-
1
-
-
79952135500
-
The potential of multimer technologies in type 1 diabetes prediction strategies
-
Fierabracci, A. The potential of multimer technologies in type 1 diabetes prediction strategies. Diabetes Metab. Res. Rev. 2011, 27, 216–229
-
(2011)
Diabetes Metab. Res. Rev
, vol.27
, pp. 216-229
-
-
Fierabracci, A.1
-
2
-
-
78751616196
-
Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity
-
Fierabracci, A. Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity. Autoimmun. Rev.2011, 10, 137–143
-
(2011)
Autoimmun. Rev
, vol.10
, pp. 137-143
-
-
Fierabracci, A.1
-
3
-
-
13944270218
-
CD4+CD25high regulatory T cells in human autoimmune diabetes
-
Putnam, A.L.; Vendrame, F.; Dotta, F.; Gottlieb, P.A. CD4+CD25high regulatory T cells in human autoimmune diabetes. J. Autoimmun.2005, 24, 55–62
-
(2005)
J. Autoimmun
, vol.24
, pp. 55-62
-
-
Putnam, A.L.1
Vendrame, F.2
Dotta, F.3
Gottlieb, P.A.4
-
4
-
-
84929520033
-
Alteration of regulatory T cells in type 1 diabetes mellitus: A comprehensive review
-
Tan, T.; Xiang, Y.; Chang, C.; Zhou, Z. Alteration of regulatory T cells in type 1 diabetes mellitus: A comprehensive review. Clin. Rev. Allergy Immunol. 2014, 47, 234–243
-
(2014)
Clin. Rev. Allergy Immunol
, vol.47
, pp. 234-243
-
-
Tan, T.1
Xiang, Y.2
Chang, C.3
Zhou, Z.4
-
5
-
-
0036141438
-
Multiple immuno-regulatory defects in type-1 diabetes
-
Kukreja, A.; Cost, G.; Marker, J.; Zhang, C.; Sun, Z.; Lin-Su, K.; Ten, S.; Sanz, M.; Exley, M.; Wilson, B., et al. Multiple immuno-regulatory defects in type-1 diabetes. J. Clin. Investig. 2002, 109, 131–140
-
(2002)
J. Clin. Investig
, vol.109
, pp. 131-140
-
-
Kukreja, A.1
Cost, G.2
Marker, J.3
Zhang, C.4
Sun, Z.5
Lin-Su, K.6
Ten, S.7
Sanz, M.8
Exley, M.9
Wilson, B.10
-
6
-
-
12144249838
-
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
-
Lindley, S.; Dayan, C.M.; Bishop, A.; Roep, B.O.; Peakman, M.; Tree, T.I. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005, 54, 92–99
-
(2005)
Diabetes
, vol.54
, pp. 92-99
-
-
Lindley, S.1
Dayan, C.M.2
Bishop, A.3
Roep, B.O.4
Peakman, M.5
Tree, T.I.6
-
7
-
-
68249100526
-
Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes
-
Łuczyński, W.; Wawrusiewicz-Kurylonek, N.; Stasiak-Barmuta, A.; Urban, R.; Iłendo, E.; Urban, M.; Hryszko, M.; Kretowski, A.; Górska, M. Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes. Acta Biochim. Pol. 2009, 56, 361–700
-
(2009)
Acta Biochim. Pol
, vol.56
, pp. 361-700
-
-
Łuczyński, W.1
Wawrusiewicz-Kurylonek, N.2
Stasiak-Barmuta, A.3
Urban, R.4
Iłendo, E.5
Urban, M.6
Hryszko, M.7
Kretowski, A.8
Górska, M.9
-
8
-
-
55449111318
-
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
-
Lawson, J.M.; Tremble, J.; Dayan, C.; Beyan, H.; Leslie, R.D.G.; Peakman, M.; Tree, T.I. Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin. Exp. Immunol. 2008, 154, 353–359
-
(2008)
Clin. Exp. Immunol
, vol.154
, pp. 353-359
-
-
Lawson, J.M.1
Tremble, J.2
Dayan, C.3
Beyan, H.4
Leslie, R.5
Peakman, M.6
Tree, T.I.7
-
9
-
-
17844364504
-
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes
-
Brusko, T.M.; Wasserfall, C.H.; Clare-Salzler, M.J.; Schatz, D.A.; Atkinson, M.A. Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes 2005, 54, 1407–1414
-
(2005)
Diabetes
, vol.54
, pp. 1407-1414
-
-
Brusko, T.M.1
Wasserfall, C.H.2
Clare-Salzler, M.J.3
Schatz, D.A.4
Atkinson, M.A.5
-
10
-
-
84890052803
-
Decreased CD127 expression on CD4+ T-cells and elevated frequencies of CD4+CD25+CD127− T-cells in children with long-lasting type 1 diabetes
-
Moniuszko, M.; Glowinska-Olszewska, B.; Rusak, M.; Jeznach, M.; Grubczak, K.; Lipinska, D.; Milewski, R.; Milewska, A.J.; Dabrowska, M.; Jablonska, E., et al. Decreased CD127 expression on CD4+ T-cells and elevated frequencies of CD4+CD25+CD127− T-cells in children with long-lasting type 1 diabetes. Clin. Dev. Immunol. 2013, 2013, 459210
