Synthesis, inhibition properties, and theoretical study of the new nanomolar trehalase inhibitor 1-thiatrehazolin: Towards a structural understanding of trehazolin inhibition

ChemBioChem

Volumn 6, Issue 1, 2005, Pages 186-191

  Chiara, Jose Luis ^a   De Gracia, Isabel Storch ^a   García, Ángela ^a   Bastida, Ágatha ^a   Bobo, Sofía ^a   Martín Ortega, María D ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

Ab initio calculations; Cyclitols; Glycosidases; Inhibitors; Sulfur heterocycles

Indexed keywords

1 THIATREHAZOLIN; CARBOHYDRATE; CYCLITOL DERIVATIVE; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; HETEROCYCLIC COMPOUND; KETONE; OXIME; THIAZOLE DERIVATIVE; THIAZOLINE DERIVATIVE; TREHALASE; TREHALASE INHIBITOR; TREHAZOLIN; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; MODEL; NUCLEOPHILIC DISPLACEMENT REACTION; PRECURSOR; PRIORITY JOURNAL; REDUCTIVE CARBOCYCLIZATION REACTION; STEREOCHEMISTRY; SYNTHESIS;

ANIMALS; DISACCHARIDES; ENZYME INHIBITORS; KIDNEY; MODELS, THEORETICAL; MONOSACCHARIDES; SWINE; TREHALASE;

EID: 12344319451     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200400231     Document Type: Article

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