Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells

Hearing Research

Volumn 251, Issue 1-2, 2009, Pages 70-82

  Kim, Se Jin ^a   Park, Channy ^a   Han, A Lum ^a   Youn, Myung Ja ^a   Lee, Jeong Han ^a   Kim, Yunha ^a   Kim, Eun Sook ^a   Kim, Hyung Jin ^a   Kim, Jin Kyung ^a   Lee, Ho Kyun ^b   Chung, Sang Young ^b   So, Hongseob ^a   Park, Raekil ^a  

^a Wonkwang University School of Medicine   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

Glutamylcysteine synthetase; Auditory brainstem response (ABR); Cisplatin; Ebselen; HEI OC1 auditory cell; Heme oxygenase 1; Lipid peroxidation; NAD(P)H:quinine oxidoreductase; Nrf2; Organotypic culture

Indexed keywords

CISPLATIN; EBSELEN; GAMMA GLUTAMYLCYSTEINE; HEME OXYGENASE 1; LIPID; LUCIFERASE; QUININE DERIVATIVE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; AUDITORY THRESHOLD; BAGG ALBINO MOUSE; BRAIN STEM RESPONSE; CELL LINE; CELL STRAIN HEI OC1; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; CYTOTOXICITY; EVOKED BRAIN STEM AUDITORY RESPONSE; EXPLANT; GENE; HAIR CELL; LIPID PEROXIDATION; MOUSE; NEUROPROTECTION; NONHUMAN; ORGAN CULTURE; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZOLES; CELL LINE, TRANSFORMED; CISPLATIN; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GENE EXPRESSION; GENES, REPORTER; LIPID PEROXIDATION; LUCIFERASES; MICE; MICE, INBRED BALB C; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; ORGAN CULTURE TECHNIQUES; ORGAN OF CORTI; ORGANOSELENIUM COMPOUNDS; PHENOLS; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; TRANSFECTION;

EID: 64249150219     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.heares.2009.03.003     Document Type: Article

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