The neglected intrinsic resistome of bacterial pathogens

PLoS ONE

Volumn 3, Issue 2, 2008, Pages

  Fajardo, Alicia ^a   Martínez Martín, Nadia ^a   Mercadillo, María ^b   Galán, Juan C ^b   Ghysels, Bart ^c   Matthijs, Sandra ^c   Cornelis, Pierre ^c   Wiehlmann, Lutz ^d   Tümmler, Burkhard ^d   Baquero, Fernando ^b   Martínez, José L ^a,b  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; CEFTAZIDIME; CIPROFLOXACIN; IMIPENEM; POLYMYXIN B; TETRACYCLINE; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM MUTANT; GENE MUTATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PREDICTION; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; RESISTOME; TRANSPOSON; BACTERIAL GENE; BACTERIAL GENOME; DRUG EFFECT; GENETICS; MUTATION;

BACTERIA (MICROORGANISMS);

ANTI-BACTERIAL AGENTS; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; GENOME, BACTERIAL; MUTATION; PSEUDOMONAS AERUGINOSA;

EID: 42049115532     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001619     Document Type: Article

References (48)

1. Levy SB (1998) Multidrug resistance a sign of the times. N Engl J Med 338: 1376-1378.
2. Smith DL, Dushoff J, Perencevich EN, Harris AD, Levin SA (2004) Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: resistance is a regional problem. Proc Natl Acad Sci U S A 101: 3709-3714.
3. World HO (2000) Overcoming antibiotic resistance. World Health Organization Report in Infectious Diseases.
4. Martinez JL, Baquero F, Andersson DI (2007) Predicting antibiotic resistance. Nat Rev Microbiol 5: 958-965.
5. Davies JE (1997) Origins, acquisition and dissemination of antibiotic resistance determinants. Ciba Found Symp 207: 15-27; discussion 27-35.
6. Martinez JL, Baquero F (2000) Mutation frequencies and antibiotic resistance. Antimicrob Agents Chemother 44: 1771-1777.
7. D'Acosta VM, McGrann KM, Hughes DW, Wright GD (2006) Sampling the antibiotic resistome. Science 311: 374-377.
8. Wright GD (2007) The antibiotic resistome: the nexus of chemical and genetic diversity. Nat Rev Microbiol 5: 175-186.
9. Alonso A, Sanchez P, Martinez JL (2001) Environmental selection of antibiotic resistance genes. Environ Microbiol 3: 1-9.
10. Quinn JP (1998) Clinical problems posed by multiresistant nonfermenting gram-negative pathogens. Clin Infect Dis 27 Suppl 1: S117-124.
11. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, et al. (2000) Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen. Nature 406: 959-964.
12. Gales AC, Jones RN, Turnidge J, Rennie R, Ramphal R (2001) Characterization of Pseudomonas aeruginosa isolates: occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the global SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 32 Suppl 2: S146-155.
13. Navon-Venezia S, Ben-Ami R, Carmeli Y (2005) Update on Pseudomonas aeruginosa and Acinetobacter baumannii infections in the healthcare setting. Curr Opin Infect Dis 18: 306-313.
14. Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, et al. (1995) The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. Jama 274: 639-644.
15. Govan JR, Deretic V (1996) Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 60: 539-574.
16. Gibson RL, Burns JL, Ramsey BW (2003) Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med 168: 918-951.
17. Hancock RE (1998) Resistance mechanisms in Pseudomonas aeruginosa and other nonfermentative gram-negative bacteria. Clin Infect Dis 27 Suppl 1: S93-99.
18. Hancock RE, Speert DP (2000) Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment. Drug Resist Updat 3: 247-255.
19. Gatell JM, Marrades R, el-Ebiary M, Torres A (1996) Severe pulmonary infections in AIDS patients. Semin Respir Infect 11: 119-128.
20. Spiers AJ, Buckling A, Rainey PB (2000) The causes of Pseudomonas diversity. Microbiology 146 (Pt 10): 2345-2350.
21. Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, et al. (1995) Common virulence factors for bacterial pathogenicity in plants and animals. Science 268: 1899-1902.
22. Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM (1999) Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96: 47-56.
