Inhibitor versus chaperone behaviour of D-fagomine, DAB and LAB sp2-iminosugar conjugates against glycosidases: A structure–activity relationship study in Gaucher fibroblasts

European Journal of Medicinal Chemistry

Volumn 121, Issue , 2016, Pages 880-891

  Mena Barragán, Teresa ^a   García Moreno, M Isabel ^a   Nanba, Eiji ^b   Higaki, Katsumi ^b   Concia, Alda Lisa ^c   Clapés, Pere ^c   García Fernández, José Manuel ^d   Ortiz Mellet, Carmen ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b TOTTORI UNIVERSITY   (Japan)

^c INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^d INSTITUTO DE INVESTIGACIONES QUÍMICAS   (Spain)

Author keywords

D Fagomine; Gaucher disease; Glycosidase inhibitor; Iminosugar; Pharmacological chaperone; Pyrrolidine

Indexed keywords

(N' BUTYLIMINOMETHYLIDENE) 1,4 DIDEOXY 1,4 IMINO 5 THIO DEXTRO ARABINITOL; (N' BUTYLIMINOMETHYLIDENE) 1,4 DIDEOXY 1,4 IMINO 5 THIO LEVO ARABINITOL; (N' BUTYLIMINOMETHYLIDENE) 6 THIO DEXTRO FAGOMINE; (N' OCTYLIMINOMETHYLIDENE) 6 THIO DEXTRO FAGOMINE; 1,4 DIDEOXY 1,4 IMINO (N' OCTYLIMINOMETHYLIDENE) 5 THIO DEXTRO ARABINITOL; 1,4 DIDEOXY 1,4 IMINO (N' OCTYLIMINOMETHYLIDENE) 5 THIO LEVO ARABINITOL; 1,4 DIDEOXY 1,4 IMINO DEXTRO ARABINITOL; 1,4 DIDEOXY 1,4 IMINO LEVO ARABINITOL; BETA GLUCOSIDASE; CHAPERONE; FAGOMINE; GLUCOSYLCERAMIDASE; GLYCOSIDASE INHIBITOR; IMINOSUGAR; N (N' BUTYLTHIOCARBAMOYL) 1,4 DIDEOXY 1,4 IMINO DEXTRO ARABINITOL; N (N' BUTYLTHIOCARBAMOYL) 1,4 DIDEOXY 1,4 IMINO LEVO ARABINITOL; N (N' BUTYLTHIOCARBAMOYL) DEXTRO FAGOMINE; N (N' HYDROXYTHIOCARBAMOYL) DEXTRO FAGOMINE; N (N' OCTYLTHIOCARBAMOYL) 1,4 DIDEOXY 1,4 IMINO DEXTRO ARABINITOL; N (N' OCTYLTHIOCARBAMOYL) 1,4 DIDEOXY 1,4 IMINO LEVO ARABINITOL; N (N' OCTYTHIOCARBAMOYL) DEXTRO FAGOMINE; N [N' (16 ACETOXYHEXADECYL)THIOCARBAMOYL] 1,4 DIDEOXY 1,4 IMINO DEXTRO ARABINITOL; N [N' (16 ACETOXYHEXADECYL)THIOCARBAMOYL] 1,4 DIDEOXY 1,4 IMINO LEVO ARABINITOL; N [N' (16 ACETOXYHEXADECYL)THIOCARBAMOYL] DEXTRO FAGOMINE; N [N' (16 HYDROXYHEXADECYL)IMINOMETHYLIDENE] 1,4 DIDEOXY 1,4 IMINO 5 THIO DEXTRO ARABINITOL; N [N' (16 HYDROXYHEXADECYL)IMINOMETHYLIDENE] 1,4 DIDEOXY 1,4 IMINO 5 THIO LEVO ARABINITOL; N [N' (16 HYDROXYHEXADECYL)IMINOMETHYLIDENE] 6 THIO DEXTRO FAGOMINE; N [N' (16 HYDROXYHEXADECYL)THIOCARBAMOYL] 1,4 DIDEOXY 1,4 IMINO DEXTRO ARABINITOL; N [N' (16 HYDROXYHEXADECYL)THIOCARBAMOYL] 1,4 DIDEOXY 1,4 IMINO LEVO ARABINITOL; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; GLYCOSIDASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; FIBROBLAST; GAUCHER DISEASE; HUMAN; HUMAN CELL; IC50; INHIBITION CONSTANT; NONHUMAN; NUCLEOPHILICITY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; PATHOLOGY;

ENZYME INHIBITORS; FIBROBLASTS; GAUCHER DISEASE; GLYCOSIDE HYDROLASES; HUMANS; IMINO PYRANOSES; IMINO SUGARS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84940984969     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.08.038     Document Type: Article

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