Rigid 2′,4′-difluororibonucleosides: Synthesis, conformational analysis, and incorporation into nascent RNA by HCV polymerase

Journal of Organic Chemistry

Volumn 79, Issue 12, 2014, Pages 5627-5635

  Martínez Montero, Saúl ^a   Deleavey, Glen F ^a   Kulkarni, Anupriya ^a   Martín Pintado, Nerea ^b   Lindovska, Petra ^a   Thomson, Michael ^a   González, Carlos ^b   Götte, Matthias ^a   Damha, Masad J ^a  

^a MCGILL UNIVERSITY   (Canada)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; LOCKS (FASTENERS);

CONFORMATIONAL ANALYSIS; CONFORMATIONAL PROPERTIES; INHIBITORY CONCENTRATION; MONOPHOSPHATES; QUANTUM-MECHANICAL CALCULATION; RIBONUCLEOSIDES; RING STRUCTURES; STEREOELECTRONIC EFFECT;

RNA;

2' DEOXY 2',4' DIFLUOROCYTIDINE NUCLEOTIDE; 2' DEOXY 2',4' DIFLUOROURIDINE NUCLEOTIDE; NONSTRUCTURAL PROTEIN 5B; NUCLEOSIDE ANALOG; PRIMER RNA; RIBONUCLEOSIDE; RNA; RNA POLYMERASE; UNCLASSIFIED DRUG; 2'-DEOXY-2',4'-DIFLUOROURIDINE; ANTIVIRUS AGENT; CYTIDINE; DNA DIRECTED RNA POLYMERASE; FLOXURIDINE; VIRUS PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG SYNTHESIS; ENZYME CONFORMATION; HEPATITIS C VIRUS; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; RNA SYNTHESIS; ANALOGS AND DERIVATIVES; CHEMISTRY; CONFORMATION; IC50; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANTIVIRAL AGENTS; CYTIDINE; DNA-DIRECTED RNA POLYMERASES; FLOXURIDINE; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; RIBONUCLEOSIDES; RNA; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84903152285     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo500794v     Document Type: Article

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