The increasing threat of Pseudomonas aeruginosa high-risk clones

Drug Resistance Updates

Volumn 21-22, Issue , 2015, Pages 41-59

  Oliver, Antonio ^a   Mulet, Xavier ^a   López Causapé, Carla ^a   Juan, Carlos ^a  

^a HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

Author keywords

Epidemic clones; High risk clones; International clones; Molecular epidemiology; Multidrug resistance; Pseudomonas aeruginosa; ST111; ST175; ST235

Indexed keywords

BETA LACTAMASE; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CLONE; CYSTIC FIBROSIS; EPIDEMIC; GENOTYPE; HEREDITY; HIGH RISK PATIENT; HUMAN; INFECTION CONTROL; MULTIDRUG RESISTANCE; NONHUMAN; POPULATION STRUCTURE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; CELL CLONE; CROSS INFECTION; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MOLECULAR EPIDEMIOLOGY; PREVALENCE; PSEUDOMONAS INFECTIONS;

ANTI-BACTERIAL AGENTS; CLONE CELLS; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENOTYPE; HUMANS; MOLECULAR EPIDEMIOLOGY; PREVALENCE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 84941181933     PISSN: 13687646     EISSN: 15322084     Source Type: Journal    
DOI: 10.1016/j.drup.2015.08.002     Document Type: Review

References (205)

1. S.D. Aaron, K.L. Vandemheen, K. Ramotar, T. Giesbrecht-Lewis, E. Tullis, A. Freitag, N. Paterson, M. Jackson, M.D. Lougheed, C. Dowson, V. Kumar, W. Ferris, F. Chan, S. Doucette, and D. Fergusson Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis JAMA 304 2010 2145 2153
2. M. Al-Aloul, J. Crawley, C. Winstanley, C.A. Hart, M.J. Ledson, and M.J. Walshaw Increased morbidity associated with chronic infection by an epidemic Pseudomonas aeruginosa strain in CF patients Thorax 59 2004 334 336
3. C. Álvarez-Ortega, I. Wiegand, J. Olivares, R.E. Hancock, and J.L. Martínez Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics Antimicrob. Agents Chemother. 54 2010 4159 4167
4. D.I. Andersson, and D. Hughes Antibiotic resistance and its cost: is it possible to reverse resistance? Nat. Rev. Microbiol. 8 2010 260 271
5. M. Anthony, B. Rose, M.B. Pegler, M. Elkins, H. Service, K. Thamotharampillai, J. Watson, M. Robinson, P. Bye, J. Merlino, and C. Harbour Genetic analysis of Pseudomonas aeruginosa isolates from the sputa of Australian adult cystic fibrosis patients J. Clin. Microbiol. 40 2002 2772 2778
6. D. Armstrong, S. Bell, M. Robinson, P. Bye, B. Rose, C. Harbour, C. Lee, H. Service, M. Nissen, M. Syrmis, and C. Wainwright Evidence for spread of a clonal strain of Pseudomonas aeruginosa among cystic fibrosis clinics J. Clin. Microbiol. 41 2003 2266 2267
7. D.S. Armstrong, G.M. Nixon, R. Carzino, A. Bigham, J.B. Carlin, R.M. Robins-Browne, and K. Grimwood Detection of a widespread clone of Pseudomonas aeruginosa in a pediatric cystic fibrosis clinic Am. J. Respir. Crit. Care Med. 166 2002 983 987
8. A. Ashish, M. Shaw, J. McShane, M.J. Ledson, and M.J. Walshaw Health-related quality of life in cystic fibrosis patients infected with transmissible Pseudomonas aeruginosa strains: cohort study JRSM Short Rep. 3 2012 12
9. A. Ashish, M. Shaw, C. Winstanley, M.J. Ledson, and M.J. Walshaw Increasing resistance of the Liverpool Epidemic Strain (LES) of Pseudomonas aeruginosa (Psa) to antibiotics in cystic fibrosis (CF) - a cause for concern? J. Cyst. Fibros. 11 2012 173 179
10. L.R. Avetisian, O.L. Voronina, M.I. Chernukha, M.S. Kunda, N.I. Gabrielian, V.G. Lunin, and I.A. Shaginian Persistence of Pseudomonas aeruginosa strains in patients of Federal Scientific Center of Transplantology and Artificial Organs Zh. Mikrobiol. Epidemiol. Immunobiol. 4 2012 99 104
11. I.K. Bae, B. Suh, S.H. Jeong, K.K. Wang, Y.R. Kim, D. Yong, and K. Lee Molecular epidemiology of Pseudomonas aeruginosa clinical isolates from Korea producing β-lactamases with extended-spectrum activity Diagn. Microbiol. Infect. Dis. 79 2014 373 377
12. D. Balasubramanian, L. Schneper, H. Kumari, and K. Mathee A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence Nucleic Acids Res. 41 2013 1 20
13. F. Baquero From pieces to patterns: evolutionary engineering in bacterial pathogens Nat. Rev. Microbiol. 2 2004 510 518
14. F. Baquero, T.M. Coque, and F. de la Cruz Ecology and evolution as targets: the need for novel eco-evo drugs and strategies to fight antibiotic resistance Antimicrob. Agents Chemother. 55 2011 3649 3660
15. K. Barrow, and D.H. Kwon Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa Antimicrob. Agents Chemother. 53 2009 5150 5154
16. S.E. Battle, F. Meyer, J. Rello, V.L. Kung, and A.R. Hauser Hybrid pathogenicity island PAGI-5 contributes to the highly virulent phenotype of a Pseudomonas aeruginosa isolate in mammals J. Bacteriol. 190 2008 7130 7140
17. A. Beceiro, M. Tomás, and G. Bou Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin. Microbiol. Rev. 26 2013 185 230
18. M. Berrazeg, K. Jeannot, V.Y. Ntsogo Enguéné, I. Broutin, S. Loeffert, D. Fournier, and P. Plésiat Mutations in ß-lactamase AmpC increase resistance of Pseudomonas aeruginosa isolates to antipseudomonal cephalosporins Antimicrob. Agents Chemother. 2015 10.1128 (Accepted manuscript posted online 27 July 2015)
19. J. Botelho, F. Grosso, C. Sousa, and L. Peixe Characterization of a new genetic environment associated with GES-6 carbapenemase from a Pseudomonas aeruginosa isolate belonging to the high-risk clone ST235 J. Antimicrob. Chemother. 70 2015 615 617
20. R. Bradbury, A. Champion, and D.W. Reid Poor clinical outcomes associated with a multi-drug resistant clonal strain of Pseudomonas aeruginosa in the Tasmanian cystic fibrosis population Respirology 13 2008 886 892
21. R.S. Bradbury, A.C. Champion, and D.W. Reid Epidemiology of Pseudomonas aeruginosa in a tertiary referral teaching hospital J. Hosp. Infect. 73 2009 151 156
22. E.B. Breidenstein, C. de la Fuente-Núñez, and R.E. Hancock Pseudomonas aeruginosa: all roads lead to resistance Trends Microbiol. 19 2011 419 426
23. S. Bruchmann, A. Dötsch, B. Nouri, I.F. Chaberny, and S. Häussler Quantitative contributions of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone resistance Antimicrob. Agents Chemother. 57 2013 1361 1368
24. N. Burns, C.E. James, and E. Harrison Polylysogeny magnifies competitiveness of a bacterial pathogen in vivo Evol. Appl. 8 2015 346 351
25. G. Cabot, A.A. Ocampo-Sosa, M.A. Domínguez, J.F. Gago, C. Juan, F. Tubau, C. Rodríguez, B. Moyà, C. Peña, L. Martínez-Martínez, A. Oliver Spanish Network for Research in Infectious Diseases (REIPI) Genetic markers of widespread extensively drug-resistant Pseudomonas aeruginosa high-risk clones Antimicrob. Agents Chemother. 56 2012 6349 6357
26. G. Cabot, A.A. Ocampo-Sosa, F. Tubau, M.D. Macià, C. Rodríguez, B. Moyà, L. Zamorano, C. Suárez, C. Peña, L. Martínez-Martínez, A. Oliver Spanish Network for Research in Infectious Diseases (REIPI) Overexpression of AmpC and efflux pumps in Pseudomonas aeruginosa isolates from bloodstream infections: prevalence and impact on resistance in a Spanish multicenter study Antimicrob. Agents Chemother. 55 2011 1906 1911
27. G. Cabot, S. Bruchmann, X. Mulet, L. Zamorano, B. Moyà, C. Juan, S. Haussler, and A. Oliver Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC Antimicrob Agents Chemother. 58 2014 3091 3099
28. N. Cabrolier, M. Sauget, X. Bertrand, and D. Hocquet Matrix-assisted laser desorption ionization-time of flight mass spectrometry identifies Pseudomonas aeruginosa high-risk clones J. Clin. Microbiol. 53 2015 1395 1398
29. A. Carattoli, D. Fortini, R. Galetti, A. Garcia-Fernandez, G. Nardi, D. Orazi, A. Capone, I. Majolino, A. Proia, B. Mariani, G. Parisi, A. Morrone, and N. Petrosillo Isolation of NDM-1-producing Pseudomonas aeruginosa sequence type ST235 from a stem cell transplant patient in Italy, May 2013 Euro. Surveill. 18 2013 20633
30. M.E. Carter, J.L. Fothergill, M.J. Walshaw, K. Rajakumar, A. Kadioglu, and C. Winstanley A subtype of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infection J. Infect. Dis. 202 2010 935 942
31. M. Castanheira, L.M. Deshpande, A. Costello, T.A. Davies, and R.N. Jones Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries J. Antimicrob. Chemother. 69 2014 1804 1814
32. Y. Chen, M. Sun, M. Wang, Y. Lu, and Z. Yan Dissemination of IMP-6-producing Pseudomonas aeruginosa ST244 in multiple cities in China Eur. J. Clin. Microbiol. Infect. Dis. 33 2014 1181 1187
33. K. Cheng, R.L. Smyth, J.R. Govan, C. Doherty, C. Winstanley, N. Denning, D.P. Heaf, H. van Saene, and C.A. Hart Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic Lancet 348 1996 639 642
34. H.H. Cho, G.C. Kwon, S.M. Kim, and S.H. Koo Distribution of Pseudomonas-derived cephalosporinase and metallo-β-lactamases in carbapenem-resistant Pseudomonas aeruginosa isolates from Korea J. Microbiol. Biotechnol. 25 April 2015 1154 1162
35. P. Cholley, R. Ka, C. Guyeux, M. Thouverez, N. Guessennd, B. Ghebremedhin, T. Frank, X. Bertrand, and D. Hocquet Population structure of clinical Pseudomonas aeruginosa from West and Central African countries PLoS ONE 9 2014 e107008
36. P. Cholley, M. Stojanov, D. Hocquet, M. Thouverez, X. Bertrand, and D.S. Blanc Comparison of double-locus sequence typing (DLST) and multilocus sequence typing (MLST) for the investigation of Pseudomonas aeruginosa populations Diagn. Microbiol. Infect. Dis. 82 2015 274 277
37. P. Cholley, M. Thouverez, D. Hocquet, N. van der Mee-Marquet, D. Talon, and X. Bertrand Most multidrug-resistant Pseudomonas aeruginosa isolates from hospitals in eastern France belong to a few clonal types J. Clin. Microbiol. 49 2011 2578 2587
38. A. Correa, R. Del Campo, M. Perenguez, V.M. Blanco, M. Rodríguez-Baños, F. Perez, J.J. Maya, L. Rojas, R. Cantón, C.A. Arias, and M.V. Villegas Dissemination of high-risk clones of extensively drug-resistant Pseudomonas aeruginosa in Colombia Antimicrob. Agents Chemother. 59 2015 2421 2425
39. N. Cramer, J. Klockgether, K. Wrasman, M. Schmidt, C.F. Davenport, and B. Tümmler Microevolution of the major common Pseudomonas aeruginosa clones C and PA14 in cystic fibrosis lungs Environ. Microbiol. 13 2011 1690 1704
40. N. Cramer, L. Wiehlmann, O. Ciofu, S. Tamm, N. Høiby, and B. Tümmler Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis PLoS ONE 7 2012 e50731
41. B. Curran, D. Jonas, H. Grundmann, T. Pitt, and C.G. Dowson Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa J. Clin. Microbiol. 42 2004 5644 5649
42. E.L. da Fonseca, V.V. Vieira, R. Cipriano, and A.C. Vicente Emergence of blaGES-5 in clinical colistin-only-sensitive (COS) Pseudomonas aeruginosa strain in Brazil J. Antimicrob. Chemother. 59 2007 576 577
43. E. Denamur, B. Picard, G. Decoux, J.B. Denis, and J. Elion The absence of correlation between allozyme and rrn RFLP analysis indicates a high gene flow rate within human clinical Pseudomonas aeruginosa isolates FEMS Microbiol. Lett. 110 1993 275 280
44. A. Deplano, O. Denis, H. Rodriguez-Villalobos, R. De Ryck, M.J. Struelens, and M. Hallin Controlled performance evaluation of the DiversiLab repetitive-sequence-based genotyping system for typing multidrug-resistant health care-associated bacterial pathogens J. Clin. Microbiol. 49 2011 3616 3620
45. J.R. Dettman, N. Rodrigue, S.D. Aaron, and R. Kassen Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa Proc. Natl. Acad. Sci. U.S.A. 110 2013 21065 21070
46. S.M. Diene, and J.M. Rolain Carbapenemase genes and genetic platforms in Gram-negative bacilli: Enterobacteriaceae, Pseudomonas and Acinetobacter species Clin. Microbiol. Infect. 20 2014 831 838
47. A. Dötsch, T. Becker, C. Pommerenke, Z. Magnowska, L. Jänsch, and S. Häussler Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa Antimicrob. Agents Chemother. 53 2009 2522 2531
48. M.V. Edelstein, E.N. Skleenova, O.V. Shevchenko, J.W. D'souza, D.V. Tapalski, I.S. Azizov, M.V. Sukhorukova, R.A. Pavlukov, R.S. Kozlov, M.A. Toleman, and T.R. Walsh Spread of extensively resistant VIM-2-positive ST235 Pseudomonas aeruginosa in Belarus, Kazakhstan, and Russia: a longitudinal epidemiological and clinical study Lancet Infect. Dis. 13 2013 867 876
49. F.P. Edenborough, H.R. Stone, S.J. Kelly, P. Zadik, C.J. Doherty, and J.R. Govan Genotyping of Pseudomonas aeruginosa in cystic fibrosis suggests need for segregation J. Cyst. Fibros. 3 2004 37 44
50. J. Elias, C. Schoen, G. Heinze, G. Valenza, E. Gerharz, H. Gerharz, and U. Vogel Nosocomial outbreak of VIM-2 metallo-β-lactamase-producing Pseudomonas aeruginosa associated with retrograde urography Clin. Microbiol. Infect. 16 2010 1494 1500
