The laxative effect of emodin is attributable to increased aquaporin 3 expression in the colon of mice and HT-29 cells

Fitoterapia

Volumn 96, Issue , 2014, Pages 25-32

  Zheng, Yan Fang ^a   Liu, Chun Fang ^b   Lai, Wen Fang ^a   Xiang, Qing ^a   Li, Zuan Fang ^a   Wang, Hui ^a,b   Lin, Na ^a,b  

^a FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Aquaporin 3; Colon; Emodin; Keywords; Laxative

Indexed keywords

AQUAPORIN 3; CYCLIC ADENOSINE MONOPHOSPHATE DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EMODIN; MESSENGER RNA; PHOSPHORYLATED CYCLIC ADENOSINE MONOPHOSPHATE RESPONSE ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG; AQP3 PROTEIN, HUMAN; AQP3 PROTEIN, MOUSE; LAXATIVE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CELL VIABILITY ASSAY; COLON; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED STUDY; DEFECATION; DIARRHEA; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME REGULATION; EVACUATION INDEX; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOLOCALIZATION; MALE; MOUSE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; UPREGULATION; WATER ABSORPTION; WATER CONTENT; WESTERN BLOTTING; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EPITHELIUM CELL; FECES; GENE EXPRESSION REGULATION; GENETICS; HT 29 CELL LINE; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; METABOLISM;

ANIMALS; AQUAPORIN 3; CELL SURVIVAL; COLON; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; EMODIN; EPITHELIAL CELLS; FECES; GENE EXPRESSION REGULATION; HT29 CELLS; HUMANS; LAXATIVES; MALE; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION; UP-REGULATION; WATER;

EID: 84899550669     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.04.002     Document Type: Article

References (29)

