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Volumn 44, Issue 4, 2015, Pages 1157-1169

The impact of supplemental macular carotenoids in Alzheimer's disease: A randomized clinical trial

Author keywords

Age related macular degeneration; Alzheimer's disease; Cognitive function; Contrast sensitivity; Lutein; Mesozeaxanthin; Randomized clinical trial; Visual function; Zeaxanthin

Indexed keywords

MACUSHIELD; MESO ZEAXANTHIN; PLACEBO; SUNFLOWER OIL; UNCLASSIFIED DRUG; VISUAL PIGMENT; XANTHOPHYLL; ZEAXANTHIN; ANTIOXIDANT; CAROTENOID;

EID: 84941008715     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-142265     Document Type: Article
Times cited : (71)

References (54)
  • 4
    • 84884952184 scopus 로고    scopus 로고
    • Concordance of macular pigment measurements obtained using customized heterochromatic flicker photometry, dual-wavelength autofluorescence, and single-wavelength reflectance
    • Dennison JL, Stack J, Beatty S, Nolan JM (2013) Concordance of macular pigment measurements obtained using customized heterochromatic flicker photometry, dual-wavelength autofluorescence, and single-wavelength reflectance. Exp Eye Res 116, 190-198.
    • (2013) Exp Eye Res , vol.116 , pp. 190-198
    • Dennison, J.L.1    Stack, J.2    Beatty, S.3    Nolan, J.M.4
  • 5
    • 0024421873 scopus 로고
    • The spatial resolution capacity of human foveal retina
    • Hirsch J, Curcio CA (1989) The spatial resolution capacity of human foveal retina. Vision Res 29, 1095-1101.
    • (1989) Vision Res , vol.29 , pp. 1095-1101
    • Hirsch, J.1    Curcio, C.A.2
  • 6
    • 0021245127 scopus 로고
    • The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas
    • Snodderly DM, Brown PK, Delori FC, Auran JD (1984) The macular pigment. I. absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas. Invest Ophthalmol Vis Sci 25, 660-673.
    • (1984) Invest Ophthalmol Vis Sci , vol.25 , pp. 660-673
    • Snodderly, D.M.1    Brown, P.K.2    Delori, F.C.3    Auran, J.D.4
  • 7
    • 0030826642 scopus 로고    scopus 로고
    • Identification of lutein and zeaxanthin oxidation products in human and monkey retinas
    • Khachik F, Bernstein PS, Garland DL (1997) Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci 38, 1802-1811.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 1802-1811
    • Khachik, F.1    Bernstein, P.S.2    Garland, D.L.3
  • 8
    • 77957924323 scopus 로고    scopus 로고
    • Studies on the singlet oxygen scavenging mechanism of human macular pigment
    • Li B, Ahmed F, Bernstein PS (2010) Studies on the singlet oxygen scavenging mechanism of human macular pigment. Arch Biochem Biophys 504, 56-60.
    • (2010) Arch Biochem Biophys , vol.504 , pp. 56-60
    • Li, B.1    Ahmed, F.2    Bernstein, P.S.3
  • 11
    • 84872201091 scopus 로고    scopus 로고
    • The impact of macular pigment augmentation on visual performance using different carotenoid formulations
    • Loughman J, Nolan JM, Howard AN, Connolly E, Meagher K, Beatty S (2012) The impact of macular pigment augmentation on visual performance using different carotenoid formulations. Invest Ophthalmol Vis Sci 53, 7871-7880.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 7871-7880
    • Loughman, J.1    Nolan, J.M.2    Howard, A.N.3    Connolly, E.4    Meagher, K.5    Beatty, S.6
  • 13
    • 84872222041 scopus 로고    scopus 로고
    • Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration
    • Huang YM, Yan SF, Ma L, Zou ZY, Xu XR, Dou HL, Lin XM (2013) Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration. Nutrition 29, 387-392.
    • (2013) Nutrition , vol.29 , pp. 387-392
    • Huang, Y.M.1    Yan, S.F.2    Ma, L.3    Zou, Z.Y.4    Xu, X.R.5    Dou, H.L.6    Lin, X.M.7
  • 14