51. J. Empel, K. Filczak, A. Mrówka, W. Hryniewicz, D.M. Livermore, and I.M. Gniadkowsk Outbreak of Pseudomonas aeruginosa infections with PER-1 extended-spectrum beta-lactamase in Warsaw, Poland: further evidence for an international clonal complex J. Clin. Microbiol. 45 2007 2829 2834
52. 2+-dependent intrinsic imipenemase from Pseudomonas aeruginosa J. Antimicrob. Chemother. 69 2014 2972 2978
53. A. Fajardo, N. Martínez-Martín, M. Mercadillo, J.C. Galán, B. Ghysels, S. Matthijs, P. Cornelis, L. Wiehlmann, B. Tümmler, F. Baquero, and J.L. Martínez The neglected intrinsic resistome of bacterial pathogens PLoS ONE 3 2008 e1619
54. S. Feliziani, R.L. Marvig, A.M. Luján, A.J. Moyano, J.A. Di Rienzo, H. Krogh Johansen, S. Molin, and A.M. Smania Coexistence and within-host evolution of diversified lineages of hypermutable Pseudomonas aeruginosa in long-term cystic fibrosis infections PLoS Genet. 16 10 2014 e1004651
55. L. Fernández, C. Alvarez-Ortega, I. Wiegand, J. Olivares, D. Kocíncová, J.S. Lam, J.L. Martínez, and R.E. Hancock Characterization of the polymyxin B resistome of Pseudomonas aeruginosa Antimicrob. Agents Chemother. 57 2013 110 119
56. G. Fluge, B. Ojeniyi, N. Høiby, A. Digranes, O. Ciofu, E. Hunstad, O.C. Haanaes, and O.T. Storrøsten Typing of Pseudomonas aeruginosa strains in Norwegian cystic fibrosis patients Clin. Microbiol. Infect. 7 2001 238 243
57. J.L. Fothergill, E. Mowat, M.J. Ledson, M.J. Walshaw, and C. Winstanley Fluctuations in phenotypes and genotypes within populations of Pseudomonas aeruginosa in the cystic fibrosis lung during pulmonary exacerbations J. Med. Microbiol. 59 2010 472 481
58. J.L. Fothergill, E. Mowat, M.J. Walshaw, M.J. Ledson, C.E. James, and C. Winstanley Effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa Antimicrob. Agents Chemother. 55 2011 426 428
59. J.L. Fothergill, S. Panagea, C.A. Hart, M.J. Walshaw, T.L. Pitt, and C. Winstanley Widespread pyocyanin over-production among isolates of a cystic fibrosis epidemic strain BMC Microbiol. 7 2007 45
60. D. Fournier, K. Jeannot, M. Robert-Nicoud, E. Muller, P. Cholley, N. van der Mee-Marquet, and P. Plésiat Spread of the bla(IMP-13) gene in French Pseudomonas aeruginosa through sequence types ST621, ST308 and ST111 Int. J. Antimicrob. Agents. 40 2012 571 573
61. M. García-Castillo, R. Del Campo, M.I. Morosini, E. Riera, G. Cabot, R. Willems, R. van Mansfeld, A. Oliver, and R. Cantón Wide dispersion of ST175 clone despite high genetic diversity of carbapenem-nonsusceptible Pseudomonas aeruginosa clinical strains in 16 Spanish hospitals J. Clin. Microbiol. 49 2011 2905 2910
62. M. García-Castillo, L. Máiz, M.I. Morosini, M. Rodríguez-Baños, L. Suarez, A. Fernández-Olmos, F. Baquero, R. Cantón, and R. del Campo Emergence of a mutL mutation causing multilocus sequence typing-pulsed-field gel electrophoresis discrepancy among Pseudomonas aeruginosa isolates from a cystic fibrosis patient J. Clin. Microbiol. 50 2012 1777 1778
63. S.L. Gellatly, and R.E. Hancock Pseudomonas aeruginosa: new insights into pathogenesis and host defenses Pathog. Dis. 67 2013 159 173
64. I. Gheorghe, Â. Novais, F. Grosso, C. Rodrigues, M.C. Chifiriuc, V. Lazar, and L. Peixe Snapshot on carbapenemase-producing Pseudomonas aeruginosa and Acinetobacter baumannii in Bucharest hospitals reveals unusual clones and novel genetic surroundings for blaOXA-23 J. Antimicrob. Chemother. 70 2015 1016 1020
65. R. Gilarranz, C. Juan, J. Castillo-Vera, F.J. Chamizo, F. Artiles, I. Álamo, and A. Oliver First detection in Europe of the metallo-β-lactamase IMP-15 in clinical strains of Pseudomonas putida and Pseudomonas aeruginosa Clin. Microbiol. Infect. 19 2013 424 427
66. D. Girlich, T. Naas, and P. Nordmann Biochemical characterization of the naturally occurring oxacillinase OXA-50 of Pseudomonas aeruginosa Antimicrob. Agents Chemother. 48 2004 2043 2048
67. Y. Glupczynski, P. Bogaerts, A. Deplano, C. Berhin, T.D. Huang, J. Van Eldere, and H. Rodriguez-Villalobos Detection and characterization of class A extended-spectrum-beta-lactamase-producing Pseudomonas aeruginosa isolates in Belgian hospitals J. Antimicrob. Chemother. 65 2010 866 871
68. W.J. Gooderham, and R.E. Hancock Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa FEMS Microbiol. Rev. 33 2009 279 294
69. A.L. Griffiths, D.F. Wurzel, P.J. Robinson, R. Carzino, and J. Massie Australian epidemic strain pseudomonas (AES-1) declines further in a cohort segregated cystic fibrosis clinic J. Cyst. Fibros. 11 2012 49 52
70. S. Guénard, C. Muller, L. Monlezun, P. Benas, I. Broutin, K. Jeannot, and P. Plésiat Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa Antimicrob. Agents Chemother. 58 2014 221 228
71. A.D. Gutu, N. Sgambati, P. Strasbourger, M.K. Brannon, M.A. Jacobs, E. Haugen, R.K. Kaul, H.K. Johansen, N. Høiby, and S.M. Moskowitz Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems Antimicrob. Agents Chemother. 57 2013 2204 2215
72. M. Guzvinec, R. Izdebski, I. Butic, M. Jelic, M. Abram, I. Koscak, A. Baraniak, W. Hryniewicz, M. Gniadkowski, and A. Tambic Andrasevic Sequence types 235, 111, and 132 predominate among multidrug-resistant Pseudomonas aeruginosa clinical isolates in Croatia Antimicrob. Agents Chemother. 58 2014 6277 6283
73. F. Hansen, H.K. Johansen, C. Østergaard, M. Arpi, D.S. Hansen, P. Littauer, A. Holm, O. Heltberg, H. Schumacher, K. Fuursted, M.A. Lykke, B. Tønning, A.M. Hammerum, and U.S. Justesen Characterization of carbapenem nonsusceptible Pseudomonas aeruginosa in Denmark: a nationwide, prospective study Microb. Drug Resist. 20 2014 22 29
74. N.J. Hare, N. Solis, C. Harmer, N.B. Marzook, B. Rose, C. Harbour, B. Crossett, J. Manos, and S.J. Cordwell Proteomic profiling of Pseudomonas aeruginosa AES-1R, PAO1 and PA14 reveals potential virulence determinants associated with a transmissible cystic fibrosis-associated strain BMC Microbiol. 12 2012 16
75. A.R. Hauser The type III secretion system of Pseudomonas aeruginosa: infection by injection Nat. Rev. Microbiol. 7 2009 654 665
76. R. Hilker, A. Munder, J. Klockgether, P.M. Losada, P. Chouvarine, N. Cramer, C.F. Davenport, S. Dethlefsen, S. Fischer, H. Peng, T. Schönfelder, O. Türk, L. Wiehlmann, F. Wölbeling, E. Gulbins, A. Goesmann, and B. Tümmler Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment Environ. Microbiol. 17 2015 29 46
