Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin's disease

British Journal of Haematology

Volumn 117, Issue 2, 2002, Pages 366-372

  Carbone, Antonino ^a,b   Gloghini, Annunziata ^a   Aldinucci, Donatella ^b   Gattei, Valter ^b   Dalla Favera, Riccardo ^c   Gaidano, Gianluca ^d  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

H cells; Histogenesis; Hodgkin's disease; L ; Microenvironment; MUM1 IRF4

Indexed keywords

CD20 ANTIGEN; CD40 LIGAND; CD57 ANTIGEN; INTERFERON REGULATORY FACTOR 4; MULTIPLE MYELOMA 1 INTERFERON REGULATORY FACTOR 4; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; HISTIOCYTE; HISTOGENESIS; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOID TISSUE; MAJOR CLINICAL STUDY; MICROENVIRONMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROSETTE FORMATION; SPECTRUM; T LYMPHOCYTE ACTIVATION; TUMOR CELL;

ANTIGENS, CD57; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; DNA-BINDING PROTEINS; HISTIOCYTES; HODGKIN DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON REGULATORY FACTORS; LYMPHOID TISSUE; REED-STERNBERG CELLS; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 0036253641     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03456.x     Document Type: Article

References (31)

1. European task force on lymphoma project on lymphocyte predominance Hodgkin's disease: Histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin's disease with nodular growth pattern and abundant lymphocytes
2. CD40 ligand is constitutively expressed in a subset of T-cell lymphomas and on the microenvironmental reactive T-cells of follicular lymphomas and Hodgkin's disease
3. Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's diseases cell lines
4. Expression of CD26 and CD40 ligand is mutually exclusive in human T-cell non Hodgkin's lymphomas/leukemias
5. Reed-Sternberg cells of classical Hodgkin's disease react with the plasma cell specific monoclonal antibody B-B4 and express human syndecan-1
6. Expression status of BCL-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin's disease
7. Expression of MUM1/IRF4 selectively clusters with primary effusion lymphoma among lymphomatous effusions. Implications for disease histogenesis and pathogenesis
8. Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas
9. Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal antialkaline phosphatase (APAAP complexes)
10. Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease
11. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells
12. The usefulness of immunophenotypic and genotypic studies in the diagnosis and classification of hematopoietic and lymphoid neoplasms. An update
13. MUM1: A step ahead toward the understanding of lymphoma histogenesis
14. Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease
15. Hodgkin's disease: Classification and differential diagnosis
16. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
17. A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies
18. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
19. Hodgkin's disease: Cell of origin, immunobiology and pathogenesis
20. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
21. Cellular origin of human B-cell lymphomas
22. Natural history of Hodg-kin's disease as related to its pathological picture
23. Report of the nomenclature committee
24. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B-cells
25. Nodular lymphocyte-predominance Hodgkin's disease: A distinct clinicopathological entity
26. The growing family of interferon regulatory factors
27. The nature of the lymphocytes surrounding Reed-Sternberg cells in nodular lymphocyte predominance and in other types of Hodgkin's disease
28. Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma
29. MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies
30. Tumors of the lymph nodes and spleen