Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular care

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Ciccone, Marco Matteo ^a   Cortese, Francesca ^a   Gesualdo, Michele ^a   Carbonara, Santa ^a   Zito, Annapaola ^a   Ricci, Gabriella ^a   De Pascalis, Francesca ^a   Scicchitano, Pietro ^a   Riccioni, Graziano ^b  

^a UNIVERSITY OF BARI   (Italy)

^b SAN CAMILLO DE LELLIS HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CAROTENE; ASTAXANTHIN; BETA CAROTENE; BETA CRYPTOXANTHIN; CAROTENOID; LYCOPENE; XANTHOPHYLL; ZEAXANTHIN; ALPHA-CAROTENE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CRYPTOXANTHIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXYGEN; SCAVENGER;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; CARDIOVASCULAR CARE; CARDIOVASCULAR DISEASE; DIETARY INTAKE; HUMAN; INFLAMMATION; MEDICAL CARE; PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; ANIMAL; ATHEROSCLEROSIS; CLINICAL TRIAL (TOPIC); DIET; METABOLISM; RISK;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; ATHEROSCLEROSIS; BETA CAROTENE; CARDIOVASCULAR DISEASES; CAROTENOIDS; CHOLESTEROL, LDL; CLINICAL TRIALS AS TOPIC; DIET; FREE RADICAL SCAVENGERS; HUMANS; LUTEIN; OXYGEN; RISK; XANTHOPHYLLS;

EID: 84896326185     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/782137     Document Type: Review

References (107)

1. World Health Organization, The World Health Report 2003: Shaping the Future 2003 Geneva, Switzerland World Health Organization
2. Mathers C. D., Loncar D., Projections of global mortality and burden of disease from 2002 to 2030. PLoS Medicine 2006 3 11 2011 2030 e442 2-s2.0-33845338724 10.1371/journal.pmed.0030442 (Pubitemid 44875937)
3. World Health Organization, Preventing Chronic Diseases: 2005: A Vital Investment 2005 Geneva, Switzerland World Health Organization
4. Libby P., Inflammation in atherosclerosis. Nature 2002 420 6917 868 874 2-s2.0-0037180771 10.1038/nature01323 (Pubitemid 36019640)
5. Hansson G. K., Mechanisms of disease: inflammation, atherosclerosis, and coronary artery disease. New England Journal of Medicine 2005 352 16 1685 1626 2-s2.0-17644412023 10.1056/NEJMra043430 (Pubitemid 40530235)
6. Voutilainen S., Nurmi T., Mursu J., Rissanen T. H., Carotenoids and cardiovascular health. American Journal of Clinical Nutrition 2006 83 6 1265 1271 2-s2.0-33745621949 (Pubitemid 44713054)
7. Di Mascio P., Kaiser S., Sies H., Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Archives of Biochemistry and Biophysics 1989 274 2 532 538 2-s2.0-0024464691 (Pubitemid 19261144)
8. El-Agamey A., Lowe G. M., McGarvey D. J., Mortensen A., Phillip D. M., Truscott T. G., Young A. J., Carotenoid radical chemistry and antioxidant/pro-oxidant properties. Archives of Biochemistry and Biophysics 2004 430 1 37 48 2-s2.0-4344634650 10.1016/j.abb.2004.03.007 (Pubitemid 39119778)
9. Riccioni G., Speranza L., Pesce M., Cusenza S., D'Orazio N., Glade M. J., Novel phytonutrient contributors to antioxidant protection against cardiovascular disease. Nutrition 2012 28 6 605 610 2-s2.0-84860626351 10.1016/j.nut.2011.11.028
10. Carew T. E., Role of biologically modified low-density lipoprotein in atherosclerosis. American Journal of Cardiology 1989 64 13 18G 22G 2-s2.0-0024325974 (Pubitemid 19244569)
11. Berliner J. A., Navab M., Fogelman A. M., Frank J. S., Demer L. L., Edwards P. A., Watson A. D., Lusis A. J., Atherosclerosis: basic mechanisms: oxidation, inflammation, and genetics. Circulation 1995 91 9 2488 2496 2-s2.0-0028925078