    • 84875475799 scopus 로고    scopus 로고
    • Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: The CLEAR study
    • Murray IJ, Makridaki M, van der Veen RL, Carden D, Parry NR, Berendschot TT (2013) Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: The CLEAR study. Invest Ophthalmol Vis Sci 54, 1781-1788.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 1781-1788
    • Murray, I.J.1    Makridaki, M.2    Van Der Veen, R.L.3    Carden, D.4    Parry, N.R.5    Berendschot, T.T.6
  • 16
    • 0036015955 scopus 로고    scopus 로고
    • Macular pigment: Influences on visual acuity and visibility
    • Wooten BR, Hammond BR (2002) Macular pigment: Influences on visual acuity and visibility. Prog Retin Eye Res 21, 225-240.
    • (2002) Prog Retin Eye Res , vol.21 , pp. 225-240
    • Wooten, B.R.1    Hammond, B.R.2
  • 21
    • 84903363032 scopus 로고    scopus 로고
    • Relationshipsbetweenmacularpigmentoptical density and cognitive function in unimpaired and mildly cognitively impaired older adults
    • Renzi LM, Dengler MJ, Puente A, Miller LS, HammondBRJr (2014) Relationshipsbetweenmacularpigmentoptical density and cognitive function in unimpaired and mildly cognitively impaired older adults. Neurobiol Aging 35, 1695-1699.
    • (2014) Neurobiol Aging , vol.35 , pp. 1695-1699
    • Renzi, L.M.1    Dengler, M.J.2    Puente, A.3    Miller, L.S.4    Hammond, B.R.5
  • 22
    • 84881549710 scopus 로고    scopus 로고
    • Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults
    • Feeney J, Finucane C, Savva GM, Cronin H, Beatty S, Nolan JM, Kenny RA (2013) Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults. Neurobiol Aging 34, 2449-2456.
    • (2013) Neurobiol Aging , vol.34 , pp. 2449-2456
    • Feeney, J.1    Finucane, C.2    Savva, G.M.3    Cronin, H.4    Beatty, S.5    Nolan, J.M.6    Kenny, R.A.7
  • 23
    • 50449090701 scopus 로고    scopus 로고
    • Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
    • Johnson EJ, McDonald K, Caldarella SM, Chung HY, Troen AM, Snodderly DM (2008) Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Nutr Neurosci 11, 75-83.
    • (2008) Nutr Neurosci , vol.11 , pp. 75-83
    • Johnson, E.J.1    McDonald, K.2    Caldarella, S.M.3    Chung, H.Y.4    Troen, A.M.5    Snodderly, D.M.6
  • 27
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
    • Wyss-Coray T (2006) Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?. Nat Med 12, 1005-1015.
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 30
    • 84867784644 scopus 로고    scopus 로고
    • A possible role for lutein and zeaxanthin in cognitive function in the elderly
    • Johnson EJ (2012) A possible role for lutein and zeaxanthin in cognitive function in the elderly. Am J Clin Nutr 96, 1161S-1165S.
    • (2012) Am J Clin Nutr , vol.96 , pp. 1161S-1165S
    • Johnson, E.J.1
  • 31
    • 0035735850 scopus 로고    scopus 로고
    • Effects of carotenoids and retinoids on gap junctional communication
    • Stahl W, Sies H (2001) Effects of carotenoids and retinoids on gap junctional communication. Biofactors 15, 95-98.
    • (2001) Biofactors , vol.15 , pp. 95-98
    • Stahl, W.1    Sies, H.2
  • 32
    • 0031418651 scopus 로고    scopus 로고
    • Biological activities of natural and synthetic carotenoids: Induction of gap junctional communication and singlet oxygen quenching
    • StahlW, Nicolai S, Briviba K, Hanusch M, Broszeit G, Peters M, Martin HD, Sies H (1997) Biological activities of natural and synthetic carotenoids: Induction of gap junctional communication and singlet oxygen quenching. Carcinogenesis 18, 89-92.
    • (1997) Carcinogenesis , vol.18 , pp. 89-92
    • Stahl, W.1    Nicolai, S.2    Briviba, K.3    Hanusch, M.4    Broszeit, G.5    Peters, M.6    Martin, H.D.7    Sies, H.8
