Ameliorative effects of Nigella sativa on dyslipidemia

Journal of Endocrinological Investigation

Volumn 38, Issue 10, 2015, Pages 1039-1046

  Asgary, S ^a   Sahebkar, A ^b   Goli Malekabadi, N ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Black cumin; Dyslipidemia; Hypercholesterolemia; Nigella sativa; Thymoquinone

Indexed keywords

ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; APIOLE; ATORVASTATIN; ESTRAGOLE; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; MYRCENE; MYRISTICIN; NIGELLA SATIVA EXTRACT; SIMVASTATIN; THYMOQUINONE; TRIACYLGLYCEROL; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; PLANT EXTRACT;

ADJUVANT THERAPY; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BLACK CUMIN; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DYSLIPIDEMIA; HUMAN; HYPERLIPIDEMIA; LIPOGENESIS; METABOLIC SYNDROME X; NONHUMAN; PHYTOCHEMISTRY; REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; BLOOD; DYSLIPIDEMIAS; HYPERLIPIDEMIAS; PHYTOTHERAPY; PLANT SEED; TREATMENT OUTCOME;

CHOLESTEROL; DYSLIPIDEMIAS; HUMANS; HYPERLIPIDEMIAS; LIPOPROTEINS, HDL; NIGELLA SATIVA; PHYTOTHERAPY; PLANT EXTRACTS; SEEDS; TREATMENT OUTCOME; TRIGLYCERIDES;

EID: 84942117635     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-015-0337-0     Document Type: Review

References (83)

1. Peterson AL, McBride PE (2012) A review of guidelines for dyslipidemia in children and adolescents. Age 20:8
2. Miller M (2003) Niacin as a component of combination therapy for dyslipidemia. In: Mayo Clinic Proceedings. Elsevier
3. Wietlisbach V et al (1997) Trends in cardiovascular risk factors (1984-1993) in a Swiss region: results of three population surveys. Prev Med 26(4):523-533
4. Cannon CP et al (2006) Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy. J Am Coll Cardiol 48(3):438-445
5. Fruchart J-C et al (2008) The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. Am J Cardiol 102(10):1K-34K
6. Hermans MP et al (2009) Centralized Pan-European survey on the under-treatment of hypercholesterolaemia (CEPHEUS): overall findings from eight countries. Curr Med Res Opin 26(2):445-454
7. Leiter L et al (2011) Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study. Diabet Med 28(11):1343-1351
8. Norata GD, Ballantyne CM, Catapano AL (2013) New therapeutic principles in dyslipidaemia: focus on LDL and Lp (a) lowering drugs. Eur Heart J 34(24):1783-1789
9. Sahebkar A, Chew GT, Watts GF (2014) Recent advances in pharmacotherapy for hypertriglyceridemia. Prog Lipid Res 56:47-66
10. Hasani-Ranjbar S, Larijani B, Abdollahi M (2009) A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm Allerg Drug Target Former Curr Drug Target Inflamm Allerg 8(1):2-10
11. Kocyigit Y, Atamer Y, Uysal E (2009) The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats. Saudi Med J 30(7):893-896
12. Muhammad TS (2009) Characterization of black cumin seed oil and exploring its role as a functional food. University of Agriculture, Faisalabad
13. Shuid AN, et al. (2012) Nigella sativa: a potential antiosteoporotic agent. Evid Based Complement Altern Med
14. Datau E et al (2010) Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Med Indones 42(3):130-134
15. Ramadan MF (2007) Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview. Int J Food Sci Technol 42(10):1208-1218
16. Babayan V, Koottungal D, Halaby G (1978) Proximate analysis, fatty acid and amino acid composition of Nigella sativa L. seeds. J Food Sci 43(4):1314-1315
17. Üstun G et al (1990) Investigation of the technological properties of Nigella sativa (black cumin) seed oil. J Am Oil Chem Soc 67(12):958-960
18. Hosseinzadeh H et al (2013) Effect of aqueous and ethanolic Extracts of Nigella sativa seeds on milk production in rats. J Acupunct Meridian Stud 6(1):18-23
19. Ahmad S, Beg ZH (2013) Elucidation of mechanisms of actions of thymoquinone-enriched methanolic and volatile oil extracts from Nigella sativa against cardiovascular risk parameters in experimental hyperlipidemia. Lipids Health Dis 12(1):86
20. Shabana A et al (2013) Cardiovascular benefits of black cumin (Nigella sativa). Cardiovasc Toxicol 13(1):9-21
21. Mannan A, Kahvic M (2010) Ibn Sina: a tribute. Gulf J Oncol 7:60-63
22. Ali B, Blunden G (2003) Pharmacological and toxicological properties of Nigella sativa. Phytother Res 17(4):299-305
23. Salem ML (2005) Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 5(13):1749-1770
24. Amarouch H et al (2002) Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol 79(1):23-26
25. Nickavar B et al (2003) Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran. Zeitschrift Fur Naturforschung C 58(9/10):629-631
26. Dicke M, Van Loon JJ, Soler R (2009) Chemical complexity of volatiles from plants induced by multiple attack. Nat Chem Biol 5(5):317-324
27. Mansour M et al (2001) Effects of the volatile oil constituents of Nigella sativa on carbon tetrachloride induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Res Commun Mol Pathol Pharmacol 110(3-4):239-251
28. Salama RHM (2011) Hypoglycemic effect of lipoic acid, carnitine and Nigella sativa in diabetic rat model. Int J Health Sci 5(2):126
29. Kanter M, Akpolat M, Aktas C (2009) Protective effects of the volatile oil of Nigella sativa seeds on β-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study. J Mol Histol 40(5-6):379-385
30. Shafiee-Nick R, et al. (2012) Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. Adv Pharmacol Sci 2012
31. Meral I et al (2001) Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet Med Ser A 48(10):593-599
32. Dehkordi FR, Kamkhah AF (2008) Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 22(4):447-452
33. Ghannadi A, Hajhashemi V, Jafarabadi H (2005) An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. J Med Food 8(4):488-493
34. Alemi M et al (2013) Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content. AAPS Pharm Sci Tech 14(1):160-167
35. Abdel-Wahhab M, Aly S (2005) Antioxidant property of Nigella sativa (black cumin) and Syzygium aromaticum (clove) in rats during aflatoxicosis. J Appl Toxicol 25(3):218-223
36. Burits M, Bucar F (2000) Antioxidant activity of Nigella sativa essential oil. Phytother Res 14(5):323-328
37. Randhawa MA, Alghamdi MS (2011) Anticancer activity of Nigella sativa (black seed) - a review. Am J Chin Med 39(06):1075-1091
38. Ezz HSA, Khadrawy YA, Noor NA (2011) The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. Neurochem Res 36(11):2195-2204
39. Abdel-Sater KA (2009) Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. Int J Physiol Pathophysiol Pharmacol 1(2):143
40. Bakathir HA, Abbas NA (2011) Detection of the antibacterial effect of Nigella sativa ground seeds with water. Afr J Tradit Complement Altern Med 8(2)
41. Khan M et al (2003) The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds. Phytother Res 17(2):183-186
42. Coban S et al (2010) The effects of Nigella sativa on bile duct ligation induced-liver injury in rats. Cell Biochem Funct 28(1):83-88
43. Sultan MT, et al. (2014) Nigella sativa fixed and essential oil supplementation modulates hyperglycemia and allied complications in streptozotocin-induced diabetes mellitus. Evid Based Complement Altern Med
