The biguanide metformin alters phosphoproteomic profiling in mouse brain

Neuroscience Letters

Volumn 579, Issue , 2014, Pages 145-150

  Khang, Rin ^a   Park, ChiHu ^a   Shin, Joo Ho ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

2DE; Brain; LC MS MS; Metformin; Phosphoproteomics

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENINE NUCLEOTIDE TRANSLOCASE 1; ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ADENOSINE PHOSPHATE; ALPHA SYNUCLEIN; ATP SYNTHASE SUBUNIT ALPHA; ATP SYNTHASE SUBUNIT BETA; ATP SYNTHASE SUBUNIT DELTA; BETA SYNUCLEIN; BRAIN PROTEIN; CYTOSKELETON PROTEIN; HISTONE H1; HISTONE H1.2; HISTONE H4; METFORMIN; MITOCHONDRIAL ENZYME; MITOCHONDRIAL PROTEIN; NADH DEHYDROGENASE 1 BETA SUBCOMPLEX SUBUNIT 7; NERVE CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE 1; NERVE CELL ADHESION MOLECULE L1; NEUROFILAMENT HEAVY POLYPEPTIDE; NEUROFILAMENT PROTEIN; NEUROMODULIN; PHOSPHOPROTEIN; PROTEIN KINASE; PROTEOLIPID PROTEIN; PROTEOLIPID PROTEIN 1; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL MEMBRANE; CELL ORGANELLE; CELL SURFACE; CELLULAR DISTRIBUTION; CHROMOSOME; CONTROLLED STUDY; DOWN REGULATION; DRUG MEGADOSE; ENDOPLASMIC RETICULUM; ENDOSOME; ENZYME PHOSPHORYLATION; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; RIBOSOME; TANDEM MASS SPECTROMETRY; TREATMENT DURATION; TWO DIMENSIONAL ELECTROPHORESIS; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BRAIN CHEMISTRY; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC DATABASE; GENETICS; METABOLISM; PROTEOMICS;

ANIMALS; BRAIN CHEMISTRY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DATABASES, GENETIC; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION STUDIES; HYPOGLYCEMIC AGENTS; MALE; METABOLIC NETWORKS AND PATHWAYS; METFORMIN; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; PROTEOMICS;

EID: 84905436039     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.07.029     Document Type: Article

References (23)

1. Kirpichnikov D., McFarlane S.I., Sowers J.R. Metformin: an update. Ann. Intern. Med. 2002, 137:25-33.
2. Viollet B., Guigas B., Sanz G.N., Leclerc J., Foretz M., Andreelli F. Cellular and molecular mechanisms of metformin: an overview. Clin. Sci. (Lond.) 2012, 122:253-270.
3. Poels J., Spasic M.R., Callaerts P., Norga K.K. Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy. Bioessays 2009, 31:944-952.
4. Spasic M.R., Callaerts P., Norga K.K. Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration. J. Neurosci. 2008, 28:6419-6429.
5. Spasic M.R., Callaerts P., Norga K.K. AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons. Neuroscientist 2009, 15:309-316.
6. Ma T.C., Buescher J.L., Oatis B., Funk J.A., Nash A.J., Carrier R.L., Hoyt K.R. Metformin therapy in a transgenic mouse model of Huntington's disease. Neurosci. Lett. 2007, 411:98-103.
7. Pintana H., Apaijai N., Pratchayasakul W., Chattipakorn N., Chattipakorn S.C. Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats. Life Sci. 2012, 91:409-414.
8. Ullah I., Ullah N., Naseer M.I., Lee H.Y., Kim M.O. Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons. BMC Neurosci. 2012, 13:11.
9. El-Mir M.Y., Detaille D., Villanueva G.R., Delgado-Esteban M., Guigas B., Attia S., Fontaine E., Almeida A., Leverve X. Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons. J. Mol. Neurosci. 2008, 34:77-87.
10. Ashabi G., Khodagholi F., Khalaj L., Goudarzvand M., Nasiri M. Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway. Metab. Brain Dis. 2014, 29:47-58.
11. Mielke J.G., Taghibiglou C., Wang Y.T. Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death. Neuroscience 2006, 143:165-173.
12. Chen Y., Zhou K., Wang R., Liu Y., Kwak Y.D., Ma T., Thompson R.C., Zhao Y., Smith L., Gasparini L., Luo Z., Xu H., Liao F.F. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:3907-3912.
13. Lemeer S., Heck A.J. The phosphoproteomics data explosion. Curr. Opin. Chem. Biol. 2009, 13:414-420.
14. Rubbi L., Titz B., Brown L., Galvan E., Komisopoulou E., Chen S.S., Low T., Tahmasian M., Skaggs B., Muschen M., Pellegrini M., Graeber T.G. Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling. Sci. Signal. 2011, 4:ra18.
15. Martin-Montalvo A., Mercken E.M., Mitchell S.J., Palacios H.H., Mote P.L., Scheibye-Knudsen M., Gomes A.P., Ward T.M., Minor R.K., Blouin M.-J., Schwab M., Pollak M., Zhang Y., Yu Y., Becker K.G., Bohr V.A., Ingram D.K., Sinclair D.A., Wolf N.S., Spindler S.R., bernier M., de Cabo R. Metformin improves healthspan and lifespan in mice. Nat. Commun. 2013, 4:2192.
16. Bhatia V.N., Perlman D.H., Costello C.E., McComb M.E. Software tool for researching annotations of proteins: open-source protein annotation software with data visualization. Anal. Chem. 2009, 81:9819-9823.
17. Jensen L.J., Kuhn M., Stark M., Chaffron S., Creever C., Muller J., Doerks T., Julien P., Roth A., Simonovic M., Bork P., von Mering C. STRING 8 - a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res. 2009, 37:D412-D416.
18. Patrone C., Eriksson O., Lindholm D. Diabetes drugs and neurological disorders: new views and therapeutic possibilities. Lancet Diabetes Endocrinol. 2014, 2:256-262.
19. Chau-Van C., Gamba M., Salvi R., Gaillard R.C., Pralong F.P. Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons. Endocrinology 2007, 148:507-511.
20. Blazquez C., Woods A., de Ceballos M.L., Carling D., Guzman M. The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. J. Neurochem. 1999, 73:1674-1682.
21. Wen J.P., Lv W.S., Yang J., Nie A.F., Cheng X.B., Yang Y., Ge Y., Li X.Y., Ning G. Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential. Biochem. Biophys. Res. Commun. 2008, 371:756-761.
22. Dulovic M., Jovanovic M., Xilouri M., Stefanis L., Harhaji-Trajkovic L., Kravic-Stevovic T., Paunovic V., Ardah M.T., El-Agnaf O.M.A., Kostic V., Markovic I., Trajkovic V. The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro. Neurobiol. Dis. 2014, 63:1-11.
23. Formentini L., Pereira M.P., Sánchez-enizo L., Santacatterina F., Lucas J.J., Navarro C., Martínez-errano A., Cuezva J.M. In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning. EMBO J. 2014, 33:762-778.