77. D. Hocquet, P. Berthelot, M. Roussel-Delvallez, R. Favre, K. Jeannot, O. Bajolet, N. Marty, F. Grattard, P. Mariani-Kurkdjian, E. Bingen, M.O. Husson, G. Couetdic, and P. Plésiat Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections Antimicrob. Agents Chemother. 51 2007 3531 3536
78. J.S. Hong, J.O. Kim, H. Lee, I.K. Bae, S.H. Jeong, and K. Lee Characteristics of metallo-β-lactamase-producing Pseudomonas aeruginosa in Korea Infect. Chemother. 47 2015 33 40
79. J. Hrabák, D. Cervená, R. Izdebski, W. Duljasz, M. Gniadkowski, M. Fridrichová, P. Urbásková, and H. Zemlicková Regional spread of Pseudomonas aeruginosa ST357 producing IMP-7 metallo-β-lactamase in Central Europe J. Clin. Microbiol. 49 2011 474 475
80. R.K. Jacobson, N. Minenza, M. Nicol, and C. Bamford VIM-2 metallo-β-lactamase-producing Pseudomonas aeruginosa causing an outbreak in South Africa J. Antimicrob. Chemother. 67 2012 1797 1798
81. L. Jelsbak, H.K. Johansen, A.L. Frost, R. Thøgersen, L.E. Thomsen, O. Ciofu, L. Yang, J.A. Haagensen, N. Høiby, and S. Molin Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients Infect. Immun. 75 5 2007 2214 2224
82. J. Jeukens, B. Boyle, I. Kukavica-Ibrulj, M.M. Ouellet, S.D. Aaron, S.J. Charette, J.L. Fothergill, N.P. Tucker, C. Winstanley, and R.C. Levesque Comparative genomics of isolates of a Pseudomonas aeruginosa epidemic strain associated with chronic lung infections of cystic fibrosis patients PLoS ONE 9 2014 e87611
83. A.M. Jones, J.R. Govan, C.J. Doherty, M.E. Dodd, B.J. Isalska, T.N. Stanbridge, and A.K. Webb Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic Lancet 358 2001 557 558
84. C. Juan, M.C. Conejo, N. Tormo, C. Gimeno, Á. Pascual, and A. Oliver Challenges for accurate susceptibility testing, detection and interpretation of β-lactam resistance phenotypes in Pseudomonas aeruginosa: results from a Spanish multicentre study J. Antimicrob. Chemother. 68 2013 619 630
85. C. Juan, M.D. Macià, O. Gutiérrez, C. Vidal, J.L. Pérez, and A. Oliver Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains Antimicrob. Agents Chemother. 49 2005 4733 4738
86. C. Juan, L. Zamorano, A. Mena, S. Albertí, J.L. Pérez, and A. Oliver Metallo-beta-lactamase-producing Pseudomonas putida as a reservoir of multidrug resistance elements that can be transferred to successful Pseudomonas aeruginosa clones J. Antimicrob. Chemother. 65 2010 474 478
87. T.J. Kidd, S.R. Ritchie, K.A. Ramsay, K. Grimwood, S.C. Bell, and P.B. Rainey Pseudomonas aeruginosa exhibits frequent recombination, but only a limited association between genotype and ecological setting PLoS ONE 7 2012 e44199
88. C. Kiewitz, and B. Tümmler Sequence diversity of Pseudomonas aeruginosa: impact on population structure and genome evolution J. Bacteriol. 182 2000 3125 3135
89. M.J. Kim, I.K. Bae, S.H. Jeong, S.H. Kim, J.H. Song, J.Y. Choi, S.S. Yoon, V. Thamlikitkul, P.R. Hsueh, R.M. Yasin, M.K. Lalitha, and K. Lee Dissemination of metallo-β-lactamase-producing Pseudomonas aeruginosa of sequence type 235 in Asian countries J Antimicrob. Chemother. 68 2013 2820 2824
90. T. Kitao, T. Tada, M. Tanaka, K. Narahara, M. Shimojima, K. Shimada, T. Miyoshi-Akiyama, and T. Kirikae Emergence of a novel multidrug-resistant Pseudomonas aeruginosa strain producing IMP-type metallo-β-lactamases and AAC(6')-Iae in Japan Int. J. Antimicrob. Agents. 39 2012 518 521
91. J. Klockgether, N. Cramer, L. Wiehlmann, C.F. Davenport, and B. Tümmler Pseudomonas aeruginosa genomic structure and diversity Front. Microbiol. 13 2 2011 150
92. T.H. Koh, C.T. Khoo, T.T. Tan, M.A. Arshad, L.P. Ang, L.J. Lau, L.Y. Hsu, and E.E. Ooi Multilocus sequence types of carbapenem-resistant Pseudomonas aeruginosa in Singapore carrying metallo-beta-lactamase genes, including the novel bla(IMP-26) gene J. Clin. Microbiol. 48 2010 2563 2564
93. T. Köhler, S.F. Epp, L.K. Curty, and J.C. Pechère Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa J. Bacteriol. 181 1999 6300 6305
94. K.F. Kong, S.R. Jayawardena, A. Del Puerto, L. Wiehlmann, U. Laabs, B. Tümmler, and K. Mathee Characterization of poxB, a chromosomal-encoded Pseudomonas aeruginosa oxacillinase Gene 358 2005 82 92
95. V.N. Kos, M. Déraspe, R.E. McLaughlin, J.D. Whiteaker, P.H. Roy, R.A. Alm, J. Corbeil, and H. Gardner The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility Antimicrob. Agents Chemother. 59 2015 427 436
96. S. Kouda, M. Ohara, M. Onodera, Y. Fujiue, M. Sasaki, T. Kohara, S. Kashiyama, S. Hayashida, T. Harino, T. Tsuji, H. Itaha, N. Gotoh, A. Matsubara, T. Usui, and M. Sugai Increased prevalence and clonal dissemination of multidrug-resistant Pseudomonas aeruginosa with the blaIMP-1 gene cassette in Hiroshima J. Antimicrob. Chemother. 64 2009 46 51
97. M. Koutsogiannou, E. Drougka, A. Liakopoulos, E. Jelastopulu, E. Petinaki, E.D. Anastassiou, I. Spiliopoulou, and M. Christofidou Spread of multidrug-resistant Pseudomonas aeruginosa clones in a university hospital J. Clin. Microbiol. 51 2013 665 668
98. I. Kukavica-Ibrulj, A. Bragonzi, M. Paroni, C. Winstanley, F. Sanschagrin, G.A. O'Toole, and R.C. Levesque In vivo growth of Pseudomonas aeruginosa strains PAO1 and PA14 and the hypervirulent strain LESB58 in a rat model of chronic lung infection J. Bacteriol. 190 2008 2804 2813
99. J. Larché, F. Pouillot, C. Essoh, B. Libisch, M. Straut, J.C. Lee, C. Soler, R. Lamarca, E. Gleize, J. Gabard, G. Vergnaud, and C. Pourcel Rapid identification of international multidrug-resistant Pseudomonas aeruginosa clones by multiple-locus variable number of tandem repeats analysis and investigation of their susceptibility to lytic bacteriophages Antimicrob. Agents Chemother. 56 2012 6175 6180
100. J.Y. Lee, M.H. Lim, S.T. Heo, and K.S. Ko Repeated isolation of Pseudomonas aeruginosa isolates resistant to both polymyxins and carbapenems from 1 patient Diagn. Microbiol. Infect. Dis. 72 2012 267 271
101. J.Y. Lee, K.R. Peck, and K.S. Ko Selective advantages of two major clones of carbapenem-resistant Pseudomonas aeruginosa isolates (CC235 and CC641) from Korea: antimicrobial resistance, virulence and biofilm-forming activity J. Med. Microbiol. 62 2013 1015 1024
102. Z. Lepsanovic, B. Libisch, B. Tomanovic, Z. Nonkovici, B. Balogh, and M. Füzi Characterisation of the first VIM metallo-beta-lactamase-producing Pseudomonas aeruginosa clinical isolate in Serbia Acta Microbiol. Immunol. Hung. 55 2008 447 454