44. Kaleem M et al (2006) Biochemical effects of Nigella sativa L seeds in diabetic rats. Ind J Exp Biol 44(9):745
45. Ikram F, Hussain F (2014) Antidiabetic Efficacy of Nigella sativa Linn. in Alloxan-induced Diabetic Rabbits. Int Med J Malays 13(1)
46. Ghorbani A et al (2013) Antihyperlipidemic effect of a polyherbal mixture in streptozotocin-induced diabetic rats. J Lipids
47. VM Suriyavathana, Krishnan N (2011) Ayurvedic formulation of Liv-Pro-08 reduces nonalcoholic fatty liver disease in rats fed with high-fat diet. J Acupunct Meridian Studies 4(4):236-241
48. Nader MA, El-Agamy DS, Suddek GM (2010) Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharmacal Res 33(4):637-643
49. Ahmad S, Beg ZH (2013) Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats. Food Chem 138(2):1116-1124
50. Ragheb A et al. (2008) Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone. Int J Angiol Off Pub Int College Angiol Inc 17(4): 186
51. Asgary S et al (2013) Nigella sativa L. improves lipid profile and prevents atherosclerosis: evidence from an experimental study on hypercholesterolemic rabbits. J Funct Foods 5(1):228-234
52. Palodhi S, Dutta S (2010) Effect of atorvastatin and black seed (Nigella Sativa) in experimentally induced hypercholesterolemia in rabbits Suhrita Paul Kalyan Kumar Paul 2
53. Ebrahimzadeh Attari V et al (2010) The effect of powdered form of nigella sativa on serum lipid profile, body weight and intake food in hyperlipidemic rabbit. Med Uni Zanjan 18(70): 31-43
54. El-Dakhakhny M, Mady NI, Halim MA (2000) Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforschung 50(09):832-836
55. Al-Rasheed N et al (2014) Potential protective effects of Nigella sativa and Allium sativum against fructose-induced metabolic syndrome in rats. J Oleo Sci 63:839-848
56. Parhizkar S et al (2011) Preventive effect of Nigella sativa on metabolic syndrome in menopause induced rats. J Med Plants Res 5(8):1478-1484
57. Parhizkar S, et al. (2011) Metabolic impact of Nigella sativa extracts on experimental menopause induced rats
58. Al-Nazawi M, El-Bahr S (2012) Hypolipidemic and hypocholestrolemic effect of medicinal plant combination in the diet of rats: black cumin seed. J Animal Vet Adv 11(12):2013-2019
59. Charlton M (2009) Obesity, hyperlipidemia, and metabolic syndrome. Liver Transpl 15(S2):S83-S89
60. 2 max in sedentary overweight females. Int J Prevent Med 5(2):210
61. Sabzghabaee AM et al (2011) Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Med Arh 66(3):198-200
62. Hamed AAA (2014) Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: a prospective randomized double-blind trial. Anti Inflamm Anti Allerg Agents Med Chem Former Curr Med Chem Anti Inflamm Anti Allerg Agents 13(1):68-74
63. Ibrahim RM et al (2014) Protective effects of Nigella sativa on metabolic syndrome in menopausal women. Adv Pharm Bull 4(1):29
64. Najmi A et al (2008) Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabet Dev Ctries 28(1):11
65. Bamosa A (2014) Nigella sativa is a safe herbal product. J Integr Med 12(1):66
66. Randhawa MA (2008) Black seed, Nigella sativa, deserves more attention. J Ayub Med Coll Abbottabad 20(2):1-2
67. Vahdati-Mashhadian N, Rakhshandeh H, Omidi A (2005) An investigation on LD50 and subacute hepatic toxicity of Nigella sativa seed extracts in mice. Die Pharm Int J Pharm Sci 60(7):544-547
68. Amarouch H, et al. (2002) Acute and chronic toxicity of Nigella sativa fixed oil
69. Al-Amri AM, Bamosa AO (2009) Phase I safety and clinical activity study of thymoquinone in patients with advanced refractory malignant disease. Shiraz E Med J 10:107-111
70. Al-Naqeeb G, Ismail M (2009) Regulation of apolipoprotein A-1 and apolipoprotein B100 genes by thymoquinone rich fraction and thymoquinone in HEPG2 cells. J Food Lipids 16(2):245-258
71. Mariod AA et al (2009) Antioxidant activity and phenolic content of phenolic rich fractions obtained from black cumin (Nigella sativa) seedcake. Food Chem 116(1):306-312
72. Badary OA et al (2003) Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol 26(2):87-98
73. Meyer AS et al (1997) Inhibition of human low-density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes (Vitis vinifera). J Agric Food Chem 45(5):1638-1643
74. Vinson JA, Teufel K, Wu N (2004) Green and black teas inhibit atherosclerosis by lipid, antioxidant, and fibrinolytic mechanisms. J Agric Food Chem 52(11):3661-3665
75. Eder K et al (2002) Excess dietary vitamin E lowers the activities of antioxidative enzymes in erythrocytes of rats fed salmon oil. The Journal of nutrition 132(11):3400-3404
76. Bamosa AO, Ali B, Sowayan S (1997) Effect of oral ingestion Nigella sativa seeds on some blood parameters. Saudi Pharmaceutical Journal 5:126-129
77. Brufau G, Canela MA, Rafecas M (2008) Phytosterols: physiologic and metabolic aspects related to cholesterol-lowering properties. Nutr Res 28(4):217-225
78. Bitzur R (2013) Phytosterols: another way to reduce LDL cholesterol levels. Vasc Dis J, p 25
79. Jones PJ et al (2003) Phytosterols in low-and nonfat beverages as part of a controlled diet fail to lower plasma lipid levels. J Lipid Res 44(9):1713-1719
80. Al-Naqeep G, Ismail M, Allaudin Z (2009) Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells. J Nutr Nutrigenom 2(4-5):163-172
81. Pourghassem-Gargari B et al (2009) Effect of dietary supplementation with Nigella sativa L. on serum lipid profile, lipid peroxidation and antioxidant defense system in hyperlipidemic rabbits. J Med Plants Res 3(10):815-821
82. Kota SK et al (2013) Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia. Ind J Endocrinol Metab 17(3):402
83. Najmi A et al (2012) Therapeutic effect of nigella sativa in patients of poor glycemic control. Asian J Pharm Clin Res 5:224-228