Conformationally-locked N -glycosides with selective β-glucosidase inhibitory activity: Identification of a new non-iminosugar-type pharmacological chaperone for gaucher disease

Journal of Medicinal Chemistry

Volumn 55, Issue 15, 2012, Pages 6857-6865

  Castilla, Javier ^a   Rísquez, Rocío ^b   Cruz, Deysi ^a   Higaki, Katsumi ^c   Nanba, Eiji ^c   Ohno, Kousaku ^c   Suzuki, Yoshiyuki ^d   Díaz, Yolanda ^a   Mellet, Carmen Ortiz ^b   Fernández, José M García ^e   Castillón, Sergio ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

^c TOTTORI UNIVERSITY   (Japan)

^d INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^e INSTITUTO DE INVESTIGACIONES QUÍMICAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D](16 HYDOXYHEXADECYL) 1,3 OXAZOLINE; 1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D][6 (1 ADAMANTANECARBOXAMIDO)HEXYL]SULFANYL 1,3 OXAZOLINE; 1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D]ALLYLSULFANYL 1,3 OXAZOLINE; 1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D]BENZYLSULFANYL 1,3 OXAZOLINE; 1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D]BUTYLSULFANYL 1,3 OXAZOLINE; 1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D]DODECYLSULFANYL 1,3 OXAZOLINE; 1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D]HEPTYLSULFANYL 1,3 OXAZOLINE; 1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D]HEXADECYLSULFANYL 1,3 OXAZOLINE; 1,2 DIDEOXY ALPHA DEXTRO GLUCOPYRANOSIDE[1,2 D]OCTYLSULFANYL 1,3 OXAZOLINE; AMBROXOL; BETA GLUCOSIDASE; ENZYME INHIBITOR; GLUCOSYLCERAMIDASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; GAUCHER DISEASE; HUMAN; HUMAN CELL; PROTEIN CONFORMATION; SUBSTITUTION REACTION;

CELLS, CULTURED; FIBROBLASTS; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; GLYCOSIDES; HUMANS; MOLECULAR CONFORMATION; MUTATION; OXAZOLES; SKIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIONES;

EID: 84864914271     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3006178     Document Type: Article

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