103. X.Z. Li, P. Plésiat, and H. Nikaido The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria Clin. Microbiol. Rev. 28 2 2015 337 418
104. A. Liakopoulos, A. Mavroidi, E.A. Katsifas, A. Theodosiou, A.D. Karagouni, V. Miriagou, and E. Petinaki Carbapenemase-producing Pseudomonas aeruginosa from central Greece: molecular epidemiology and genetic analysis of class I integrons BMC Infect. Dis. 13 2013 505
105. B. Libisch, B. Balogh, and M. Füzi Identification of two multidrug-resistant Pseudomonas aeruginosa clonal lineages with a countrywide distribution in Hungary Curr. Microbiol. 58 2009 111 116
106. B. Libisch, L. Poirel, Z. Lepsanovic, V. Mirovic, B. Balogh, J. Pászti, i.Z. Hunyad, A. Dobák, M. Füzi, and P. Nordmann Identification of PER-1 extended-spectrum beta-lactamase producing Pseudomonas aeruginosa clinical isolates of the international clonal complex CC11 from Hungary and Serbia FEMS Immunol. Med. Microbiol. 54 2008 330 338
107. B. Libisch, J. Watine, B. Balogh, M. Gacs, M. Muzslay, G. Szabó, and M. Füzi Molecular typing indicates an important role for two international clonal complexes in dissemination of VIM-producing Pseudomonas aeruginosa clinical isolates in Hungary Res. Microbiol. 159 2008 162 168
108. J.F. Linares, J.A. López, E. Camafeita, J.P. Albar, F. Rojo, and J.L. Martínez Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa J. Bacteriol. 187 2005 1384 1391
109. P.D. Lister, D.J. Wolter, and N.D. Hanson Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms Clin. Microbiol. Rev. 22 2009 582 610
110. Y. Liu, X.Y. Li, L.G. Wan, W.Y. Jiang, F.Q. Li, and J.H. Yang Efflux system overexpression and decreased OprD contribute to the carbapenem resistance among extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa isolates from a Chinese university hospital Microb. Drug Resist. 19 2013 463 468
111. D.M. Livermore Interplay of impermeability and chromosomal beta-lactamase activity in imipenem-resistant Pseudomonas aeruginosa Antimicrob. Agents Chemother. 36 1992 2046 2048
112. D.M. Livermore Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin. Infect. Dis. 34 2002 634 640
113. D.M. Livermore Has the era of untreatable infections arrived? J. Antimicrob. Chemother. 64 Suppl. 1 2009 i29 i36
114. C. Logan, A. Habington, G. Lennon, J. Grogan, M. Byrne, J. O'Leary, and N. O'Sullivan Genetic relatedness of Pseudomonas aeruginosa isolates among a paediatric cystic fibrosis patient cohort in Ireland J. Med. Microbiol. 61 2012 64 70
115. C. López-Causapé, E. Rojo-Molinero, X. Mulet, G. Cabot, B. Moyà, J. Figuerola, B. Togores, J.L. Pérez, and A. Oliver Clonal dissemination, emergence of mutator lineages and antibiotic resistance evolution in Pseudomonas aeruginosa cystic fibrosis chronic lung infection PLoS ONE 8 2013 e71001
116. R.A. Luna, L.A. Millecker, C.R. Webb, S.K. Mason, E.M. Whaley, J.R. Starke, P.W. Hiatt, and J. Versalovic Molecular epidemiological surveillance of multidrug-resistant Pseudomonas aeruginosa isolates in a pediatric population of patients with cystic fibrosis and determination of risk factors for infection with the Houston-1 strain J. Clin. Microbiol. 5 2013 1237 1240
117. M. Maâtallah, A. Bakhrouf, M.A. Habeeb, A. Turlej-Rogacka, A. Iversen, C. Pourcel, O. Sioud, and C.G. Giske Four genotyping schemes for phylogenetic analysis of Pseudomonas aeruginosa: comparison of their congruence with multi-locus sequence typing PLoS ONE 8 12 2013 e82069
118. M. Maatallah, J. Cheriaa, A. Backhrouf, A. Iversen, H. Grundmann, T. Do, P. Lanotte, M. Mastouri, M.S. Elghmati, F. Rojo, S. Mejdi, and C.G. Giske Population structure of Pseudomonas aeruginosa from five Mediterranean countries: evidence for frequent recombination and epidemic occurrence of CC235 PLoS ONE 6 2011 e25617
119. M.D. Macià, D. Blanquer, B. Togores, J. Sauleda, J.L. Pérez, and A. Oliver Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections Antimicrob. Agents Chemother. 49 2005 3382 3386
120. A.P. Magiorakos, A. Srinivasan, R.B. Carey, Y. Carmeli, M.E. Falagas, C.G. Giske, S. Harbarth, J.F. Hindler, G. Kahlmeter, B. Olsson-Liljequist, D.L. Paterson, L.B. Rice, J. Stelling, M.J. Struelens, A. Vatopoulos, J.T. Weber, and D.L. Monnet Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance Clin. Microbiol. Infect. 18 2012 268 281
121. Y. Mano, T. Saga, Y. Ishii, A. Yoshizumi, R.A. Bonomo, K. Yamaguchi, and K. Tateda Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan BMC Microbiol. 21 15 2015 41
122. J. Manos, J. Arthur, B. Rose, S. Bell, P. Tingpej, H. Hu, J. Webb, S. Kjelleberg, M.D. Gorrell, P. Bye, and C. Harbour Gene expression characteristics of a cystic fibrosis epidemic strain of Pseudomonas aeruginosa during biofilm and planktonic growth FEMS Microbiol. Lett. 292 2009 107 114
123. J.L. Martínez, and F. Baquero Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance Clin. Microbiol. Rev. 15 4 2002 647 679
124. E. Martinez, J.E. Pérez, F. Buelvas, C. Tovar, N. Vanegas, and H.W. Stokes Establishment and multi drug resistance evolution of ST235 Pseudomonas aeruginosa strains in the intensive care unit of a Colombian hospital Res. Microbiol. 165 2014 852 856
125. I. Martínez-Ramos, X. Mulet, B. Moyà, M. Barbier, A. Oliver, and S. Albertí Overexpression of MexCD-OprJ reduces Pseudomonas aeruginosa virulence by increasing its susceptibility to complement-mediated killing Antimicrob. Agents Chemother. 58 4 2014 2426 2429
126. R.L. Marvig, H.K. Johansen, S. Molin, and L. Jelsbak Genome analysis of a transmissible lineage of Pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators PLoS Genet. 9 2013 e1003741
127. S.J. McCallum, J. Corkill, M. Gallagher, M.J. Ledson, C.A. Hart, and M.J. Walshaw Superinfection with a transmissible strain of Pseudomonas aeruginosa in adults with cystic fibrosis chronically colonised by P. aeruginosa Lancet 358 2001 558 560
128. S.J. McCallum, M.J. Gallagher, J.E. Corkill, C.A. Hart, M.J. Ledson, and M.J. Walshaw Spread of an epidemic Pseudomonas aeruginosa strain from a patient with cystic fibrosis (CF) to non-CF relatives Thorax 57 2002 559 560
129. A. Mena, E.E. Smith, J.L. Burns, D.P. Speert, S.M. Moskowitz, J.L. Perez, and A. Oliver Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation J. Bacteriol. 190 2008 7910 7917
