Human paraoxonase double mutants hydrolyze v and G class organophosphorus nerve agents

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 181-185

  Kirby, Stephen D ^a,b   Norris, Joseph R ^a   Richard Smith, J ^a   Bahnson, Brian J ^b   Cerasoli, Douglas M ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

Human; Nerve agent; OP; Organophosphorus; Paraoxonase; PON1

Indexed keywords

ARYLDIALKYLPHOSPHATASE; ARYLDIALKYLPHOSPHATASE 1; CHEMICAL WARFARE AGENT; ORGANOPHOSPHATE INSECTICIDE; SARIN; SOMAN; TABUN; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; CATALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; MUTAGENESIS; STEREOCHEMISTRY; STEREOISOMERISM;

AMINO ACID SUBSTITUTION; ANTIDOTES; ARYLDIALKYLPHOSPHATASE; CATALYTIC DOMAIN; CHEMICAL WARFARE AGENTS; HUMANS; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; ORGANOPHOSPHATES; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PARAOXON; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SARIN; SOMAN; SUBSTRATE SPECIFICITY;

EID: 84875811941     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.10.023     Document Type: Conference Paper

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