory Hodgkin lymphoma responds to pentostatin (2′- deoxycoformycin)
    • Braiteh F, Ng C, Kurzrock R. Refractory Hodgkin lymphoma responds to pentostatin (2′-deoxycoformycin). Leuk Lymphoma 2006; 47: 373-375.
    • (2006) Leuk Lymphoma , vol.47 , pp. 373-375
    • Braiteh, F.1    Ng, C.2    Kurzrock, R.3
  • 101
    • 0842311626 scopus 로고    scopus 로고
    • CD26 expression correlates with a reduced sensitivity to 2′-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas
    • Aldinucci D, Poletto D, Lorenzon D, Nanni P, Degan M, Olivo K, et al . CD26 expression correlates with a reduced sensitivity to 2′- deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas. Clin Cancer Res 2004; 10: 508-520.
    • (2004) Clin Cancer Res , vol.10 , pp. 508-520
    • Aldinucci, D.1    Poletto, D.2    Lorenzon, D.3    Nanni, P.4    Degan, M.5    Olivo, K.6
  • 102
    • 46749090038 scopus 로고    scopus 로고
    • Current role of gemcitabine in the treatment of Hodgkin lymphoma
    • Oki Y, Younes A. Current role of gemcitabine in the treatment of Hodgkin lymphoma. Leuk Lymphoma 2008; 49: 883-889.
    • (2008) Leuk Lymphoma , vol.49 , pp. 883-889
    • Oki, Y.1    Younes, A.2
  • 103
    • 48249096809 scopus 로고    scopus 로고
    • Immunity feedback and clinical outcome in colon cancer patients undergoing chemoimmunotherapy with gemcitabine + FOLFOX followed by subcutaneous granulocyte macrophage colony-stimulating factor and aldesleukin (GOLFIG-1 trial)
    • Correale P, Tagliaferri P, Fioravanti A, Del Vecchio MT, Remondo C, Montagnani F, et al . Immunity feedback and clinical outcome in colon cancer patients undergoing chemoimmunotherapy with gemcitabine + FOLFOX followed by subcutaneous granulocyte macrophage colony-stimulating factor and aldesleukin (GOLFIG-1 trial). Clin Cancer Res 2008; 14: 4192-4199.
    • (2008) Clin Cancer Res , vol.14 , pp. 4192-4199
    • Correale, P.1    Tagliaferri, P.2    Fioravanti, A.3    Del Vecchio, M.T.4    Remondo, C.5    Montagnani, F.6
  • 104
    • 0036498728 scopus 로고    scopus 로고
    • CD20 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin's disease: Associations with presenting features and clinical outcome
    • Rassidakis GZ, Medeiros LJ, Viviani S, Bonfante V, Nadali GP, Vassilakopoulos TP, et al . CD20 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin's disease: associations with presenting features and clinical outcome. J Clin Oncol 2002; 20: 1278-1287.
    • (2002) J Clin Oncol , vol.20 , pp. 1278-1287
    • Rassidakis, G.Z.1    Medeiros, L.J.2    Viviani, S.3    Bonfante, V.4    Nadali, G.P.5    Vassilakopoulos, T.P.6
  • 105
    • 0036143638 scopus 로고    scopus 로고
    • Expression of CD40 ligand (CD154) in B and T lymphocytes of Hodgkin disease: Potential therapeutic significance
    • Clodi K, Asgari Z, Younes M, Palmer JL, Cabanillas F, Carbone A, et al . Expression of CD40 ligand (CD154) in B and T lymphocytes of Hodgkin disease: potential therapeutic significance. Cancer 2002; 94: 1-5.
    • (2002) Cancer , vol.94 , pp. 1-5
    • Clodi, K.1    Asgari, Z.2    Younes, M.3    Palmer, J.L.4    Cabanillas, F.5    Carbone, A.6
  • 106
    • 63849185609 scopus 로고    scopus 로고
    • Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome
    • Chetaille B, Bertucci F, Finetti P, Esterni B, Stamatoullas A, Picquenot JM, et al . Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome. Blood 2009; 113: 2765-3775.
    • (2009) Blood , vol.113 , pp. 2765-3775
    • Chetaille, B.1    Bertucci, F.2    Finetti, P.3    Esterni, B.4    Stamatoullas, A.5    Picquenot, J.M.6
  • 107
    • 0030743219 scopus 로고    scopus 로고
    • CD30-ligand and CD40-ligand expression in lymph nodes involved with Hodgkin's disease
    • Younes A, Zhao S, Zhang X, Snell V, Clodi K, Kliche KO, et al . CD30-ligand and CD40-ligand expression in lymph nodes involved with Hodgkin's disease. Ann Oncol 1997; 8: 97-100.
    • (1997) Ann Oncol , vol.8 , pp. 97-100
    • Younes, A.1    Zhao, S.2    Zhang, X.3    Snell, V.4    Clodi, K.5    Kliche, K.O.6
  • 108
    • 0030933621 scopus 로고    scopus 로고
    • CD30 ligand is frequently expressed in human hematopoietic malignancies of myeloid and lymphoid origin
    • Gattei V, Degan M, Gloghini A, De Iuliis A, Improta S, Rossi FM, et al . CD30 ligand is frequently expressed in human hematopoietic malignancies of myeloid and lymphoid origin. Blood 1997; 89: 2048-2059.
