Poor clinical outcomes associated with a multi-drug resistant clonal strain of Pseudomonas aeruginosa in the Tasmanian cystic fibrosis population

Respirology

Volumn 13, Issue 6, 2008, Pages 886-892

  Bradbury, Richard ^a,b   Champion, Alan ^a   Reid, David W ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b ROYAL HOBART HOSPITAL   (Australia)

Author keywords

Clonal; Cystic fibrosis; Epidemiology; Pseudomonas aeruginosa

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; MONOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; AUSTRALIA; BACTERIAL STRAIN; BACTERIUM ISOLATE; CLINICAL ARTICLE; CYSTIC FIBROSIS; FEMALE; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HOSPITALIZATION; HUMAN; INCIDENCE; MALE; MULTIDRUG RESISTANCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PULSED FIELD GEL ELECTROPHORESIS; RANDOM AMPLIFIED POLYMORPHIC DNA; STRAIN DIFFERENCE;

ADULT; ANTI-BACTERIAL AGENTS; CYSTIC FIBROSIS; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; FEMALE; HUMANS; MALE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RANDOM AMPLIFIED POLYMORPHIC DNA TECHNIQUE; SEROEPIDEMIOLOGIC STUDIES; SPUTUM; TASMANIA; TREATMENT OUTCOME; VIRULENCE; YOUNG ADULT;

EID: 51349087738     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2008.01383.x     Document Type: Article

References (15)

1. Scott FW, Pitt TL. Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and Wales. J. Med. Microbiol. 2004 53 (Pt 7 609 15.
2. Anthony M, Rose B, Pegler MB, Elkins M, Service H et al. Genetic analysis of Pseudomonas aeruginosa isolates from the sputa of Australian adult cystic fibrosis patients. J. Clin. Microbiol. 2002 40 : 2772 8.
3. Smith DL, Gumery LB, Smith EG, Stableforth DE, Kaufmann ME et al. Epidemic of Pseudomonas cepacia in an adult cystic fibrosis unit: evidence of person-to-person transmission. J. Clin. Microbiol. 1993 31 : 3017 22.
4. Al-Aloul M, Crawley J, Winstanley C, Hart CA, Ledson MJ et al. Increased morbidity associated with chronic infection by an epidemic Pseudomonas aeruginosa strain in CF patients. Thorax 2004 59 : 334 6.
5. Salunkhe P, Smart CH, Morgan JA, Panagea S, Walshaw MJ et al. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. J. Bacteriol. 2005 187 : 4908 20.
6. Syrmis MW, O'Carroll MR, Sloots TP, Coulter C, Wainwright CE et al. Rapid genotyping of Pseudomonas aeruginosa isolates harboured by adult and paediatric patients with cystic fibrosis using repetitive-element-based PCR assays. J. Med. Microbiol. 2004 53 (Pt 11 1089 96.
7. O'Carroll MR, Syrmis MW, Wainwright CE, Greer RM, Mitchell P et al. Clonal strains of Pseudomonas aeruginosa in paediatric and adult cystic fibrosis units. Eur. Respir. J. 2004 24 : 101 6.
8. Armstrong DS, Nixon GM, Carzino R, Bigham A, Carlin JB et al. Detection of a widespread clone of Pseudomonas aeruginosa in a pediatric cystic fibrosis clinic. Am. J. Respir. Crit. Care Med. 2002 166 : 983 7.
9. Wikler MA, Cockerill FR, Craig WA, Dudley MN, Eliopoulos GM et al. Performance Standards for Antimicrobial Susceptibility Testing; Fourteenth Information Supplement. National Committee for Clinical Laboratory Standards, Wayne, PA, 2004. 24 (1).
10. Cystic Fibrosis Foundation. Microbiology and Infectious Diseases in Cystic Fibrosis. Consensus Conference: Concepts in Care. Cystic Fibrosis Foundation, Bethesda, MD, 1994. 5 (1).
11. Pedersen SS, Koch C, Hoiby N, Rosendal K. An epidemic spread of multiresistant Pseudomonas aeruginosa in a cystic fibrosis centre. J. Antimicrob. Chemother. 1986 17 : 505 16.
12. Salunkhe P, Smart CH, Morgan JA, Panagea S, Walshaw MJ et al. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. J. Bacteriol. 2005 187 : 4908 20.
13. Tingpej P, Smith L, Rose B, Zhu H, Conibear T et al. Phenotypic characterization of clonal and non-clonal Pseudomonas aeruginosa from the lungs of adults with cystic fibrosis. J. Clin. Microbiol. 2007 45 : 1697 704.
14. Smith L, Rose B, Tingpej P, Zhu H, Conibear T et al. Protease IV production in Pseudomonas aeruginosa from the lungs of adults with cystic fibrosis. J. Med. Microbiol. 2006 55 (Pt 12 1641 4.
15. Jones AM, Martin L, Bright-Thomas RJ, Dodd ME, McDowell A et al. Inflammatory markers in cystic fibrosis patients with transmissible Pseudomonas aeruginosa. Eur. Respir. J. 2003 22 : 503 6.