Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 11, 2011, Pages 8174-8178

  Weigert, Günther ^a   Kaya, Semira ^a   Pemp, Berthold ^a   Sacu, Stefan ^a   Lasta, Michael ^a   Werkmeister, René Marcel ^b   Dragostinoff, Nikolaus ^b   Simader, Christian ^a   Garhöfer, Gerhard ^a   Schmidt Erfurth, Ursula ^a   Schmetterer, Leopold ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

LUTAMAX; PLACEBO; UNCLASSIFIED DRUG; VISUAL PIGMENT; XANTHOPHYLL;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INTRAOCULAR PRESSURE; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; OPTICAL DENSITY; PERIMETRY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REFLECTOMETRY; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; SLIT LAMP; STAGING; VISION; VISUAL ACUITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; HEART RATE; METABOLISM; OPTICAL COHERENCE TOMOGRAPHY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA; RETINA MACULA DEGENERATION;

AGED; BLOOD PRESSURE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HEART RATE; HUMANS; INTRAOCULAR PRESSURE; LUTEIN; MACULAR DEGENERATION; MALE; RETINA; RETINAL PIGMENTS; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY; VISUAL FIELD TESTS;

EID: 84855379337     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7522     Document Type: Article

References (37)

1. Klein R, Peto T, Bird A, Vannewkirk MR. The epidemiology of age-related macular degeneration. Am J Ophthalmol. 2004;137: 486-495.
2. Klein R. Overview of progress in the epidemiology of age-related macular degeneration. Ophthalmic Epidemiol. 2007;14:184-187.
3. Jager RD, Mieler WF, Miller JW. Age-related macular degeneration. N Engl J Med. 2008;358:2606-2617.
4. Boltz A, Luksch A, Wimpissinger B, et al. Choroidal blood flow and progression of age-related macular degeneration in the fellow eye in patients with unilateral choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:4220-4225.
5. Ding X, Patel M, Chan CC. Molecular pathology of age-related macular degeneration. Prog Retin Eye Res. 2009;28:1-18.
6. Zeitz O, Berna-Thill M, Bartsch U, Strauss O, Richard G. Oxidative stress at the retinal pigment epithelium: experimental implications for protection (in German). Klin Monbl Augenheilkd. 2009;226: 27-30.
7. Bartlett H, Howells O, Eperjesi F. The role of macular pigment assessment in clinical practice: a review. Clin Exp Optom. 2010; 93:300-308.
8. Moeller SM, Parekh N, Tinker L, et al. CAREDS Research Study Group. Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Agerelated Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative. Arch Ophthalmol. 2006;124:1151-1162.
9. Age-Related Eye Disease Study Research Group, SanGiovanni JP, Chew EY, Clemons TE, et al. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007;125:1225-1232.
10. Tan AG, Mitchell P, Burlutsky G, Rochtchina E, Kanthan G, Islam FM, Wang JJ. Retinal vessel caliber and the long-term incidence of age-related cataract: the Blue Mountains Eye Study. Ophthalmology. 2008;115:1693-1698.
11. LaRowe TL, Mares JA, Snodderly DM, Klein ML, Wooten BR, Chappell R. CAREDS Macular Pigment Study Group. Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study: an ancillary study of the women's health initiative. Ophthalmology. 2008;115:876-883.
12. Gellermann W, Bernstein PS. Noninvasive detection of macular pigments in the human eye. J Biomed Opt. 2004;9:75-85.
13. Hammond BR Jr, Johnson EJ, Russell RM, et al. Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci. 1997;38:1795-1801.
14. Richer S, Stiles W, Statkute L, et al. Double-masked, placebocontrolled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004;75:216-230.
15. Schalch W, Cohn W, Barker FM, et al. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin: the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Arch Biochem Biophys. 2007;458:128-135.
