Synthesis and antitumor activity of emodin quaternary ammonium salt derivatives

European Journal of Medicinal Chemistry

Volumn 56, Issue , 2012, Pages 308-319

  Shao, Jingwei ^a   Zhang, Fengsen ^a   Bai, Zedong ^a   Wang, Conghui ^a   Yuan, Yaofeng ^a   Wang, Wenfeng ^a  

^a FUZHOU UNIVERSITY   (China)

Author keywords

Anticancer activity; Apoptosis; Emodin; Long carbon chain; Quaternary ammonium salt

Indexed keywords

CASPASE 3; CASPASE 9; CYCLOPHOSPHAMIDE; EMODIN; N [(4,5 DIHYDROXY 7 METHOXY 9,10 ANTHRAQUINON 2 YL)METHYL] N HEXADECYL N METHYLHEXADECAN 1 AMINIUM BROMIDE; N [(4,5 DIHYDROXY 7 METHOXY 9,10 ANTHRAQUINON 2 YL)METHYL] N METHYL N OCTYLOCTAN 1 AMINIUM BROMIDE; PACLITAXEL; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MEGADOSE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; EMODIN; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; QUATERNARY AMMONIUM COMPOUNDS; SALTS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84867982756     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.047     Document Type: Article

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