    • (1997) Blood , vol.89 , pp. 2048-2059
    • Gattei, V.1    Degan, M.2    Gloghini, A.3    De Iuliis, A.4    Improta, S.5    Rossi, F.M.6
  • 110
    • 77951784116 scopus 로고    scopus 로고
    • Abnormally elevated levels of serum-free immunoglobulin light chains are frequently found in classic Hodgkin lymphoma (cHL) and predict outcome of patients with early stage disease
    • De Filippi R, Russo F, Iaccarino G, Crisci S, Frigeri F, Riemma C, et al . Abnormally elevated levels of serum-free immunoglobulin light chains are frequently found in classic Hodgkin lymphoma (cHL) and predict outcome of patients with early stage disease. Blood: ASH Annu Meet Abstr 2009; 114: 267.
    • Blood: ASH Annu Meet Abstr 2009 , vol.114 , pp. 267
    • De Filippi, R.1    Russo, F.2    Iaccarino, G.3    Crisci, S.4    Frigeri, F.5    Riemma, C.6
  • 113
    • 39049155001 scopus 로고    scopus 로고
    • Phase 2 study of gemcitabine in combination with rituximab in patients with recurrent or refractory Hodgkin lymphoma
    • Oki Y, Pro B, Fayad LE, Romaguera J, Samaniego F, Hagemeister F, et al . Phase 2 study of gemcitabine in combination with rituximab in patients with recurrent or refractory Hodgkin lymphoma. Cancer 2008; 112: 831-836.
    • (2008) Cancer , vol.112 , pp. 831-836
    • Oki, Y.1    Pro, B.2    Fayad, L.E.3    Romaguera, J.4    Samaniego, F.5    Hagemeister, F.6
  • 114
    • 77953531841 scopus 로고    scopus 로고
    • ASCO Annual Meeting Proceedings 2008; [Abstr]
    • Corazzelli G. J Clin Oncol 2008 ASCO Annual Meeting Proceedings 2008; 26: 8532 [Abstr].
    • (2008) J Clin Oncol , vol.26 , pp. 8532
    • Corazzelli, G.1
  • 115
    • 68449090699 scopus 로고    scopus 로고
    • Rituximab ABVD improves event-free survival (EFS) in patients with classical Hodgkin lymphoma in all international prognostic score (IPS) groups and in patients who have PET-positive disease after 2-3 cycles of therapy
    • Wedgwood AR, Fanale MA, Fayad LE, McLaughlin P, Hagemeister FB, Pro B, et al . Rituximab ABVD improves event-free survival (EFS) in patients with classical Hodgkin lymphoma in all international prognostic score (IPS) groups and in patients who have PET-positive disease after 2-3 cycles of therapy. ASH Annu Meet Abstr 2007; 110: 215.
    • ASH Annu Meet Abstr 2007 , vol.110 , pp. 215
    • Wedgwood, A.R.1    Fanale, M.A.2    Fayad, L.E.3    McLaughlin, P.4    Hagemeister, F.B.5    Pro, B.6
  • 117
    • 66149155829 scopus 로고    scopus 로고
    • Experience with 90Y-ibritumomab tiuxetan for relapsed classical Hodgkin lymphoma
    • Younes A, Wong F. Experience with 90Y-ibritumomab tiuxetan for relapsed classical Hodgkin lymphoma. Ann Oncol 2009; 20: 1147-1148.
    • (2009) Ann Oncol , vol.20 , pp. 1147-1148
    • Younes, A.1    Wong, F.2
  • 119
    • 70449483876 scopus 로고    scopus 로고
    • Neutrophils express CD52 and exhibit complement-mediated lysis in the presence of alemtuzumab
    • Ambrose LR, Morel AS, Warrens AN. Neutrophils express CD52 and exhibit complement-mediated lysis in the presence of alemtuzumab. Blood 2009; 114: 3052-3055.
    • (2009) Blood , vol.114 , pp. 3052-3055
    • Ambrose, L.R.1    Morel, A.S.2    Warrens, A.N.3
  • 121
    • 33745899005 scopus 로고    scopus 로고
    • CD52 is expressed on human mast cells and is a potential therapeutic target in Waldenstrom's macroglobulinemia and mast cell disorders
    • Santos DD, Hatjiharissi E, Tournilhac O, Chemaly MZ, Leleu X, Xu L, et al . CD52 is expressed on human mast cells and is a potential therapeutic target in Waldenstrom's macroglobulinemia and mast cell disorders. Clin Lymphoma Myeloma 2006; 6: 478-483.
    • (2006) Clin Lymphoma Myeloma , vol.6 , pp. 478-483
    • Santos, D.D.1    Hatjiharissi, E.2    Tournilhac, O.3    Chemaly, M.Z.4    Leleu, X.5    Xu, L.6
  • 123
    • 10344244536 scopus 로고    scopus 로고
    • Human eosinophils express functional CD30 ligand and stimulate proliferation of a Hodgkin's disease cell line
    • Pinto A, Aldinucci D, Gloghini A, Zagonel V, Degan M, Improta S, et al . Human eosinophils express functional CD30 ligand and stimulate proliferation of a Hodgkin's disease cell line. Blood 1996; 88: 3299-3305.
