Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction

Cardiovascular Drugs and Therapy

Volumn 24, Issue 1, 2010, Pages 25-32

  Paiva, Marta A ^a,b   Gonçalves, Lino M ^b   Providência, Luis A ^b   Davidson, Sean M ^a   Yellon, Derek M ^a   Mocanu, Mihaela M ^a  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

AMPK; Compound C; Metformin; Myocardial infarction; Myocardial ischaemia; Reperfusion injury

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE INHIBITOR; METFORMIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; HEART; HEART HEMODYNAMICS; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ENZYME ACTIVATION; HEART; HEMODYNAMICS; HYPOGLYCEMIC AGENTS; INFARCTION; MALE; METFORMIN; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIMIDINES; RATS; RATS, WISTAR; RIBONUCLEOTIDES;

EID: 77951297902     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-010-6222-3     Document Type: Article

References (38)

1. DG Hardie 2008 Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease FEBS Lett 582 81 89 10.1016/j.febslet.2007.11.018 18022388 (Pubitemid 350297243)
2. KA Wong HF Lodish 2006 A revised model for AMP-activated protein kinase structure: the alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits J Biol Chem 281 36434 36442 10.1074/jbc.M607410200 17012231 (Pubitemid 46041377)
3. GR Steinberg BE Kemp 2009 AMPK in health and disease Physiol Rev 89 1025 1078 10.1152/physrev.00011.2008 19584320
4. B Viollet F Andreelli SB Jorgensen C Perrin A Geloen D Flamez, et al. 2003 The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity J Clin Invest 111 91 98 12511592
5. GD Lopaschuk 2008 AMP-activated protein kinase control of energy metabolism in the ischemic heart Int J Obes (Lond) 32 S29 S35 10.1038/ijo.2008.120
6. JM Corton JG Gillespie SA Hawley DG Hardie 1995 5-aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229 558 565 10.1111/j.1432-1033. 1995.tb20498.x 7744080
7. CJ Bailey RC Turner 1996 Metformin N Engl J Med 334 574 579 10.1056/NEJM199602293340906 8569826 (Pubitemid 26066132)
8. G Zhou R Myers Y Li Y Chen X Shen J Fenyk-Melody, et al. 2001 Role of AMP-activated protein kinase in mechanism of metformin action J Clin Invest 108 1167 1174 11602624
9. MR Owen E Doran AP Halestrap 2000 Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochem J 348 607 614 10.1042/0264-6021:3480607 10839993 (Pubitemid 30410251)
10. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352: 854-65.
11. GS Bhamra DJ Hausenloy SM Davidson RD Carr M Paiva AM Wynne, et al. 2008 Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening Basic Res Cardiol 103 274 284 10.1007/s00395-007-0691-y 18080084
12. JW Calvert S Gundewar S Jha JJ Greer WH Bestermann R Tian, et al. 2008 Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling Diabetes 57 696 705 10.2337/db07-1098 18083782
13. M Paiva NP Riksen SM Davidson DJ Hausenloy P Monteiro L Goncalves, et al. 2009 Metformin prevents myocardial reperfusion injury by activating the adenosine receptor J Cardiovasc Pharmacol 53 373 378 10.1097/FJC. 0b013e31819fd4e7 19295441
14. A Tsuchida XM Yang B Burckhartt KM Mullane MV Cohen JM Downey 1994 Acadesine extends the window of protection afforded by ischaemic preconditioning Cardiovasc Res 28 379 383 10.1093/cvr/28.3.379 8174159
15. AM Wynne MM Mocanu DM Yellon 2005 Pioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42/44MAPK J Cardiovasc Pharmacol 46 817 822 10.1097/01.fjc.0000188365.07635.57 16306807 (Pubitemid 44378255)
16. RJ Legtenberg RJ Houston B Oeseburg P Smits 2002 Metformin improves cardiac functional recovery after ischemia in rats Horm Metab Res 34 182 185 10.1055/s-2002-26705 11987026 (Pubitemid 34553530)
17. H Leon LL Atkinson J Sawicka K Strynadka GD Lopaschuk R Schulz 2004 Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts Can J Physiol Pharmacol 82 409 416 10.1139/y04-050 15381965 (Pubitemid 39233766)
18. MM Mocanu RM Bell DM Yellon 2002 PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning J Mol Cell Cardiol 34 661 668 10.1006/jmcc.2002.2006 12054853 (Pubitemid 35222851)