  • 34
    • 0028092805 scopus 로고
    • Cambridge Neuropsychological Test Automated Battery (CANTAB): A factor analytic study of a large sample of normal elderly volunteers
    • Robbins TW, James M, Owen AM, Sahakian BJ, McInnes L, Rabbitt P (1994) Cambridge Neuropsychological Test Automated Battery (CANTAB): A factor analytic study of a large sample of normal elderly volunteers. Dementia 5, 266-281.
    • (1994) Dementia , vol.5 , pp. 266-281
    • Robbins, T.W.1    James, M.2    Owen, A.M.3    Sahakian, B.J.4    McInnes, L.5    Rabbitt, P.6
  • 35
    • 0023904094 scopus 로고
    • A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease
    • Sahakian BJ, Morris RG, Evenden JL, Heald A, Levy R, Philpot M, Robbins TW (1988) A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain 111(Pt 3), 695-718.
    • (1988) Brain , vol.111 , Issue.PART 3 , pp. 695-718
    • Sahakian, B.J.1    Morris, R.G.2    Evenden, J.L.3    Heald, A.4    Levy, R.5    Philpot, M.6    Robbins, T.W.7
  • 37
    • 80052610495 scopus 로고    scopus 로고
    • Psychophysical impact and optical and morphological characteristics of symptomatic non-advanced cataract
    • Charalampidou S, Nolan J, Loughman J, Stack J, Higgins G, Cassidy L, Beatty S (2011) Psychophysical impact and optical and morphological characteristics of symptomatic non-advanced cataract. Eye (Lond) 25, 1147-1154.
    • (2011) Eye (Lond) , vol.25 , pp. 1147-1154
    • Charalampidou, S.1    Nolan, J.2    Loughman, J.3    Stack, J.4    Higgins, G.5    Cassidy, L.6    Beatty, S.7
  • 39
    • 84896302132 scopus 로고    scopus 로고
    • Central Retinal Enrichment Supplementation Trials (CREST): Design and methodology of the CREST randomized controlled trials
    • Akuffo KO, Beatty S, Stack J, Dennison J, O'Regan S, Meagher KA, Peto T, Nolan J (2014) Central Retinal Enrichment Supplementation Trials (CREST): Design and methodology of the CREST randomized controlled trials. Ophthalmic Epidemiol 21, 111-123.
    • (2014) Ophthalmic Epidemiol , vol.21 , pp. 111-123
    • Akuffo, K.O.1    Beatty, S.2    Stack, J.3    Dennison, J.4    O'Regan, S.5    Meagher, K.A.6    Peto, T.7    Nolan, J.8
  • 40
    • 0028934221 scopus 로고
    • An international classification and grading system for age-related maculopathy and age-related macular degeneration. the International ARM Epidemiological Study Group
    • Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis DM, de Jong PT, Klaver CC, Klein BE, Klein R, et al. (1995) An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol 39, 367-374.
    • (1995) Surv Ophthalmol , vol.39 , pp. 367-374
    • Bird, A.C.1    Bressler, N.M.2    Bressler, S.B.3    Chisholm, I.H.4    Coscas, G.5    Davis, D.M.6    De Jong, P.T.7    Klaver, C.C.8    Klein, B.E.9    Klein, R.10
  • 41
    • 63249102098 scopus 로고    scopus 로고
    • Grading of age-related maculopathy: Slitlamp biomicroscopy versus an accredited grading center
    • Neelam K, Muldrew A, Hogg R, Stack J, Chakravarthy U, Beatty S (2009) Grading of age-related maculopathy: Slitlamp biomicroscopy versus an accredited grading center. Retina 29, 192-198.
    • (2009) Retina , vol.29 , pp. 192-198
    • Neelam, K.1    Muldrew, A.2    Hogg, R.3    Stack, J.4    Chakravarthy, U.5    Beatty, S.6
  • 42
    • 4444376700 scopus 로고    scopus 로고
    • Autofluorescence method to measure macular pigment optical densities fluorometry and autofluorescence imaging
    • Delori FC (2004) Autofluorescence method to measure macular pigment optical densities fluorometry and autofluorescence imaging. Arch Biochem Biophys 430, 156-162.
    • (2004) Arch Biochem Biophys , vol.430 , pp. 156-162
    • Delori, F.C.1
  • 43
    • 61849087905 scopus 로고    scopus 로고
    • Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products
    • Perry A, Rasmussen H, Johnson EJ (2009) Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products. J Food Compost Anal 22, 9-15.
    • (2009) J Food Compost Anal , vol.22 , pp. 9-15
    • Perry, A.1    Rasmussen, H.2    Johnson, E.J.3
  • 44
    • 56349166164 scopus 로고    scopus 로고
    • A supplementation study in human subjects with a combination of meso-zeaxanthin, (3R, 3'R)-zeaxanthin and (3R, 3'R, 6'R)-lutein
    • Thurnham DI, Tremel A, Howard AN (2008) A supplementation study in human subjects with a combination of meso-zeaxanthin, (3R, 3'R)-zeaxanthin and (3R, 3'R, 6'R)-lutein. Br J Nutr 100, 1307-1314.
    • (2008) Br J Nutr , vol.100 , pp. 1307-1314
    • Thurnham, D.I.1    Tremel, A.2    Howard, A.N.3
  • 45
    • 55349126615 scopus 로고    scopus 로고
    • NCSS LLC
    • Hintze J (2008) PASS 2008. NCSS LLC, http://www. ncss.com
    • (2008) PASS 2008
    • Hintze, J.1
  • 47
    • 76749128557 scopus 로고    scopus 로고
    • Nutrition and the brain
    • Morley JE (2010) Nutrition and the brain. Clin Geriatr Med 26, 89-98.
    • (2010) Clin Geriatr Med , vol.26 , pp. 89-98
    • Morley, J.E.1
  • 48
    • 34548472202 scopus 로고    scopus 로고
    • The relationship between nutrient intake and cognitive performance in people at risk of dementia
    • Salerno-Kennedy R, Cashman KD (2007) The relationship between nutrient intake and cognitive performance in people at risk of dementia. Ir J Med Sci 176, 193-198.
    • (2007) Ir J Med Sci , vol.176 , pp. 193-198
    • Salerno-Kennedy, R.1    Cashman, K.D.2
  • 49
    • 84881376185 scopus 로고    scopus 로고
    • Nutritional approaches in the risk reduction and management of Alzheimer's disease
    • MiW, vanWijk N, CansevM, SijbenJW, Kamphuis PJ (2013) Nutritional approaches in the risk reduction and management of Alzheimer's disease. Nutrition 29, 1080-1089.
    • (2013) Nutrition , vol.29 , pp. 1080-1089
    • Mi, W.1    Van Wijk, N.2    Cansev, M.3    Sijben, J.W.4    Kamphuis, P.J.5
  • 50
    • 84899840300 scopus 로고    scopus 로고
    • Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults
    • Min JY, Min KB (2014) Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults. Dement Geriatr Cogn Disord 37, 246-256.
    • (2014) Dement Geriatr Cogn Disord , vol.37 , pp. 246-256
    • Min, J.Y.1    Min, K.B.2
  • 52
    • 84879190984 scopus 로고    scopus 로고
    • Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration
    • Meagher KA, Thurnham DI, Beatty S, Howard AN, Connolly E, Cummins W, Nolan JM (2013) Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration. Br J Nutr 110, 289-300.
    • (2013) Br J Nutr , vol.110 , pp. 289-300
    • Meagher, K.A.1    Thurnham, D.I.2    Beatty, S.3    Howard, A.N.4    Connolly, E.5    Cummins, W.6    Nolan, J.M.7
  • 53
    • 84864295641 scopus 로고    scopus 로고
    • Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment
    • Nolan JM, Akkali MC, Loughman J, Howard AN, Beatty S (2012) Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment. Exp Eye Res 101, 9-15.
    • (2012) Exp Eye Res , vol.101 , pp. 9-15
    • Nolan, J.M.1    Akkali, M.C.2    Loughman, J.3    Howard, A.N.4    Beatty, S.5
  • 54
    • 84875142938 scopus 로고    scopus 로고
    • Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration
    • Beatty S, Chakravarthy U, Nolan JM, Muldrew KA, Woodside JV, Denny F, Stevenson MR (2013) Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration. Ophthalmology 120, 600-606.
    • (2013) Ophthalmology , vol.120 , pp. 600-606
    • Beatty, S.1    Chakravarthy, U.2    Nolan, J.M.3    Muldrew, K.A.4    Woodside, J.V.5    Denny, F.6    Stevenson, M.R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.