Locked 2′-Deoxy-2′,4′-Difluororibo Modified Nucleic Acids: Thermal Stability, Structural Studies, and siRNA Activity

ACS Chemical Biology

Volumn 10, Issue 9, 2015, Pages 2016-2023

  Martínez Montero, Saúl ^a   Deleavey, Glen F ^a   Martín Pintado, Nerea ^b   Fakhoury, Johans F ^a   González, Carlos ^b   Damha, Masad J ^a  

^a MCGILL UNIVERSITY   (Canada)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DNA OLIGONUCLEOTIDE; FLOXURIDINE DERIVATIVE; OLIGONUCLEOTIDE; RNA OLIGONUCLEOTIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 2'-DEOXY-2',4'-DIFLUOROURIDINE; DNA; FLOXURIDINE; RNA;

ARTICLE; BASE PAIRING; DNA SEQUENCE; DNA STRAND; ELECTROSPRAY MASS SPECTROMETRY; GENE SILENCING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; MOLECULAR DYNAMICS; NUCLEAR OVERHAUSER EFFECT; NUCLEIC ACID STRUCTURE; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTUM MECHANICS; SOLID PHASE SYNTHESIS; THERMOSTABILITY; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DNA DENATURATION; GENETICS; HELA CELL LINE; HUMAN; RNA INTERFERENCE;

BASE SEQUENCE; DNA; FLOXURIDINE; HELA CELLS; HUMANS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; OLIGONUCLEOTIDES; RNA; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84942018702     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00218     Document Type: Article

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