Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt-mTOR signaling pathway

Cancer Letters

Volumn 358, Issue 1, 2015, Pages 17-26

  Zhao, Zhi ^a   Han, Fanghai ^a   Yang, Shibin ^a   Wu, Jianhai ^a   Zhan, Wenhua ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Autophagy; Gastric cancer; Glycolysis; Lactate dehydrogenase; Oxamate

Indexed keywords

ACETYLCYSTEINE; ANTIMITOTIC AGENT; BECLIN 1; CHLOROQUINE; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SODIUM OXAMATE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MTOR PROTEIN, HUMAN; ONCOPROTEIN; OXALIC ACID; TARGET OF RAPAMYCIN KINASE;

ADULT; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHAGY; CANCER STAGING; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME INHIBITION; FEMALE; GASTRIC CANCER CELL LINE; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; SIGNAL TRANSDUCTION; AGED; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BIOSYNTHESIS; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; STOMACH NEOPLASMS; TUMOR CELL LINE;

ADULT; AGED; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; L-LACTATE DEHYDROGENASE; MALE; MEMBRANE PROTEINS; MIDDLE AGED; ONCOGENE PROTEIN V-AKT; OXALIC ACID; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TOR SERINE-THREONINE KINASES;

EID: 84921300038     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.11.046     Document Type: Article

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