SCOPUS 정보 검색 플랫폼

Volumn 23, Issue 19, 2015, Pages 6427-6436

Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists

(7) Song, Kebiao a Xu, Xing b,c Liu, Peng a Chen, Lili b Shen, Xu b Liu, Junhua b Hu, Lihong a,b

a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)

b SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (China)

Author keywords

FXR; FXR antagonist; Non steroidal; SAR study

Indexed keywords

2 (TERT BUTYL) 4 (HYDROXYIMINO)CYCLOHEXA 2,5 DIENONE; 2,4 DICHLORO N (3,5 DI TERT BUTYL 4 HYDROXYPHENYL)BENZAMIDE; 2,4 DICHLORO N (4 HYDROXY 3 ETHYLPHENYL)BENZAMIDE; 2,4 DICHLORO N (4 HYDROXY 3 ISOPROPYLPHENYL)BENZAMIDE; 2,4 DICHLORO N (4 HYDROXY 3 METHYLPHENYL)BENZAMIDE; 3 (TERT BUTYL) 4 HYDROXYPHENYL 2 CHLORO 4 AMINOBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 2 CHLORO 4 NITROBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 2 METHOXYLBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 2 METHYLBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 2 PHENYLACETIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 2,4 DICHLOROBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 2,6 CHLORO 4 NITROBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 2,6 DICHLORO 4 AMINOBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 4 AMINOBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 4 CHLOROBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 4 METHYLBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL 4 NITROBENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL BENZOIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL CINNAMIC ACID; 3 (TERT BUTYL) 4 HYDROXYPHENYL FURAN 2 CARBOXYLIC ACID; 4 AMINO 2 (TERT BUTYL)PHENOL; 4 AMINO 2 ETHYLPHENOL; 4 AMINO 2 ISOPROPYLPHENOL; 4 AMINO 2 METHYLPHENOL; 4 AMINO 2,6 DI TERT BUTYLPHENOL; BENZAMIDE DERIVATIVE; HORMONE RECEPTOR BLOCKING AGENT; N (3 (TERT BUTYL) 4 HYDROXYPHENYL) 2,4 DICHLOROBENZAMIDE; N (3 (TERT BUTYL) 4 METHOXYPHENYL) 2,4 DICHLOROBENZAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; BENZAMIDE; BENZOIC ACID DERIVATIVE; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; PROTEIN BINDING;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; METABOLISM; PRECLINICAL STUDY;

BENZAMIDES; BENZOATES; DRUG EVALUATION, PRECLINICAL; HUMANS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84942191591 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2015.08.021 Document Type: Article

Times cited : (8)

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