12. Allen C. L., Bayraktutan U., Oxidative stress and its role in the pathogenesis of ischaemic stroke. International Journal of Stroke 2009 4 6 461 470 2-s2.0-77449152992
13. Riccioni G., D'Orazio N., Franceschelli S., Speranza L., Marine carotenoids and cardiovascular risk markers. Marine Drugs 2011 9 7 1166 1175 2-s2.0-79960787291 10.3390/md9071166
14. Gori T., Münzel T., Oxidative stress and endothelial dysfunction: therapeutic implications. Annals of Medicine 2011 43 4 259 272 10.3109/07853890.2010.543920
15. Adameova A., Xu Y. J., Duhamel T. A., Tappia P. S., Shan L., Dhalla N. S., Anti-atherosclerotic molecules targeting oxidative stress and inflammation. Current Pharmaceutical Design 2009 15 27 3094 3107 2-s2.0-70449419111 10.2174/138161209789058048
16. Juraschek S. P., Guallar E., Appel L. J., Miller E. R. III, Effects of vitamin c supplementation on blood pressure: a meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition 2012 95 5 1079 1088 2-s2.0-84860278737 10.3945/ajcn.111.027995
17. Fitó M., Guxens M., Corella D., Sáez G., Estruch R., De La Torre R., Francés F., Cabezas C., López-Sabater M. D. C., Marrugat J., García-Arellano A., Arós F., Ruiz-Gutierrez V., Ros E., Salas-Salvadó J., Fiol M., Solá R., Covas M., Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Archives of Internal Medicine 2007 167 11 1195 1203 2-s2.0-34250342984 10.1001/archinte.167.11.1195 (Pubitemid 46919824)
18. Salonen R. M., Nyyssönen K., Kaikkonen J., Porkkala-Sarataho E., Voutilainen S., Rissanen T. H., Tuomainen T., Valkonen V., Ristonmaa U., Lakka H., Vanharanta M., Salonen J. T., Poulsen H. E., Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the antioxidant supplementation in atherosclerosis prevention (ASAP) study. Circulation 2003 107 7 947 953 2-s2.0-0037465430 10.1161/01.CIR.0000050626.25057.51 (Pubitemid 36258715)
19. Boeing H., Bechthold A., Bub A., Ellinger S., Haller D., Kroke A., Leschik-Bonnet E., Müller M. J., Oberritter H., Schulze M., Stehle P., Watzl B., Critical review: vegetables and fruit in the prevention of chronic diseases. European Journal of Nutrition 2012 51 6 637 663 10.1007/s00394-012- 0380-y
20. Verlangieri A. J., Kapeghian J. C., El-Dean S., Bush M., Fruit and vegetable consumption and cardiovascular mortality. Medical Hypotheses 1985 16 1 7 15 2-s2.0-0021905277 (Pubitemid 15117420)
21. He F. J., Nowson C. A., Lucas M., MacGregor G. A., Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort studies. Journal of Human Hypertension 2007 21 9 717 728 2-s2.0-34548348356 10.1038/sj.jhh.1002212 (Pubitemid 47335302)
22. Bakhru A., Erlinger T. P., Smoking cessation and cardiovascular disease risk factors: results from the third national health and nutrition examination survey. PLoS Medicine 2005 2 6 e160 2-s2.0-22144442811 10.1371/journal.pmed. 0020160 (Pubitemid 40973506)
23. Reddigan J. I., Ardern C. I., Riddell M. C., Kuk J. L., Relation of physical activity to cardiovascular disease mortality and the influence of cardiometabolic risk factors. American Journal of Cardiology 2011 108 10 1426 1431 2-s2.0-80255127528 10.1016/j.amjcard.2011.07.005
24. Martínez-González M. A., Guillén-Grima F., De Irala J., Ruíz-Canela M., Bes-Rastrollo M., Beunza J. J., López del Burgo C., Toledo E., Carlos S., Sánchez-Villegas A., The Mediterranean diet is associated with a reduction in premature mortality among middle-aged adults. Journal of Nutrition 2012 142 9 1672 1678 10.3945/jn.112.162891
