Mechanism of cisplatin-induced cytotoxicity is correlated to impaired metabolism due to mitochondrial ROS generation

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Choi, Yong Min ^a   Kim, Han Kyul ^a   Shim, Wooyoung ^a   Anwar, Muhammad Ayaz ^a   Kwon, Ji Woong ^a   Kwon, Hyuk Kwon ^a   Kim, Hyung Joong ^a   Jeong, Hyobin ^b   Kim, Hwan Myung ^a   Hwang, Daehee ^b   Kim, Hyung Sik ^c   Choi, Sangdun ^a  

^a Ajou University   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; GLUCOSE; LACTATE DEHYDROGENASE; LIPOCORTIN 5; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RNA; TRICARBOXYLIC ACID; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CISPLATIN INDUCED CYTOTOXICITY; COLORIMETRY; CONTROLLED STUDY; CYTOTOXICITY; ENERGY YIELD; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; GLYCOLYSIS; KIDNEY TUBULE EPITHELIUM; LIQUID CHROMATOGRAPHY; MALE; MICROARRAY ANALYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PROTEIN EXPRESSION; RAT; RNA ISOLATION; TANDEM MASS SPECTROMETRY; URINALYSIS; WESTERN BLOTTING; AGONISTS; ANIMAL; CELL LINE; CITRIC ACID CYCLE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY TUBULE; METABOLISM; SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE; CELL PROLIFERATION; CISPLATIN; CITRIC ACID CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLYCOLYSIS; HUMANS; INJECTIONS, INTRAPERITONEAL; KIDNEY TUBULES; L-LACTATE DEHYDROGENASE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84941922865     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135083     Document Type: Article

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