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Volumn 109, Issue 26, 2012, Pages 10468-10473

Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo

Author keywords

Autoantibodies; Autoimmunity; Inhibitory receptors; Peripheral tolerance

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CELL SURFACE PROTEIN; KIDNEY ANTIGEN; PROGRAMMED DEATH 1 LIGAND 1;

EID: 84862997711     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201131109     Document Type: Article
Times cited : (112)

References (45)
  • 1
    • 20144370643 scopus 로고    scopus 로고
    • The role of regulatory T cells in antigen-induced arthritis: Aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells
    • Frey O, et al. (2005) The role of regulatory T cells in antigen-induced arthritis: Aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther 7:R291-R301.
    • (2005) Arthritis Res Ther , vol.7
    • Frey, O.1
  • 3
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, et al. (2000) B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 4
    • 0035198252 scopus 로고    scopus 로고
    • B cells and professional APCs recruit regulatory T cells via CCL4
    • DOI 10.1038/ni735
    • Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (2001) B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2:1126-1132. (Pubitemid 33130146)
    • (2001) Nature Immunology , vol.2 , Issue.12 , pp. 1126-1132
    • Bystry, R.S.1    Aluvihare, V.2    Welch, K.A.3    Kallikourdis, M.4    Betz, A.G.5
  • 5
    • 18344369175 scopus 로고    scopus 로고
    • The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells
    • Seo SJ, et al. (2002) The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity 16:535-546.
    • (2002) Immunity , vol.16 , pp. 535-546
    • Seo, S.J.1
  • 6
    • 60549115486 scopus 로고    scopus 로고
    • CD25+ T(reg) specifically suppress auto-Ab generation against pancreatic tissue autoantigens
    • Ludwig-Portugall I, Hamilton-Williams EE, Gotot J, Kurts C (2009) CD25+ T(reg) specifically suppress auto-Ab generation against pancreatic tissue autoantigens. Eur J Immunol 39:225-233.
    • (2009) Eur J Immunol , vol.39 , pp. 225-233
    • Ludwig-Portugall, I.1    Hamilton-Williams, E.E.2    Gotot, J.3    Kurts, C.4
  • 7
    • 58149294032 scopus 로고    scopus 로고
    • Cutting edge: CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens
    • Ludwig-Portugall I, Hamilton-Williams EE, Gottschalk C, Kurts C (2008) Cutting edge: CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. J Immunol 181:4447-4451.
    • (2008) J Immunol , vol.181 , pp. 4447-4451
    • Ludwig-Portugall, I.1    Hamilton-Williams, E.E.2    Gottschalk, C.3    Kurts, C.4
  • 10
    • 68149158968 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus
    • Iikuni N, Lourenço EV, Hahn BH, La Cava A (2009) Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus. J Immunol 183:1518-1522.
    • (2009) J Immunol , vol.183 , pp. 1518-1522
    • Iikuni, N.1    Lourenço, E.V.2    Hahn, B.H.3    La Cava, A.4
  • 12
    • 33646567156 scopus 로고    scopus 로고
    • + T cells selectively kill B lymphocytes
    • DOI 10.1182/blood-2005-11-4502
    • Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM (2006) Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 107:3925-3932. (Pubitemid 43726798)
    • (2006) Blood , vol.107 , Issue.10 , pp. 3925-3932
    • Zhao, D.-M.1    Thornton, A.M.2    DiPaolo, R.J.3    Shevach, E.M.4
  • 13
    • 79961158055 scopus 로고    scopus 로고
    • Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
    • Chung Y, et al. (2011) Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17:983-988.
    • (2011) Nat Med , vol.17 , pp. 983-988
    • Chung, Y.1
  • 14
    • 79961151137 scopus 로고    scopus 로고
    • Foxp3+ follicular regulatory T cells control the germinal center response
    • Linterman MA, et al. (2011) Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med 17:975-982.
    • (2011) Nat Med , vol.17 , pp. 975-982
    • Linterman, M.A.1
  • 15
    • 79961153751 scopus 로고    scopus 로고
    • Treg cells: Patrolling a dangerous neighborhood
    • Campbell DJ, Koch MA (2011) Treg cells: Patrolling a dangerous neighborhood. Nat Med 17:929-930.
    • (2011) Nat Med , vol.17 , pp. 929-930
    • Campbell, D.J.1    Koch, M.A.2
  • 17
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach EM (2009) Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30:636-645.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 19
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T (1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 11:3887-3895.
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 20
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • DOI 10.1038/ni1443, PII NI1443
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ (2007) The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 8:239-245. (Pubitemid 46745373)
    • (2007) Nature Immunology , vol.8 , Issue.3 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 22
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn SD, et al. (2009) Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10(1):29-37.
    • (2009) Nat Immunol , vol.10 , Issue.1 , pp. 29-37
    • Blackburn, S.D.1
  • 23
    • 77954966127 scopus 로고    scopus 로고
    • PD-L1 has distinct functions in hematopoietic and non-hematopoietic cells in regulating T cell responses during chronic infection in mice
