Dramatic effect of furanose C2′ substitution on structure and stability: Directing the folding of the human telomeric quadruplex with a single fluorine atom

Journal of the American Chemical Society

Volumn 135, Issue 14, 2013, Pages 5344-5347

  Martín Pintado, Nerea ^a   Yahyaee Anzahaee, Maryam ^b   Deleavey, Glen F ^b   Portella, Guillem ^c   Orozco, Modesto ^c   Damha, Masad J ^b   González, Carlos ^a  

^a INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROSTATIC REPULSION; FLUORINE ATOMS; G-QUADRUPLEXES; HUMAN TELOMERIC DNA; NUCLEIC ACID STRUCTURE; QUADRUPLEX STRUCTURES; STABILIZING INTERACTIONS; STRUCTURAL DETERMINATION;

NUCLEIC ACIDS;

ELECTROSTATICS;

ARABINOSE; DNA; FLUORINE; GUANINE QUADRUPLEX; PHOSPHATE; RIBOSE; TELOMERIC DNA QUADRUPLEX; UNCLASSIFIED DRUG;

ARTICLE; HYDROGEN BOND; MOLECULAR STABILITY; NUCLEAR MAGNETIC RESONANCE; NUCLEIC ACID STRUCTURE; STATIC ELECTRICITY; SUBSTITUTION REACTION;

ARABINOSE; DNA; FLUORINE; G-QUADRUPLEXES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN FOLDING; TELOMERE;

EID: 84876065455     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja401954t     Document Type: Article

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