Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR

Biochemistry

Volumn 54, Issue 35, 2015, Pages 5502-5512

  Bigley, Andrew N ^a   Mabanglo, Mark F ^a   Harvey, Steven P ^b   Raushel, Frank M ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b EDGEWOOD CHEMICAL BIOLOGICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; CHEMICAL WARFARE; DETOXIFICATION; ENZYMES; HAZARDOUS MATERIALS; HYDROGEN BONDS; HYDROLYSIS; METAL IONS; METALS; STEREOCHEMISTRY; STEREOSELECTIVITY;

BACTERIAL ENZYMES; CHEMICAL WARFARE AGENTS; HAZARDOUS COMPOUNDS; HYDROGEN BONDING INTERACTIONS; ORDERS OF MAGNITUDE; PHOSPHOTRIESTERASES; STRUCTURAL FEATURE; THREE-DIMENSIONAL STRUCTURE;

ENANTIOMERS;

ASPARTIC ACID; GLUTAMINE; HYDROGEN; HYDROXIDE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; MUTANT PROTEIN; PHOSPHOTRIESTERASE; PHOSPHOTRIESTERASE L7EP 3A; TYROSINE; UNCLASSIFIED DRUG; CHEMICAL WARFARE AGENT; PHOSPHOROTHIOIC ACID DERIVATIVE; S-(N,N-DIETHYLAMINOETHYL) ISOBUTYL METHYLPHOSPHOTHIOLATE;

ARTICLE; DETOXIFICATION; ENZYME ACTIVE SITE; HYDROGEN BOND; HYDROLYSIS; PRIORITY JOURNAL; STEREOCHEMISTRY; CHEMISTRY; GENETIC VARIABILITY; GENETICS; METABOLISM; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CHEMICAL WARFARE AGENTS; CRYSTALLOGRAPHY, X-RAY; GENETIC VARIATION; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHOSPHORIC TRIESTER HYDROLASES; PROTEIN STRUCTURE, SECONDARY;

EID: 84941116942     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00629     Document Type: Article

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