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Volumn 8, Issue 2, 2013, Pages

Foxp3+ Treg Expanded from Patients with Established Diabetes Reduce Helios Expression while Retaining Normal Function Compared to Healthy Individuals

Author keywords

[No Author keywords available]

Indexed keywords

CD45RA ANTIGEN; CD45RO ANTIGEN; GAMMA INTERFERON; HELIOS PROTEIN; IKAROS TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84873689748     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056209     Document Type: Article
Times cited : (31)

References (43)
  • 2
    • 74049110516 scopus 로고    scopus 로고
    • Checkpoints in lymphocyte development and autoimmune disease
    • von Boehmer H, Melchers F, (2010) Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol 11: 14-20.
    • (2010) Nat Immunol , vol.11 , pp. 14-20
    • von Boehmer, H.1    Melchers, F.2
  • 3
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S, (2010) Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 11: 7-13.
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 4
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M, (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 5
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano M, Toda M, Sakaguchi N, Sakaguchi S, (1996) Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 184: 387-396.
    • (1996) J Exp Med , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 6
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR, (2002) The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99: 3493-3499.
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 7
    • 65549107993 scopus 로고    scopus 로고
    • Ex vivo expanded human CD4+CD25+Foxp3+ regulatory T cells prevent lethal xenogenic graft versus host disease (GVHD)
    • Cao T, Soto A, Zhou W, Wang W, Eck S, et al. (2009) Ex vivo expanded human CD4+CD25+Foxp3+ regulatory T cells prevent lethal xenogenic graft versus host disease (GVHD). Cell Immunol 258: 65-71.
    • (2009) Cell Immunol , vol.258 , pp. 65-71
    • Cao, T.1    Soto, A.2    Zhou, W.3    Wang, W.4    Eck, S.5
  • 8
    • 79958814636 scopus 로고    scopus 로고
    • Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease
    • Hippen KL, Merkel SC, Schirm DK, Nelson C, Tennis NC, et al. (2011) Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant 11: 1148-1157.
    • (2011) Am J Transplant , vol.11 , pp. 1148-1157
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3    Nelson, C.4    Tennis, N.C.5
  • 9
    • 78650835204 scopus 로고    scopus 로고
    • Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
    • Issa F, Hester J, Goto R, Nadig SN, Goodacre TE, et al. (2010) Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation 90: 1321-1327.
    • (2010) Transplantation , vol.90 , pp. 1321-1327
    • Issa, F.1    Hester, J.2    Goto, R.3    Nadig, S.N.4    Goodacre, T.E.5
  • 10
    • 77954539326 scopus 로고    scopus 로고
    • In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    • Nadig SN, Wieckiewicz J, Wu DC, Warnecke G, Zhang W, et al. (2010) In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med 16: 809-813.
    • (2010) Nat Med , vol.16 , pp. 809-813
    • Nadig, S.N.1    Wieckiewicz, J.2    Wu, D.C.3    Warnecke, G.4    Zhang, W.5
  • 11
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, et al. (2004) In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199: 1455-1465.
    • (2004) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5
  • 12
    • 80052869960 scopus 로고    scopus 로고
    • Immune intervention with T regulatory cells: past lessons and future perspectives for type 1 diabetes
    • Battaglia M, Roncarolo MG, (2011) Immune intervention with T regulatory cells: past lessons and future perspectives for type 1 diabetes. Semin Immunol 23: 182-194.
    • (2011) Semin Immunol , vol.23 , pp. 182-194
    • Battaglia, M.1    Roncarolo, M.G.2
  • 13
    • 34547204632 scopus 로고    scopus 로고
    • Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    • You S, Leforban B, Garcia C, Bach JF, Bluestone JA, et al. (2007) Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci U S A 104: 6335-6340.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6335-6340
    • You, S.1    Leforban, B.2    Garcia, C.3    Bach, J.F.4    Bluestone, J.A.5
  • 14
    • 33746368487 scopus 로고    scopus 로고
    • Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells
    • Battaglia M, Stabilini A, Draghici E, Migliavacca B, Gregori S, et al. (2006) Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells. Diabetes 55: 1571-1580.
    • (2006) Diabetes , vol.55 , pp. 1571-1580