-
(2013)
Clin. Dev. Immunol
, vol.2013
-
-
Moniuszko, M.1
Glowinska-Olszewska, B.2
Rusak, M.3
Jeznach, M.4
Grubczak, K.5
Lipinska, D.6
Milewski, R.7
Milewska, A.J.8
Dabrowska, M.9
Jablonska, E.10
-
11
-
-
84905040916
-
Leukocyte profiles differ between type 1 and type 2 diabetes and are associated with metabolic phenotypes: Results from the German Diabetes Study (GDS)
-
Menart-Houtermans, B.; Rütter, R.; Nowotny, B.; Rosenbauer, J.; Koliaki, C.; Kahl, S.; Simon, M.C.; Szendroedi, J.; Schloot, N.C.; Roden, M., et al. Leukocyte profiles differ between type 1 and type 2 diabetes and are associated with metabolic phenotypes: Results from the German Diabetes Study (GDS). Diabetes Care 2014, 37, 2326–2333
-
(2014)
Diabetes Care
, vol.37
, pp. 2326-2333
-
-
Menart-Houtermans, B.1
Rütter, R.2
Nowotny, B.3
Rosenbauer, J.4
Koliaki, C.5
Kahl, S.6
Simon, M.C.7
Szendroedi, J.8
Schloot, N.C.9
Roden, M.10
-
12
-
-
33847373481
-
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
-
Brusko, T.; Wasserfall, C.; McGrail, K.; Schatz, R.; Viener, H.L.; Schatz, D.; Haller, M.; Rockell, J.; Gottlieb, P.; Clare-Salzler, M., et al. No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes. Diabetes 2007, 56, 604–612
-
(2007)
Diabetes
, vol.56
, pp. 604-612
-
-
Brusko, T.1
Wasserfall, C.2
McGrail, K.3
Schatz, R.4
Viener, H.L.5
Schatz, D.6
Haller, M.7
Rockell, J.8
Gottlieb, P.9
Clare-Salzler, M.10
-
13
-
-
58149188480
-
The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
-
Schneider, A.; Rieck, M.; Sanda, S.; Pihoker, C.; Greenbaum, C.; Buckner, J.H. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J. Immunol. 2008, 181, 7350–7355
-
(2008)
J. Immunol
, vol.181
, pp. 7350-7355
-
-
Schneider, A.1
Rieck, M.2
Sanda, S.3
Pihoker, C.4
Greenbaum, C.5
Buckner, J.H.6
-
14
-
-
51849122220
-
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
-
Monti, P.; Scirpoli, M.; Maffi, P.; Piemonti, L.; Secchi, A.; Bonifacio, E.; Roncarolo, M.G.; Battaglia, M. Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells. Diabetes 2008, 57, 2341–2347
-
(2008)
Diabetes
, vol.57
, pp. 2341-2347
-
-
Monti, P.1
Scirpoli, M.2
Maffi, P.3
Piemonti, L.4
Secchi, A.5
Bonifacio, E.6
Roncarolo, M.G.7
Battaglia, M.8
-
15
-
-
34447640430
-
At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction
-
Glisic-Milosavljevic, S.; Waukau, J.; Jailwala, P.; Jana, S.; Khoo, H.-J.; Albertz, H.; Woodliff, J.; Koppen, M.; Alemzadeh, R.; Hagopian, W., et al. At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction. PLoS ONE 2007, 2, e146
-
(2007)
Plos ONE
, vol.2
-
-
Glisic-Milosavljevic, S.1
Waukau, J.2
Jailwala, P.3
Jana, S.4
Khoo, H.-J.5
Albertz, H.6
Woodliff, J.7
Koppen, M.8
Alemzadeh, R.9
Hagopian, W.10
-
16
-
-
80052841136
-
Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes
-
Hughson, A.; Bromberg, I.; Johnson, B.; Quataert, S.; Jospe, N.; Fowell, D.J. Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes. Diabetes 2011, 60, 2125–2133
-
(2011)
Diabetes
, vol.60
, pp. 2125-2133
-
-
Hughson, A.1
Bromberg, I.2
Johnson, B.3
Quataert, S.4
Jospe, N.5
Fowell, D.J.6
-
17
-
-
77949265942
-
Inducible regulatory T cells (ITregs) from recent-onset type 1 diabetes subjects show increased in vitro suppression and higher ITCH levels compared with controls
-
Glisic, S.; Ehlenbach, S.; Jailwala, P.; Waukau, J.; Jana, S.; Ghosh, S. Inducible regulatory T cells (iTregs) from recent-onset type 1 diabetes subjects show increased in vitro suppression and higher ITCH levels compared with controls. Cell Tissue Res. 2010, 339, 585–595
-
(2010)
Cell Tissue Res
, vol.339
, pp. 585-595
-
-
Glisic, S.1
Ehlenbach, S.2
Jailwala, P.3
Waukau, J.4
Jana, S.5
Ghosh, S.6
-
18
-
-
79955028001
-
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
