Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography

FEBS Letters

Volumn 587, Issue 7, 2013, Pages 833-839

  Nkansah, Edwin ^a   Shah, Rahi ^a   Collie, Gavin W ^a   Parkinson, Gary N ^a   Palmer, Jonathan ^a,c   Rahman, Khondaker M ^a,c   Bui, Tam T ^b   Drake, Alex F ^b   Husby, Jarmila ^a   Neidle, Stephen ^a   Zinzalla, Giovanna ^a,b   Thurston, David E ^a,c   Wilderspin, Andrew F ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

M67; PEMSA; SH2; Signal transducer and activator of transcription 3; STAT3; X ray crystallography

Indexed keywords

DOUBLE STRANDED DNA; STAT3 PROTEIN; UNCLASSIFIED DRUG; UNPHOSPHORYLATED STAT3 PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; DNA SEQUENCE; GEL MOBILITY SHIFT ASSAY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN ELECTROPHORETIC MOBILITY SHIFT ASSAY; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; LUMINESCENT PROTEINS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PHOSPHOPEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STAT3 TRANSCRIPTION FACTOR; TYROSINE;

EID: 84875245858     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.01.065     Document Type: Article

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