19. H Sasaki H Asanuma M Fujita H Takahama M Wakeno S Ito, et al. 2009 Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase Circulation 119 2568 2577
20. RR Russell 3rd J Li DL Coven M Pypaert C Zechner M Palmeri, et al. 2004 AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury J Clin Invest 114 495 503 15314686
21. CD Folmes CS Wagg M Shen AS Clanachan R Tian GD Lopaschuk 2009 Suppression of 5prime;-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts Am J Physiol Heart Circ Physiol 297 H313 H321 10.1152/ajpheart.01298.2008 19429810
22. R Shibata K Sato DR Pimentel Y Takemura S Kihara K Ohashi, et al. 2005 Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK-and COX-2-dependent mechanisms Nat Med 11 1096 1103 10.1038/nm1295 16155579 (Pubitemid 41486832)
23. H Kawabata K Ishikawa 2003 Cardioprotection by metformin is abolished by a nitric oxide synthase inhibitor in ischemic rabbit hearts Hypertens Res 26 107 110 10.1291/hypres.26.107 12661919
24. EJ Shin K Schram XL Zheng G Sweeney 2009 Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells J Cell Physiol 221 490 497 10.1002/jcp.21883 19653255
25. B Huisamen S Genade A Lochner 2008 Signalling pathways activated by glucagon-like peptide-1 (7-36) amide in the rat heart and their role in protection against ischaemia Cardiovasc J Afr 19 77 83 18516352
26. L Zhang H He JA Balschi 2007 Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration Am J Physiol Heart Circ Physiol 293 H457 H466 10.1152/ajpheart. 00002.2007 17369473 (Pubitemid 47105103)
27. MH Zou SS Kirkpatrick BJ Davis JS Nelson WGt Wiles U Schlattner, et al. 2004 Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species J Biol Chem 279 43940 43951 10.1074/jbc.M404421200 15265871 (Pubitemid 39390702)
28. L Zhang M Frederich H He JA Balschi 2006 Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart Am J Physiol Heart Circ Physiol 290 H1235 H1243 10.1152/ajpheart.00906.2005 16258030
29. MV Cohen XM Yang JM Downey 2007 The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis Circulation 115 1895 1903 10.1161/CIRCULATIONAHA.106.675710 17389262 (Pubitemid 46598903)
30. JR Dyck GD Lopaschuk 2006 AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol 574 95 112 10.1113/jphysiol.2006.109389 16690706 (Pubitemid 43905800)
31. TR Moopanar XH Xiao L Jiang ZP Chen BE Kemp DG Allen 2006 AICAR inhibits the Na+/H+ exchanger in rat hearts-possible contribution to cardioprotection Pflugers Arch 453 147 156 10.1007/s00424-006-0124-z 16983558 (Pubitemid 44630449)
32. TD King L Song RS Jope 2006 AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3 Biochem Pharmacol 28 1637 1647 10.1016/j.bcp.2006.03.005
33. HC Chen G Bandyopadhyay MP Sajan Y Kanoh M Standaert RV Farese Jr, et al. 2002 Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport J Biol Chem 28 23554 23562 10.1074/jbc.M201152200 (Pubitemid 34952191)
34. R Saeedi HL Parsons RB Wambolt K Paulson V Sharma JR Dyck, et al. 2008 Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms Am J Physiol Heart Circ Physiol 294 H2497 H2506 10.1152/ajpheart. 00873.2007 18375721
35. GD Lopaschuk DD Belke J Gamble T Itoi BO Schonekess 1994 Regulation of fatty acid oxidation in the mammalian heart in health and disease Biochim Biophys Acta 1213 263 276 8049240
36. Q Liu JC Docherty JC Rendell AS Clanachan GD Lopaschuk 2002 High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation J Am Coll Cardiol 39 718 725 10.1016/S0735-1097(01)01803-4 11849874 (Pubitemid 34158171)
37. H Clark D Carling D Saggerson 2004 Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids Eur J Biochem 271 2215 2224 10.1111/j.1432-1033.2004. 04151.x 15153111 (Pubitemid 38747990)
38. L Solskov B Lofgren SB Kristiansen N Jessen R Pold TT Nielsen, et al. 2008 Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 h after administration Basic Clin Pharmacol Toxicol 103 82 87 10.1111/j.1742-7843.2008.00234.x 18484962 (Pubitemid 351874532)