Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin

Toxicology and Applied Pharmacology

Volumn 265, Issue 3, 2012, Pages 316-324

  Liu, Wei ^a   Feng, Qian ^a   Li, Ye ^a   Ye, Ling ^a   Hu, Ming ^a,b   Liu, Zhongqiu ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

AIC; AP; BCRP; BL; Caco 2 cells; CL; DMEM; Emodin; HBSS; Intestinal disposition; LTC4; MRP; Multidrug resistance associated proteins; NTP; SD; TEER; UDP glucuronosyltransferases; UDPGA; UGT; UPLC

Indexed keywords

ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; DIPYRIDAMOLE; EMODIN; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG EXCRETION; DRUG PENETRATION; DRUG TRANSPORT; GLUCURONIDATION; INTESTINE ABSORPTION;

BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CACO-2 CELLS; EMODIN; GLUCURONOSYLTRANSFERASE; HUMANS; INTESTINAL ABSORPTION; INTESTINES; LEUKOTRIENE C4; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROPIONATES; QUINOLINES;

EID: 84870296391     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.08.032     Document Type: Article

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