16. Bone RA, Landrum JT. Dose-dependent response of serum lutein and macular pigment optical density to supplementation with lutein esters. Arch Biochem Biophys. 2010;504:50-55.
17. van der Veen RL, Berendschot TT, Makridaki M, Hendrikse F, Carden D, Murray IJ. Correspondence between retinal reflectometry and a flicker-based technique in the measurement of macular pigment spatial profiles. J Biomed Opt. 2009;14:064046.
18. Trieschmann M, Beatty S, Nolan JM, et al. Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study. Exp Eye Res. 2007;84:718-728.
19. Berendschot TT, Willemse-Assink JJ, Bastiaanse M, de Jong PT, van Norren D. Macular pigment and melanin in age-related maculopathy in a general population. Invest Ophthalmol Vis Sci. 2002;43: 1928-1932.
20. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C, E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119:1417-1436.
21. Berendschot TT, Goldbohm RA, Klöpping WA, van de Kraats J, van Norel J, van Norren D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Ophthalmol Vis Sci. 2000;41(11):3322-3326.
22. Zagers NP, van de Kraats J, Berendschot TT, van Norren D. Simultaneous measurement of foveal spectral reflectance and conephotoreceptor directionality. Appl Opt. 2002;41:4686-4696.
23. Springer C, Bültmann S, Völcker HE, Rohrschneider K. Fundus perimetry with the Micro Perimeter 1 in normal individuals: comparison with conventional threshold perimetry. Ophthalmology. 2005;112:848-854.
24. Prager F, Michels S, Simader C, Geitzenauer W, Schmidt-Erfurth U. Changes in retinal sensitivity in patients with neovascular agerelated macular degeneration after systemic bevacizumab (avastin) therapy. Retina. 2008;28:682-688.
25. Bartlett HE, Eperjesi F. A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. Clin Nutr. 2008;27:218-227.
26. Ma L, Lin XM, Zou ZY, Xu XR, Li Y, Xu R. A 12-week lutein supplementation improves visual function in Chinese people with long-term computer display light exposure. Br J Nutr. 2009;102: 186-190.
27. Beatty S, Murray IJ, Henson DB, Carden D, Koh H, Boulton ME. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest Ophthalmol Vis Sci. 2001;42:439-446.
28. Bernstein PS, Zhao DY, Wintch SW, Ermakov IV, McClane RW, Gellermann W. Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients. Ophthalmology. 2002;109:1780-1787.
29. Jahn C, Wüstemeyer H, Brinkmann C, Trautmann S, Mössner A, Wolf S. Macular pigment density in age-related maculopathy. Graefes Arch Clin Exp Ophthalmol. 2005;243:222-227.
30. Ciulla TA, Hammond BR Jr. Macular pigment density and aging, assessed in the normal elderly and those with cataracts and agerelated macular degeneration. Am J Ophthalmol. 2004;138:582-587.
31. Nolan JM, Stack J, O' Donovan O, Loane E, Beatty S. Risk factors for age-related maculopathy are associated with a relative lack of macular pigment. Exp Eye Res. 2007;84:61-74.
32. Wooten BR, Hammond BR. Macular pigment: influences on visual acuity and visibility. Prog Retin Eye Res. 2002;21:225-240.
33. Falsini B, Piccardi M, Iarossi G, Fadda A, Merendino E, Valentini P. Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment. Ophthalmology. 2003;110:51-60.
34. Parisi V, Tedeschi M, Gallinaro G, Varano M, Saviano S, Piermarocchi S. CARMIS Study Group. Carotenoids and antioxidants in agerelated maculopathy italian study: multifocal electroretinogram modifications after 1 year. Ophthalmology. 2008;115:324-333.
35. Alves-Rodrigues A, Shao A. The science behind lutein. Toxicol Lett. 2004;150:57-83.
36. Hammond BR Jr, Wooten BR, Smollon B. Assessment of the validity of in vivo methods of measuring human macular pigment optical density. Optom Vis Sci. 2005;82:387-404.
37. Li B, Vachali P, Bernstein PS. Human ocular carotenoid-binding proteins. Photochem Photobiol Sci. 2010;9:1418-1425.