1. L.S. King, D. Kozono, and P. Agre From structure to disease: the evolving tale of aquaporin biology Nat Rev Mol Cell Biol 5 2004 687 698 (Pubitemid 39208179)
2. T. Ma, and A.S. Verkman Aquaporin water channels in gastrointestinal physiology J Physiol 517 1999 317 326 (Pubitemid 29294879)
3. U. Laforenza Water channel proteins in the gastrointestinal tract Mol Aspects Med 33 2012 642 650
4. C. Silberstein, A. Kierbel, G. Amodeo, E. Zotta, F. Bigi, and D. Berkowski et al. Functional characterization and localization of AQP3 in the human colon Braz J Med Biol Res 32 1999 1303 1313 (Pubitemid 129546660)
5. J.A. Guttman, F.N. Samji, Y. Li, W. Deng, A. Lin, and B.B. Finlay Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens Cell Microbiol 9 2007 131 141 (Pubitemid 44896840)
6. A. Itoh, T. Tsujikawa, T. Yasuoka, T. Nakahara, M. Sasaki, and Y. Fujiyama Natriuretic peptides up-regulate aquaporin 3 in a human colonic epithelial cell line Int J Mol Med 14 2004 621 626
7. N. Ikarashi, T. Ushiki, T. Mochizuki, T. Toda, T. Kudo, and K. Baba et al. Effects of magnesium sulphate administration on aquaporin 3 in rat gastrointestinal tract Biol Pharm Bull 34 2011 238 242
8. T.S. Feng, Z.Y. Yuan, R.Q. Yang, S. Zhao, F. Lei, and X.Y. Xiao et al. Purgative components in rhubarbs: adrenergic receptor inhibitors linked with glucose carriers Fitoterapia 912 2013 36 46
9. Y.C. Kuo, H.C. Meng, and W.J. Tsai Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum Ohwi Inflamm Res 50 2001 73 82
10. National Toxicology Program NTP toxicology and carcinogenesis studies of emodin (CAS NO. 518-82-1) feed studies in F344/N rats and B6C3F1 mice Natl Toxicol Program Tech Rep Ser 493 2001 1 278
11. H.Z. Lee Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma Br J Pharmacol 134 2001 11 20
12. S. Ali, M.S. Watson, and R.H. Osborne The stimulant cathartic, emodin, contracts the rat isolated ileum by triggering release of endogenous acetylcholine Auton Autacoid Pharmacol 24 2004 103 105 (Pubitemid 39657639)
13. L. Xu, Lv N. Ting-Lou, X. Zhu, Y. Chen, and J. Yang Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein Eur J Pharmacol 615 2009 171 176
14. W.S. Zhang, F. Li, and J.Q. Bao Regulatory effect of anthraquinone derivatives from rhubarb on aquaporin 4 expression in colon of rats and in LoVo cell line Zhongguo Zhong Xi Yi Jie He Za Zhi 28 2008 818 823 [In Chinese]
15. Y. Qin, J.B. Wang, W.J. Kong, Y.L. Zhao, H.Y. Yang, and C.M. Dai et al. The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism J Ethnopharmacol 133 2011 1096 1102
16. J.A. Guttman, Y. Li, M.E. Wickham, W. Deng, A.W. Vogl, and B.B. Finlay Attaching and effacing pathogen-induced tight junction disruption in vivo Cell Microbiol 8 2006 634 645 (Pubitemid 43372742)
17. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J Biol Chem 193 1951 265 275
18. N. Ikarashi, T. Mochiduki, A. Takasaki, T. Ushiki, K. Baba, and M. Ishii et al. A mechanism by which the osmotic laxative magnesium sulphate increases the intestinal aquaporin 3 expression in HT-29 cells Life Sci 88 2011 194 200
19. D. Marples, M.A. Knepper, E.I. Christensen, and S. Nielsen Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct Am J Physiol 269 1995 C655 C664
20. G. Hawcroft, C.W. Ko, and M.A. Hull Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells Oncogene 26 2007 3006 3019 (Pubitemid 46733647)
21. C.D. Toscano, J.L. McGlothan, and T.R. Guilarte Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain Brain Res Dev Brain Res 145 2003 219 228 (Pubitemid 37357131)
22. Y. Ishii, H. Tanizawa, and Y. Takino Studies of aloe. III. Mechanism of cathartic effect. (2) Chem Pharm Bull (Tokyo) 38 1990 197 200 (Pubitemid 20138392)
23. D.D. Loo, E.M. Wright, and T. Zeuthen Water pumps J Physiol 542 2002 53 60 (Pubitemid 35190271)
24. P. Gallardo, L.P. Cid, C.P. Vio, and F.V. Sepúlveda Aquaporin-2, a regulated water channel, is expressed in apical membranes of rat distal colon epithelium Am J Physiol Gastrointest Liver Physiol 281 2001 G856 G863
25. Y. Koyama, T. Yamamoto, T. Tani, K. Nihei, D. Kondo, and H. Funaki et al. Expression and localization of aquaporins in rat gastrointestinal tract Am J Physiol 276 1999 C621 C627
26. A. Itoh, T. Tsujikawa, Y. Fujiyama, and T. Bamba Enhancement of aquaporin-3 by vasoactive intestinal polypeptide in a human colonic epithelial cell line J Gastroenterol Hepatol 18 2003 203 210 (Pubitemid 36349869)
27. T. Tsujikawa, A. Itoh, T. Fukunaga, J. Satoh, T. Yasuoka, and Y. Fujiyama Alteration of aquaporin mRNA expression after small bowel resection in the rat residual ileum and colon J Gastroenterol Hepatol 18 2003 803 808 (Pubitemid 36936572)
28. G. Parnaud, D.E. Corpet, and L. Gamet-Payrastre Cytostatic effect of polyethylene glycol on human colonic adenocarcinoma cells Int J Cancer 92 2001 63 69 (Pubitemid 32187033)
29. S. Wang, F. Amidi, M. Beall, L. Gui, and M.G. Ross Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture J Soc Gynecol Investig 13 2006 181 185