130. N. Mesaros, P. Nordmann, P. Plésiat, M. Roussel-Delvallez, J. Van Eldere, Y. Glupczynski, Y. Van Laethem, F. Jacobs, P. Lebecque, A. Malfroot, P.M. Tulkens, and F. Van Bambeke Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium Clin. Microbiol. Infect. 13 2007 560 578
131. B. Moyà, A. Beceiro, G. Cabot, C. Juan, L. Zamorano, S. Alberti, and A. Oliver Pan-β-lactam resistance development in Pseudomonas aeruginosa clinical strains: molecular mechanisms, penicillin-binding protein profiles, and binding affinities Antimicrob. Agents Chemother. 56 2012 4771 4778
132. B. Moyà, A. Dötsch, C. Juan, J. Blázquez, L. Zamorano, S. Haussler, and A. Oliver Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein PLoS Pathog. 5 2009 e1000353
133. X. Mulet, G. Cabot, A.A. Ocampo-Sosa, M.A. Domínguez, L. Zamorano, C. Juan, F. Tubau, C. Rodríguez, B. Moyà, C. Peña, L. Martínez-Martínez, A. Oliver Spanish Network for Research in Infectious Diseases (REIPI) Biological markers of Pseudomonas aeruginosa epidemic high-risk clones Antimicrob. Agents Chemother. 57 2013 5527 5535
134. X. Mulet, B. Moyà, C. Juan, M.D. Macià, J.L. Pérez, J. Blázquez, and A. Oliver Antagonistic interactions of Pseudomonas aeruginosa antibiotic resistance mechanisms in planktonic but not biofilm growth Antimicrob. Agents Chemother. 55 2011 4560 4568
135. C. Muller, P. Plésiat, and K. Jeannot A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa Antimicrob. Agents Chemother. 55 2011 1211 1221
136. S. Naughton, D. Parker, T. Seemann, T. Thomas, L. Turnbull, B. Rose, P. Bye, S. Cordwell, C. Whitchurch, and J. Manos Pseudomonas aeruginosa AES-1 exhibits increased virulence gene expression during chronic infection of cystic fibrosis lung PLoS ONE 6 2011 e24526
137. A. Nemec, L. Krizova, M. Maixnerova, and M. Musilek Multidrug-resistant epidemic clones among bloodstream isolates of Pseudomonas aeruginosa in the Czech Republic Res. Microbiol. 161 2010 234 242
138. A.O. Olaitan, S. Morand, and J.M. Rolain Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria Front. Microbiol. 5 2014 643
139. A. Oliver, F. Baquero, and J. Blázquez The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants Mol. Microbiol. 43 2002 1641 1650
140. A. Oliver, R. Cantón, P. Campo, F. Baquero, and J. Blázquez High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection Science 288 5469 2000 1251 1254
141. A. Oliver, A. Mena, and M.D. Macià Evolution of Pseudomonas aeruginosa pathogenicity: from acute to chronic infections F. Baquero, C. Nombela, G.H. Cassell, J.A. Gutiérrez, Evolutionary Biology of Bacterial and Fungal Pathogens 2008 ASM Press 978-1-55581-414-4 433 444
142. S. Panagea, C. Winstanley, M.J. Walshaw, M.J. Ledson, and C.A. Hart Environmental contamination with an epidemic strain of Pseudomonas aeruginosa in a Liverpool cystic fibrosis centre, and study of its survival on dry surfaces J. Hosp. Infect. 59 2005 102 107
143. C.C. Papagiannitsis, V. Studentova, F. Ruzicka, R. Tejkalova, and J. Hrabak Molecular characterization of metallo-β-lactamase-producing Pseudomonas aeruginosa in a Czech hospital (2009-2011) J. Med. Microbiol. 62 2013 945 947
144. M.D. Parkins, B.A. Glezerson, C.D. Sibley, K.A. Sibley, J. Duong, S. Purighalla, C.H. Mody, M.L. Workentine, D.G. Storey, M.G. Surette, and H.R. Rabin Twenty-five-year outbreak of Pseudomonas aeruginosa infecting individuals with cystic fibrosis: identification of the prairie epidemic strain J. Clin. Microbiol. 52 4 2014 1127 1135
145. G. Patel, and R.A. Bonomo Status report on carbapenemases: challenges and prospects Expert Rev. Anti. Infect. Ther. 9 2011 555 570
146. S.S. Pedersen, C. Koch, N. Høiby, and K. Rosendal An epidemic spread of multiresistant Pseudomonas aeruginosa in a cystic fibrosis centre J. Antimicrob. Chemother. 17 4 1986 505 516
147. C. Peña, G. Cabot, S. Gómez-Zorrilla, L. Zamorano, A. Ocampo-Sosa, J. Murillas, B. Almirante, V. Pomar, M. Aguilar, A. Granados, E. Calbo, J. Rodríguez-Baño, F. Rodríguez-López, F. Tubau, L. Martínez-Martínez, A. Oliver Spanish Network for Research in Infectious Diseases (REIPI) Influence of virulence genotype and resistance profile in the mortality of Pseudomonas aeruginosa bloodstream infections Clin. Infect. Dis. 60 2015 539 548
148. C. Peña, C. Suarez, M. Gozalo, J. Murillas, B. Almirante, V. Pomar, M. Aguilar, A. Granados, E. Calbo, J. Rodríguez-Baño, F. Rodríguez, F. Tubau, L. Martínez-Martínez, A. Oliver Spanish Network for Research in Infectious Diseases REIPI Prospective multicenter study of the impact of carbapenem resistance on mortality in Pseudomonas aeruginosa bloodstream infections Antimicrob. Agents Chemother. 56 2012 1265 1272
149. F. Perez, A.M. Hujer, S.H. Marshall, A.J. Ray, P.N. Rather, N. Suwantarat, D. Dumford 3rd, P. O'Shea, T.N. Domitrovic, R.A. Salata, K.D. Chavda, L. Chen, B.N. Kreiswirth, A.J. Vila, S. Haussler, M.R. Jacobs, and R.A. Bonomo Extensively drug-resistant Pseudomonas aeruginosa isolates containing blaVIM-2 and elements of Salmonella genomic island 2: a new genetic resistance determinant in Northeast Ohio Antimicrob. Agents Chemother. 58 2014 5929 5935
150. N. Pfennigwerth, G. Geis, S.G. Gatermann, and M. Kaase Description of IMP-31, a novel metallo-β-lactamase found in an ST235 Pseudomonas aeruginosa strain in Western Germany J. Antimicrob. Chemother. 70 2015 1973 1980
151. B. Picard, E. Denamur, A. Barakat, J. Elion, and P. Goullet Genetic heterogeneity of Pseudomonas aeruginosa clinical isolates revealed by esterase electrophoretic polymorphism and restriction fragment length polymorphism of the ribosomal RNA gene region J. Med. Microbiol. 40 1994 313 322
152. J.P. Pirnay, F. Bilocq, B. Pot, P. Cornelis, M. Zizi, J. Van Eldere, P. Deschaght, M. Vaneechoutte, S. Jennes, T. Pitt, and D. De Vos Pseudomonas aeruginosa population structure revisited PLoS ONE 4 2009 e7740
153. J.P. Pirnay, D. De Vos, C. Cochez, F. Bilocq, A. Vanderkelen, M. Zizi, B. Ghysels, and P. Cornelis Pseudomonas aeruginosa displays an epidemic population structure Environ. Microbiol. 4 2002 898 911
154. L. Poirel, L. Brinas, A. Verlinde, L. Ide, and P. Nordmann BEL-1, a novel clavulanic acid-inhibited extended-spectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa Antimicrob. Agents Chemother. 49 2005 3743 3748
155. L. Poirel, L. Cabanne, H. Vahaboglu, and P. Nordmann Genetic environment and expression of the extended-spectrum beta-lactamase blaPER-1 gene in gram-negative bacteria Antimicrob. Agents Chemother. 49 2005 1708 1713