-
McClymont, S.A.; Putnam, A.L.; Lee, M.R.; Esensten, J.H.; Liu, W.; Hulme, M.A.; Woodliff, J.; Koppen, M.; Alemzadeh, R.; Hagopian, W., et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J. Immunol. 2011,186, 3918–3926
-
(2011)
J. Immunol
, vol.186
, pp. 3918-3926
-
-
McClymont, S.A.1
Putnam, A.L.2
Lee, M.R.3
Esensten, J.H.4
Liu, W.5
Hulme, M.A.6
Woodliff, J.7
Koppen, M.8
Alemzadeh, R.9
Hagopian, W.10
-
19
-
-
84873689748
-
Foxp3+ Treg expanded from patients with established diabetes reduce Helios expression while retaining normal function compared to healthy individuals
-
Du, W.; Shen, Y.-W.; Lee, W.-H.; Wang, D.; Paz, S.; Kandeel, F.; Liu C.P. Foxp3+ Treg expanded from patients with established diabetes reduce Helios expression while retaining normal function compared to healthy individuals. PLoS ONE 2013, 8, e56209
-
(2013)
Plos ONE
, vol.8
-
-
Du, W.1
Shen, Y.-W.2
Lee, W.-H.3
Wang, D.4
Paz, S.5
Kandeel, F.6
Liu, C.P.7
-
20
-
-
77958136352
-
Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes
-
Marwaha, A.K.; Crome, S.Q.; Panagiotopoulos, C.; Berg, K.B.; Qin, H.; Ouyang, Q.; Xu, L.; Priatel, J.J.; Levings, M.K.; Tan, R. Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J. Immunol. 2010, 185, 3814–3818
-
(2010)
J. Immunol
, vol.185
, pp. 3814-3818
-
-
Marwaha, A.K.1
Crome, S.Q.2
Panagiotopoulos, C.3
Berg, K.B.4
Qin, H.5
Ouyang, Q.6
Xu, L.7
Priatel, J.J.8
Levings, M.K.9
Tan, R.10
-
21
-
-
70149107014
-
Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis
-
Alonso, N.; Martínez-Arconada, M.J.; Granada, M.L.; Soldevila, B.; Cantón, A.; Mate, J.L.; Sanmartí, A.; Martínez-Cáceres, E.M. Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis. Endocrine 2009, 35, 420–428
-
(2009)
Endocrine
, vol.35
, pp. 420-428
-
-
Alonso, N.1
Martínez-Arconada, M.J.2
Granada, M.L.3
Soldevila, B.4
Cantón, A.5
Mate, J.L.6
Sanmartí, A.7
Martínez-Cáceres, E.M.8
-
22
-
-
84880033192
-
CD4+ CD45RA− FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes
-
Haseda, F.; Imagawa, A.; Murase-Mishiba, Y.; Terasaki, J.; Hanafusa, T. CD4+ CD45RA− FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes. Clin. Exp. Immunol. 2013, 173, 207–216
-
(2013)
Clin. Exp. Immunol
, vol.173
, pp. 207-216
-
-
Haseda, F.1
Imagawa, A.2
Murase-Mishiba, Y.3
Terasaki, J.4
Hanafusa, T.5
-
23
-
-
80052829380
-
Defective differentiation of regulatory FoxP3+ T cells by small-intestinal dendritic cells in patients with type 1 diabetes
-
Badami, E.; Sorini, C.; Coccia, M.; Usuelli, V.; Molteni, L.; Bolla, A.M.; Scavini, M.; Mariani, A.; King, C.; Bosi, E., et al. Defective differentiation of regulatory FoxP3+ T cells by small-intestinal dendritic cells in patients with type 1 diabetes. Diabetes 2011, 60, 2120–2124
-
(2011)
Diabetes
, vol.60
, pp. 2120-2124
-
-
Badami, E.1
Sorini, C.2
Coccia, M.3
Usuelli, V.4
Molteni, L.5
Bolla, A.M.6
Scavini, M.7
Mariani, A.8
King, C.9
Bosi, E.10
-
24
-
-
80755148666
-
Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes
-
Ferraro, A.; Socci, C.; Stabilini, A.; Valle, A.; Monti, P.; Piemonti, L.; Nano, R.; Olek, S.; Maffi, P.; Scavini, M., et al. Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes 2011, 60, 2903–2913
-
(2011)
Diabetes
, vol.60
, pp. 2903-2913
-
-
Ferraro, A.1
Socci, C.2
Stabilini, A.3
Valle, A.4
Monti, P.5
Piemonti, L.6
Nano, R.7
Olek, S.8
Maffi, P.9
Scavini, M.10
-
25
-
-
33745817085
-
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
-
Liu, W.; Putnam, A.L.; Zhou, X.-Y.; Szot, G.L.; Lee, M.R.; Zhu, S.; Gottlieb, P.A.; Kapranov, P.; Gingeras, T.R.; Fazekas de St Groth, B., et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med.2006, 203, 1701–1711
-
(2006)
J. Exp. Med
, vol.203
, pp. 1701-1711
-
-
Liu, W.1
Putnam, A.L.2
Zhou, X.-Y.3
Szot, G.L.4
Lee, M.R.5
Zhu, S.6
Gottlieb, P.A.7
Kapranov, P.8
Gingeras, T.R.9
De Fazekas St Groth, B.10
-
26
-
-
84897935715
-
Genetic and epigenetic basis of Treg cell development and function: From a FoxP3-centered view to an epigenome-defined view of natural Treg cells
-
Morikawa, H.; Sakaguchi, S. Genetic and epigenetic basis of Treg cell development and function: From a FoxP3-centered view to an epigenome-defined view of natural Treg cells. Immunol. Rev. 2014, 259, 192–205
-
(2014)
Immunol. Rev
, vol.259
, pp. 192-205
-
-
Morikawa, H.1
Sakaguchi, S.2
-
27
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing, K.; Onishi, Y.; Prieto-Martin, P.; Yamaguchi, T.; Miyara, M.; Fehervari, Z.; Nomura, T.; Sakaguchi, S. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008, 322, 271–275
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
Fehervari, Z.6
Nomura, T.7
Sakaguchi, S.8
-
28
-
-
33947647317
-
CD39 and control of cellular immune responses
-
Dwyer, K.M.; Deaglio, S.; Gao, W.; Friedman, D.; Strom, T.B.; Robson, S.C. CD39 and control of cellular immune responses. Purinergic Signal 2007, 3, 171–180
-
(2007)
Purinergic Signal
, vol.3
, pp. 171-180
-
-
Dwyer, K.M.1
Deaglio, S.2
Gao, W.3
Friedman, D.4
Strom, T.B.5
Robson, S.C.6
-
29
-
-
5644263642
-
Role of LAG-3 in regulatory T cells
-
Huang, C.-T.; Workman, C.J.; Flies, D.; Pan, X.; Marson, A.L.; Zhou, G.; Hipkiss, E.L.; Ravi, S.; Kowalski, J.; Levitsky, H.I., et al. Role of LAG-3 in regulatory T cells. Immunity 2004, 21, 503–513
-
(2004)
Immunity
, vol.21
, pp. 503-513
-
-
Huang, C.-T.1
Workman, C.J.2
Flies, D.3
Pan, X.4
Marson, A.L.5
Zhou, G.6
Hipkiss, E.L.7
Ravi, S.8
Kowalski, J.9
Levitsky, H.I.10
-
30
-
-
33847376532
-
Galectin-1: A key effector of regulation mediated by CD4+CD25+ T cells
-
Garín, M.I.; Chu, C.-C.; Golshayan, D.; Cernuda-Morollón, E.; Wait, R.; Lechler, R.I. Galectin-1: A key effector of regulation mediated by CD4+CD25+ T cells. Blood 2007, 109, 2058–2065
-
(2007)
Blood
, vol.109
, pp. 2058-2065
-
-
Garín, M.I.1
Chu, C.-C.2
Golshayan, D.3
Cernuda-Morollón, E.4
Wait, R.5
Lechler, R.I.6
-
31
-
-
33646164362
-
Transforming growth factor-beta regulation of immune responses
-
Li, M.O.; Wan, Y.Y.; Sanjabi, S.; Robertson, A.-K.L.; Flavell, R.A. Transforming growth factor-beta regulation of immune responses. Annu. Rev. Immunol. 2006, 24, 99–146
-
(2006)
Annu. Rev. Immunol
, vol.24
, pp. 99-146
-
-
Li, M.O.1
Wan, Y.Y.2
Sanjabi, S.3
Robertson, A.-K.L.4
Flavell, R.A.5
-
32
-
-
35449006679
-
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
-
Cao, X.; Cai, S.F.; Fehniger, T.A.; Song, J.; Collins, L.I.; Piwnica-Worms, D.R.; Ley, T.J. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007, 27, 635–646
-
(2007)
Immunity
, vol.27
, pp. 635-646
-
-
Cao, X.1
Cai, S.F.2
Fehniger, T.A.3
Song, J.4
Collins, L.I.5
Piwnica-Worms, D.R.6
Ley, T.J.7
-
33
-
-
63249123219
-
CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression
-
Shen, L.-S.; Wang, J.; Shen, D.-F.; Yuan, X.-L.; Dong, P.; Li, M.-X.; Xue, J.; Zhang, F.M.; Ge, H.L.; Xu, D. CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression. Clin. Immunol. 2009, 131, 109–118
-
(2009)
Clin. Immunol
, vol.131
, pp. 109-118
-
-
Shen, L.-S.1
Wang, J.2
Shen, D.-F.3
Yuan, X.-L.4
Dong, P.5
Li, M.-X.6
Xue, J.7
Zhang, F.M.8
Ge, H.L.9
Xu, D.10
-
34
-
-
84881541416
-
Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity
-
Gianchecchi, E.; Delfino, D.V.; Fierabracci, A. Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity. Autoimmun. Rev.2013, 12, 1091–1100
-
(2013)
Autoimmun. Rev
, vol.12
, pp. 1091-1100
-
-
Gianchecchi, E.1
Delfino, D.V.2
Fierabracci, A.3
-
35
-
-
0037087472
-
CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells
-
Appleman, L.J.; van Puijenbroek, A.A.; Shu, K.M.; Nadler, L.M.; Boussiotis, V.A. CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J. Immunol. 2002, 168, 2729–2736
-
(2002)
J. Immunol
, vol.168
, pp. 2729-2736
-
-
Appleman, L.J.1
Van Puijenbroek, A.A.2
Shu, K.M.3
Nadler, L.M.4
Boussiotis, V.A.5
-
36
-
-
0033575290
-
Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1
-
Barthel, A.; Okino, S.T.; Liao, J.; Nakatani, K.; Li, J.; Whitlock, J.P.; Roth, R.A. Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. J. Biol. Chem.1999, 274, 20281–20286
-
(1999)
J. Biol. Chem
, vol.274
, pp. 20281-20286
-
-
Barthel, A.1
Okino, S.T.2
Liao, J.3
Nakatani, K.4
Li, J.5
Whitlock, J.P.6
Roth, R.A.7
-
37
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
Parry, R.V.; Chemnitz, J.M.; Frauwirth, K.A.; Lanfranco, A.R.; Braunstein, I.; Kobayakshi, S.V.; Linsley, P.S.; Thompson, C.B.; Riley, J.L. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell. Biol.2005, 25, 9543–9553
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 9543-9553
-
-
Parry, R.V.1
Chemnitz, J.M.2
Frauwirth, K.A.3
Lanfranco, A.R.4
Braunstein, I.5
Kobayakshi, S.V.6
Linsley, P.S.7
Thompson, C.B.8
Riley, J.L.9
-
38
-
-
0030686560
-
Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
-
Parry, R. V.; Reif, K.; Smith, G.; Sansom, D.M.; Hemmings, B.A.; Ward, S.G. Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B. Eur. J. Immunol. 1997, 27, 2495–2501
-
(1997)
Eur. J. Immunol
, vol.27
, pp. 2495-2501
-
-
Parry, R.V.1
Reif, K.2
Smith, G.3
Sansom, D.M.4
Hemmings, B.A.5
Ward, S.G.6
-
39
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
Frauwirth, K.A.; Riley, J.L.; Harris, M.H.; Parry, R.V.; Rathmell, J.C.; Plas, D.R.; Yamazaki, T.; Azuma, M.; Iwai, H.; Khoury, S.J. The CD28 signaling pathway regulates glucose metabolism. Immunity 2002,16, 769–777
-
(2002)
Immunity
, vol.16
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
Yamazaki, T.7
Azuma, M.8
Iwai, H.9
Khoury, S.J.10
-
40
-
-
0037477605
-
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
-
Ansari, M.J.; Salama, A.D.; Chitnis, T.; Smith, R.N.; Yagita, H.; Akiba, H.; Yamazaki, T.; Azuma, M.; Iwai, H.; Khoury, S.J., et al. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 2003, 198, 63–69
-
(2003)
J. Exp. Med
, vol.198
, pp. 63-69
-
-
Ansari, M.J.1
Salama, A.D.2
Chitnis, T.3
Smith, R.N.4
Yagita, H.5
Akiba, H.6
Yamazaki, T.7
Azuma, M.8
Iwai, H.9
Khoury, S.J.10
-
41
-
-
0038505613
-
CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid
-
Hatachi, S.; Iwai, Y.; Kawano, S.; Morinobu, S.; Kobayashi, M.; Koshiba, M.; Yamazaki, T.; Azuma, M.; Iwai, H.; Khoury, S.J. CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid. J. Rheumatol.2003, 30, 1410–1419
-
(2003)
J. Rheumatol
, vol.30
, pp. 1410-1419
-
-
Hatachi, S.1
Iwai, Y.2
Kawano, S.3
Morinobu, S.4
Kobayashi, M.5
Koshiba, M.6
Yamazaki, T.7
Azuma, M.8
Iwai, H.9
Khoury, S.J.10
-
42
-
-
27744480218
-
Enhanced expression of programmed death-1 (PD-1)/ PD-L1 in salivary glands of patients with Sjögren’s syndrome
-
Kobayashi, M.; Kawano, S.; Hatachi, S.; Kurimoto, C.; Okazaki, T.; Iwai, Y.; Yamazaki, T.; Azuma, M.; Iwai, H.; Khoury, S.J., et al. Enhanced expression of programmed death-1 (PD-1)/ PD-L1 in salivary glands of patients with Sjögren’s syndrome. J. Rheumatol. 2005, 32, 2156–2163
-
(2005)
J. Rheumatol
, vol.32
, pp. 2156-2163
-
-
Kobayashi, M.1
Kawano, S.2
Hatachi, S.3
Kurimoto, C.4
Okazaki, T.5
Iwai, Y.6
Yamazaki, T.7
Azuma, M.8
Iwai, H.9
Khoury, S.J.10
-
43
-
-
58249094864
-
Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in systemic lupus erythematosus
-
Bertias, G.K.; Nakou, M.; Choulaki, C.; Raptopoulos, A.; Papadimitraki, E.; Goulielmos, G.; Kritikos, H.; Sidiropoulos, P.; Tzardi, M.; Kardassis, D., et al. Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in systemic lupus erythematosus. Arthritis Rheum. 2009, 60, 207–218
-
(2009)
Arthritis Rheum
, vol.60
, pp. 207-218
-
-
Bertias, G.K.1
Nakou, M.2
Choulaki, C.3
Raptopoulos, A.4
Papadimitraki, E.5
Goulielmos, G.6
Kritikos, H.7
Sidiropoulos, P.8
Tzardi, M.9
Kardassis, D.10
-
44
-
-
84861395931
-
Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo
-
Lili, Y.; Yi, W.; Ji, Y.; Yue, S.; Weimin, S.; Ming, L. Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo. PLoS ONE 2012, 7, e37513
-
(2012)
Plos ONE
, vol.7
-
-
Lili, Y.1
Yi, W.2
Ji, Y.3
Yue, S.4
Weimin, S.5
Ming, L.6
-
45
-
-
84926185843
-
Alteration in regulatory T cells and programmed death (PD)1 expressing regulatory T cells in active generalized vitiligo and their clinical correlation
-
Tembhre, M.K.; Parihar, A.S.; Sharma, V.K.; Sharma, A.; Chattopadhyay, P.; Gupta, S. Alteration in regulatory T cells and programmed death (PD)1 expressing regulatory T cells in active generalized vitiligo and their clinical correlation. Br. J. Dermatol. 2015, 172, 940–950
-
(2015)
Br. J. Dermatol
, vol.172
, pp. 940-950
-
-
Tembhre, M.K.1
Parihar, A.S.2
Sharma, V.K.3
Sharma, A.4
Chattopadhyay, P.5
Gupta, S.6
-
46
-
-
33748745463
-
Phenotypic and genetic analyses of T-cell-mediated immunoregulation in patients with Type 1 diabetes
-
Tsutsumi, Y.; Jie, X.; Ihara, K.; Nomura, A.; Kanemitsu, S.; Takada, H.; Hara, T. Phenotypic and genetic analyses of T-cell-mediated immunoregulation in patients with Type 1 diabetes. Diabet. Med.2006, 23, 1145–1150
-
(2006)
Diabet. Med
, vol.23
, pp. 1145-1150
-
-
Tsutsumi, Y.1
Jie, X.2
Ihara, K.3
Nomura, A.4
Kanemitsu, S.5
Takada, H.6
Hara, T.7
-
47
-
-
84929337772
-
Low PD-1 expression in peripheral CD4+ T-cells in Japanese patients with autoimmune type 1 diabetes
-
Fujisawa, R.; Haseda, F.; Tsutsumi, C.; Hiromine, Y.; Noso, S.; Kawabata, Y.; Mitsui, S.; Terasaki, J.; Ikegami, H.; Imagawa, A., et al. Low PD-1 expression in peripheral CD4+ T-cells in Japanese patients with autoimmune type 1 diabetes. Clin. Exp. Immunol. 2015, 180, 452–457
-
(2015)
Clin. Exp. Immunol
, vol.180
, pp. 452-457
-
-
Fujisawa, R.1
Haseda, F.2
Tsutsumi, C.3
Hiromine, Y.4
Noso, S.5
Kawabata, Y.6
Mitsui, S.7
Terasaki, J.8
Ikegami, H.9
Imagawa, A.10
-
48
-
-
0344099132
-
Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes
-
Nielsen, C.; Hansen, D.; Husby, S.; Jacobsen, B.B.; Lillevang, S.T. Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes. Tissue Antigens 2003, 62, 492–497
-
(2003)
Tissue Antigens
, vol.62
, pp. 492-497
-
-
Nielsen, C.1
Hansen, D.2
Husby, S.3
Jacobsen, B.B.4
Lillevang, S.T.5
-
49
-
-
33947097389
-
PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children
-
Ni, R.; Ihara, K.; Miyako, K.; Kuromaru, R.; Inuo, M.; Kohno, H.; Matsuura, N.; Yoshimura, A.; Hara, T. PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. Hum. Genet. 2007, 121, 223–232
-
(2007)
Hum. Genet
, vol.121
, pp. 223-232
-
-
Ni, R.1
Ihara, K.2
Miyako, K.3
Kuromaru, R.4
Inuo, M.5
Kohno, H.6
Matsuura, N.7
Yoshimura, A.8
Hara, T.9
-
50
-
-
62749201002
-
Expansion of human regulatory T-cells from patients with type 1 diabetes
-
Putnam, A.L.; Brusko, T.M.; Lee, M.R.; Liu, W.; Szot, G.L.; Ghosh, T.; Atkinson, M.A.; Bluestone, J.A. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes 2009, 58, 652–662
-
(2009)
Diabetes
, vol.58
, pp. 652-662
-
-
Putnam, A.L.1
Brusko, T.M.2
Lee, M.R.3
Liu, W.4
Szot, G.L.5
Ghosh, T.6
Atkinson, M.A.7
Bluestone, J.A.8
-
51
-
-
84878069410
-
Blockade of programmed death-1 in young (New Zealand Black x New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease
-
Wong, M.; La Cava, A.; Hahn, B.H. Blockade of programmed death-1 in young (New Zealand Black x New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease. J. Immunol. 2013, 190, 5402–5410
-
(2013)
J. Immunol
, vol.190
, pp. 5402-5410
-
-
Wong, M.1
La Cava, A.2
Hahn, B.H.3
-
52
-
-
33644548654
-
Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells
-
Raimondi, G.; Shufesky, W.J.; Tokita, D.; Morelli, A.E.; Thomson, A.W. Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells. J. Immunol. 2006, 176, 2808–2816
-
(2006)
J. Immunol
, vol.176
, pp. 2808-2816
-
-
Raimondi, G.1
Shufesky, W.J.2
Tokita, D.3
Morelli, A.E.4
Thomson, A.W.5
-
53
-
-
65649139622
-
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
-
Franceschini, D.; Paroli, M.; Francavilla, V.; Videtta, M.; Morrone, S.; Labbadia, G.; Atkinson, M.A.; Bluestone, J.A. PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J. Clin. Investig. 2009, 119, 551–564
-
(2009)
J. Clin. Investig
, vol.119
, pp. 551-564
-
-
Franceschini, D.1
Paroli, M.2
Francavilla, V.3
Videtta, M.4
Morrone, S.5
Labbadia, G.6
Atkinson, M.A.7
Bluestone, J.A.8
-
54
-
-
84862997711
-
Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo
-
Gotot, J.; Gottschalk, C.; Leopold, S.; Knolle, P.A.; Yagita, H.; Kurts, C.; Ludwig-Portugall, I. Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo. Proc. Natl. Acad. Sci. USA 2012, 109, 10468–10473
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 10468-10473
-
-
Gotot, J.1
Gottschalk, C.2
Leopold, S.3
Knolle, P.A.4
Yagita, H.5
Kurts, C.6
Ludwig-Portugall, I.7
-
55
-
-
23844529169
-
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
-
Wang, J.; Yoshida, T.; Nakaki, F.; Hiai, H.; Okazaki, T.; Honjo, T. Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Proc. Natl. Acad. Sci. USA 2005, 102, 11823–11828
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 11823-11828
-
-
Wang, J.1
Yoshida, T.2
Nakaki, F.3
Hiai, H.4
Okazaki, T.5
Honjo, T.6
-
56
-
-
84887445713
-
PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes
-
Pauken, K.E.; Jenkins, M.K.; Azuma, M.; Fife, B.T. PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes. Diabetes 2013, 62, 2859–2869
-
(2013)
Diabetes
, vol.62
, pp. 2859-2869
-
-
Pauken, K.E.1
Jenkins, M.K.2
Azuma, M.3
Fife, B.T.4
-
57
-
-
0032859662
-
Constitutive impaired TCR/CD3-mediated activation of T cells in IDDM patients co-exist with normal co-stimulation pathways
-
Nervi, S.; Atlan-Gepner, C.; Fossat, C.; Vialettes, B. Constitutive impaired TCR/CD3-mediated activation of T cells in IDDM patients co-exist with normal co-stimulation pathways. J. Autoimmun. 1999, 13, 247–255
-
(1999)
J. Autoimmun
, vol.13
, pp. 247-255
-
-
Nervi, S.1
Atlan-Gepner, C.2
Fossat, C.3
Vialettes, B.4
-
58
-
-
33845691031
-
Mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: Report of the Immunology of Diabetes Society T Cell Workshop
-
Tree, T.I.M.; Roep, B.O.; Peakman, M. A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: Report of the Immunology of Diabetes Society T Cell Workshop. Ann. N. Y. Acad. Sci. 2006, 1079, 9–18
-
(2006)
Ann. N. Y. Acad. Sci
, vol.1079
, pp. 9-18
-
-
Tree, T.1
Roep, B.O.2
Peakman, M.A.3
-
59
-
-
77449143100
-
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+ regulatory T-cells of type 1 diabetic subjects
-
Long, S.A.; Cerosaletti, K.; Bollyky, P.L.; Tatum, M.; Shilling, H.; Zhang, S.; Zhang, Z.Y.; Pihoker, C.; Sanda, S.; Greenbaum, C., et al. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+ regulatory T-cells of type 1 diabetic subjects. Diabetes 2010, 59, 407–415
-
(2010)
Diabetes
, vol.59
, pp. 407-415
-
-
Long, S.A.1
Cerosaletti, K.2
Bollyky, P.L.3
Tatum, M.4
Shilling, H.5
Zhang, S.6
Zhang, Z.Y.7
Pihoker, C.8
Sanda, S.9
Greenbaum, C.10
-
60
-
-
33749540457
-
Immune regulatory T cells in siblings of children suffering from type 1 diabetes mellitus
-
Michalek, J.; Vrabelova, Z.; Hrotekova, Z.; Kyr, M.; Pejchlova, M.; Kolouskova, S.; Faresjö, M.; Stechova, K. Immune regulatory T cells in siblings of children suffering from type 1 diabetes mellitus. Scand. J. Immunol. 2006, 64, 531–535
-
(2006)
Scand. J. Immunol
, vol.64
, pp. 531-535
-
-
Michalek, J.1
Vrabelova, Z.2
Hrotekova, Z.3
Kyr, M.4
Pejchlova, M.5
Kolouskova, S.6
Faresjö, M.7
Stechova, K.8
-
61
-
-
84884723400
-
Low frequency of GITR+ T cells in ex vivo and in vitro expanded Treg cells from type 1 diabetic patients
-
Xufré, C.; Costa, M.; Roura-Mir, C.; Codina-Busqueta, E.; Usero, L.; Pizarro, E.; Faresjö, M.; Stechova, K. Low frequency of GITR+ T cells in ex vivo and in vitro expanded Treg cells from type 1 diabetic patients. Int. Immunol.2013, 25, 563–574
-
(2013)
Int. Immunol
, vol.25
, pp. 563-574
-
-
Xufré, C.1
Costa, M.2
Roura-Mir, C.3
Codina-Busqueta, E.4
Usero, L.5
Pizarro, E.6
Faresjö, M.7
Stechova, K.8
-
62
-
-
59249097729
-
APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes
-
Jin, Y.; Chen, X.; Podolsky, R.; Hopkins, D.; Makala, L.H.C.; Muir, A.; She, J.X. APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes. Clin. Immunol.2009, 130, 272–279
-
(2009)
Clin. Immunol
, vol.130
, pp. 272-279
-
-
Jin, Y.1
Chen, X.2
Podolsky, R.3
Hopkins, D.4
Makala, L.5
Muir, A.6
She, J.X.7
-
63
-
-
2442628376
-
Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II
-
Kriegel, M.A.; Lohmann, T.; Gabler, C.; Blank, N.; Kalden, J.R.; Lorenz, H.-M. Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J. Exp. Med. 2004, 199, 1285–1291
-
(2004)
J. Exp. Med
, vol.199
, pp. 1285-1291
-
-
Kriegel, M.A.1
Lohmann, T.2
Gabler, C.3
Blank, N.4
Kalden, J.R.5
Lorenz, H.-M.6
-
64
-
-
84908180955
-
Altered B cell homeostasis and Toll-like receptor 9-driven response in Type 1 diabetes carriers of the C1858T PTPN22 allelic variant: Implications in the disease pathogenesis
-
Gianchecchi, E.; Crinò, A.; Giorda, E.; Luciano, R.; Perri, V.; Lo Russo, A.; Cappa, M.; Rosado, M.M.; Fierabracci, A. Altered B cell homeostasis and Toll-like receptor 9-driven response in Type 1 diabetes carriers of the C1858T PTPN22 allelic variant: Implications in the disease pathogenesis. PLoS ONE 2014, 9, e110755
-
(2014)
Plos ONE
, vol.9
-
-
Gianchecchi, E.1
Crinò, A.2
Giorda, E.3
Luciano, R.4
Perri, V.5
Lo Russo, A.6
Cappa, M.7
Rosado, M.M.8
Fierabracci, A.9
-
65
-
-
84949749008
-
Immunoregulatory effects of mesenchymal stem cell-derived extracellular vesicles on t lymphocytes
-
Del Fattore, A.; Luciano, R.; Pascucci, L.; Goffredo, B.M.; Giorda, E.; Scapaticci, M.; Fierabracci, A.; Muraca, M. Immunoregulatory effects of mesenchymal stem cell-derived extracellular vesicles on t lymphocytes. Cell Transplant.2015, doi:10.3727/096368915X687543
-
(2015)
Cell Transplant
-
-
Del Fattore, A.1
Luciano, R.2
Pascucci, L.3
Goffredo, B.M.4
Giorda, E.5
Scapaticci, M.6
Fierabracci, A.7
Muraca, M.8
-
66
-
-
0036207926
-
PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2
-
Carter, L.; Fouser, L.A.; Jussif, J.; Fitz, L.; Deng, B.; Wood, C.R.; Collins, M.; Honjo, T.; Freeman, G.J.; Carreno, B.M. PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2. Eur. J. Immunol.2002, 32, 634–643
-
(2002)
Eur. J. Immunol
, vol.32
, pp. 634-643
-
-
Carter, L.1
Fouser, L.A.2
Jussif, J.3
Fitz, L.4
Deng, B.5
Wood, C.R.6
Collins, M.7
Honjo, T.8
Freeman, G.J.9
Carreno, B.M.10
-
67
-
-
84904240761
-
Michel, L. Peripheral blood regulatory T cells in patients with diffuse systemic sclerosis (SSc) before and after autologous hematopoietic SCT: A pilot study
-
Baraut, J.; Grigore, E.I.; Jean-Louis, F.; Khelifa, S.H.; Durand, C.; Verrecchia, F.; Farge, D.; Michel, L. Peripheral blood regulatory T cells in patients with diffuse systemic sclerosis (SSc) before and after autologous hematopoietic SCT: A pilot study. Bone Marrow Transplant. 2014, 49, 349–354.
-
(2014)
Bone Marrow Transplant
, vol.49
, pp. 349-354
-
-
Baraut, J.1
Grigore, E.I.2
Jean-Louis, F.3
Khelifa, S.H.4
Durand, C.5
Verrecchia, F.6
Farge, D.7
|