25. Suzuki K., Ishii J., Kitagawa F., Kuno A., Kusuhara Y., Ochiai J., Ichino N., Osakabe K., Sugimoto K., Yamada H., Ito Y., Hamajima N., Inoue T., Association of serum carotenoid levels with N-terminal pro-brain-type natriuretic peptide: a cross-sectional study in Japan. Journal of Epidemiology & Community Health 2013 23 3 163 168
26. Koh W. P., Yuan J. M., Wang R., Lee Y. P., Lee B.-L., Yu M. C., Ong C.-N., Plasma carotenoids and risk of acute myocardial infarction in the Singapore Chinese Health Study. Nutrition, Metabolism and Cardiovascular Diseases 2011 21 9 685 690 2-s2.0-79953177638 10.1016/j.numecd.2009.12.005
27. Rissanen T., Voutilainen S., Nyyssönen K., Salonen R., Salonen J. T., Low plasma lycopene concentration is associated with increased intima-media thickness of the carotid artery wall. Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 12 2677 2687 2-s2.0-0033664636
28. Kim O. Y., Yoe H. Y., Kim H. J., Park J. Y., Kim J. Y., Lee S., Lee J. H., Lee K. P., Jang Y., Lee J. H., Independent inverse relationship between serum lycopene concentration and arterial stiffness. Atherosclerosis 2010 208 2 581 586 2-s2.0-74749086113 10.1016/j.atherosclerosis.2009.08.009
29. Karppi J., Kurl S., Ronkainen K., Kauhanen J., Laukkanen J. A., Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among Eastern Finnish men. PLoS ONE 2013 8 5 e64107
30. Lidebjer C., Leanderson P., Ernerudh J., Jonasson L., Low plasma levels of oxygenated carotenoids in patients with coronary artery disease. Nutrition, Metabolism and Cardiovascular Diseases 2007 17 6 448 456 2-s2.0-34447544439 10.1016/j.numecd.2006.02.006 (Pubitemid 47069912)
31. Akbaraly T. N., Fontbonne A., Favier A., Berr C., Plasma carotenoids and onset of dysglycemia in an elderly population: results of the epidemiology of vascular ageing study. Diabetes Care 2008 31 7 1355 1359 2-s2.0-49649099764 10.2337/dc07-2113
32. Hozawa A., Jacobs D. R., Steffes M. W., Gross M. D., Steffen L. M., Lee D., Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Journal of Hypertension 2009 27 2 237 242 2-s2.0-63849343946 10.1097/HJH.0b013e32832258c9
33. Rydén M., Garvin P., Kristenson M., Leanderson P., Ernerudh J., Jonasson L., Provitamin A carotenoids are independently associated with matrix metalloproteinase-9 in plasma samples from a general population. Journal of Internal Medicine 2012 272 4 371 384 2-s2.0-84859394697 10.1111/j.1365-2796. 2012.2534.x
34. Agarwal S., Rao A. V., Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. Lipids 1998 33 10 981 984 2-s2.0-0031796505 (Pubitemid 28516475)
35. Choi H. D., Youn Y. K., Shin W. G., Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods for Human Nutrition 2011 66 4 363 369 2-s2.0-83055188019 10.1007/s11130-011-0258-9
36. Yoshida H., Yanai H., Ito K., Tomono Y., Koikeda T., Tsukahara H., Tada N., Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis 2010 209 2 520 523 2-s2.0-77950023075 10.1016/j.atherosclerosis.2009.10.012
37. Hozawa A., Jacobs D. R. Jr., Steffes M. W., Gross M. D., Steffen L. M., Lee D., Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Clinical Chemistry 2007 53 3 447 455 2-s2.0-33947389955 10.1373/clinchem.2006.074930 (Pubitemid 46447941)
38. Kim J. H., Chang M. J., Choi H. D., Youn Y., Kim J. T., Oh J. M., Shin W. G., Protective effects of haematococcus astaxanthin on oxidative stress in healthy smokers. Journal of Medicinal Food 2011 14 11 1469 1475 2-s2.0-80755125216 10.1089/jmf.2011.1626
39. Beutner S., Bloedorn B., Frixel S., Blanco I. H., Hoffmann T., Martin H., Mayer B., Noack P., Ruck C., Schmidt M., Schülke I., Sell S., Ernst H., Haremza S., Seybold G., Sies H., Stahl W., Walsh R., Quantitative assessment of antioxidant properties of natural colorants and phytochemicals: carotenoids, flavonoids, phenols and indigoids. The role of β -carotene in antioxidant functions. Journal of the Science of Food and Agriculture 2001 81 6 559 568 2-s2.0-0035341020 10.1002/jsfa.849 (Pubitemid 32386131)
40. Xu X. R., Zou Z. Y., Huang Y. M., Xiao X., Ma L., Lin X. M., Serum carotenoids in relation to risk factors for development of atherosclerosis. Clinical Biochemistry 2012 45 16-17 1357 1361 10.1016/j.clinbiochem.2012.07.101
41. Losonczy K. G., Harris T. B., Havlik R. J., Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the established populations for epidemiologic studies of the elderly. American Journal of Clinical Nutrition 1996 64 2 190 196 2-s2.0-0030013268 (Pubitemid 26250838)
42. Sahyoun N. R., Jacques P. F., Russell R. M., Carotenoids, vitamins C and E, and mortality in an elderly population. American Journal of Epidemiology 1996 144 5 501 511 2-s2.0-0029840810 (Pubitemid 26296134)
43. Ito Y., Kurata M., Suzuki K., Hamajima N., Hishida H., Aoki K., Cardiovascular disease mortality and serum carotenoid levels: a Japanese population-based follow-up study. Journal of Epidemiology 2006 16 4 154 160 2-s2.0-33746354354 10.2188/jea.16.154 (Pubitemid 44110934)
44. Shaish A., Harari A., Hananshvili L., Cohen H., Bitzur R., Luvish T., Ulman E., Golan M., Ben-Amotz A., Gavish D., Rotstein Z., Harats D., 9-cis β -carotene-rich powder of the alga Dunaliella bardawil increases plasma HDL-cholesterol in fibrate-treated patients. Atherosclerosis 2006 189 1 215 221 2-s2.0-33745956209 10.1016/j.atherosclerosis.2005.12.004 (Pubitemid 44468070)
45. Street D. A., Comstock G. W., Salkeld R. M., Schüep W., Klag M. J., Serum antioxidants and myocardial infarction: are low levels of carotenoids and α -tocopherol risk factors for myocardial infarction? Circulation 1994 90 3 1154 1161 2-s2.0-0028021957 (Pubitemid 24284435)
46. Street D. A., Comstock G. W., Salkeld R. M., Schüep W., Klag M. J., Serum antioxidants and myocardial infarction: are low levels of carotenoids and α -tocopherol risk factors for myocardial infarction? Circulation 1994 90 3 1154 1161 2-s2.0-0028021957 (Pubitemid 24284435)
47. Karppi J., Kurl S., Ma»kikallio T. H., Ronkainen K., Laukkanen J. A., Serum β -carotene concentrations and the risk of congestive heart failure in men: a population-based study. International Journal of Cardiology 2013 168 3 1841 1846 10.1016/j.ijcard.2012.12.072
48. Shaish A., Harari A., Hananshvili L., Cohen H., Bitzur R., Luvish T., Ulman E., Golan M., Ben-Amotz A., Gavish D., Rotstein Z., Harats D., 9-cis β -carotene-rich powder of the alga Dunaliella bardawil increases plasma HDL-cholesterol in fibrate-treated patients. Atherosclerosis 2006 189 1 215 221 2-s2.0-33745956209 10.1016/j.atherosclerosis.2005.12.004 (Pubitemid 44468070)
49. Schürks M., Glynn R. J., Rist P. M., Tzourio C., Kurth T., Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. British Medical Journal 2010 341 c5702 2-s2.0-78449265399 10.1136/bmj.c5702
50. Sesso H. D., Buring J. E., Norkus E. P., Gaziano J. M., Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. American Journal of Clinical Nutrition 2004 79 1 47 53 2-s2.0-2342468143 (Pubitemid 41132061)
