메뉴 건너뛰기




Volumn 35, Issue 19, 2015, Pages 3284-3300

Impact of the N-terminal domain of STAT3 in STAT3-dependent transcriptional activity

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DIMER; EARLY GROWTH RESPONSE FACTOR 1; KRUPPEL LIKE FACTOR 4; LEUKEMIA INHIBITORY FACTOR; MESSENGER RNA; NICKEL; OLIGOMER; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR JUNB; LIF PROTEIN, MOUSE; PROTEIN BINDING; STAT3 PROTEIN, MOUSE;

EID: 84941142868     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00060-15     Document Type: Article
Times cited : (49)

References (77)
  • 1
    • 84859992161 scopus 로고    scopus 로고
    • The JAK-STAT pathway at twenty
    • Stark GR, Darnell JE, Jr. 2012. The JAK-STAT pathway at twenty. Immunity 36:503-514. http://dx.doi.org/10.1016/j.immuni.2012.03.013.
    • (2012) Immunity , vol.36 , pp. 503-514
    • Stark, G.R.1    Darnell, J.E.2
  • 2
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg J. 2002. Stat proteins and oncogenesis. J Clin Invest 109:1139-1142. http://dx.doi.org/10.1172/JCI0215617.
    • (2002) J Clin Invest , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 4
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB, Jove R. 2002. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8:945-954.
    • (2002) Clin Cancer Res , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 5
    • 33745905938 scopus 로고    scopus 로고
    • STAT3: a multifaceted oncogene
    • Levy DE, Inghirami G. 2006. STAT3: a multifaceted oncogene. Proc Natl Acad Sci U S A 103:10151-10152. http://dx.doi.org/10.1073/pnas.0604042103.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10151-10152
    • Levy, D.E.1    Inghirami, G.2
  • 6
    • 84860630975 scopus 로고    scopus 로고
    • Targeting the interleukin-6/Jak/Stat pathway in human malignancies
    • Sansone P, Bromberg J. 2012. Targeting the interleukin-6/Jak/Stat pathway in human malignancies. J Clin Oncol 30:1005-1014. http://dx.doi.org/10.1200/JCO.2010.31.8907.
    • (2012) J Clin Oncol , vol.30 , pp. 1005-1014
    • Sansone, P.1    Bromberg, J.2
  • 8
    • 0032499801 scopus 로고    scopus 로고
    • Three-dimensional structure of the Stat3beta homodimer bound to DNA
    • Becker S, Groner B, Muller CW. 1998. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394:145-151. http://dx.doi.org/10.1038/28101.
    • (1998) Nature , vol.394 , pp. 145-151
    • Becker, S.1    Groner, B.2    Muller, C.W.3
  • 11
    • 0035823547 scopus 로고    scopus 로고
    • Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene
    • Zhang X, Darnell JE, Jr. 2001. Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene. J Biol Chem 276: 33576-33581. http://dx.doi.org/10.1074/jbc. M104978200.
    • (2001) J Biol Chem , vol.276 , pp. 33576-33581
    • Zhang, X.1    Darnell, J.E.2
  • 12
    • 0142091544 scopus 로고    scopus 로고
    • STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene
    • Lerner L, Henriksen MA, Zhang X, Darnell JE, Jr. 2003. STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. Genes Dev 17:2564-2577. http://dx.doi.org/10.1101/gad.1135003.
    • (2003) Genes Dev , vol.17 , pp. 2564-2577
    • Lerner, L.1    Henriksen, M.A.2    Zhang, X.3    Darnell, J.E.4
  • 14
    • 79956285590 scopus 로고    scopus 로고
    • Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-beta1
    • Cimica V, Chen HC, Iyer JK, Reich NC. 2011. Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-beta1. PLoS One 6:e20188. http://dx.doi.org/10.1371/journal.pone.0020188.