    • Battaglia, M.1    Stabilini, A.2    Draghici, E.3    Migliavacca, B.4    Gregori, S.5
  • 15
    • 40549120324 scopus 로고    scopus 로고
    • Role of regulatory T cells for the treatment of type 1 diabetes mellitus
    • Jaeckel E, Mpofu N, Saal N, Manns MP, (2008) Role of regulatory T cells for the treatment of type 1 diabetes mellitus. Horm Metab Res 40: 126-136.
    • (2008) Horm Metab Res , vol.40 , pp. 126-136
    • Jaeckel, E.1    Mpofu, N.2    Saal, N.3    Manns, M.P.4
  • 16
    • 17844364504 scopus 로고    scopus 로고
    • Functional defects and the influence of age on the frequency of CD4+CD25+ T-cells in type 1 diabetes
    • Brusko TM, Wasserfall CH, Clare-Salzler MJ, Schatz DA, Atkinson MA, (2005) Functional defects and the influence of age on the frequency of CD4+CD25+ T-cells in type 1 diabetes. Diabetes 54: 1407-1414.
    • (2005) Diabetes , vol.54 , pp. 1407-1414
    • Brusko, T.M.1    Wasserfall, C.H.2    Clare-Salzler, M.J.3    Schatz, D.A.4    Atkinson, M.A.5
  • 17
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, et al. (2005) Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54: 92-99.
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5
  • 18
    • 34447640430 scopus 로고    scopus 로고
    • At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction
    • Glisic-Milosavljevic S, Waukau J, Jailwala P, Jana S, Khoo HJ, et al. (2007) At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction. PLoS One 2: e146.
    • (2007) PLoS One , vol.2
    • Glisic-Milosavljevic, S.1    Waukau, J.2    Jailwala, P.3    Jana, S.4    Khoo, H.J.5
  • 19
    • 51849122220 scopus 로고    scopus 로고
    • Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
    • Monti P, Scirpoli M, Maffi P, Piemonti L, Secchi A, et al. (2008) Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells. Diabetes 57: 2341-2347.
    • (2008) Diabetes , vol.57 , pp. 2341-2347
    • Monti, P.1    Scirpoli, M.2    Maffi, P.3    Piemonti, L.4    Secchi, A.5
  • 20
    • 13944270218 scopus 로고    scopus 로고
    • CD4+CD25high regulatory T cells in human autoimmune diabetes
    • Putnam AL, Vendrame F, Dotta F, Gottlieb PA, (2005) CD4+CD25high regulatory T cells in human autoimmune diabetes. J Autoimmun 24: 55-62.
    • (2005) J Autoimmun , vol.24 , pp. 55-62
    • Putnam, A.L.1    Vendrame, F.2    Dotta, F.3    Gottlieb, P.A.4
  • 21
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203: 1701-1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3    Szot, G.L.4    Lee, M.R.5
  • 22
    • 55449111318 scopus 로고    scopus 로고
    • Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
    • Lawson JM, Tremble J, Dayan C, Beyan H, Leslie RD, et al. (2008) Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin Exp Immunol 154: 353-359.
    • (2008) Clin Exp Immunol , vol.154 , pp. 353-359
    • Lawson, J.M.1    Tremble, J.2    Dayan, C.3    Beyan, H.4    Leslie, R.D.5
  • 23
    • 58149188480 scopus 로고    scopus 로고
    • The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
    • Schneider A, Rieck M, Sanda S, Pihoker C, Greenbaum C, et al. (2008) The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol 181: 7350-7355.
    • (2008) J Immunol , vol.181 , pp. 7350-7355
    • Schneider, A.1    Rieck, M.2    Sanda, S.3    Pihoker, C.4    Greenbaum, C.5
  • 24
    • 33847373481 scopus 로고    scopus 로고
    • No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
    • Brusko T, Wasserfall C, McGrail K, Schatz R, Viener HL, et al. (2007) No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes. Diabetes 56: 604-612.
    • (2007) Diabetes , vol.56 , pp. 604-612
    • Brusko, T.1    Wasserfall, C.2    McGrail, K.3    Schatz, R.4    Viener, H.L.5
  • 25
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, et al. (2011) Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol 186: 3918-3926.
    • (2011) J Immunol , vol.186 , pp. 3918-3926
    • McClymont, S.A.1    Putnam, A.L.2    Lee, M.R.3    Esensten, J.H.4    Liu, W.5
  • 26
    • 80755148666 scopus 로고    scopus 로고
    • Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes
    • Ferraro A, Socci C, Stabilini A, Valle A, Monti P, et al. (2011) Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes 60: 2903-2913.
    • (2011) Diabetes , vol.60 , pp. 2903-2913
    • Ferraro, A.1    Socci, C.2    Stabilini, A.3    Valle, A.4    Monti, P.5
  • 27
    • 62749201002 scopus 로고    scopus 로고
    • Expansion of human regulatory T-cells from patients with type 1 diabetes
    • Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, et al. (2009) Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes 58: 652-662.
    • (2009) Diabetes , vol.58 , pp. 652-662