51. Howard A. N., Williams N. R., Palmer C. R., Cambou J. P., Evans A. E., Foote J. W., Marques-Vidai P., McCrum E. E., Ruidavets J. B., Nigdikar S. V., Rajput-Williams J., Thurnham D. I., Do hydroxy-carotenoids prevent coronary heart disease? A comparison between Belfast and Toulouse. International Journal for Vitamin and Nutrition Research 1996 66 2 113 118 2-s2.0-9444264318 (Pubitemid 26263551)
52. Bjelakovic G., Nikolova D., Gluud L. L., Simonetti R. G., Gluud C., Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database of Systematic Reviews 2008 2 3 CD007176 2-s2.0-44949136378
53. Myung S. K., Ju W., Cho B., Oh S. W., Park S. M., Koo B. K., Park B. J., Korean Meta-Analysis Study Group, Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. British Medical Journal 2013 346 f10
54. Bin Q., Hu X., Cao Y., Gao F., The role of vitamin E (tocopherol) supplementation in the prevention of stroke: a meta-analysis of 13 randomised controlled trials. Thrombosis and Haemostasis 2011 105 4 579 585 2-s2.0-79955457391 10.1160/TH10-11-0729
55. Hirvonen T., Virtamo J., Korhonen P., Albanes D., Pietinen P., Intake of flavonoids, carotenoids, Vitamins C and E, and risk of stroke in male smokers. Stroke 2000 31 10 2301 2306 2-s2.0-0033800904
56. Karppi J., Laukkanen J. A., Mäkikallio T. H., Ronkainen K., Kurl S., Low β -carotene concentrations increase the risk of cardiovascular disease mortality among Finnish men with risk factors. Nutrition, Metabolism and Cardiovascular Diseases 2012 22 10 921 928 2-s2.0-84859404827 10.1016/j.numecd.2012.01.008
57. Karppi J., Laukkanen J. A., Mäkikallio T. H., Ronkainen K., Kurl S., Serum β -carotene and the risk of sudden cardiac death in men: a population-based follow-up study. Atherosclerosis 2013 226 1 172 177 10.1016/j.atherosclerosis.2012.10.077
58. Heart Protection Study Collaborative Group, MRC/BHF heart protection study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial. The Lancet 2002 360 9326 23 33 2-s2.0-0037031094 10.1016/S0140-6736(02)09328-5 (Pubitemid 34756488)
59. Hankey G. J., Vitamin supplementation and stroke prevention. Stroke 2012 43 10 2814 2818 10.1161/STROKEAHA.111.639930
60. Ye Y., Li J., Yuan Z., Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials. PLoS ONE 2013 8 2 e56803
61. Vivekananthan D. P., Penn M. S., Sapp S. K., Hsu A., Topol E. J., Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. The Lancet 2003 361 9374 2017 2023 2-s2.0-0037840165 10.1016/S0140-6736(03)13637-9 (Pubitemid 36695043)
62. Morris D. L., Kritchevsky S. B., Davis C. E., Serum carotenoids and coronary heart disease: the lipid research clinics coronary primary prevention trial and follow-up study. Journal of the American Medical Association 1994 272 18 1439 1441 2-s2.0-0028037099 10.1001/jama.272.18.1439 (Pubitemid 24328387)
63. Rissanen T. H., Voutilainen S., Nyyssönen K., Lakka T. A., Sivenius J., Salonen R., Kaplan G. A., Salonena J. T., Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. British Journal of Nutrition 2001 85 6 749 754 2-s2.0-0034959941 (Pubitemid 32586506)
64. Hak A. E., Stampfer M. J., Campos H., Sesso H. D., Gaziano J. M., Willett W., Ma J., Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians. Circulation 2003 108 7 802 807 2-s2.0-0041886981 10.1161/01.CIR.0000084546.82738.89 (Pubitemid 37022120)
65. Evans R. W., Jessica Shaten B., Day B. W., Kuller L. H., Prospective association between lipid soluble antioxidants and coronary heart disease in men. The multiple risk factor intervention trial. American Journal of Epidemiology 1998 147 2 180 186 2-s2.0-2642679249 (Pubitemid 28060490)
