Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-κB

JARO - Journal of the Association for Research in Otolaryngology

Volumn 8, Issue 3, 2007, Pages 338-355

  So, Hongseob ^a   Kim, HyungJin ^a,b   Lee, Jeong Han ^a   Park, Channy ^a   Kim, Yunha ^a   Kim, Eunsook ^a   Kim, Jin Kyung ^a   Yun, Ki Jung ^a   Lee, Kang Min ^b   Lee, Haa Yung ^c   Moon, Sung Kyun ^c   Lim, David J ^c   Park, Raekil ^a  

^a Wonkwang University School of Medicine   (South Korea)

^b Chonbuk National University   (South Korea)

^c HOUSE EAR INSTITUTE   (United States)

Author keywords

Apoptosis; Inflammation; Ototoxic mechanisms; TNF

Indexed keywords

CISPLATIN; CYTOKINE; ETANERCEPT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ACOUSTIC NERVE FIBER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL IMMORTALIZATION; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; CYTOKINE RELEASE; CYTOTOXICITY; DNA ADDUCT; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID PEROXIDATION; NICK END LABELING; NONHUMAN; OTOTOXICITY; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; STRIA VASCULARIS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL LINE; CISPLATIN; COCHLEA; CYTOKINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GUINEA PIGS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MAP KINASE KINASE 1; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34547655638     PISSN: 15253961     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10162-007-0084-9     Document Type: Article

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