    • Mueller SN, et al. (2010) PD-L1 has distinct functions in hematopoietic and non-hematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest 120:2508-2515.
    • (2010) J Clin Invest , vol.120 , pp. 2508-2515
    • Mueller, S.N.1
  • 25
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, et al. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192:1027-1034.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1
  • 27
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH (2010) The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 236:219-242.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 29
    • 2142815649 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo
    • discussion 88-91, 106-114
    • Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA (2003) CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp, 252: 67-88; discussion 88-91, 106-114.
    • (2003) Novartis Found Symp , vol.252 , pp. 67-88
    • Baecher-Allan, C.1    Brown, J.A.2    Freeman, G.J.3    Hafler, D.A.4
  • 30
    • 77952557954 scopus 로고    scopus 로고
    • PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
    • Good-Jacobson KL, et al. (2010) PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol 11:535-542.
    • (2010) Nat Immunol , vol.11 , pp. 535-542
    • Good-Jacobson, K.L.1
  • 31
    • 0031685190 scopus 로고    scopus 로고
    • Immunological studies on PD-1-deficient mice: Implication of PD-1 as a negative regulator for B cell responses
    • DOI 10.1093/intimm/10.10.1563
    • Nishimura H, Minato N, Nakano T, Honjo T (1998) Immunological studies on PD-1 deficient mice: Implication of PD-1 as a negative regulator for B cell responses. Int Immunol 10:1563-1572. (Pubitemid 28451451)
    • (1998) International Immunology , vol.10 , Issue.10 , pp. 1563-1572
    • Nishimura, H.1    Minato, N.2    Nakano, T.3    Honjo, T.4
  • 32
    • 66449086623 scopus 로고    scopus 로고
    • Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury
    • Heymann F, et al. (2009) Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest 119:1286-1297.
    • (2009) J Clin Invest , vol.119 , pp. 1286-1297
    • Heymann, F.1
  • 33
    • 35948929764 scopus 로고    scopus 로고
    • Role of T cells and dendritic cells in glomerular immunopathology
    • DOI 10.1007/s00281-007-0096-x, Glomerulonephritis
    • Kurts C, Heymann F, Lukacs-Kornek V, Boor P, Floege J (2007) Role of T cells and dendritic cells in glomerular immunopathology. Semin Immunopathol 29:317-335. (Pubitemid 350077267)
    • (2007) Seminars in Immunopathology , vol.29 , Issue.4 , pp. 317-335
    • Kurts, C.1    Heymann, F.2    Lukacs-Kornek, V.3    Boor, P.4    Floege, J.5
  • 35
    • 79959375167 scopus 로고    scopus 로고
    • Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
    • Kao C, et al. (2011) Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol 12:663-671.
    • (2011) Nat Immunol , vol.12 , pp. 663-671
    • Kao, C.1
  • 36
    • 22544443325 scopus 로고    scopus 로고
    • + T cell proliferation by augmenting IFN-gamma-induced nitric oxide production
    • Yamazaki T, et al. (2005) Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production. J Immunol 175:1586-1592. (Pubitemid 41023060)
    • (2005) Journal of Immunology , vol.175 , Issue.3 , pp. 1586-1592
    • Yamazaki, T.1    Akiba, H.2    Koyanagi, A.3    Azuma, M.4    Yagita, H.5    Okumura, K.6
  • 37
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T, et al. (2004) T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 173(1):68-78. (Pubitemid 38797327)
    • (2004) Journal of Immunology , vol.173 , Issue.1 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6    Mackay, C.R.7
  • 38
    • 78650656619 scopus 로고    scopus 로고
    • Blockade of programmed death-1 in young (New Zealand black x New Zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like disease
    • Wong M, La Cava A, Singh RP, Hahn BH (2010) Blockade of programmed death-1 in young (New Zealand black x New Zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like disease. J Immunol 185:6563-6571.
    • (2010) J Immunol , vol.185 , pp. 6563-6571
    • Wong, M.1    La Cava, A.2    Singh, R.P.3    Hahn, B.H.4
  • 43
    • 79955570584 scopus 로고    scopus 로고
    • Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy
    • Stagg J, et al. (2011) Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy. Proc Natl Acad Sci USA 108:7142-7147.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 7142-7147
    • Stagg, J.1
  • 44
    • 44649102065 scopus 로고    scopus 로고
    • Unraveling the Role of PD-1/PD-L Interactions in Persistent Hepatotropic Infections: Potential for Therapeutic Application?
    • DOI 10.1053/j.gastro.2008.04.012, PII S001650850800663X
    • Radziewicz H, Hanson HL, Ahmed R, Grakoui A (2008) Unraveling the role of PD-1/PDL interactions in persistent hepatotropic infections: Potential for therapeutic application? Gastroenterology 134:2168-2171. (Pubitemid 351783277)
    • (2008) Gastroenterology , vol.134 , Issue.7 , pp. 2168-2171
    • Radziewicz, H.1    Hanson, H.L.2    Ahmed, R.3    Grakoui, A.4
  • 45
    • 62249172189 scopus 로고    scopus 로고
    • Enhancing SIV-specific immunity in vivo by PD-1 blockade
    • Velu V, et al. (2009) Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458:206-210.
    • (2009) Nature , vol.458 , pp. 206-210
    • Velu, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.