Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone

International Journal of Angiology

Volumn 17, Issue 4, 2008, Pages 186-192

  Ragheb, Ahmed ^a   Elbarbry, Fawzy ^b   Prasad, Kailash ^c   Mohamed, Adel ^c   Ahmed, Mohamed S ^c   Shoker, Ahmed ^a  

^a ROYAL UNIVERSITY HOSPITAL   (Canada)

^b PACIFIC UNIVERSITY   (United States)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Atherosclerosis; Hypercholesterolemia; Reactive oxygen species; Thymoquinone

Indexed keywords

EID: 80053042437     PISSN: 10611711     EISSN: 16155939     Source Type: Journal    
DOI: 10.1055/s-0031-1278307     Document Type: Article

References (28)

1. Steinberg D. Antioxidants in the prevention of human atherosclerosis. Summary of the proceedings of a National Heart, Lung, and Blood Institute Workshop: September 5-6, 1991, Bethesda, Maryland. Circulation 2002;85:2337-44.
2. Prasad K, Karla J, Lee P. Oxygen free radicals as a mechanism of hypercholesterolemic atherosclerosis: Eeffects of probucol. Int J Angiol 1994;3:100-12.
3. Prasad K, Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis: Effect of vitamin E. Am Heart J 1993;125:958-73. (Pubitemid 23117326)
4. Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis 1997;132:69-76. (Pubitemid 27306741)
5. Prasad K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 1999;99:1355-62. (Pubitemid 29129922)
6. Prasad K, Lee P. Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism. Atherosclerosis 2007;192:313-22. (Pubitemid 46726333)
7. Griendling KK, Harrison DG. Out, damned dot: Studies of the NADPH oxidase in atherosclerosis. J Clin Invest 2001;108:1423-4. (Pubitemid 33091978)
8. Gali-Muhtasib H, Roessner A, Schneider-Stock R. Thymoquinone: A promising anti-cancer drug from natural sources. Int J Biochem Cell Biol 2006;38:1249-53.
9. Al Rowais NA. Herbal medicine in the treatment of diabetes mellitus. Saudi Med J 2002;23:1327-31.
10. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005;5:1749-70. (Pubitemid 41594584)
11. Zaoui A, Cherrah Y, Alaoui K, Mahassine N, Amarouch H, Hassar M. Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol 2002;79:23-6. (Pubitemid 34017236)
12. Kapoor R, Prasad K. Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: Effect of SOD and catalase. Circ Shock 1994;43:79-94. (Pubitemid 24331183)
13. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-58. (Pubitemid 9194347)
14. Holman RL, McGill HC Jr, Strong JP, Geer JC. Technics for studying atherosclerotic lesions. Lab Invest 1958;7:42-7.
15. Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine 2007;14:621-7. (Pubitemid 47176407)
16. Pakala R, Stabile E, Jang GJ, Clavijo L, Waksman R. Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: Inhibitory effect on monocyte chemotaxis. J Cardiovasc Pharmacol 2005;46:481-6. (Pubitemid 41407577)
17. Bamosa AO, Ali BA, al Hawsawi ZA. The effect of thymoquinone on blood lipids in rats. Indian J Physiol Pharmacol 2002;46:195-201. (Pubitemid 34415118)
18. Stadtman ER, Berlett BS. Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab Rev 1998;30:225-43. (Pubitemid 28266861)
19. Peiser L, Mukhopadhyay S, Gordon S. Scavenger receptors in innate immunity. Curr Opin Immunol 2002;14:123-8. (Pubitemid 34085116)
20. Libby P. Molecular bases of the acute coronary syndromes. Circulation 1995;91:2844-50.
21. Warren JS, Ward PA. Oxidative injury to the vascular endothelium. Am J Med Sci 1986;292:97-103.
22. Martin A, Foxall T, Blumberg JB, Meydani M. Vitamin E inhibits low-density lipoprotein-induced adhesion of monocytes to human aortic endothelial cells in vitro. Arterioscler Thromb Vasc Biol 1997;17:429-36. (Pubitemid 27133131)
23. Williams CS, Mann M, DuBois RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999;18:7908-16. (Pubitemid 30066236)
24. van Ryn J, Trummlitz G, Pairet M. COX-2 selectivity and inflammatory processes. Curr Med Chem 2000;7:1145-61.
25. Lee P, Prasad K. Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by cyclooxygenase inhibitors. Int J Angiol 2003;12:13-23. (Pubitemid 37153422)
26. Badary OA, Nagi MN, Al Shabanah OA, al Sawaf HA, al Sohaibani MO, Al Bekairi AM. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can J Physiol Pharmacol 1997;75:1356-61. (Pubitemid 28130377)
27. Mansour MA. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sci 2000;66:2583-91. (Pubitemid 30327473)
28. Sayed-Ahmed MM, Nagi MN. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol 2007;34:399-405. (Pubitemid 46494460)