Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells

Cell Death and Disease

Volumn 5, Issue 3, 2014, Pages

  Liao, Y J ^a   Bai, H Y ^a,b   Li, Z H ^b   Zou, J ^c   Chen, J W ^a   Zheng, F ^d   Zhang, J X ^a   Mai, S J ^a   Zeng, M S ^a   Sun, H D ^c   Pu, J X ^c   Xie, D ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

^d SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle arrest; Hepatocellular carcinoma; Longikaurin A; Skp2

Indexed keywords

ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; CYCLIN B1; DITERPENOID; LONGIKAURIN A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; ISODON; ISODON TERNIFOLIUS; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CYCLIN B; CYCLIN B1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DITERPENES, KAURANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; G2 PHASE CELL CYCLE CHECKPOINTS; HEP G2 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-JUN; REACTIVE OXYGEN SPECIES; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84897417818     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.66     Document Type: Article

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