66. Omenn G. S., Goodman G. E., Thornquist M. D., Balmes J., Cullen M. R., Glass A., Keogh J. P., Meyskens F. L. Jr., Valanis B., Williams J. H. Jr., Barnhart S., Hammar S., Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 1996 334 18 1150 1155 2-s2.0-9244262406 10.1056/NEJM199605023341802 (Pubitemid 26137973)
67. Jialal I., Norkus E. P., Cristol L., Grundy S. M., β -Carotene inhibits the oxidative modification of low-density lipoprotein. Biochimica et Biophysica Acta 1991 1086 1 134 138 2-s2.0-0025947041 10.1016/0005-2760(91) 90164-D
68. Lavy A., Ben Amotz A., Aviram M., Preferential inhibition of LDL oxidation by the all-trans isomer of β -carotene in comparison with 9-cis β -carotene. European Journal of Clinical Chemistry and Clinical Biochemistry 1993 31 2 83 90 2-s2.0-0027479760 (Pubitemid 23088892)
69. Navab M., Imes S. S., Hama S. Y., Hough G. P., Ross L. A., Bork R. W., Valente A. J., Berliner J. A., Drinkwater D. C., Laks H., Fogelman A. M., Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. Journal of Clinical Investigation 1991 88 6 2039 2046 2-s2.0-0026325498
70. Reaven P. D., Ferguson E., Navab M., Powell F. L., Susceptibility of human LDL to oxidative modification: effects of variations in β -carotene concentration and oxygen tension. Arteriosclerosis and Thrombosis 1994 14 7 1162 1169 2-s2.0-0028216480
71. Di Tomo P., Canali R., Ciavardelli D., Di Silvestre S., De Marco A., Giardinelli A., Pipino C., Di Pietro N., Virgili F., Pandolfi A., β -Carotene and lycopene affect endothelial response to TNF- α reducing nitro-oxidative stress and interaction with monocytes. Molecular Nutrition and Food Research 2012 56 2 217 227 2-s2.0-84858312618 10.1002/mnfr.201100500
72. Shaish A., Daugherty A., O'Sullivan F., Schonfeld G., Heinecke J. W., Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits. Journal of Clinical Investigation 1995 96 4 2075 2082 2-s2.0-0028791660
73. Harari A., Harats D., Marko D., Cohen H., Barshack I., Kamari Y., Gonen A., Gerber Y., Ben-Amotz A., Shaish A., A 9-cis β -carotene-enriched diet inhibits atherogenesis and fatty liver formation in LDL receptor knockout mice. Journal of Nutrition 2008 138 10 1923 1930 2-s2.0-54749097881
74. D'Odorico A., Martines D., Kiechl S., Egger G., Oberhollenzer F., Bonvicini P., Sturniolo G. C., Naccarato R., Willeit J., High plasma levels of α-and β -carotene are associated with a lower risk of atherosclerosisResults from the Bruneck study. Atherosclerosis 2000 153 1 231 239 2-s2.0-0033789381 10.1016/S0021-9150(00)00403-2
75. Vivekananthan D. P., Penn M. S., Sapp S. K., Hsu A., Topol E. J., Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. The Lancet 2003 361 9374 2017 2023 2-s2.0-0037840165 10.1016/S0140-6736(03)13637-9 (Pubitemid 36695043)
76. Hennekens C. H., Buring J. E., Manson J. E., Stampfer M., Rosner B., Cook N. R., Belanger C., Lamotte F., Gaziano J. M., Ridker P. M., Willett W., Peto R., Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. New England Journal of Medicine 1996 334 18 1145 1149 2-s2.0-0345157579 10.1056/NEJM199605023341801 (Pubitemid 26137972)
77. Omenn G. S., Goodman G. E., Thornquist M. D., Balmes J., Cullen M. R., Glass A., Keogh J. P., Meyskens F. L. Jr., Valanis B., Williams J. H. Jr., Barnhart S., Hammar S., Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 1996 334 18 1150 1155 2-s2.0-9244262406 10.1056/NEJM199605023341802 (Pubitemid 26137973)
78. Palozza P., Prooxidant actions of carotenoids in biologic systems. Nutrition Reviews 1998 56 9 257 265 2-s2.0-0031669520 (Pubitemid 28445801)
