Development, optimization and evaluation of emodin loaded nanoemulsion prepared by ultrasonic emulsification

Journal of Drug Delivery Science and Technology

Volumn 27, Issue , 2015, Pages 46-55

  Shi, Yanbin ^a   Li, Huili ^a   Li, Jincheng ^a   Zhi, Dejuan ^a   Zhang, Xiaoyun ^a   Liu, Hui ^a   Wang, Haiqing ^a   Li, Hongyu ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Emodin; Nanoemulsion; Releasing mechanism; Response surface methodology; Ultrasonic emulsification

Indexed keywords

COSURFACTANT; CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; EMODIN; OLEIC ACID; STABILIZING AGENT;

ARTICLE; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; IN VITRO STUDY; NANOEMULSION; RESPONSE SURFACE METHOD; ULTRASONIC EMULSIFICATION; ZETA POTENTIAL;

EID: 84941619783     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jddst.2015.04.003     Document Type: Article

References (35)

1. Y.F. Zheng, C.F. Liu, W.F. Lai, Q. Xiang, Z.F. Li, H. Wang, N. Lin, The laxative effect of emodin is attributable to increased aquaporin 3 expression in the colon of mice and HT-29 cells, Fitoterapia 96 (2014) 25-32.
2. J. Shao, F. Zhang, Z. Bai, C. Wang, Y. Yuan, W. Wang, Synthesis and antitumor activity of emodin quaternary ammonium salt derivatives, Eur. J. Med. Chem. 56 (2012) 308-319.
3. D. Shrimali, M.K. Shanmugam, A.P. Kumar, J. Zhang, B.K.H. Tan, K.S. Ahn, G. Sethi, Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer, Cancer Lett. 341 (2013) 139-149.
4. Z. Yang, E. Zhou, D. Wei, D. Li, Z. Wei, W. Zhang, X. Zhang, Emodin inhibits LPS-induced inflammatory response by activating PPAR-g in mouse mammary epithelial cells, Int. J. Immunogenet. 21 (2014) 354-360.
5. D.Y. Kim, T.B. Kang, D.W. Shim, X. Sun, J.W. Han, Y.E. Ji, T.J. Kim, S. Koppula, K.H. Lee, Emodin attenuates A23187-induced mast cell degranulation and tumor necrosis factor-a secretion through protein kinase C and IkB kinase 2 signaling, Eur. J. Pharmacol. 723 (2014) 501-506.
6. H.R. Xiong, J. Luo, W. Hou, H. Xiao, Z.Q. Yang, The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo, J. Ethnopharmacol. 133 (2011) 718-723.
7. W.N. Xu, W.B. Liu, W.W. Yang, D.D. Zhang, G.Z. Jiang, Identification and differential expression of hepatopancreas microRNAs in red swamp crayfish fed with emodin diet, Fish. Shellfish Immun. 39 (2014) 1-7.
8. T. Liu, H. Jin, Q.R. Sun, J.H. Xu, H.T. Hu, Neuroprotective effects of emodin in rat cortical neurons against b-amyloid-induced neurotoxicity, Brain Res. 1347 (2010) 149-160.
9. W. Liu, Q. Feng, Y. Li, L. Ye, M. Hu, Z. Liu, Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin, Toxicol. Appl. Pharm. 265 (2012) 316-324.
10. S. Kotta, A.W. Khan, S.H. Ansari, R.K. Sharma, J. Ali, Anti HIV nanoemulsion formulation: optimization and in vitro-in vivo evaluation, Int. J. Pharm. 462 (2014) 129-134.
11. N. Atrux-Tallau, J. Lasselin, S.H. Han, T. Delmas, J. Bibette, Quantitative analysis of ligand effects on bioefficacy of nanoemulsion encapsulating depigmenting active, Colloids Surfaces B 122 (2014) 390-395.
12. V. Bali, M. Ali, J. Ali, Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe, Colloids Surfaces B 76 (2010) 410-420.
13. M.J. Lawrence, G.D. Rees, Microemulsion-based media as novel drug delivery systems, Adv. Drug Deliv. Rev. 64 (2012) 175-193.
14. Z. Ma, L. Bai, Anti-inflammatory effects of Z-ligustilide nanoemulsion, Inflammation 36 (2013) 294-299.
15. H. Ragelle, S. Crauste-Manciet, J. Seguin, D. Brossard, D. Scherman, P. Arnaud, G.G. Chabot, Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice, Int. J. Pharm. 427 (2012) 452-459.
16. Y. Zhang, Z. Shang, C. Gao, M. Du, S. Xu, H. Song, T. Liu, Nanoemulsion for solubilization, stabilization, and in vitro release of pterostilbene for oral delivery, AAPS Pharm. Sci. Technol. 15 (2014) 1000-1008.