    • (2011) PLoS One , vol.6
    • Cimica, V.1    Chen, H.C.2    Iyer, J.K.3    Reich, N.C.4
  • 15
    • 2442504891 scopus 로고    scopus 로고
    • Real time analysis of STAT3 nucleocytoplasmic shuttling
    • Pranada AL, Metz S, Herrmann A, Heinrich PC, Muller-Newen G. 2004. Real time analysis of STAT3 nucleocytoplasmic shuttling. J Biol Chem 279:15114-15123. http://dx.doi.org/10.1074/jbc. M312530200.
    • (2004) J Biol Chem , vol.279 , pp. 15114-15123
    • Pranada, A.L.1    Metz, S.2    Herrmann, A.3    Heinrich, P.C.4    Muller-Newen, G.5
  • 24
    • 37549068947 scopus 로고    scopus 로고
    • The functional role of an interleukin 6-inducible CDK9 · STAT3 complex in human gamma-fibrinogen gene expression
    • Hou T, Ray S, Brasier AR. 2007. The functional role of an interleukin 6-inducible CDK9 · STAT3 complex in human gamma-fibrinogen gene expression. J Biol Chem 282:37091-37102. http://dx.doi.org/10.1074/jbc. M706458200.
    • (2007) J Biol Chem , vol.282 , pp. 37091-37102
    • Hou, T.1    Ray, S.2    Brasier, A.R.3
  • 25
    • 27744499936 scopus 로고    scopus 로고
    • 2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen
    • 2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. Gastroenterology 129:1616-1632. http://dx.doi.org/10.1053/j.gastro.2005.07.055.
    • (2005) Gastroenterology , vol.129 , pp. 1616-1632
    • Ray, S.1    Boldogh, I.2    Brasier, A.R.3
  • 26
    • 75149123984 scopus 로고    scopus 로고
    • Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response
    • Ray S, Lee C, Hou T, Bhakat KK, Brasier AR. 2010. Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response. Mol Endocrinol 24:391-401. http://dx.doi.org/10.1210/me.2009-0319.
    • (2010) Mol Endocrinol , vol.24 , pp. 391-401
    • Ray, S.1    Lee, C.2    Hou, T.3    Bhakat, K.K.4    Brasier, A.R.5
  • 27
    • 48349105443 scopus 로고    scopus 로고
    • Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
    • Ray S, Lee C, Hou T, Boldogh I, Brasier AR. 2008. Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution. Nucleic Acids Res 36:4510-4520. http://dx.doi.org/10.1093/nar/gkn419.
    • (2008) Nucleic Acids Res , vol.36 , pp. 4510-4520
    • Ray, S.1    Lee, C.2    Hou, T.3    Boldogh, I.4    Brasier, A.R.5
  • 28
    • 84897486329 scopus 로고    scopus 로고
    • 2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis
    • 2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis. Cell Signal 26:1445-1455. http://dx.doi.org/10.1016/j.cellsig.2014.03.007.
    • (2014) Cell Signal , vol.26 , pp. 1445-1455
    • Ray, S.1    Zhao, Y.2    Jamaluddin, M.3    Edeh, C.B.4    Lee, C.5    Brasier, A.R.6
  • 29
    • 80052687211 scopus 로고    scopus 로고
    • STAT3 negatively regulates type I IFN-mediated antiviral response
    • Wang WB, Levy DE, Lee CK. 2011. STAT3 negatively regulates type I IFN-mediated antiviral response. J Immunol 187:2578-2585. http://dx.doi.org/10.4049/jimmunol.1004128.
    • (2011) J Immunol , vol.187 , pp. 2578-2585
    • Wang, W.B.1    Levy, D.E.2    Lee, C.K.3
  • 30
    • 0033520313 scopus 로고    scopus 로고
    • Cellular physiology of STAT3: where's the cytoplasmic monomer?
    • Ndubuisi MI, Guo GG, Fried VA, Etlinger JD, Sehgal PB. 1999. Cellular physiology of STAT3: where's the cytoplasmic monomer? J Biol Chem 274:25499-25509. http://dx.doi.org/10.1074/jbc.274.36.25499.
