Cholesterol, oxidative stress, and Alzheimer's disease: Expanding the horizons of pathogenesis

Free Radical Biology and Medicine

Volumn 33, Issue 2, 2002, Pages 173-181

  Pappolla, Miguel A ^a,h   Smith, Mark A ^b   Bryant Thomas, Tara ^a   Bazan, Nicolas ^c   Petanceska, Suzana ^d   Perry, George ^b   Thal, Leon J ^e   Sano, Mary ^f   Refolo, Lorenzo M ^g  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d NEW YORK UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f College of Physicians and Surgeons ^*  (United States)

^g Alzheimers Drug Discovery Foundation   (United States)

^h UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid peptide; Cholesterol; Free radicals; Neurodegeneration; Neurofibrillary tangles; Oxidative stress

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; CHOLESTEROL; FREE RADICAL; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; CELL FUNCTION; CELL LOSS; CENTRAL NERVOUS SYSTEM; CHOLESTEROL METABOLISM; DISEASE ASSOCIATION; HUMAN; LIPID ANALYSIS; MOLECULAR BIOLOGY; NERVE CELL; NERVE DEGENERATION; NEUROPATHOLOGY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; ANIMAL; BRAIN; METABOLISM; MOUSE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID; ANIMALS; BRAIN; CHOLESTEROL; HUMANS; MICE; MICE, TRANSGENIC; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 0037098872     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00841-9     Document Type: Article

References (92)

1. Aging and dementia
2. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
3. Amyloid plaque core protein in Alzheimer disease and down syndrome
4. Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer's cytoskeletal pathology
5. The molecular and cellular biology of tau
6. Mechanisms of synaptic dysfunction in Alzheimer's disease
7. Quantitative neuropathology in Alzheimer's disease: Neuronal loss in high-order association cortex parallels dementia
8. Aβ mediated oxidative damage of mitochondrial DNA: Prevention by melatonin
9. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
10. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
11. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides
12. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
13. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors
14. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
15. Regulation of APP cleavage by alpha-, beta- and gamma-secretases
16. Abeta-generating enzymes: Recent advances in beta- and gamma-secretase research
17. In search of gamma-secretase: Presenilin at the cutting edge
18. Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure
19. Apolipoprotein E and amyloidogenesis
20. Oxidative processes in Alzheimer's disease: The role of abeta-metal interactions
21. Solution structures of β peptide and its constituent fragments: Relation to amyloid deposition
22. Structural and kinetic features of amyloid beta-protein fibrillogenesis
23. Alzheimer's disease: A re-examination of the amyloid hypothesis
24. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
25. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
26. A cholesterol-lowering drug attenuates the Alzheimer's amyloid pathology in a transgenic mouse model of Alzheimer's disease
27. Modulation of secreted β-amyloid precursor protein and amyloid β-peptide in brain by cholesterol
28. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
29. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
30. The role of cholesterol in the biosynthesis of beta amyloid
31. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease
32. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study
33. Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: A population-based study of African Americans
34. Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study
35. Hypercholesterolemia is an early risk factor in the development of human amyloid pathology
36. Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
37. Statins and the risk of dementia
38. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
39. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
40. Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides
41. Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion
42. Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals
43. Neuropathology and molecular biology of Alzheimer's disease
44. Oxidative stress and the amyloid conundrum. What is the connection?
45. Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins
46. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokin gene expression and release of amyloid β peptide
47. 2-induced apoptosis in human neuronal cells
48. Oxygen free radicals and hypercholesterolemic atherosclerosis: Effect of vitamin E
49. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed
50. Membrane microdomains and caveolae
51. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients
52. Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta
53. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease
54. The genesis of the senile plaque. Immunohistochemical evidence of oxidative stress in Alzheimer's disease
55. Localization of superoxide dismutases in Alzheimer's disease and Down syndrome neocortex and hippocampus
56. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
57. Early contribution of oxidative glycation in Alzheimer disease
58. 4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease
59. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
60. Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo
61. Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress
62. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro
63. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
64. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease
65. D1-dopamine receptor abnormality in frontal cortex points to a functional alteration of cortical cell membranes in Alzheimer's disease
66. Cerebrovascular hypoperfusion: A risk factor for Alzheimer's disease? Animal model and postmortem human studies
67. Hydrogen peroxide mediates amyloid β protein toxicity
68. Free radical damage, iron, and Alzheimer's disease
69. Oxidative stress hypothesis in Alzheimer's disease
70. Apoptosis is induced by β amyloid in cultured central nervous system neurons
71. Dual anti-amyloidogenic and anti-oxidant properties of melatonin. A new therapy for Alzheimer's Disease?
72. 2+ homeostasis and cell death
73. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
74. Excitatory amino acids growth factors and calcium: A teeter-totter model for neural plasticity and degeneration
75. The superoxide-generating oxidase of phagocytic cells. Physiological, molecular and pathological aspects
76. Pathological implications of nitric oxide superoxide and peroxynitrite formation
77. Evidence for neuronal oxidative damage in Alzheimer's disease
78. Widespread peroxynitrite-mediated damage in Alzheimer's disease
79. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
80. Activation of microglial cells by β-amyloid protein and interferon
81. Heat shock proteins protect against stress-related phosphorylation of tau in neuronal PC12 cells that have acquired thermotolerance
82. In vitro polymerization of oxidated tau into filaments
83. Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments
84. β-amyloid fibrils induce tau phosphorylation and loss of microtubule binding
85. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
86. Two new genes for Alzheimer's disease
87. The gene defects responsible for familial Alzheimer's disease
88. Binding of human apolipoprotein E to synthetic amyloid beta peptide: Isoform-specific effects and implications for late-onset Alzheimer's disease
89. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
90. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
91. Concentration-dependent inhibitory effects of apolipoprotein E on Alzheimer's beta-amyloid fibril formation in vitro
92. Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease