Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells

Journal of Experimental and Clinical Cancer Research

Volumn 34, Issue 1, 2015, Pages

  Wu, Jingjing ^a   Zhao, Shunyu ^a   Tang, Qing ^a   Zheng, Fang ^a   Chen, YuQin ^a   Yang, LiJun ^a   Yang, Xiaobing ^a   Li, Liuning ^a   Wu, WanYin ^a   Hann, Swei Sunny ^a,b  

^a GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

^b Department of Medical Oncology Guangdong Provincial Hospital of Chinese Medicine Second Clinical Medical Collage University of Guangzhou Traditional Chinese Medicine ^*  (China)

Author keywords

DNMT1; EZH2; Human lung cancer cells; SAPK JNK; SP1; Ursolic acid

Indexed keywords

DNA METHYLTRANSFERASE 1; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR SP1; URSOLIC ACID; ANTINEOPLASTIC AGENT; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; EZH2 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; POLYCOMB REPRESSIVE COMPLEX 2; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CARCINOMA, NON-SMALL-CELL LUNG; DRUG SCREENING; LUNG NEOPLASMS; METABOLISM; PHOSPHORYLATION; PROTEIN PROCESSING; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DRUG SCREENING ASSAYS, ANTITUMOR; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; HUMANS; LUNG NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84941654242     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-015-0215-9     Document Type: Article

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