Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration

Nutrition

Volumn 29, Issue 2, 2013, Pages 387-392

  Huang, Yang Mu ^a   Yan, Shao Fang ^a   Ma, Le ^a   Zou, Zhi Yong ^a   Xu, Xian Rong ^a   Dou, Hong Liang ^b   Lin, Xiao Ming ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Early age related macular degeneration; Lutein; Macular pigment optical density; Serum concentration; Zeaxanthin

Indexed keywords

PLACEBO; XANTHOPHYLL; ZEAXANTHIN;

ADULT; AGED; ARTICLE; AUTOFLUORESCENCE IMAGING; BIOCHEMISTRY; CAROTENODERMIA; CHINESE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; HEMATOLOGICAL PARAMETERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VIVO STUDY; LOW DRUG DOSE; MACULAR PIGMENT OPTICAL DENSITY; MAJOR CLINICAL STUDY; MALE; PIGMENT DISORDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA MACULA AGE RELATED DEGENERATION; SIDE EFFECT; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; VISUAL SYSTEM PARAMETERS;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LINEAR MODELS; LUTEIN; MACULAR DEGENERATION; MALE; MIDDLE AGED; XANTHOPHYLLS;

EID: 84872222041     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2012.06.009     Document Type: Article

References (32)

1. Chopdar A., Chakravarthy U., Verma D. Age related macular degeneration. BMJ 2003, 326:485-488.
2. Kawasaki R., Yasuda M., Song S.J., Chen S.J., Jonas J.B., Wang J.J., et al. The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis. Ophthalmology 2010, 117:921-927.
3. Krinsky N.I., Landrum J.T., Bone R.A. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr 2003, 23:171-201.
4. Tan J.S., Wang J.J., Flood V., Rochtchina E., Smith W., Mitchell P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Ophthalmology 2008, 115:334-341.
5. Sangiovanni J.P., Chew E.Y., Clemons T.E., Ferris F.R., Gensler G., Lindblad A.S., et al. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS report no. 22. Arch Ophthalmol 2007, 125:1225-1232.
6. Elliott J.G., Williams N.S. Nutrients in the battle against age-related eye diseases. Optometry 2012, 83:47-55.
7. Schalch W., Cohn W., Barker F.M., Kopcke W., Mellerio J., Bird A.C., et al. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin-the LUXEA (Lutein Xanthophyll Eye Accumulation) study. Arch Biochem Biophys 2007, 458:128-135.
8. Trieschmann M., Beatty S., Nolan J.M., Hense H.W., Heimes B., Austermann U., et al. Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study. Exp Eye Res 2007, 84:718-728.
9. Bone R.A., Landrum J.T., Fernandez L., Tarsis S.L. Analysis of the macular pigment by HPLC: retinal distribution and age study. Invest Ophthalmol Vis Sci 1988, 29:843-849.
10. Richer S.P., Stiles W., Graham-Hoffman K., Levin M., Ruskin D., Wrobel J., et al. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78,973. Optometry 2011, 82:667-680.
11. Rosenthal J.M., Kim J., de Monasterio F., Thompson D.J., Bone R.A., Landrum J.T., et al. Dose-ranging study of lutein supplementation in persons aged 60 years or older. Invest Ophthalmol Vis Sci 2006, 47:5227-5233.
12. Woo J.H., Sanjay S., Au E.K. Benefits of early awareness in age-related macular degeneration. Eye (Lond) 2009, 23:2271-2272.
13. Kanis M.J., Berendschot T.T., van Norren D. Influence of macular pigment and melanin on incident early AMD in a white population. Graefes Arch Clin Exp Ophthalmol 2007, 245:767-773.
14. Dietzel M., Zeimer M., Heimes B., Claes B., Pauleikhoff D., Hense H.W. Determinants of macular pigment optical density and its relation to age-related maculopathy-results from the Muenster Aging and Retina Study (MARS). Invest Ophthalmol Vis Sci 2011, 52(6):3452-3457.
15. Koh H.H., Murray I.J., Nolan D., Carden D., Feather J., Beatty S. Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study. Exp Eye Res 2004, 79:21-27.
16. Davis M.D., Gangnon R.E., Lee L.Y., Hubbard L.D., Klein B.E., Klein R., et al. The age-related eye disease study severity scale for age-related macular degeneration: AREDS report no. 17. Arch Ophthalmol 2005, 123:1484-1498.
17. AREDS Research Group. The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1. Control Clin Trials 1999, 20:573-600.
18. Khachik F., Englert G., Daitch C.E., Beecher G.R., Tonucci L.H., Lusby W.R. Isolation and structural elucidation of the geometrical isomers of lutein and zeaxanthin in extracts from human plasma. J Chromatogr 1992, 582:153-166.
19. Zou Z., Xu X., Huang Y., Xiao X., Ma L., Sun T., et al. High serum level of lutein may be protective against early atherosclerosis: the Beijing Atherosclerosis Study. Atherosclerosis 2011, 219:789-793.
20. Lois N., Halfyard A.S., Bird A.C., Fitzke F.W. Quantitative evaluation of fundus autofluorescence imaged "in vivo" in eyes with retinal disease. Br J Ophthalmol 2000, 84:741-745.
21. Delori F.C. Autofluorescence method to measure macular pigment optical densities: fluorometry and autofluorescence imaging. Arch Biochem Biophys 2004, 430:156-162.
22. Trieschmann M., Spital G., Lommatzsch A., van Kuijk E., Fitzke F., Bird A.C., et al. Macular pigment: quantitative analysis on autofluorescence images. Graefes Arch Clin Exp Ophthalmol 2003, 241:1006-1012.
23. Perry A., Rasmussen H., Johnson E.J. Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products. Journal of Food Composition and Analysis 2009, 22:9-15.
24. Bone R.A., Landrum J.T. Dose-dependent response of serum lutein and macular pigment optical density to supplementation with lutein esters. Arch Biochem Biophys 2010, 504:50-55.
25. Bhosale P., Li B., Sharifzadeh M., Gellermann W., Frederick J.M., Tsuchida K., et al. Purification and partial characterization of a lutein-binding protein from human retina. Biochemistry 2009, 48:4798-4807.
26. Richer S., Stiles W., Statkute L., Pulido J., Frankowski J., Rudy D., et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST Study (Lutein Antioxidant Supplementation Trial). Optometry 2004, 75:216-230.
27. Richer S., Devenport J., Lang J.C. LAST II: differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. Optometry 2007, 78:213-219.
28. Robson A.G., Moreland J.D., Pauleikhoff D., Morrissey T., Holder G.E., Fitzke F.W., et al. Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry. Vision Res 2003, 43:1765-1775.
29. Johnson E.J., Chung H.Y., Caldarella S.M., Snodderly D.M. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. Am J Clin Nutr 2008, 87:1521-1529.
30. Neuringer M., Sandstrom M.M., Johnson E.J., Snodderly D.M. Nutritional manipulation of primate retinas, I: effects of lutein or zeaxanthin supplements on serum and macular pigment in xanthophyll-free rhesus monkeys. Invest Ophthalmol Vis Sci 2004, 45:3234-3243.
31. Bone R.A., Landrum J.T., Guerra L.H., Ruiz C.A. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J Nutr 2003, 133:992-998.
32. Gale C.R., Hall N.F., Phillips D.I., Martyn C.N. Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci 2003, 44:2461-2465.