79. Young A. J., Lowe G. M., Antioxidant and prooxidant properties of carotenoids. Archives of Biochemistry and Biophysics 2001 385 1 20 27 2-s2.0-0034775553 10.1006/abbi.2000.2149 (Pubitemid 32988978)
80. Niki E., Noguchi N., Tsuchihashi H., Gotoh N., Interaction among vitamin C, vitamin E, and β -carotene. American Journal of Clinical Nutrition 1995 62 supplement 6 1322S 1326S 2-s2.0-0028834677
81. Truscott T. G., β -Carotene and disease: a suggested pro-oxidant and anti-oxidant mechanism and speculations concerning its role in cigarette smoking. Journal of Photochemistry and Photobiology B 1996 35 3 233 235 2-s2.0-0030250169 10.1016/S1011-1344(96)07299-5 (Pubitemid 26383626)
82. Böhm F., Edge R., McGarvey D. J., Truscott T. G., β -Carotene with vitamins E and C offers synergistic cell protection against NO(x). FEBS Letters 1998 436 3 387 389 2-s2.0-0242644199 10.1016/S0014-5793(98)01173-9 (Pubitemid 28482967)
83. Osganian S. K., Stampfer M. J., Rimm E., Spiegelman D., Manson J. E., Willett W. C., Dietary carotenoids and risk of coronary artery disease in women. American Journal of Clinical Nutrition 2003 77 6 1390 1399 2-s2.0-0037563921 (Pubitemid 39655271)
84. Li C., Ford E. S., Zhao G., Balluz L. S., Giles W. H., Liu S., Serum α -carotene concentrations and risk of death among US adults: the third national health and nutrition examination survey follow-up study. Archives of Internal Medicine 2011 171 6 507 515 2-s2.0-79955452731 10.1001/archinternmed. 2010.440
85. Buijsse B., Feskens E. J. M., Kwape L., Kok F. J., Kromhout D., Both α-and β -carotene, but not tocopherols and vitamin C, are inversely related to 15-year cardiovascular mortality in Dutch elderly men. Journal of Nutrition 2008 138 2 344 350 2-s2.0-38949170998 (Pubitemid 351213650)
86. Iribarren C., Folsom A. R., Jacobs D. R. Jr., Gross M. D., Belcher J. D., Eckfeldt J. H., Association of serum vitamin levels, LDL susceptibility to oxidation, and autoantibodies against MDA-LDL with carotid atherosclerosis: a case- control study. Arteriosclerosis, Thrombosis, and Vascular Biology 1997 17 6 1171 1177 2-s2.0-0030912927 (Pubitemid 27260339)
87. De Waart F. G., Schouten E. G., Stalenhoef A. F. H., Kok F. J., Serum carotenoids, α -tocopherol and mortality risk in a prospective study among Dutch elderly. International Journal of Epidemiology 2001 30 1 136 143 2-s2.0-0035098387 (Pubitemid 32203802)
88. Tavani A., Gallus S., Negri E., Parpinel M., La Vecchia C., Dietary intake of carotenoids and retinol and the risk of acute myocardial infarction in Italy. Free Radical Research 2006 40 6 659 664 2-s2.0-33744793244 10.1080/10715760600615649 (Pubitemid 43832521)
89. Rissanen T. H., Voutilainen S., Nyyssönen K., Salonen R., Kaplan G. A., Salonen J. T., Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. American Journal of Clinical Nutrition 2003 77 1 133 138 2-s2.0-0037214164 (Pubitemid 36015382)
90. Klipstein-Grobusch K., Launer L. J., Geleijnse J. M., Boeing H., Hofman A., Witteman J. C. M., Serum carotenoids and atherosclerosis: the Rotterdam Study. Atherosclerosis 2000 148 1 49 56 2-s2.0-0033991509 10.1016/S0021-9150(99) 00221-X
91. Rissanen T. H., Voutilainen S., Nyyssönen K., Lakka T. A., Sivenius J., Salonen R., Kaplan G. A., Salonena J. T., Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. British Journal of Nutrition 2001 85 6 749 754 2-s2.0-0034959941 (Pubitemid 32586506)
92. Polidori M. C., Savino K., Alunni G., Freddio M., Senin U., Sies H., Stahl W., Mecocci P., Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity. Free Radical Biology and Medicine 2002 32 2 148 152 2-s2.0-0037081433 10.1016/S0891-5849(01)00782-1 (Pubitemid 34127704)
