Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

Nucleic Acids Research

Volumn 43, Issue 16, 2015, Pages 7702-7716

  Scuotto, Maria ^a   Rivieccio, Elisa ^a   Varone, Alessia ^b   Corda, Daniela ^b   Bucci, Mariarosaria ^a   Vellecco, Valentina ^a   Cirino, Giuseppe ^a   Virgilio, Antonella ^a   Esposito, Veronica ^a   Galeone, Aldo ^a   Borbone, Nicola ^a   Varra, Michela ^a   Mayol, Luciano ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; BENZENE; FIBRINOGEN; GUANINE QUADRUPLEX; NUCLEOSIDE; THROMBIN BINDING APTAMER; THROMBIN BINDING APTAMER BS12; THROMBIN BINDING APTAMER BS13; THROMBIN BINDING APTAMER BS3; THROMBIN BINDING APTAMER BS4; THROMBIN BINDING APTAMER BS7; THROMBIN BINDING APTAMER BS8; THROMBIN BINDING APTAMER BS9; UNCLASSIFIED DRUG; ANTICOAGULANT AGENT; ANTINEOPLASTIC AGENT; BENZYL DERIVATIVE; OLIGONUCLEOTIDE; THROMBIN APTAMER;

ANTICOAGULATION; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BLOOD CLOTTING; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN CELL; MTT ASSAY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTHROMBIN TIME; BLOOD CLOTTING TEST; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DNA DENATURATION; DRUG EFFECTS; HELA CELL LINE; SYNTHESIS;

ANTICOAGULANTS; ANTINEOPLASTIC AGENTS; APTAMERS, NUCLEOTIDE; BENZYL COMPOUNDS; BLOOD COAGULATION TESTS; CELL PROLIFERATION; FIBRINOGEN; G-QUADRUPLEXES; HELA CELLS; HUMANS; MODELS, MOLECULAR; NUCLEIC ACID DENATURATION; OLIGONUCLEOTIDES; PROTHROMBIN TIME;

EID: 84942279983     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv789     Document Type: Article

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