    • (1999) J Biol Chem , vol.274 , pp. 25499-25509
    • Ndubuisi, M.I.1    Guo, G.G.2    Fried, V.A.3    Etlinger, J.D.4    Sehgal, P.B.5
  • 31
    • 84892423730 scopus 로고    scopus 로고
    • Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice
    • Chua AC, Klopcic BR, Ho DS, Fu SK, Forrest CH, Croft KD, Olynyk JK, Lawrance IC, Trinder D. 2013. Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice. PLoS One 8:e78850. http://dx.doi.org/10.1371/journal.pone.0078850.
    • (2013) PLoS One , vol.8
    • Chua, A.C.1    Klopcic, B.R.2    Ho, D.S.3    Fu, S.K.4    Forrest, C.H.5    Croft, K.D.6    Olynyk, J.K.7    Lawrance, I.C.8    Trinder, D.9
  • 32
    • 0032577871 scopus 로고    scopus 로고
    • STAT3 forms stable homodimers in the presence of divalent cations prior to activation
    • Novak U, Ji H, Kanagasundaram V, Simpson R, Paradiso L. 1998. STAT3 forms stable homodimers in the presence of divalent cations prior to activation. Biochem Biophys Res Commun 247:558-563. http://dx.doi.org/10.1006/bbrc.1998.8829.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 558-563
    • Novak, U.1    Ji, H.2    Kanagasundaram, V.3    Simpson, R.4    Paradiso, L.5
  • 34
    • 30944435466 scopus 로고    scopus 로고
    • Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin
    • Ng DC, Lin BH, Lim CP, Huang G, Zhang T, Poli V, Cao X. 2006. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol 172:245-257. http://dx.doi.org/10.1083/jcb.200503021.
    • (2006) J Cell Biol , vol.172 , pp. 245-257
    • Ng, D.C.1    Lin, B.H.2    Lim, C.P.3    Huang, G.4    Zhang, T.5    Poli, V.6    Cao, X.7
  • 37
    • 0035131190 scopus 로고    scopus 로고
    • Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver
    • Alonzi T, Maritano D, Gorgoni B, Rizzuto G, Libert C, Poli V. 2001. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol Cell Biol 21:1621-1632. http://dx.doi.org/10.1128/MCB.21.5.1621-1632.2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 1621-1632
    • Alonzi, T.1    Maritano, D.2    Gorgoni, B.3    Rizzuto, G.4    Libert, C.5    Poli, V.6
  • 38
    • 79953300078 scopus 로고    scopus 로고
    • FIMO: scanning for occurrences of a given motif
    • Grant CE, Bailey TL, Noble WS. 2011. FIMO: scanning for occurrences of a given motif. Bioinformatics 27:1017-1018. http://dx.doi.org/10.1093/bioinformatics/btr064.
    • (2011) Bioinformatics , vol.27 , pp. 1017-1018
    • Grant, C.E.1    Bailey, T.L.2    Noble, W.S.3
  • 39
    • 11144241637 scopus 로고    scopus 로고
    • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification
    • Nelson EA, Walker SR, Alvarez JV, Frank DA. 2004. Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem 279:54724-54730. http://dx.doi.org/10.1074/jbc. M408464200.
    • (2004) J Biol Chem , vol.279 , pp. 54724-54730
    • Nelson, E.A.1    Walker, S.R.2    Alvarez, J.V.3    Frank, D.A.4
  • 40
    • 84861425552 scopus 로고    scopus 로고
    • Linking crystallographic model and data quality
    • Karplus PA, Diederichs K. 2012. Linking crystallographic model and data quality. Science 336:1030-1033. http://dx.doi.org/10.1126/science.1218231.
    • (2012) Science , vol.336 , pp. 1030-1033
    • Karplus, P.A.1    Diederichs, K.2
  • 44
    • 37049014272 scopus 로고    scopus 로고
    • Version 1.2 of the crystallography and NMR system
    • Brunger AT. 2007. Version 1.2 of the crystallography and NMR system. Nat Protoc 2:2728-2733. http://dx.doi.org/10.1038/nprot.2007.406.
    • (2007) Nat Protoc , vol.2 , pp. 2728-2733
    • Brunger, A.T.1
  • 46
    • 3843074353 scopus 로고    scopus 로고
    • Liquid-chromatography-coupled SAXS for accurate sizing of aggregating proteins
    • Mathew E, Mirza A, Menhart N. 2004. Liquid-chromatography-coupled SAXS for accurate sizing of aggregating proteins. J Synchrotron Radiat 11(Pt 4):314-318. http://dx.doi.org/10.1107/S0909049504014086.
