Effect of ground black seed (Nigella sativa L.) on serum lipid profile, body weight and food intake in hyperlipidemic rabbits

Journal of Zanjan University of Medical Sciences and Health Services

Volumn 18, Issue 70, 2010, Pages 31-43

  Ebrahimzadeh Attari, V ^a   Pourghassem Gargari, B ^a,b   Rafraf, M ^a   Gorbani, A ^b   Tabibi, H ^c  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Black seed; Body weight; Hyperlipidemia; Lipid profile

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NIGELLA SATIVA EXTRACT; TRIACYLGLYCEROL;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLACK CUMIN; BLOOD SAMPLING; BODY WEIGHT; CALORIE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; FOOD INTAKE; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIPOPROTEIN BLOOD LEVEL; MALE; NEW ZEALAND; NONHUMAN; RABBIT; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 77954351787     PISSN: 16069366     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Ramadan MF. Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview. Int J Food Sci Tech. 2007; 42: 1208-18.
2. El-Din K, El-Tahir H, Bakeet DM. The black seed (Nigella sativa Linnaeus)- a mine for multi cures: A plea for urgent clinical evaluation of its volatile oil. JTU Med Sc. 2006; 1: 1-19.
3. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003; 17: 299-305. (Pubitemid 36565330)
4. Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008; 6: 495-510.
5. Akram khan M. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacol. 1999; 7: 15-35.
6. Gilani AH, Jabeen Q, Asad Ullah Khan M. A review of medicinal uses and pharmacological activities of Nigella sativa. Pak J Biol Sci. 2004; 7: 441-51.
7. Khattab MM, Nagi MN. Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytother Res. 2007; 21: 410-4.
8. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol. 2008; 22: 447-52.
9. Kaleem M, Kirmani D, Asif M, Ahmed Q, Bano B. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp Biol. 2006; 44: 745-8. (Pubitemid 44369305)
10. Meddah B, Ducroc Rp, El Abbes Faouzi M, et al. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol. 2009; 121: 419-24.
11. Bamosa AO, Ali BA, al-Hawsawi ZA. The effect of thymoquinone on blood lipids in rats. Indian J Physiol Pharmacol. 2002; 46: 195-201. (Pubitemid 34415118)
12. El-Dakhakhny M, Mady NI, Halim MA. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittel forsch. 2000; 50: 832-6.
13. Zaoui A, Cherrah Y, Alaoui K, Mahassine N, Amarouch H, Hassar M. Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol. 2002; 79: 23-6. (Pubitemid 34017236)
14. Le PM, Benhaddou-Andaloussi A, Elimadi A, Settaf A, Cherrah Y, Haddad PS. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol. 2004; 94: 251-9. (Pubitemid 39119926)
15. Dahri AH, Chandiol AM, Rahoo AA, Memon RA. Effect of Nigella sativa (kalonji) on serum cholesterol of albino rats. J Ayub Med Coll Abbottabad. 2005; 17: 72-4.
16. Uz E, Uz B, Selcoki Y, et al. Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol. 2008; 103: 574-80.
17. Kanter M, Coskun O, Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol. 2005; 11: 6684-8. (Pubitemid 43072712)
18. Al-Ghamdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol. 2001; 76: 45-8.
19. Ait Mbarek L, Ait Mouse H, Elabbadi N, et al. Anti tumor properties of blackseed (Nigella sativa L.) extracts. Braz J Med Biol Res. 2007; 40: 839-47.
20. Al-Johar D, Shinwari N, Arif J, et al. Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats. Phytother Res. 2008; 22: 1311-23.
21. Chen JT, Wesley R, Shamburek RD, Pucino F, Csako G. Meta-analysis of natural therapies for hyperlipidemia: Plant sterols and stanols versus policosanol. Pharmacotherapy. 2005; 25: 171-183.
22. Andréjak M, Gras V, Massy ZA, Caron J. Adverse effects of statins. Therapie. 2003; 58: 77-83.
23. Badary OA, Abdel-Naim AB, Abdel-Wahab MH, Hamada FM. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicol. 2000; 143: 219-26.
24. Fish RE, Brown MJ, Danneman PJ, Karas AZ. Anesthesia and analgesia in rabbit: anesthesia and analgesia in laboratory animals. Philadelphia: American College of Laboratory Animal Medicine Series; 2008.
25. Moghadasian MH, Frohlich JJ, Scudamore CH. Specificity of the commonly used enzymatic assay for plasma cholesterol determination. J Clin Pathol. 2002; 55: 859-61.
26. Friedewald WT, Levy RRI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.
27. Ibraheim ZZ. Effect of Nigella sativa seeds and total oil on some blood parameters in female doxorubicin volunteers. Saudi Pharmaceutical J. 2002; 10: 54-9.
28. Moruisi KG, Oosthuizen W, Opperman AM. Phytosterols/stanols lower cholesterol concentrations in familial hypercholesterolemic subjects: a systematic review with meta-analyses. J Am Coll Nutr. 2006; 25: 41-8.
29. Jones PJ. Cholesterol-lowering action of plant sterols. Curr Atheroscler Rep. 1999; 1: 230-5.
30. Weggemans RM, Trautwein EA. Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a Meta analyses. Eur J Clin Nutr. 2003; 57: 940-6.
31. El-Beshbishy HA, Singab ANB, Sinkkonen J, Pihlaja K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sciences. 2006; 78: 2724-33.
32. Kuroda T, Kondo K, Iwasaki T, Ohtani A, Takashima K. Synthesis and hypolipidemic activity of diesters of arylnaphthalene lignan and their heteroaromatic analogs. Chem Pharm Bull. 1997; 45: 678-84.
33. Djoussé L, Hunt SC, Arnett DK. Dietary linoleic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr. 2003; 78: 1098-102.
34. Nydahl MC, Gustafsson IB, Vessby B. Lipid-lowering diets enriched with monounsaturated or polyunsaturated fatty acids but low in saturated fatty acids have similar effects on serum lipid concentrations in hyperlipidemic patients. Am J Clin Nutr. 1994; 59: 115-22.
35. Talati R, Baker WL, Pabilonia MS, White CM, Coleman CI. The effects of barley-derived soluble fiber on serum lipids. Ann Fam Med. 2009; 7: 157-63.
36. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analyses. Am J Clin Nutr. 1999; 69: 30-42.
37. Marlett JA, Hosig KB, Vollendrof NW. Mechanism of serum cholesterol reduction by oat bran. Hepatol. 1994; 20: 1450-7.
38. Morikawa T, Xu F, Ninomiya K, Matsuda H, Yoshikawa M. Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin. Chem Pharm Bull. 2004; 52: 494-7.