Metabolic response to various β-adrenoceptor agonists in β3-adrenoceptor knockout mice: Evidence for a new β-adrenergic receptor in brown adipose tissue

British Journal of Pharmacology

Volumn 124, Issue 8, 1998, Pages 1684-1688

  Preitner, Frédéric ^a   Muzzin, Patrick ^a   Revelli, Jean Pierre ^a   Seydoux, Josiane ^a   Galitzky, Jean ^b   Berlan, Michel ^b   Lafontan, Max ^b   Giacobino, Jean Paul ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b INSERM   (France)

Author keywords

adrenoceptor agonists; 3 adrenoceptor; Brown adipose tissue; CGP 12177; Knockout; Lipolysis; Respiratory rate; White adipocytes

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ADRENALIN; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUCLADESINE; CORTICOTROPIN; DOBUTAMINE; FORSKOLIN; NORADRENALIN; PROCATEROL; RECEPTOR SUBTYPE; TERBUTALINE; TO 509; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; KNOCKOUT MOUSE; LIPOLYSIS; METABOLISM; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-AGONISTS; ANIMALS; EPINEPHRINE; GLYCEROL; LIPOLYSIS; MALE; MICE; MICE, KNOCKOUT; OXYGEN CONSUMPTION; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-3;

EID: 0031869348     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702007     Document Type: Article

References (25)

1. BARDE, Y.A., CHINET, A. & GIRARDIER, L. (1975). Potassium-induced increase in oxygen consumption of brown adipose tissue from the rat. J. Physiol. Lond., 252, 523-536.
2. BRADLEY, D.C. & KASLOW, H.R. (1989). Radiometric assays for glycerol, glucose and glycogen. Anal. Biochem., 180, 11-16.
3. 3-adrenoceptors in human brown and white adipose tissues. Brit. J. Pharmacol., 118, 929-934.
4. 3-adrenergic receptor. Science, 245, 1118-1121.
5. 3-adrenoceptor in man. J. Clin. Invest., 95, 2239-2245.
6. 4-adrenoceptor. Br. J. Pharmacol., 122, 1244-1250.
7. 3-adrenoceptor: an update. Eur. J. Endocrinol., 132, 377-385.
8. GRANNEMAN, J.G. (1990). Norepinephrine and BRL 37344 stimulate adenylate cyclase by different receptors in rat brown adipose tissue. J. Pharmacol. Exp. Ther., 254, 508-513.
9. 3-adrenergic receptor. Mol. Pharmacol., 40, 895-899.
10. 3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J. Biol. Chem., 272, 17686-17693.
11. HOLLENGA, C., BROUWER, F. & ZAAGSMA, J. (1991). Relationship between lipolysis and cyclic AMP generation mediated by atypical β-adrenoceptors in rat adipocytes. Br. J. Pharmacol., 102, 577-580.
12. KAUMANN, A.J. (1997). Four β-adrenoceptor subtypes in the mammalian heart. TiPS, 18, 70-76.
13. KAUMANN, A.J. & LYNHAM, J.A. (1997). Stimulation of cyclic AMP-dependent protein kinase in rat atria by (-)-CGP 12177 through an atypical β-adrenoceptor. Brit. J. Pharmacol., 120, 1187-1189.
14. 3-adrenoceptors in obesity. J. Clin. Invest., 95, 1109-1116.
15. 3-adrenoceptors in the pithed rat. Brit. J. Pharmacol., 122, 1303-1314.
16. 3H]CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue. Biochem. J., 261, 401-405.
17. 125I]cyanopindolol binding sites in rat skeletal muscle. Eur. J. Pharmacol., 209, 257-262.
18. MUZZIN, P., REVELLI, J.P., KUHNE, F., GOCAYNE, J.D., MCCOMBIE, W.R., VENTER, J.C., GIACOBINO, J.-P. & FRASER, C.M. (1991). An adipose tissue-specific β-adrenergic receptor. Molecular cloning and down-regulation in obesity. J. Biol. Chem., 266, 24053-24058.
19. 3H]CGP 12177. FEBS Lett., 298, 162-164.
20. 1-adrenergic receptors. J. Rec. Signal Trans. Res., 16, 1-23.
21. 3-adrenoceptor in the regulation of body composition. J. Clin. Invest., 100, 1098-1106.
22. 3-adrenergic receptor gene. J. Biol. Chem., 270, 29483-29492.
23. TAVERNIER, G., BARBE, P., GALITZKY, J., BERLAN, M., CAPUT, D., LAFONTAN, M. & LANGIN, D. (1996). Expression of β3-adrenoceptors with low lipolytic action in human subcutaneous white adipocytes. J. Lipid. Res., 37, 87-97.
24. VAN LIEFDE, L., VAN WITZENBURG, A. & VAUQUELIN, G. (1993). Isoproterenol and selective agonists stimulate similar atypical β-adrenoceptors in rat adipocytes. Biochem. Pharmacol., 45, 974-977.
25. ZHAO, J., UNELIUS, L., BENGTSSON, T., CANNON, B. & NEDERGAARD, J. (1994). Coexisting β-adrenoceptor subtypes: Significance for thermogenic process in brown fat cells. Am. J. Physiol., 267, C969-C979.