A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 2, 2015, Pages 319-331

  Guo, Yuli ^a   Yu, Wenjun ^a   Sun, Dongdong ^a   Wang, Jiaxing ^a   Li, Congye ^a   Zhang, Rongqing ^a   Babcock, Sara A ^b   Li, Yan ^a   Liu, Min ^a   Ma, Meijuan ^a   Shen, Mingzhi ^a   Zeng, Chao ^a   Li, Na ^a   He, Wei ^a   Zou, Qian ^a   Zhang, Yingmei ^a,b   Wang, Haichang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

ALDH2; AMPK; Autophagy; FOXO3a; High glucose; Myocardial dysfunction

Indexed keywords

ADENYLATE KINASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CALCIUM; GLUCOSE; LECTIN; PROTEIN P62; RAPAMYCIN; STREPTOZOCIN; TRANSCRIPTION FACTOR FKHRL1; 1,3 BENZODIOXOLE DERIVATIVE; 3-METHYLADENINE; ADENINE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; BENZAMIDE DERIVATIVE; CARDIOTONIC AGENT; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; N-(1,3-BENZODIOXOL-5-YLMETHYL)-2,6-DICHLOROBENZAMIDE; PROTEIN SERINE THREONINE KINASE; ULK1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CALCIUM CELL LEVEL; CELL DAMAGE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DISEASE ASSOCIATION; ENZYME PHOSPHORYLATION; EXPERIMENTAL DIABETES MELLITUS; GENE OVEREXPRESSION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE INJURY; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MITOCHONDRION; MOUSE; NONHUMAN; RAT; STAINING; TRANSGENE; UPREGULATION; WESTERN BLOTTING; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; CALCIUM SIGNALING; CELL SURVIVAL; CHICKEN; DRUG EFFECTS; ENZYMOLOGY; HEART; HEART CONTRACTION; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; TRANSGENIC MOUSE;

MUS MUSCULUS;

ADENINE; ALDEHYDE DEHYDROGENASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; AUTOPHAGY; BENZAMIDES; BENZODIOXOLES; CALCIUM SIGNALING; CARDIOTONIC AGENTS; CELL SURVIVAL; CHICKENS; DIABETES MELLITUS, TYPE 1; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; HEART; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, TRANSGENIC; MITOCHONDRIA; MODELS, BIOLOGICAL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; STREPTOZOCIN;

EID: 84919825937     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.05.017     Document Type: Article

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