Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: Enhancement of anticoagulant activity by a single nucleobase modification

Journal of Medicinal Chemistry

Volumn 55, Issue 23, 2012, Pages 10716-10728

  Borbone, Nicola ^a   Bucci, Mariarosaria ^a   Oliviero, Giorgia ^a   Morelli, Elena ^a   Amato, Jussara ^a   D'Atri, Valentina ^a   D'Errico, Stefano ^a   Vellecco, Valentina ^a   Cirino, Giuseppe ^a   Piccialli, Gennaro ^a   Fattorusso, Caterina ^a   Varra, Michela ^a   Mayol, Luciano ^a   Persico, Marco ^a   Scuotto, Maria ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; APTAMER; FIBRINOGEN; GUANINE QUADRUPLEX; NUCLEIC ACID BASE; THROMBIN; THROMBIN BINDING APTAMER; UNCLASSIFIED DRUG; ANTICOAGULANT AGENT; THROMBIN APTAMER;

ANTICOAGULATION; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD CLOTTING TIME; HUMAN; NONHUMAN; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; TEMPERATURE; ANIMAL; BASE PAIRING; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE;

ANIMALS; ANTICOAGULANTS; APTAMERS, NUCLEOTIDE; BASE PAIRING; BASE SEQUENCE; CATTLE; CIRCULAR DICHROISM; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 84871007036     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301414f     Document Type: Article

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