    • (2004) J Synchrotron Radiat , vol.11 , pp. 314-318
    • Mathew, E.1    Mirza, A.2    Menhart, N.3
  • 47
    • 33645214738 scopus 로고    scopus 로고
    • ATSAS 2.1, a program package for small-angle scattering data analysis
    • Konarev P, Petoukhov M, Volkov V, Svergun D. 2006. ATSAS 2.1, a program package for small-angle scattering data analysis. J Appl Crystallogr 39:277-286. http://dx.doi.org/10.1107/S0021889806004699.
    • (2006) J Appl Crystallogr , vol.39 , pp. 277-286
    • Konarev, P.1    Petoukhov, M.2    Volkov, V.3    Svergun, D.4
  • 48
    • 69249107379 scopus 로고    scopus 로고
    • Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog
    • Bourillot PY, Aksoy I, Schreiber V, Wianny F, Schulz H, Hummel O, Hubner N, Savatier P. 2009. Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Stem Cells 27:1760-1771. http://dx.doi.org/10.1002/stem.110.
    • (2009) Stem Cells , vol.27 , pp. 1760-1771
    • Bourillot, P.Y.1    Aksoy, I.2    Schreiber, V.3    Wianny, F.4    Schulz, H.5    Hummel, O.6    Hubner, N.7    Savatier, P.8
  • 49
    • 84898921083 scopus 로고    scopus 로고
    • STAT3 target genes relevant to human cancers
    • Carpenter RL, Lo HW. 2014. STAT3 target genes relevant to human cancers. Cancers 6:897-925. http://dx.doi.org/10.3390/cancers6020897.
    • (2014) Cancers , vol.6 , pp. 897-925
    • Carpenter, R.L.1    Lo, H.W.2
  • 50
    • 42949120754 scopus 로고    scopus 로고
    • Identification of novel direct Stat3 target genes for control of growth and differentiation
    • Snyder M, Huang XY, Zhang JJ. 2008. Identification of novel direct Stat3 target genes for control of growth and differentiation. J Biol Chem 283: 3791-3798. http://dx.doi.org/10.1074/jbc. M706976200.
    • (2008) J Biol Chem , vol.283 , pp. 3791-3798
    • Snyder, M.1    Huang, X.Y.2    Zhang, J.J.3
  • 51
    • 20444446371 scopus 로고    scopus 로고
    • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors
    • Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA. 2005. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res 65: 5054-5062. http://dx.doi.org/10.1158/0008-5472.CAN-04-4281.
    • (2005) Cancer Res , vol.65 , pp. 5054-5062
    • Alvarez, J.V.1    Febbo, P.G.2    Ramaswamy, S.3    Loda, M.4    Richardson, A.5    Frank, D.A.6
  • 52
    • 0347125328 scopus 로고    scopus 로고
    • JASPAR: an open-access database for eukaryotic transcription factor binding profiles
    • Sandelin A, Alkema W, Engstrom P, Wasserman WW, Lenhard B. 2004. JASPAR: an open-access database for eukaryotic transcription factor binding profiles. Nucleic Acids Res 32:D91-D94. http://dx.doi.org/10.1093/nar/gkh012.
    • (2004) Nucleic Acids Res , vol.32 , pp. D91-D94
    • Sandelin, A.1    Alkema, W.2    Engstrom, P.3    Wasserman, W.W.4    Lenhard, B.5
  • 55
    • 0032512661 scopus 로고    scopus 로고
    • Structure of the amino-terminal protein interaction domain of STAT-4
    • Vinkemeier U, MoarefiI, Darnell JE, Jr, Kuriyan J. 1998. Structure of the amino-terminal protein interaction domain of STAT-4. Science 279: 1048-1052. http://dx.doi.org/10.1126/science.279.5353.1048.