    • Putnam, A.L.1    Brusko, T.M.2    Lee, M.R.3    Liu, W.4    Szot, G.L.5
  • 28
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea JJ, Paul WE, (2010) Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327: 1098-1102.
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 29
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, et al. (2009) The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 10: 595-602.
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5
  • 30
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    • Zheng Y, Chaudhry A, Kas A, deRoos P, Kim JM, et al. (2009) Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458: 351-356.
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3    deRoos, P.4    Kim, J.M.5
  • 31
    • 0012431804 scopus 로고    scopus 로고
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26 Suppl 1: S5-20.
    • (2003) Diabetes Care , vol.26 , Issue.SUPPL. 1
  • 32
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    • Curotto de Lafaille MA, Lafaille JJ, (2009) Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30: 626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 33
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, et al. (2010) Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 184: 3433-3441.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5
  • 35
    • 77951077218 scopus 로고    scopus 로고
    • Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood
    • Chen X, Subleski JJ, Hamano R, Howard OM, Wiltrout RH, et al. (2010) Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood. Eur J Immunol 40: 1099-1106.
    • (2010) Eur J Immunol , vol.40 , pp. 1099-1106
    • Chen, X.1    Subleski, J.J.2    Hamano, R.3    Howard, O.M.4    Wiltrout, R.H.5
  • 36
    • 69449086689 scopus 로고    scopus 로고
    • Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
    • Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H, et al. (2009) Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A 106: 13439-13444.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13439-13444
    • Wang, R.1    Kozhaya, L.2    Mercer, F.3    Khaitan, A.4    Fujii, H.5
  • 38
    • 0036141438 scopus 로고    scopus 로고
    • Multiple immuno-regulatory defects in type-1 diabetes
    • Kukreja A, Cost G, Marker J, Zhang C, Sun Z, et al. (2002) Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 109: 131-140.
    • (2002) J Clin Invest , vol.109 , pp. 131-140
    • Kukreja, A.1    Cost, G.2    Marker, J.3    Zhang, C.4    Sun, Z.5
  • 39
    • 77952754636 scopus 로고    scopus 로고
    • Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO
    • Booth NJ, McQuaid AJ, Sobande T, Kissane S, Agius E, et al. (2010) Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO. J Immunol 184: 4317-4326.
    • (2010) J Immunol , vol.184 , pp. 4317-4326
    • Booth, N.J.1    McQuaid, A.J.2    Sobande, T.3    Kissane, S.4    Agius, E.5
  • 40
    • 0035062581 scopus 로고    scopus 로고
    • Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population
    • Taams LS, Smith J, Rustin MH, Salmon M, Poulter LW, et al. (2001) Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 31: 1122-1131.
    • (2001) Eur J Immunol , vol.31 , pp. 1122-1131
    • Taams, L.S.1    Smith, J.2    Rustin, M.H.3    Salmon, M.4    Poulter, L.W.5
  • 41
    • 84873691771 scopus 로고    scopus 로고
    • Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells
    • Gottschalk RA, Corse E, Allison JP, (2011) Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells. J Immunol.
    • (2011) J Immunol
    • Gottschalk, R.A.1    Corse, E.2    Allison, J.P.3
  • 42
    • 33644834674 scopus 로고    scopus 로고
    • Regulatory T cells can mediate their function through the stimulation of APCs to produce immunosuppressive nitric oxide
    • Chen C, Lee WH, Zhong L, Liu CP, (2006) Regulatory T cells can mediate their function through the stimulation of APCs to produce immunosuppressive nitric oxide. J Immunol 176: 3449-3460.
    • (2006) J Immunol , vol.176 , pp. 3449-3460
    • Chen, C.1    Lee, W.H.2    Zhong, L.3    Liu, C.P.4
  • 43
    • 70849083675 scopus 로고    scopus 로고
    • Regulatory function of a novel population of mouse autoantigen-specific Foxp3 regulatory T cells depends on IFN-gamma, NO, and contact with target cells
    • Chen C, Liu CP, (2009) Regulatory function of a novel population of mouse autoantigen-specific Foxp3 regulatory T cells depends on IFN-gamma, NO, and contact with target cells. PLoS One 4: e7863.
    • (2009) PLoS One , vol.4
    • Chen, C.1    Liu, C.P.2


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