    • (1996) Blood , vol.88 , pp. 3299-3305
    • Pinto, A.1    Aldinucci, D.2    Gloghini, A.3    Zagonel, V.4    Degan, M.5    Improta, S.6
  • 125
    • 41149168649 scopus 로고    scopus 로고
    • Lenalidomide for the treatment of B cell malignancies
    • Chanan-Khan AA, Cheson BD. Lenalidomide for the treatment of B cell malignancies. J Clin Oncol 2008; 26: 1544-1552.
    • (2008) J Clin Oncol , vol.26 , pp. 1544-1552
    • Chanan-Khan, A.A.1    Cheson, B.D.2
  • 127
    • 74049139971 scopus 로고    scopus 로고
    • Tumor flare reactions and response to lenalidomide in patients with refractory classic Hodgkin lymphoma
    • Corazzelli G, De Filippi R, Capobianco G, Frigeri F, De Rosa V, Iaccarino G, et al . Tumor flare reactions and response to lenalidomide in patients with refractory classic Hodgkin lymphoma. Am J Hematol 2010; 85: 87-90.
    • (2010) Am J Hematol , vol.85 , pp. 87-90
    • Corazzelli, G.1    De Filippi, R.2    Capobianco, G.3    Frigeri, F.4    De Rosa, V.5    Iaccarino, G.6
  • 130
    • 35348991105 scopus 로고    scopus 로고
    • Comprehensive identification of proteins in Hodgkin lymphoma-derived Reed-Sternberg cells by LC-MS/MS
    • Wallentine JC, Kim KK, Seiler CE 3rd, Vaughn CP, Crockett DK, Tripp SR, et al . Comprehensive identification of proteins in Hodgkin lymphoma-derived Reed-Sternberg cells by LC-MS/MS. Lab Invest 2007; 87: 1113-1124.
    • (2007) Lab Invest , vol.87 , pp. 1113-1124
    • Wallentine, J.C.1    Kim, K.K.2    Seiler III, C.E.3    Vaughn, C.P.4    Crockett, D.K.5    Tripp, S.R.6
  • 131
    • 63849261384 scopus 로고    scopus 로고
    • Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients
    • Sauer S, Erba PA, Petrini M, Menrad A, Giovannoni L, Grana C, et al . Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients. Blood 2009; 113: 2265-2274.
    • (2009) Blood , vol.113 , pp. 2265-2274
    • Sauer, S.1    Erba, P.A.2    Petrini, M.3    Menrad, A.4    Giovannoni, L.5    Grana, C.6
  • 132
    • 70249129332 scopus 로고    scopus 로고
    • Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma
    • Schliemann C, Wiedmer A, Pedretti M, Szczepanowski M, Klapper W, Neri D. Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma. Leuk Res 2009; 33: 1718-1722.
    • (2009) Leuk Res , vol.33 , pp. 1718-1722
    • Schliemann, C.1    Wiedmer, A.2    Pedretti, M.3    Szczepanowski, M.4    Klapper, W.5    Neri, D.6
  • 134
    • 67650638846 scopus 로고    scopus 로고
    • T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumour activity in a Hodgkin tumour model
    • Di Stasi A, De Angelis B, Rooney CM, et al . T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumour activity in a Hodgkin tumour model. Blood 2009; 113: 6392-6402.
    • (2009) Blood , vol.113 , pp. 6392-6402
    • Di Stasi, A.1    De Angelis, B.2    Rooney, C.M.3
  • 135
    • 31944433180 scopus 로고    scopus 로고
    • Expression of CCL5 (RANTES) and CCR5 in prostate cancer
    • Vaday GG, Peehl DM, Kadam PA, Lawrence DM. Expression of CCL5 (RANTES) and CCR5 in prostate cancer. Prostate 2006; 66: 124-134.
    • (2006) Prostate , vol.66 , pp. 124-134
    • Vaday, G.G.1    Peehl, D.M.2    Kadam, P.A.3    Lawrence, D.M.4
  • 136
    • 67949107932 scopus 로고    scopus 로고
    • CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation
    • Murooka TT, Rahbar R, Fish EN. CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation. Biochem Biophys Res Commun 2009; 387: 381-386.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 381-386
    • Murooka, T.T.1    Rahbar, R.2    Fish, E.N.3
  • 137
    • 51649109943 scopus 로고    scopus 로고
    • Chemotherapeutic drugs and human tumour cells cytokine network
    • Levina V, Su Y, Nolen B, Liu X, Gordin Y, Lee M, et al . Chemotherapeutic drugs and human tumour cells cytokine network. Int J Cancer 2008; 123: 2031-2040.
    • (2008) Int J Cancer , vol.123 , pp. 2031-2040
    • Levina, V.1    Su, Y.2    Nolen, B.3    Liu, X.4    Gordin, Y.5    Lee, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.