    • (1998) Science , vol.279 , pp. 1048-1052
    • Vinkemeier, U.1    Moarefi, I.2    Darnell, J.E.3    Kuriyan, J.4
  • 56
    • 0037304457 scopus 로고    scopus 로고
    • A reinterpretation of the dimerization interface of the N-terminal domains of STATs
    • Chen X, Bhandari R, Vinkemeier U, Van Den Akker F, Darnell JE, Jr, Kuriyan J. 2003. A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci 12:361-365. http://dx.doi.org/10.1110/ps.0218903.
    • (2003) Protein Sci , vol.12 , pp. 361-365
    • Chen, X.1    Bhandari, R.2    Vinkemeier, U.3    Van Den Akker, F.4    Darnell, J.E.5    Kuriyan, J.6
  • 57
    • 0142024974 scopus 로고    scopus 로고
    • Two tandemly linked interferon-gamma-activated sequence elements in the promoter of glycosylation-dependent cell adhesion molecule 1 gene synergistically respond to prolactin in mouse mammary epithelial cells
    • Hou Z, Srivastava S, Mistry MJ, Herbst MP, Bailey JP, Horseman ND. 2003. Two tandemly linked interferon-gamma-activated sequence elements in the promoter of glycosylation-dependent cell adhesion molecule 1 gene synergistically respond to prolactin in mouse mammary epithelial cells. Mol Endocrinol 17:1910-1920. http://dx.doi.org/10.1210/me.2003-0045.
    • (2003) Mol Endocrinol , vol.17 , pp. 1910-1920
    • Hou, Z.1    Srivastava, S.2    Mistry, M.J.3    Herbst, M.P.4    Bailey, J.P.5    Horseman, N.D.6
  • 58
    • 2442577024 scopus 로고    scopus 로고
    • A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of Stat transcription factors
    • Meyer T, Hendry L, Begitt A, John S, Vinkemeier U. 2004. A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of Stat transcription factors. J Biol Chem 279:18998-19007. http://dx.doi.org/10.1074/jbc. M400766200.
    • (2004) J Biol Chem , vol.279 , pp. 18998-19007
    • Meyer, T.1    Hendry, L.2    Begitt, A.3    John, S.4    Vinkemeier, U.5
  • 59
    • 1142287411 scopus 로고    scopus 로고
    • N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation
    • Ota N, Brett TJ, Murphy TL, Fremont DH, Murphy KM. 2004. N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nat Immunol 5:208-215. http://dx.doi.org/10.1038/ni1032.
    • (2004) Nat Immunol , vol.5 , pp. 208-215
    • Ota, N.1    Brett, T.J.2    Murphy, T.L.3    Fremont, D.H.4    Murphy, K.M.5
  • 60
    • 33845718240 scopus 로고    scopus 로고
    • Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain
    • Mertens C, Zhong M, Krishnaraj R, Zou W, Chen X, Darnell JE, Jr. 2006. Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes Dev 20:3372-3381. http://dx.doi.org/10.1101/gad.1485406.
    • (2006) Genes Dev , vol.20 , pp. 3372-3381
    • Mertens, C.1    Zhong, M.2    Krishnaraj, R.3    Zou, W.4    Chen, X.5    Darnell, J.E.6
  • 61
    • 48249142418 scopus 로고    scopus 로고
    • Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations
    • Wenta N, Strauss H, Meyer S, Vinkemeier U. 2008. Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations. Proc Natl Acad Sci U S A 105:9238-9243. http://dx.doi.org/10.1073/pnas.0802130105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9238-9243
    • Wenta, N.1    Strauss, H.2    Meyer, S.3    Vinkemeier, U.4
  • 63
    • 0033835830 scopus 로고    scopus 로고
    • Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation
    • Murphy TL, Geissal ED, Farrar JD, Murphy KM. 2000. Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. Mol Cell Biol 20:7121-7131. http://dx.doi.org/10.1128/MCB.20.19.7121-7131.2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 7121-7131
    • Murphy, T.L.1    Geissal, E.D.2    Farrar, J.D.3    Murphy, K.M.4
  • 65
  • 66
    • 51049123447 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas
    • Brantley EC, Benveniste EN. 2008. Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol Cancer Res 6:675-684. http://dx.doi.org/10.1158/1541-7786.MCR-07-2180.