17. S.H. Musa, M. Basri, H.R.F. Masoumi, R.A. Karjiban, E.A. Malek, H. Basri, A.F. Shamsuddin, Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment, Colloids Surfaces B 112 (2013) 113-119.
18. F.A. Araújo, R.G. Kelmann, B.V. Araújo, R.B. Finatto, H.F. Teixeira, L.S. Koester, Development and characterization of parenteral nanoemulsions containing thalidomide, Eur. J. Pharm. Sci. 42 (2011) 238-245.
19. M.A. Bezerra, R.E. Santelli, E.P. Oliveira, L.S. Villar, L.A. Escaleira, Response surface methodology (RSM) as a tool for optimization in analytical chemistry, Talanta 76 (2008) 965-977.
20. A.L. Ahmad, S. Ismail, S. Bhatia, Optimization of coagulation-flocculation process for palm oil mill effluent using response surface methodology, Environ. Sci. Technol. 39 (2005) 2828-2834.
21. S.Y. Tang, S. Manickam, T.K. Wei, B. Nashiru, Formulation development and optimization of a novel cremophore EL-based nanoemulsion using ultrasound cavitation, Ultrason. Sonochem. 19 (2012) 330-345.
22. B.K. Ahuja, S.K. Jena, S.K. Paidi, S. Bagri, S. Suresh, Formulation, optimization and in vitro-in vivo evaluation of febuxostat nanosuspension, Int. J. Pharm. 478 (2015) 540-552.
23. E.E. Hassan, R.C. Parish, J.M. Gallo, Optimized formulation of magnetic chitosan microspheres containing the anticancer agent, oxantrazole, Pharm. Res. 9 (1992) 390-397.
24. O. Behrend, K. Ax, H. Schubert, Influence of continuous phase viscosity on emulsification by ultrasound, Ultrason. Sonochem. 7 (2000) 77-85.
25. S. Kentish, T.J. Wooster, M. Ashokkumar, S. Balachandran, R. Mawson, L. Simons, The use of ultrasonics for nanoemulsion preparation, Innov. Food Sci. Emerg. 9 (2008) 170-175.
26. C.Y. Lin, L.W. Chen, Comparison of fuel properties and emission characteristics of two-and three-phase emulsions prepared by ultrasonically vibrating and mechanically homogenizing emulsification methods, Fuel 87 (2008) 2154-2161.
27. C.Y. Lin, L.W. Chen, Emulsification characteristics of three-and two-phase emulsions prepared by the ultrasonic emulsification method, Fuel Process. Technol. 87 (2006) 309-317.
28. A. Azeem, M. Rizwan, F.J. Ahmad, Z. Iqbal, R.K. Khar, M. Aqil, S. Talegaonkar, Nanoemulsion components screening and selection: a technical note, AAPS Pharm. Sci. Technol. 10 (2009) 69-76.
29. V. Borhade, S. Pathak, S. Sharma, V. Patravale, Clotrimazole nanoemulsion for malaria chemotherapy. Part I: preformulation studies, formulation design and physicochemical evaluation, Int. J. Pharm. 431 (2012) 138-148.
30. T.H. Tran, Y. Guo, D. Song, R.S. Bruno, X. Lu, Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability, J. Pharm. Sci. 103 (2014) 840-852.
31. S. Sood, K. Jain, K. Gowthamarajan, Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment, Colloids Surfaces B 113 (2014) 330-337.
32. D. Deshpande, S. Kethireddy, F. Gattacceca, M. Amiji, Comparative pharmacokinetics and tissue distribution analysis of systemically administered 17-β-estradiol and its metabolites in vivo delivered using a cationic nanoemulsion or a peptide-modified nanoemulsion system for targeting atherosclerosis, J. Control. Release 180 (2014) 117-124.
33. E. Rezvani, G. Schleining, A.R. Taherian, Assessment of physical and mechanical properties of orange oil-in-water beverage emulsions using response surface methodology, LWT-Food Sci. Technol. 48 (2012) 82-88.
34. N. Anarjan, H. Mirhosseini, B.S. Baharin, C.P. Tan, Effect of processing conditions on physicochemical properties of sodium caseinate-stabilized astaxanthin nanodispersions, LWT-Food Sci. Technol. 44 (2011) 1658-1665.
35. V. Franklin, F. German, V. Mait, C. Heriberto, G. Fonseca, M. Marín, M. Eunice, Y. Sanchez, Studies on the photostability and phototoxicity of aloe-emodin, emodin and rhein, Pharmazie 57 (2002) 399-404.