156. S. Pollini, S. Maradei, P. Pecile, G. Olivo, F. Luzzaro, J.D. Docquier, and G.M. Rossolini FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy Antimicrob. Agents Chemother. 57 2013 410 416
157. K. Poole Pseudomonas aeruginosa: resistance to the max Front. Microbiol. 2 2011 65
158. A. Potron, L. Poirel, and P. Nordmann Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: Mechanisms and epidemiology Int. J. Antimicrob. Agents. 45 2015 568 585 (pii: S0924-8579(15)00104-1)
159. K. Ranellou, K. Kadlec, A. Poulou, E. Voulgari, G. Vrioni, S. Schwarz, and A. Tsakris Detection of Pseudomonas aeruginosa isolates of the international clonal complex 11 carrying the blaPER-1 extended-spectrum β-lactamase gene in Greece J. Antimicrob. Chemother. 67 2012 357 361
160. E. Riera, G. Cabot, X. Mulet, M. García-Castillo, R. del Campo, C. Juan, R. Cantón, and A. Oliver Pseudomonas aeruginosa carbapenem resistance mechanisms in Spain: impact on the activity of imipenem, meropenem and doripenem J. Antimicrob. Chemother. 66 9 2011 2022 2027
161. B. Rojo-Bezares, V. Estepa, R. Cebollada, M. de Toro, S. Somalo, C. Seral, F. Castillo, C. Torres, and Y. Sáenz Carbapenem-resistant Pseudomonas aeruginosa strains from a Spanish hospital: characterization of metallo-beta-lactamases, porin OprD and integrons Int. J. Med. Microbiol. 304 2014 405 414
162. H.S. Sader, D.J. Farrell, R.K. Flamm, and R.N. Jones Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalised with pneumonia in US and European hospitals: results from the SENTRY Antimicrobial Surveillance Program, 2009-2012 Int. J. Antimicrob. Agents. 43 2014 328 334
163. P. Salunkhe, C.H. Smart, J.A. Morgan, S. Panagea, M.J. Walshaw, C.A. Hart, R. Geffers, B. Tümmler, and C. Winstanley A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance J. Bacteriol. 187 2005 4908 4920
164. O. Samuelsen, M.A. Toleman, A. Sundsfjord, J. Rydberg, T.M. Leegaard, M. Walder, A. Lia, T.E. Ranheim, Y. Rajendra, N.O. Hermansen, T.R. Walsh, and C.G. Giske Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion Antimicrob. Agents Chemother. 54 2010 346 352
165. S. Sardelic, B. Bedenic, C. Colinon-Dupuich, S. Orhanovic, Z. Bosnjak, V. Plecko, B. Cournoyer, and G.M. Rossolini Infrequent finding of metallo-β-lactamase VIM-2 in carbapenem-resistant Pseudomonas aeruginosa strains from Croatia Antimicrob. Agents Chemother. 56 2012 2746 2749
166. T. Sawa, M. Shimizu, K. Moriyama, and J.P. Wiener-Kronish Association between Pseudomonas aeruginosa type III secretion, antibiotic resistance, and clinical outcome: a review Crit. Care 18 2014 668
167. F.W. Scott, and T.L. Pitt Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and Wales J. Med. Microbiol. 53 2004 609 615
168. C. Scotta, C. Juan, G. Cabot, A. Oliver, J. Lalucat, A. Bennasar, and S. Albertí Environmental microbiota represents a natural reservoir for dissemination of clinically relevant metallo-beta-lactamases Antimicrob. Agents Chemother. 55 11 2011 5376 5379
169. Y. Seok, I.K. Bae, S.H. Jeong, S.H. Kim, H. Lee, and K. Lee Dissemination of IMP-6 metallo-β-lactamase-producing Pseudomonas aeruginosa sequence type 235 in Korea J. Antimicrob. Chemother. 66 2011 2791 2796
170. W. Shimizu, S. Kayama, S. Kouda, Y. Ogura, K. Kobayashi, N. Shigemoto, N. Shimada, R. Yano, J. Hisatsune, F. Kato, T. Hayashi, T. Sueda, H. Ohge, and M. Sugai Persistence and epidemic propagation of a Pseudomonas aeruginosa sequence type 235 clone harboring an IS26 composite transposon carrying the blaIMP-1 integron in Hiroshima, Japan, 2005 to 2012 Antimicrob. Agents Chemother. 59 2015 2678 2687
171. F.M. Silva, M.S. Carmo, S. Silbert, and A.C. Gales SPM-1-producing Pseudomonas aeruginosa: analysis of the ancestor relationship using multilocus sequence typing, pulsed-field gel electrophoresis, and automated ribotyping Microb. Drug Resist. 17 2011 215 220
172. M.W. Silby, C. Winstanley, S.A. Godfrey, S.B. Levy, and R.W. Jackson Pseudomonas genomes: diverse and adaptable FEMS Microbiol. Rev. 35 2011 652 680
173. D. Skurnik, D. Roux, V. Cattoir, O. Danilchanka, X. Lu, D.R. Yoder-Himes, K. Han, T. Guillard, D. Jiang, C. Gaultier, F. Guerin, H. Aschard, R. Leclercq, J.J. Mekalanos, S. Lory, and G.B. Pier Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing Proc. Natl. Acad. Sci. U.S.A. 110 2013 20747 20752
174. C. Slekovec, J. Plantin, P. Cholley, M. Thouverez, D. Talon, X. Bertrand, and D. Hocquet Tracking down antibiotic-resistant Pseudomonas aeruginosa isolates in a wastewater network PLoS ONE 7 2012 e49300
175. J.M. Smith, N.H. Smith, M. O'Rourke, and B.G. Spratt How clonal are bacteria? Proc. Natl. Acad. Sci. U.S.A. 90 1993 4384 4388
176. M. Souli, I. Galani, and H. Giamarellou Emergence of extensively drug-resistant and pandrug-resistant Gram-negative bacilli in Europe Euro Surveill. 13 2008 pii: 19045
177. N. Srour, C. Chaparro, K. Vandemheen, L.G. Singer, S. Keshavjee, and S.D. Aaron Effect of infection with transmissible strains of Pseudomonas aeruginosa on lung transplantation outcomes in patients with cystic fibrosis J. Heart Lung Transplant. 34 2015 588 593
178. P. Tingpej, M. Elkins, B. Rose, H. Hu, C. Moriarty, J. Manos, B. Barras, P. Bye, and C. Harbour Clinical profile of adult cystic fibrosis patients with frequent epidemic clones of Pseudomonas aeruginosa Respirology 15 2010 923 929
179. M. Tomás, M. Doumith, M. Warner, J.F. Turton, A. Beceiro, G. Bou, D.M. Livermore, and N. Woodford Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients Antimicrob. Agents Chemother. 54 2010 2219 2224
180. J.F. Turton, L. Wright, A. Underwood, A.A. Witney, Y.T. Chan, A. Al-Shahib, C. Arnold, M. Doumith, B. Patel, T.D. Planche, J. Green, R. Holliman, and N. Woodford High-resolution analysis by whole genome sequencing of an international lineage (ST-111) of Pseudomonas aeruginosa associated with metallo-carbapenemases in the United Kingdom J. Clin. Microbiol. 53 2015 2622 2631 (pii: JCM.00505-15)
181. A.K. Van der Bij, D. Van der Zwan, G. Peirano, J.A. Severin, J.D. Pitout, M. Van Westreenen, W.H. Goessens, and MBL-PA Surveillance Study Group Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type Clin. Microbiol. Infect. 18 2012 369 372
182. R. van Mansfeld, R. Willems, R. Brimicombe, H. Heijerman, F.T. van Berkhout, T. Wolfs, C. van der Ent, and M. Bonten Pseudomonas aeruginosa genotype prevalence in Dutch cystic fibrosis patients and age dependency of colonization by various P. aeruginosa sequence types J. Clin. Microbiol. 47 2009 4096 4101
183. J.M. Vanegas, A.V. Cienfuegos, A.M. Ocampo, L. López, H. del Corral, G. Roncancio, P. Sierra, L. Echeverri-Toro, S. Ospina, N. Maldonado, C. Robledo, A. Restrepo, and J.N. Jiménez Similar frequencies of Pseudomonas aeruginosa isolates producing KPC and VIM carbapenemases in diverse genetic clones at tertiary-care hospitals in Medellín, Colombia J. Clin. Microbiol. 52 2014 3978 3986
184. R. Vatcheva-Dobrevska, X. Mulet, I. Ivanov, L. Zamorano, E. Dobreva, T. Velinov, T. Kantardjiev, and A. Oliver Molecular epidemiology and multidrug resistance mechanisms of Pseudomonas aeruginosa isolates from Bulgarian hospitals Microb. Drug Resist. 19 2013 355 361
185. E. Viedma, V. Estepa, C. Juan, J. Castillo-Vera, B. Rojo-Bezares, C. Seral, F.J. Castillo, Y. Sáenz, C. Torres, F. Chaves, and A. Oliver Comparison of local features from two Spanish hospitals reveals common and specific traits at multiple levels of the molecular epidemiology of metallo-β-lactamase-producing Pseudomonas spp Antimicrob. Agents Chemother. 58 2014 2454 2458
186. E. Viedma, C. Juan, J. Acosta, L. Zamorano, J.R. Otero, F. Sanz, F. Chaves, and A. Oliver Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain Antimicrob. Agents Chemother. 53 2009 4930 4933
187. E. Viedma, C. Juan, J.R. Otero, A. Oliver, and F. Chaves Draft genome sequence of VIM-2-producing multidrug-resistant Pseudomonas aeruginosa ST175, an epidemic high-risk clone Genome Announc. 1 2013 e0011213
188. E. Viedma, C. Juan, J. Villa, L. Barrado, M.A. Orellana, F. Sanz, J.R. Otero, A. Oliver, and F. Chaves VIM-2-producing multidrug-resistant Pseudomonas aeruginosa ST175 clone, Spain Emerg. Infect. Dis. 18 2012 1235 1241
189. E. Viedma, J. Villa, C. Juan, A. Oliver, and F. Chaves Draft genome sequence of colistin-only-susceptible Pseudomonas aeruginosa Strain ST235, a hypervirulent high-risk clone in Spain Genome Announc. 2 5 2014 e01097-14
190. J.L. Vincent Nosocomial infections in adult intensive-care units Lancet 361 9374 2003 2068 2077
191. Y. Wang, X. Wang, S. Schwarz, R. Zhang, L. Lei, X. Liu, D. Lin, and J. Shen IMP-45-producing multidrug-resistant Pseudomonas aeruginosa of canine origin J. Antimicrob. Chemother. 69 2014 2579 2581
192. L. Wiehlmann, G. Wagner, N. Cramer, B. Siebert, P. Gudowius, G. Morales, T. Köhler, C. van Delden, C. Weinel, P. Slickers, and B. Tümmler Population structure of Pseudomonas aeruginosa Proc. Natl. Acad. Sci. U.S.A. 104 2007 8101 8106
193. D. Williams, B. Evans, S. Haldenby, M.J. Walshaw, M.A. Brockhurst, C. Winstanley, and S. Paterson Divergent, coexisting Pseudomonas aeruginosa lineages in chronic cystic fibrosis lung infections Am. J. Respir. Crit. Care Med. 191 2015 775 785
194. M. Willmann, D. Bezdan, L. Zapata, H. Susak, W. Vogel, K. Schröppel, J. Liese, C. Weidenmaier, I.B. Autenrieth, S. Ossowski, and S. Peter Analysis of a long-term outbreak of XDR Pseudomonas aeruginosa: a molecular epidemiological study J. Antimicrob. Chemother. 70 2015 1322 1330
195. M. Willmann, I. Kuebart, M. Marschal, K. Schröppel, W. Vogel, I. Flesch, U. Markert, I.B. Autenrieth, F. Hölzl, and S. Peter Effect of metallo-β-lactamase production and multidrug resistance on clinical outcomes in patients with Pseudomonas aeruginosa bloodstream infection: a retrospective cohort study BMC Infect. Dis. 13 2013 515
196. C. Winstanley, M.G. Langille, J.L. Fothergill, I. Kukavica-Ibrulj, C. Paradis-Bleau, F. Sanschagrin, N.R. Thomson, G.L. Winsor, M.A. Quail, N. Lennard, A. Bignell, L. Clarke, K. Seeger, D. Saunders, D. Harris, J. Parkhill, R.E. Hancock, F.S. Brinkman, and R.C. Levesque Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa Genome Res. 19 2009 12 23
197. A.A. Witney, K.A. Gould, C.F. Pope, F. Bolt, N.G. Stoker, M.D. Cubbon, C.R. Bradley, A. Fraise, A.S. Breathnach, P.D. Butcher, T.D. Planche, and J. Hinds Genome sequencing and characterization of an extensively drug-resistant sequence type 111 serotype O12 hospital outbreak strain of Pseudomonas aeruginosa Clin. Microbiol. Infect. 20 2014 O609 O618
198. N. Woodford, J.F. Turton, and D.M. Livermore Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance FEMS Microbiol. Rev. 35 2011 736 755
199. L.L. Wright, J.F. Turton, D.M. Livermore, K.L. Hopkins, and N. Woodford Dominance of international 'tild;high-risk clones' among metallo-β-lactamase-producing Pseudomonas aeruginosa in the UK J. Antimicrob. Chemother. 70 2015 103 110
200. L. Yang, L. Jelsbak, R.L. Marvig, S. Damkiær, C.T. Workman, M.H. Rau, S.K. Hansen, A. Folkesson, H.K. Johansen, O. Ciofu, N. Høiby, M.O. Sommer, and S. Molin Evolutionary dynamics of bacteria in a human host environment Proc. Natl. Acad. Sci. U.S.A. 108 2011 7481 7486
201. J.S. Yoo, J.W. Yang, H.M. Kim, J. Byeon, H.S. Kim, J.I. Yoo, G.T. Chung, and Y.S. Lee Dissemination of genetically related IMP-6-producing multidrug-resistant Pseudomonas aeruginosa ST235 in South Korea Int. J. Antimicrob Agents. 39 2012 300 304
202. S. Yousefi, M.R. Nahaei, S. Farajnia, M. Aghazadeh, A. Iversen, P. Edquist, M. Maãtallah, and C.G. Giske A multiresistant clone of Pseudomonas aeruginosa sequence type 773 spreading in a burn unit in Orumieh, Iran APMIS 121 2013 146 152
203. M.M. Zafer, M.H. Al-Agamy, H.A. El-Mahallawy, M.A. Amin, and S. El Din Ashour Dissemination of VIM-2 producing Pseudomonas aeruginosa ST233 at tertiary care hospitals in Egypt BMC Infect. Dis. 15 2015 122
204. G.G. Zhanel, M. DeCorby, H. Adam, M.R. Mulvey, M. McCracken, P. Lagacé-Wiens, K.A. Nichol, A. Wierzbowski, P.J. Baudry, F. Tailor, J.A. Karlowsky, A. Walkty, F. Schweizer, J. Johnson, D.J. Hoban Canadian Antimicrobial Resistance Alliance Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian Ward Surveillance Study (CANWARD 2008) Antimicrob. Agents Chemother. 54 2010 4684 4693
205. M.D. Zilberberg, and A.F. Shorr Prevalence of multidrug-resistant Pseudomonas aeruginosa and carbapenem-resistant Enterobacteriaceae among specimens from hospitalized patients with pneumonia and bloodstream infections in the United States from 2000 to 2009 J. Hosp. Med. 8 2013 559 563