    • (2008) Mol Cancer Res , vol.6 , pp. 675-684
    • Brantley, E.C.1    Benveniste, E.N.2
  • 67
    • 35448979864 scopus 로고    scopus 로고
    • A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients
    • Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, Fokt I, Priebe W, Heimberger AB. 2007. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res 67:9630-9636. http://dx.doi.org/10.1158/0008-5472.CAN-07-1243.
    • (2007) Cancer Res , vol.67 , pp. 9630-9636
    • Hussain, S.F.1    Kong, L.Y.2    Jordan, J.3    Conrad, C.4    Madden, T.5    Fokt, I.6    Priebe, W.7    Heimberger, A.B.8
  • 68
    • 33745587303 scopus 로고    scopus 로고
    • Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
    • Kasprzycka M, Marzec M, Liu X, Zhang Q, Wasik MA. 2006. Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3. Proc Natl Acad Sci U S A 103:9964-9969. http://dx.doi.org/10.1073/pnas.0603507103.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 9964-9969
    • Kasprzycka, M.1    Marzec, M.2    Liu, X.3    Zhang, Q.4    Wasik, M.A.5
  • 70
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. 2007. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7:41-51. http://dx.doi.org/10.1038/nri1995.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 71
    • 84885845728 scopus 로고    scopus 로고
    • Alternative ways of modulating JAKSTAT pathway: looking beyond phosphorylation
    • Timofeeva OA, Tarasova NI. 2012. Alternative ways of modulating JAKSTAT pathway: looking beyond phosphorylation. JAKSTAT 1:274-284. http://dx.doi.org/10.4161/jkst.22313.
    • (2012) JAKSTAT , vol.1 , pp. 274-284
    • Timofeeva, O.A.1    Tarasova, N.I.2
  • 72
    • 79956299086 scopus 로고    scopus 로고
    • Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO)
    • Droescher M, Begitt A, Marg A, Zacharias M, Vinkemeier U. 2011. Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). J BiolChem286: 18731-18746. http://dx.doi.org/10.1074/jbc. M111.235978.
    • (2011) J BiolChem , vol.286 , pp. 18731-18746
    • Droescher, M.1    Begitt, A.2    Marg, A.3    Zacharias, M.4    Vinkemeier, U.5
  • 74
    • 80455163166 scopus 로고    scopus 로고
    • Zinc, cadmium and nickel increase the activation of NF-kappaB and the release of cytokines from THP-1 monocytic cells
    • Freitas M, Fernandes E. 2011. Zinc, cadmium and nickel increase the activation of NF-kappaB and the release of cytokines from THP-1 monocytic cells. Metallomics 3:1238-1243. http://dx.doi.org/10.1039/c1mt00050k.
    • (2011) Metallomics , vol.3 , pp. 1238-1243
    • Freitas, M.1    Fernandes, E.2
  • 76
    • 0035424044 scopus 로고    scopus 로고
    • The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B
    • Bode JG, Fischer R, Haussinger D, Graeve L, Heinrich PC, Schaper F. 2001. The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B. J Immunol 167: 1469-1481. http://dx.doi.org/10.4049/jimmunol.167.3.1469.
    • (2001) J Immunol , vol.167 , pp. 1469-1481
    • Bode, J.G.1    Fischer, R.2    Haussinger, D.3    Graeve, L.4    Heinrich, P.C.5    Schaper, F.6
  • 77
    • 0031467318 scopus 로고    scopus 로고
    • Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin 2 (IL-2) stimulation of IL-2 receptor alpha gene transcription
    • Meyer WK, Reichenbach P, Schindler U, Soldaini E, Nabholz M. 1997. Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin 2 (IL-2) stimulation of IL-2 receptor alpha gene transcription. J Biol Chem 272:31821-31828. http://dx.doi.org/10.1074/jbc.272.50.31821.
    • (1997) J Biol Chem , vol.272 , pp. 31821-31828
    • Meyer, W.K.1    Reichenbach, P.2    Schindler, U.3    Soldaini, E.4    Nabholz, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.