High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

Nucleic Acids Research

Volumn 40, Issue 16, 2012, Pages 8119-8128

  Russo Krauss, Irene ^a   Merlino, Antonello ^a,b   Randazzo, Antonio ^a   Novellino, Ettore ^a   Mazzarella, Lelio ^a,b   Sica, Filomena ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; CALCIUM ION; CATION; POTASSIUM ION; THROMBIN; THROMBIN BINDING APTAMER; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; CRYSTALLOGRAPHY; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

APTAMERS, NUCLEOTIDE; CATIONS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; POTASSIUM; SODIUM; THROMBIN;

EID: 84870535712     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks512     Document Type: Article

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