93. Sesso H. D., Buring J. E., Norkus E. P., Gaziano J. M., Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. American Journal of Clinical Nutrition 2005 81 5 990 997 2-s2.0-20544459642 (Pubitemid 41724938)
94. Sesso H. D., Liu S., Gaziano J. M., Buring J. E., Dietary lycopene, tomato-based food products and cardiovascular disease in women. Journal of Nutrition 2003 133 7 2336 2341 2-s2.0-0038267188 (Pubitemid 36841562)
95. Dwyer J. H., Navab M., Dwyer K. M., Hassan K., Sun P., Shircore A., Hama-Levy S., Hough G., Wang X., Drake T., Bairey Merz C. N., Fogelman A. M., Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study. Circulation 2001 103 24 2922 2927 2-s2.0-0035912902 (Pubitemid 32578129)
96. Street D. A., Comstock G. W., Salkeld R. M., Schüep W., Klag M. J., Serum antioxidants and myocardial infarction: are low levels of carotenoids and α -tocopherol risk factors for myocardial infarction? Circulation 1994 90 3 1154 1161 2-s2.0-0028021957 (Pubitemid 24284435)
97. Ascherio A., Rimm E. B., Hernán M. A., Giovannucci E., Kawachi I., Stampfer M. J., Willett W. C., Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Annals of Internal Medicine 1999 130 12 963 970 2-s2.0-0033564157 (Pubitemid 29283986)
98. Polidori M. C., Cherubini A., Stahl W., Senin U., Sies H., Mecocci P., Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome. Free Radical Research 2002 36 3 265 268 2-s2.0-0036521850 10.1080/10715760290019273 (Pubitemid 35154069)
99. Yuan J. P., Peng J., Yin K., Wang J. H., Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Molecular Nutrition and Food Research 2011 55 1 150 165 2-s2.0-78650923595 10.1002/mnfr.201000414
100. Martin H., Jäger C., Ruck C., Schmidt M., Walsh R., Paust J., Anti- and prooxidant properties of carotenoids. Advanced Synthesis and Catalysis 1999 341 3 302 308 2-s2.0-0347080294
101. Kishimoto Y., Tani M., Uto-Kondo H., Iizuka M., Saita E., Sone H., Kurata H., Kondo K., Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages. European Journal of Nutrition 2010 49 2 119 126 2-s2.0-77950867481 10.1007/s00394-009-0056-4
102. Guerin M., Huntley M. E., Olaizola M., Haematococcus astaxanthin: applications for human health and nutrition. Trends in Biotechnology 2003 21 5 210 216 2-s2.0-0037407158 10.1016/S0167-7799(03)00078-7 (Pubitemid 36515074)
103. Kurashige M., Okimasu E., Inoue M., Utsumi K., Inhibition of oxidative injury of biological membranes by astaxanthin. Physiological Chemistry and Physics and Medical NMR 1990 22 1 27 38 2-s2.0-0025579563
104. Naguib Y. M. A., Antioxidant activities of astaxanthin and related carotenoids. Journal of Agricultural and Food Chemistry 2000 48 4 1150 1154 2-s2.0-0034011558 10.1021/jf991106k (Pubitemid 30243677)
105. Li W., Hellsten A., Jacobsson L. S., Blomqvist H. M., Olsson A. G., Yuan X., Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits. Journal of Molecular and Cellular Cardiology 2004 37 5 969 978 2-s2.0-7444266395 10.1016/j.yjmcc. 2004.07.009 (Pubitemid 39446822)
106. Kishimoto Y., Tani M., Uto-Kondo H., Iizuka M., Saita E., Sone H., Kurata H., Kondo K., Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages. European Journal of Nutrition 2010 49 2 119 126 2-s2.0-77950867481 10.1007/s00394-009-0056-4
107. Pashkow F. J., Watumull D. G., Campbell C. L., Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. American Journal of Cardiology 2008 101 10 58D 68D 2-s2.0-43049167532 10.1016/j.amjcard.2008.02.010