23. Tan MW, Mahajan-Mildos S, Ausubel FM (1999) Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proc Natl Acad Sci U S A 96: 715-720.
24. Sifri CD, Begun J, Ausubel FM (2005) The worm has turned-microbial virulence modeled in Caenorhabditis elegans. Trends Microbiol 13: 119-127.
25. Navas A, Cobas G, Talavera M, Ayala JA, Lopez JA, et al. (2007) Experimental validation of Haldane's hypothesis on the role of infection as an evolutionary force for Metazoans. Proc Natl Acad Sci U S A 104: 13728-13731.
26. Morales G, Wiehlmann L, Gudowius P, van Delden C, Tummler B, et al. (2004) Structure of Pseudomonas aeruginosa populations analyzed by single nucleotide polymorphism and pulsed-field gel electrophoresis genotyping. J Bacteriol 186: 4228-4237.
27. Wiehlmann L, Wagner G, Cramer N, Siebert B, Gudowius P, et al. (2007) Population structure of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 104: 8101-8106.
28. Alonso A, Rojo F, Martinez JL (1999) Environmental and clinical isolates of Pseudomonas acruginosa show pathogenic and biodegradative properties irrespective of their origin. Environ Microbiol 1: 421-430.
29. Nakaido H (2001) Preventing drug access to targets: cell surface permeability barries and active efflux in bacteria. Semin Cell Dev Biol 12: 215-223.
30. Wiehlmann L, Salunke P, Larbig K, Ritzka M, Tummler B (2002) Signature tagged mutagenesis of Pseudomonas aeruginosa. Genome Letters 1: 1-9.
31. de Chial M, Ghysels B, Beatson SA, Geofroy V, Meyer JM, et al. (2003) Identification of type II and type III pryoverdine receptors from Pseudomonas aeruginosa. Microbiology 149: 821-831.
32. Lee N, Yuen KY, Kumana CR (2003) Clinical role of beta-lactam/beta- lactamase inhibitor combinations. Drugs 63: 1511-1524.
33. Benveniste R, Davies J (1973) Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad U S A 70: 2276-2280.
34. Linares JF, Gustafsson I, Baquero F, Martinez JL (2006) Antibiotics as intermicrobial signaling agents instead of weapons. Proc Natl Acad Sci U S A 103: 19484-19489.
35. Yim G, Wang HH, Davies J (2007) Antibiotics as signalling molecules. Philos Trans R Soc Lond B Biol Sci 362: 1195-1200.
36. Levin BR, Rozen DE (2006) Non-inherited antibiotic resistance. Nat Rev Microbiol 4: 556-562.
37. Wiuff C, Zappala RM, Regoes RR, Garner KN, Baquero F, et al. (2005) Phenotypic tolerance antibiotic enrichment of noninherited resistance in bacterial populations. Antimicrob Agents Chemother 49: 1483-1494.
38. Hogan D, Kolter R (2002) Why are bacteria refractory refractory to antimicrobials? Curr Opin Microbiol 5: 472-477.
39. Martinez JL, Blazquez J, Baquero F (1994) Non-canonical mechanisms of antibiotic resistance. Eur J Clin Microbiol Infect Dis 13: 1015-1022.
40. Pang Y, Brown BA, Steingrube VA, Wallace RJ Jr, Roberts MC (1994) Tetracycline resistance determinants in Mycobacterium and Streptomyces species. Antimicrob Agents Chemother 38: 1408-1412.
41. Macinga DR, Rather PN (1999) The chromosomal 2′-N-acetyltransferase of Providencia stuartii: physiological functions and genetic regulation. Front Biosci 4: D132-140.
42. Amsa JA, Perez E, Pelicic V, Berthet FX, Gicquel B, et al. (1997) Aminoglycoside 2′-N-acetyltransferase genes are universally present in mycobacteria: characterization of the aac(2′)-Ic gene from Mycobacterium tuberculosis and the aac(2′)-Id gene from Mycobacterium smegmatis. Mol Microbiol 24: 431-441.
43. Gould SJ, Lloyd EA (1999) Individuality and adaptation across levels of selection: how shall we name and generalize the unit of Darwinism? Proc Natl Acad Sci U S A 96: 11904-11909.
44. Atlas RM (1993) Handbook of Microbiological Media; Parks LC, editor. Boca Raton: CRC Press.
45. Luria SE, Burrous JW (1957) Hybridization between Escherichia coli and Shigella. J Bacteriol 74: 461-476.
46. Alonso A, Campanario E, Martinez JL (1999) Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa. Microbiology 145 (Pt 10): 2857-2862.
47. Sambrook J, Russell DW (2001) Molecular Cloning. A laboratory manual 3rd. edition. Cold Spring Harbor, N. Y.: Cold Spring Harbor Laboratory Press.
48. Eisen MB, Spellman PT, Brown PO, Botstein D (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 95: 14863-14868.